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Recent Longevity News for the seven days ending
11/21/12. You should consult your doctor if you are taking any
In People with Hand
Osteoarthritis, Chondroitin Sulphate Therapy for 6 Months Improves Pain and
Function Compared With Placebo - Medscape, 11/20/12 -
"Osteoarthritis of the
finger joints is present in about 10% of individuals aged 40 to 49, rising to
92% in individuals over 70 years of age ... Patients were of either sex, aged 40
years and older and given 800 mg of
chondroitin sulphate as a single tablet each
day or placebo for a total period of 6 months. The chondroitin preparation
contained highly purified chondroitins 4 and 6 sulphate of fish origin ...
Improvement in the patient's assessment of global hand pain on the VAS was
significantly more pronounced in the chondroitin sulphate group than in the
placebo group. The decrease in the FIHOA score demonstrated similar pattern. The
relative benefit of chondroitin sulphate on both primary end points became
evident only after 3 months of treatment. No serious adverse reaction occurred
in any study patients" - See
chondroitin sulfate at Amazon.com.
Vitamin D levels in pregnancy may protect mother more than baby against multiple
sclerosis - Science Daily, 11/19/12 - "scientists
reviewed information about 291,500 blood samples from 164,000 people collected
since 1975 in the northern half of Sweden ... women who had high levels of
vitamin D in their blood had a 61 percent lower
risk of developing MS, compared to those who had low
levels of vitamin D in their blood ... No association was found between the
mother's vitamin D level and whether her child would later develop MS ... our
study suggests the protective effect may start in later
pregnancy and beyond" - See
vitamin D at Amazon.com.
medication addiction reaching epidemic level - Science Daily, 11/19/12 -
"In 2011, hydrocodone was the most prescribed drug in
America ... This is really a state problem or even a national problem"
jobs linked to increased breast cancer risk - Science Daily, 11/19/12 -
"across all sectors, women in jobs with potentially high
exposures to carcinogens and
endocrine disrupters had an elevated
breast cancer risk. Sectors with increased risk
included agriculture, bar/gambling, automotive plastics manufacturing, food
canning and metal-working. Importantly, premenopausal breast cancer risk was
highest in the automotive plastics and food canning industries"
The 10 Germiest Places in a Restaurant Hint: Bathroom Isn't No. 1 - ABC
News, 11/16/12 - "Seats ... Menus ... Lemon Wedges ...
Salt and Pepper Shakers ... Tables ... Rims of Glasses ... Bathroom Door Knobs
... Bathroom Faucets ... Ketchup Bottles ... Salad Bar Tongs"
suffers when mother lacks vitamin C - Science Daily, 11/16/12 -
"Maternal vitamin C
pregnancy can have serious consequences for
the fetal brain. And once brain damage has occurred, it cannot be reversed by
vitamin C supplements after birth ... Even marginal vitamin C deficiency in the
mother stunts the fetal hippocampus, the important memory centre, by 10-15 per
cent, preventing the brain from optimal development"
- See vitamin C at Amazon.com.
more fish could reduce postpartum depression - Science Daily, 11/15/12 -
"Low levels of omega-3
may be behind postpartum depression ...
Because omega-3 is transferred from the mother to her fetus and later to her
breastfeeding infant, maternal omega-3 levels decrease during pregnancy, and
remain lowered for at least six-weeks following the birth" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
D deficiency linked to type 1 diabetes - Science Daily, 11/15/12 -
"The six-year study of blood levels of nearly 2,000
individuals suggests a preventive role for vitamin
D3 in this disease ... This study used samples from millions of blood serum
specimens frozen by the Department of Defense Serum Registry for disease
surveillance ... Based mainly on results of this study, Garland estimates that
the level of 25(OH)D needed to prevent half the cases of type 1
diabetes is 50 ng/ml ... While there are a few
conditions that influence vitamin D metabolism, for most people, 4000 IU per day
of vitamin D3 will be needed to achieve the effective levels" - See
vitamin D at Amazon.com.
and proline enriched diet may speed wound healing in diabetes - Science
Daily, 11/15/12 - "Researchers divided 18 rats into
three groups that were either fed a standard diet, a high-protein diet, or a
high protein diet supplemented with arginine
and proline (ARG+PRO) ... Rats on both high protein diets had better nitrogen
balance than those on the standard diet. However, the wounds of the rats on the
ARG+PRO diet showed more new blood vessel growth on day 5. New blood vessel
growth is an essential part of
wound healing as the blood vessels supply
nutrition and oxygen to growing tissue ... arginine and proline supplementation
could offer new hope for effective treatment in
diabetic patients with
chronic wounds" - See
L-arginine products at Amazon.com and
proline at Amazon.com.
birth effect: Give pregnant women vitamin D supplements to ward off multiple
sclerosis, say researchers - Science Daily, 11/14/12 -
"The risk of developing multiple
sclerosis (MS) is highest in the month of April, and lowest in October ...
there is now a strong case for vitamin D
supplementation of pregnant women in countries
where ultraviolet light levels are low between October and March ... The
analysis indicated a significant excess risk of 5% among those born in April
compared with what would be expected. Similarly, the risk of MS was 5 to 7%
lower among those born between October and November, the data indicated"
vitamin D at Amazon.com.
Tablets – especially iPads – offer reading magic to people with vision loss
- The Daily, 11/14/12 - "All of the subjects gained at
least 42 words per minute using the iPad 2 on the 18-point font setting. Kindles
set to the same font produced gains of at least 12 words a minute"
Common Chemicals Affecting Your Fertility? - WebMD, 11/14/12 -
"These chemicals, called persistent organochlorine
pollutants, may persist in the environment for
decades. Some, such as persistent lipophilic organochlorine pollutants,
accumulate in fatty tissues in animals, while perfluorochemicals or PFCs are
used in clothing, furniture, adhesives, food packaging, nonstick cooking
surfaces, and electrical wire insulation ... The new study shows that men and
women with high levels of these chemicals in their blood took
longer to conceive than couples with lower
affects distance men keep from unknown women they find attractive: Oxytocin may
promote fidelity - Science Daily, 11/13/12 - "Men in
committed relationships choose to keep a greater distance between themselves and
an unknown woman they find attractive when given the hormone
oxytocin ... The findings suggest oxytocin may
help promote fidelity within monogamous relationships ... men in committed
relationships who were given oxytocin kept a greater distance when approaching
or being approached by an unknown woman they found attractive compared with
those given a placebo. In contrast, oxytocin had no effect on single men"
Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems
‘It’s a crisis for Quebec women’ - montrealgazette.com, 11/13/12 -
"Gilbert says there are days she can’t face going into
work at the Royal Victoria Hospital, a renowned cancer centre in gynecology, and
dealing with crying patients. “Put yourself in their place. … I have difficulty
making eye contact with patients. I am ashamed to be in such a situation."
D may prevent clogged arteries in diabetics - Science Daily, 11/13/12 -
"blood vessels are less like to clog in people with
diabetes who get adequate vitamin D. But in patients with insufficient vitamin
D, immune cells bind to blood vessels near the heart, then trap cholesterol to
block those blood vessels ... in diabetes patients with low vitamin D -- less
than 30 nanograms per milliliter of blood -- the macrophage cells were more
likely to adhere to the walls of blood vessels, which triggers cells to get
loaded with cholesterol, eventually causing the vessels to stiffen and block
blood flow ... We looked at blood pressure, cholesterol, diabetes control, body
weight and race. But only vitamin D levels correlated to whether these cells
stuck to the blood vessel wall" - See
vitamin D at Amazon.com.
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
Multivitamins in the prevention of cancer in men: the Physicians' Health Study
II randomized controlled trial - JAMA. 2012 Nov 14;308(18):1871-80 -
"A large-scale, randomized, double-blind, placebo
controlled trial (Physicians" Health Study II) of 14 641 male US physicians
initially aged 50 years or older (mean [SD] age, 64.3 [9.2] years), including
1312 men with a history of cancer at randomization, enrolled in a common
multivitamin study that began in 1997 with treatment and follow-up through June
1, 2011 ... In this large prevention trial of male physicians, daily
multivitamin supplementation modestly but significantly reduced the risk of
total cancer" - I think this was the following which I published last
Multivitamins Cut Cancer Risk in Men, Study Finds - ABC News, 10/17/12 -
"a new study of almost 15,000 men over 50 suggests
popping that daily supplement could cut cancer rates by 8 percent ... It's
unclear whether the results apply to women or men under 50 ... First, the new
study randomly assigned men to two groups, one of which took a daily Centrum
Silver® while the other took a placebo pill ... Second, it followed the men, who
were 65 years old on average, over 11 years – a longer follow-up than previous
studies and sufficient time for cancer to develop ...Other trials have tested a
single vitamin such as calcium or vitamin A, E or D in large doses, which is
very different from how people normally get the vitamins and minerals they need
from food" - Yeah but I wouldn't call Centrum Silver a top of the line
Click here and click on "Product Labeling" for ingredients. Some
examples; it's only has the synthetic dl-Alpha Tocopheryl Acetate form of
vitamin E plus there are 8 forms of that vitamin. There are over 600
carotenoids and some claim taking just one of those can cause a deficiency of
the others, etc. See
Garden of Life, Vitamin Code, 50 & Wiser Men at Amazon.com
Garden of Life, Vitamin Code, 50 & Wiser Women at Amazon.com.
proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal
muscle of low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced
diabetic rats - Mol Nutr Food Res. 2012 Nov 17 -
"Although ER stress in pancreas, liver, and adipose tissue was reported to be a
novel event linked to the pathogenesis of type 2
diabetes mellitus, there is much less information on this event in skeletal
muscle ... This study focuses on the effects of a strong antioxidant,
grape seed proanthocyanidin extracts (GSPE),
on skeletal muscle in diabetic rats induced with low dose streptozotocin- and a
high-carbohydrate/high-fat diet. After 16 wk of GSPE treatment, diabetic rats
showed decreased plasma glucose levels and insulin resistance ... These findings
suggest that GSPE may have auxiliary therapeutic potential for type 2 diabetes
mellitus by decreasing oxidative stress and ER stress in skeletal muscle"
- See Jarrow Formulas OPCs + 95 at Amazon.com.
Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in
Early Atherosclerosis Population - J Atheroscler Thromb. 2012 Nov 15 -
atherosclerosis patients (n= 65) were randomized to receive placebo (A+P, n=
31) or 20 mg/d lutein (A+L, n= 34) for 3
months ... An increase in serum lutein after supplementation can reduce
inflammatory cytokines and regulate serum lipids, which may pay important roles
in early atherosclerosis" - See
lutein at Amazon.com or
Jarrow Formulas, CarotenALL at Amazon.com
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
Note: There are over 600 carotenoids. I read at least one study that
claims that taking large doses of just one carotenoid can cause a deficiency of
and kidney stone risk in osteoporosis: a systematic literature review - Clin
Exp Rheumatol. 2012 Nov 6 - "According to our results,
calcium supplements in the treatment of
osteoporosis alone or in combination with another type of treatment does not
significantly increase the risk of
nephrolithiasis or renal colic"
growth, omega-3 (n-3) fatty acids, and progression of subclinical
atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in
Young Finns Study - Am J Clin Nutr. 2012 Nov 14 -
"Impaired fetal growth is independently
associated with an increased risk of cardiovascular events in adulthood ...
Dietary intake of omega-3 fatty acids is
associated with a slower rate of increase in carotid intima-media thickness in
those with impaired fetal growth" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
and caffeine-free beverages and risk of type 2 diabetes - Am J Clin Nutr.
2012 Nov 14 - "observed 74,749 women from the Nurses'
Health Study (NHS, 1984-2008) and 39,059 men from the Health Professionals
Follow-Up Study (HPFS, 1986-2008) ...
sugar-sweetened beverages (SSBs), and carbonated
artificially sweetened beverages (ASBs) ...
caffeinated and caffeine-free SSB intake was significantly associated with a
higher risk of T2D in the NHS (RR per serving:
13% for caffeinated SSB, 11% for caffeine-free
SSB; P < 0.05) and in the HPFS (RR per serving: 16% for caffeinated SSB, 23% for
caffeine-free SSB; P < 0.01). Only caffeine-free ASB intake in NHS participants
was associated with a higher risk of T2D (RR: 6% per serving; P < 0.001).
Conversely, the consumption of caffeinated and decaffeinated coffee was
associated with a lower risk of T2D [RR per serving: 8% for both caffeinated and
decaffeinated coffee in the NHS (P < 0.0001) and 4% for caffeinated and 7% for
decaffeinated coffee in the HPFS (P < 0.01)]. Only caffeinated tea was
associated with a lower T2D risk among NHS participants"
oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid
levels in the JCR:LA-cp rat, a model of the metabolic syndrome - Br J Nutr.
2012 Nov 15:1-9 - "These results suggest a potential
role for dietary fish oil to improve
dysfunctional renal eicosanoid metabolism associated with
kidney damage during conditions of the
MetS" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
affects survival and metabolism of human sperm - Mol Nutr Food Res. 2012
Nov;56(11):1655-64 - "estrogen receptor (ER) ... These
results provide a novel mechanism involving ERs through which low doses of
EGCG exerted benefits to
sperm physiology, also detected data evidence
the adverse action of high EGCG concentrations probably related to its
prooxidant and antiestrogenic potential"
green tea extract at Amazon.com.
effects of melatonin against oxidative injury in rat testis induced by wireless
(2.45 GHz) devices - Andrologia. 2012 Nov 12 - "In
conclusion, wireless (2.45 GHz) EMR caused oxidative damage in testis by
increasing the levels of lipid peroxidation and decreasing in vitamin A and E
levels. Melatonin supplementation prevented
oxidative damage induced by EMR and also supported the antioxidant redox system
in the testis" - See
melatonin at Amazon.com.
Health Focus (Melatonin):
News & Research:
Ups the Risk for Various Cancers in Men - Medscape, 10/31/12 -
"The study compared 3137 men with cancer and 512 matched
control subjects who completed a detailed questionnaire about occupational work
and lifestyle from 1979 to 1985 ... Compared with men who never worked at night,
men who worked night shifts had an increased risk for prostate cancer (odds
ratio [OR], 2.77), non-Hodgkin's lymphoma (OR, 2.31), pancreatic cancer (OR,
2.27), rectal cancer (OR, 2.09), colon cancer (OR, 2.03), bladder cancer (OR,
1.74), and lung cancer (OR, 1.76) ... "When I first proposed the light-at-night
hypothesis, it linked circadian disturbance to hormone disruption and breast
cancer," Dr. Stevens explained. Since then, circadian disruption has been linked
to many other adverse effects, it has been demonstrated that melatonin has a
direct effect on tumor growth, and some of the latest research he has been
involved with has shown that circadian disruption has an epigenetic impact"
Melatonin and exercise work against Alzheimer's in mice - Science Daily,
9/26/12 - "The mice were divided into one control group
and three other groups which would undergo different treatments: exercise
-unrestricted use of a running wheel-, melatonin -a dose equivalent to 10 mg per
kg of body weight-, and a combination of melatonin and voluntary physical
exercise ... After six months, the state of the mice undergoing treatment was
closer to that of the mice with no mutations than to their own initial
pathological state. From this we can say that the disease has significantly
regressed ... The results, which were published in the journal Neurobiology of
Aging, show a general improvement in behaviour, learning, and memory with the
three treatments ... These procedures also protected the brain tissue from
oxidative stress and provided good levels of protection from excesses of amyloid
beta peptide and hyperphosphorylated TAU protein caused by the mutations"
- Note: That's a huge amount of melatonin though but then on the other hand it
was a short six month period but on the third hand, mice have a much shorter
life span so it might interpolate to a much longer time span for humans.
from self-luminous tablet computers can affect evening melatonin, delaying sleep
- Science Daily, 8/27/12 - "To produce white light,
these electronic devices must emit light at short wavelengths, which makes them
potential sources for suppressing or delaying the onset of melatonin in the
evening, reducing sleep duration and disrupting sleep. This is particularly
worrisome in populations such as young adults and adolescents, who already tend
to be night owls ... Melatonin suppression after a one-hour exposure to the
tablet was not significantly affected. However, after a two-hour exposure there
was significant suppression"
Melatonin might help in controlling weight gain and preventing heart diseases
associated to obesity - Science Daily, 4/28/11 -
"melatonin -a natural hormone produced by the body- helps in controlling weight
gain -even without reducing the intake of food-, improves blood lipid profile
-as it reduces triglicerids-, increases HDL cholesterol and reduces LDL
cholesterol ... analyzed in young Zucker diabetic obese rats the effects of
melatonin on obesity, dyslipidemia and high blood pressure associated to
obesity. Melatonin was found to be beneficial for young rats that had not still
developed any methabolic or heart disease"
light before bedtime may impact sleep quality, blood pressure and diabetes risk
- Science Daily, 1/13/11 - "exposure to electrical light
between dusk and bedtime strongly suppresses melatonin levels and may impact
physiologic processes regulated by melatonin signaling, such as sleepiness,
thermoregulation, blood pressure and glucose homeostasis ... researchers
evaluated 116 healthy volunteers aged 18-30 years who were exposed to room light
or dim light in the eight hours preceding bedtime for five consecutive days. An
intravenous catheter was inserted into the forearms of study participants for
continuous collection of blood plasma every 30-60 minutes for melatonin
measurements. Results showed exposure to room light before bedtime shortened
melatonin duration by about 90 minutes when compared to dim light exposure.
Furthermore, exposure to room light during the usual hours of sleep suppressed
melatonin by greater than 50 percent"
light at night at night may lead to obesity, study finds - Science Daily,
10/11/10 - "mice exposed to a relatively dim light at
night over eight weeks had a body mass gain that was about 50 percent more than
other mice that lived in a standard light-dark cycle ... Something about light
at night was making the mice in our study want to eat at the wrong times to
properly metabolize their food ... So how does light at night lead to changes in
metabolism? The researchers believe the light could disrupt levels of the
hormone melatonin, which is involved in metabolism. In addition, it may disrupt
the expression of clock genes, which help control when animals feed and when
they are active"
Melatonin: The Fountain Of Youth? - Science Daily, 6/22/09 -
"Melatonin can slow down the effects of aging. A team at
laboratoire Arago in Banyuls sur Mer (CNRS / Université Pierre et Marie Curie)
has found that a treatment based on melatonin can delay the first signs of aging
in a small mammal ... studied the long-term effects of melatonin on the Greater
White-toothed shrew, a small nocturnal insectivorous mammal. Under normal
conditions, this animal shows the first signs of aging after reaching 12 months,
mainly through the loss of circadian rhythm in its activities. By continuously
administering melatonin, starting a little before 12 months, the appearance of
these first signs was delayed by at least 3 months, which is a considerable
period in relation to the lifespan of this shrew ... Melatonin is now known to
play several beneficial roles. These include being an antioxidant, an
anti-depressant, and helping to remediate sleep problems"
Melatonin Associated with Increased Risk of Breast Cancer in Postmenopausal
Women - Science Daily, 6/15/08 - "women with the
lowest levels of melatonin had a statistically significantly higher incidence of
breast cancer than those with the highest levels"
Night Shift Work May Cause Cancer - WebMD, 11/30/07 -
"They note that shift work may raise cancer risk by
suppressing production of melatonin, a chemical involved in the circadian
Melatonin Content Can Help Delay Aging, Mouse Study Suggests - Science
Daily, 4/24/07 - "Therefore, the researcher asserts,
daily melatonin intake in humans from the age of 30 or 40 could prevent – or, at
least, delay – illnesses related to aging, free radicals and inflammatory
processes, such as many neurodegenerative disorders (e.g. Parkinson's disease)
and complications linked to other illnesses, like diabetes"
Salivary Melatonin May Help Fight Gum Disease - Science Daily, 9/13/06 -
"the melatonin may fight against infection and
inflammation possibly due to its antioxidant, anti-aging and immunoenhancing
Grapes May Help With Sleep - WebMD, 6/19/06 -
"The juicy fruit might be packing melatonin, a sleep
Another Grape Excuse To Hit The Bottle - Science Daily, 6/16/06 -
"the grapes used to make some of the most popular
red wines contain high levels of the sleep hormone melatonin"
Melatonin Improves Mood In Winter Depression - Science Daily, 5/2/06 -
"melatonin, a naturally occurring brain substance,
can relieve the doldrums of winter depression, also known as seasonal
affective disorder, or SAD"
Melatonin Most Effective For Sleep When Taken For Off-hour Sleeping -
Science Daily, 5/1/06 - "sleep efficiency during the
six hour, 40 minute episodes was significantly higher in the groups that
took melatonin during times when the body was not producing melatonin. At
those times, participants taking 5.0mg of melatonin had a sleep efficiency
of 83 percent and those taking 0.3mg melatonin had a sleep efficiency of 84
Melatonin may cut hypertension - Nutra USA, 2/2/06 -
"A 10 per cent decline of BP over daytime values is
considered appropriate to reduce the cardiovascular risk ... During placebo
use only 39 per cent of the subjects reached this value, but this rate
surged to 84 per cent during melatonin administration"
Study Demonstrates Role Of Exercise In Modifying Melatonin Levels; Increase
Believed To Offer Breast Cancer Protection - Science Daily, 12/3/05
Stopping Jet Lag Before It Starts - WebMD, 11/2/05 -
"The body clocks of those who took melatonin adapted
better to the new schedule. The higher dose of melatonin fared best in that
regard, but not by much. Plus, people who took the higher dose were sleepier
in the evenings after taking the pill"
Travelers Can Avoid Jet Lag By Resetting Their Body Clocks - Science
Melatonin to Fight Insomnia: Timing Is Key - WebMD, 10/25/05 -
"melatonin was most effective in resetting the
body's internal, or circadian, clock when it was timed to the individual's
sleep patterns ... If you only want to induce sleep you can take it about
two hours before you want to go to sleep"
Melatonin May Reduce the Pain of Irritable Bowel Syndrome - Medscape,
10/14/05 - "Use of 3 mg of melatonin once daily for
two weeks in IBS patients is associated with
improvement in bowel pain and rectal distension thresholds for urgency and
pain but not with a change in stool frequency, type, or quality of life"
Popular Supplement Melatonin Found To Have Broader Effects In Brain Than
Once Thought - Science Daily, 2/11/05 -
"In experiments on the Japanese quail, the
researchers found that melatonin switches on a recently discovered hormone
called gonadotropin inhibitory hormone (GnIH), which has been found to have
the opposite effect to the key hormone priming the body for sex –
gonadotropin releasing hormone (GnRH). In birds, switching off GnRH causes
the gonads – testes and ovary – to shrink as part of the birds' yearly
U.S. Study Sees Little Benefit From Melatonin - HealthDay, 12/22/04 -
"The one area where melatonin did seem to work was
with a group of people with a condition called "delayed sleep phase
syndrome," which means that otherwise healthy people have a biological quirk
that prevents a normal sleep cycle"
- Melatonin Decreases
Migraine Frequency and Intensity
- Medscape, 9/9/04 -
"Of 32 patients who completed the study, 25 patients
(78.1%) had at least a 50% reduction in headache frequency from baseline,
eight patients (25%) had no headaches, and none of the patients had
increased headaches after three months of therapy"
Nightime Melatonin Supplementation May Be Useful in the Treatment of
Essential Hypertension - Doctor's Guide, 2/4/04 -
"2.5 mg/day ... mean sleep systolic blood pressure
decreased by 6 mm Hg and mean sleep diastolic
decreased by 4 mm Hg ... Repeated melatonin significantly increased sleep
efficiency from 80% to 85% and increased actual sleep time from 5.6 to 6.1
hours. Melatonin therapy also reduced sleep latency from 33 to 22 minutes"
- Jet Lag Hormone
Lowers Blood Pressure - WebMD, 1/20/04
Melatonin May Cut Hypertension Risk - HealthDay, 1/19/04 -
"The men were randomly assigned to receive either a
placebo, a single dose of melatonin or 2.5 milligrams of melatonin one hour
before bedtime for three weeks ... those taking the hormone each night
throughout the three weeks had lower nighttime systolic and diastolic
blood pressure. Systolic blood pressure (the top number in the reading)
decreased by an average of six millimeters of mercury while the diastolic
blood pressure (the bottom number) decreased by an average of four
millimeters of mercury" - See
melatonin at Amazon.com.
Prolonged Release : In the Treatment of Insomnia in Patients Aged ≥55 years
- Drugs Aging. 2012 Oct 9 - "Melatonin prolonged release
(PR) 2 mg is approved for the treatment of primary insomnia characterized by
poor sleep quality in patients aged ≥55 years in the EU and elsewhere ...
Administration of melatonin PR 2 mg 1-2 h before bedtime mimics the natural
secretion pattern of melatonin, thereby leading to improvements in the circadian
regulation of the sleep-wake cycle. In older adults, melatonin PR 2 mg had no
effect on psychomotor functions, memory recall or driving skills during the
night or the next morning relative to placebo, and was associated with
significantly less impairment on many of these tasks relative to zolpidem 10 mg
alone or in combination with melatonin PR 2 mg. In 3-week and 6-month,
randomized, double-blind clinical trials in patients with primary insomnia aged
≥55 years, melatonin PR 2 mg 1-2 h before bedtime was associated with
significant improvements relative to placebo in many sleep and daytime
parameters, including sleep quality and latency, morning alertness and
health-related quality of life. Melatonin PR 2 mg was very well tolerated in
clinical trials in older patients, with a tolerability profile that was similar
to that of placebo. Short- or longer-term treatment with melatonin PR 2 mg was
not associated with dependence, tolerance, rebound insomnia or withdrawal
symptoms" - See Source
Naturals, Melatonin, Peppermint Flavored Sublingual, 2.5 mg, 240 Tablets.
prevents testicular damage in hyperlipidaemic mice - Andrologia. 2012 Jan 20
- "Hyperlipidaemia was induced in ApoE-knockout C57BL/6J
male mice fed with high-fat diet alone (group A), or with high-fat diet and
melatonin (group B) ... The results suggest that melatonin may be potential to
attenuate testicular damage by improving histopathological changes and reducing
germ cell apoptosis in hyperlipidaemic mice"
improves the restoration of endothelium-derived constricting factor signalling
and inner diameter in the rat femoral artery after cessation of L-NAME treatment
- J Hypertens. 2010 Sep;28 Suppl 1:S19-2 - "Although
melatonin did not accelerate blood pressure reduction, it attenuated
EDCF-contractions and oxidative load and enlarged arterial diameter. These
effects may be beneficial for cardiovascular protection"
light and L-NAME-induced left ventricular remodelling: different protection with
melatonin and captopril - J Hypertens. 2010 Sep;28 Suppl 1:S13-8 -
"In hypertension induced by a combination of
continuous light and L-NAME treatment, melatonin and captopril protect the heart
against pathological left ventricular remodelling differently"
hypertrophy and remodelling: pathophysiological consequences and protective
effects of melatonin - J Hypertens. 2010 Sep;28 Suppl 1:S7-12 -
"Whereas melatonin did not reduce left ventricular
hypertrophy in spontaneously hypertensive rats or in nitric oxide-deficient
hypertension, it did have other beneficial effects, e.g. it curtailed
oxidative damage to the heart that resulted in an attenuation of left
ventricular fibrosis. In contrast to the findings in hypertensive rats,
melatonin administration was effective in overcoming cardiac enlargement
resulting from induced hyperthyroidism or chronic hypoxia exposure. In
addition, in these situations, melatonin also conferred protection against
free radical-mediated damage at the level of cardiomyocytes. Collectively,
the results of the publications summarized herein along with numerous other
published reports on other aspects of cardiovascular physiology indicate
that, when damage to the heart is a result of free radicals, melatonin is
clearly protective. This is not unexpected considering the now well
documented potent antioxidative actions of both melatonin and its
metabolites. In general, melatonin improves cardiovascular physiology and
melatonin and risk of incident hypertension among young women J
Hypertens. 2010 Jan 19 - "During 8 years of
follow-up, a total of 125 women developed hypertension. The relative risk
for incident hypertension among women in the highest quartile of urinary
melatonin (>27.0 ng/mg creatinine) as compared with the lowest quartile
(<10.1 ng/mg creatinine) was 0.49 (95% confidence interval 0.28-0.85, P <
0.001). CONCLUSION: First morning melatonin levels are independently and
inversely associated with incident hypertension; low melatonin production
may be a pathophysiologic factor in the development of hypertension"
Melatonin Treatment for Insomnia in Pediatric Patients with
Attention-Deficit/Hyperactivity Disorder (January) - Ann Pharmacother.
2009 Dec 22 - "Available data suggest that melatonin
is a well-tolerated and efficacious treatment option for pediatric patients
with chronic SOI and ADHD"
correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses'
Health Study cohorts2 - Am J Clin Nutr. 2009 Aug 12 -
"In multivariate analyses, we found no significant
associations between the intake of various nutrients, including tryptophan
and urinary melatonin concentrations. A higher intake of meat, particularly
red meat, was associated with lower concentrations of aMT6s (adjusted mean
concentrations of aMT6s across increasing quartiles of red meat intake were
17.9, 17.0, 18.1, and 15.3 ng/mg creatinine; P for trend = 0.02). In
contrast, neither intake of poultry (including turkey) nor fish was
associated with aMT6s concentrations ... Although no specific nutrients were
associated with altered concentrations of melatonin, our findings raise the
possibility that several specific foods, including red meat, could affect
cancer risk through the lowering of melatonin concentrations"
circadian melatonin rhythm and its modulation: possible impact on
hypertension - J Hypertens. 2009 Aug;27 Suppl 6:S17-20 -
"The chronic administration of melatonin to
individuals with hypertension induces a measurable drop in night time
systolic and diastolic blood pressure. Moreover, the higher the night time
level of endogenous melatonin (estimated from urinary metabolite of
melatonin, 6-hydroxymelatonin sulphate), the greater the reduction in
arterial blood pressure at night. The implication of these findings is that
melatonin may have utility as an antihypertensive agent"
of melatonin, captopril, spironolactone and simvastatin on blood pressure
and left ventricular remodelling in spontaneously hypertensive rats - J
Hypertens. 2009 Aug;27 Suppl 6:S5-10 - "It is
concluded that although melatonin, in comparison with captopril, did not
reverse left ventricle hypertrophy, it reversed left ventricular fibrosis.
This protection by melatonin may be caused by its prominent antioxidative
melatonin levels and postmenopausal breast cancer risk in the nurses' health
study cohort - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9 -
"An increased concentration of urinary aMT6s was
statistically significantly associated with a lower risk of breast cancer
(odds ratio for the highest versus lowest quartile of morning urinary aMT6s,
0.62 ... Results from this prospective study add substantially to the
growing literature that supports an inverse association between melatonin
levels and breast cancer risk"
Endocrine regulation of the course of menopause by oral melatonin: first
case report - Menopause. 2007 Nov 8 - "The data
obtained in this case report show that melatonin administration was able to
delay the characteristic endocrine changes that occur during the course of
Night Shift Work and the Risk of Endometrial Cancer - Cancer Res. 2007
Nov 1;67(21):10618-10622 - "Women who worked 20+
years of rotating night shifts had a significantly increased risk of
endometrial cancer [MVRR, 1.47 ... obese women working rotating night shifts
doubled their baseline risk of endometrial cancer (MVRR, 2.09; 95% CI,
1.24-3.52) compared with obese women who did no night work ... Women working
rotating night shifts for a long duration have a significantly increased
risk of endometrial cancer, particularly if they are obese. We speculate
that this increased risk is attributable to the effects of melatonin on
hormonal and metabolic factors"
Acute effect of metformin on exercise capacity in active males -
Diabetes Obes Metab. 2007 Oct 29 - "A single dose of
metformin does not acutely influence maximal oxygen consumption or
ventilatory threshold in healthy active males. The lower lactate
concentration observed during continuous exercise with metformin was an
unexpected finding considering that, in the resting state, metformin has
been previously associated with a modest increase in lactate concentrations"
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years:
quality of sleep and next-day alertness outcomes - Curr Med Res Opin. 2007
Sep 14 - "PR-melatonin results in significant and
clinically meaningful improvements in sleep quality, morning alertness, sleep
onset latency and quality of life in primary insomnia patients aged 55 years and
Effects of melatonin and rilmazafone on nocturia in the elderly - J Int
Med Res. 2007 Sep-Oct;35(5):685-91 - "melatonin (2
mg/day; n = 20) or rilmazafone (2 mg/day; n = 22) for 4 weeks ... After 4
weeks' treatment, the number of nocturnal urinations was significantly
decreased and the QoL score was significantly improved in both groups. There
was no significant difference between the patient-reported effectiveness
ratings between the two groups" - See
melatonin at Amazon.com.
Daily nighttime melatonin reduces blood pressure in male patients with
essential hypertension - Hypertension. 2004 Feb;43(2):192-7 -
"In patients with essential hypertension, repeated
intake significantly reduced nocturnal blood pressure"- See
melatonin at Amazon.com.
Melatonin-induced reduction in age-related accumulation of oxidative damage
in mice - Biogerontology. 2003;4(3):133-9 - "The
findings indicate that low-dose chronic administration of melatonin acts as
a free radical scavenger and anti-aging agent"
Antioxidative effects of melatonin in protection against cellular damage
caused by ionizing radiation - Proc Soc Exp Biol Med. 2000
Oct;225(1):9-22 - "The radioprotective effects of
melatonin against cellular damage caused by oxidative stress and its low
toxicity make this molecule a potential supplement in the treatment or
co-treatment in situations where the effects of ionizing radiation are to be
Evidence for a local action of melatonin on the rat prostate - J Urol
1998 Mar;159(3):1069-73 - "The results demonstrate
putative melatonin receptors in the rat prostate and suggest a direct
suppression by melatonin of testosterone-dependent prostate growth"
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