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Recent Longevity News for the seven days ending 11/7/12.  You should consult your doctor if you are taking any medications.

Daily doses of a new probiotic reduces 'bad' and total cholesterol - Science Daily, 11/5/12 - "The study involved 127 adult patients with high cholesterol. About half the participants took L. reuteri NCIMB 30242 twice a day, while the rest were given placebo capsules ... Those taking the probiotic had LDL levels 11.6 percent lower than those on placebo after nine weeks. Furthermore, cholesterol esters were reduced by 6.3 percent and cholesterol ester saturated fatty acids by 8.8 percent, compared with the placebo group ... Furthermore, people taking the probiotic had total cholesterol reduced by 9.1 percent. HDL "good" cholesterol and blood triglycerides, a dangerous form of fat in the blood, were unchanged ... Scientists have proposed that Lactobacillus bacteria alone may impact cholesterol levels in several ways, including breaking apart molecules known as bile salts. L. reuteri NCIMB 30242 was fermented and formulated to optimize its effect on cholesterol and bile salts ... the study results suggest the probiotic broke up bile salts, leading to reduced cholesterol absorption in the gut and less LDL ... The probiotic worked at doses of just 200 milligrams a day, far lower than those for soluble fiber or other natural products used to reduce cholesterol" - See probiotic products at Amazon.com.

Healthy living adds fourteen years to your life, study suggests - Science Daily, 11/5/12 - "researchers pulled data from five different cohorts included in the Cardiovascular Lifetime Risk Pooling Project and looked at the participants' risk of all forms of fatal and nonfatal cardiovascular disease from ages 45, 55 and 65 through 95 years of age ... Individuals with optimal risk factor profiles lived up to 14 years longer free of total CVD than individuals with at least two risk factors ... Men in middle age had lifetime risks of approximately 60 percent for developing cardiovascular disease ... Women in middle age had lifetime risks of approximately 56 percent for developing cardiovascular disease ... Lifetime risks for cardiovascular disease were strongly associated with risk factor burden in middle age"

Men who do exercise produce better quality semen, study finds - Science Daily, 10/31/12 - "conducted by researchers at the University of Cordoba ... The results conclude that the physically active subjects display better semen values. More specifically, the differences found were in the seminological parameters of total progressive velocity and morphology, in the FSH, LH and T hormones and in the T/C ratio. Hormone data thus supports the hypothesis of a more favourable environment for sperm formation"

Green tea found to reduce rate of some GI cancers - Science Daily, 10/31/12 - "the investigators surveyed women enrolled in the Shanghai Women's Health Study, a population-based study of approximately 75,000 middle-aged and older Chinese women ... regular tea consumption, defined as tea consumption at least three times a week for more than six months, was associated with a 17 percent reduced risk of all digestive cancers combined. A further reduction in risk was found to be associated with an increased level of tea drinking. Specifically, those who consumed about two to three cups per day (at least 150 grams of tea per month) had a 21 percent reduced risk of digestive system cancers ... For all digestive system cancers combined, the risk was reduced by 27 percent among women who had been drinking tea regularly for at least 20 years ... For colorectal cancer, risk was reduced by 29 percent among the long-term tea drinkers. These results suggest long-term cumulative exposure may be particularly important ... Tea contains polyphenols or natural chemicals that include catechins like EGCG and ECG. Catechins have antioxidant properties and may inhibit cancer by reducing DNA damage and blocking tumor cell growth and invasion" - See green tea extract at Amazon.com.

Night-Shift Work Ups the Risk for Various Cancers in Men - Medscape, 10/31/12 - "The study compared 3137 men with cancer and 512 matched control subjects who completed a detailed questionnaire about occupational work and lifestyle from 1979 to 1985 ... Compared with men who never worked at night, men who worked night shifts had an increased risk for prostate cancer (odds ratio [OR], 2.77), non-Hodgkin's lymphoma (OR, 2.31), pancreatic cancer (OR, 2.27), rectal cancer (OR, 2.09), colon cancer (OR, 2.03), bladder cancer (OR, 1.74), and lung cancer (OR, 1.76) ... "When I first proposed the light-at-night hypothesis, it linked circadian disturbance to hormone disruption and breast cancer," Dr. Stevens explained. Since then, circadian disruption has been linked to many other adverse effects, it has been demonstrated that melatonin has a direct effect on tumor growth, and some of the latest research he has been involved with has shown that circadian disruption has an epigenetic impact" - See melatonin at Amazon.com.

High levels of vitamin D in plasma protects against bladder cancer - Science Daily, 10/20/12 - "The authors of the study took blood samples from more than 2,000 individuals -- including patients with bladder cancer and control subjects free from the disease -- in 18 Spanish hospitals, making of this the largest study carried out to-date in this field. "We have seen that those subjects with the highest levels of 25(OH)D3, a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness or, similarly, that low levels are associated with a higher risk of suffering from it," says Malats" - See vitamin D at Amazon.com.

Fluorouracil - Wikipedia, the free encyclopedia - "The chemotherapy agent 5-FU, which has been used against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor ... Some of its principal uses are in colorectal cancer, and pancreatic cancer"

  • Note: A dermatologist prescribed the fluorouracil 5% topical cream (40 grams) for one spot of actinic keratosis on my cheek that the nitrogen spray wouldn’t cure but said to put it on my entire face twice daily for two weeks.  See the video below which someone else made.  It looks really bad from about day 9 put heals at about day 21.  After it heals, it gives you significantly younger looking skin.  I doubt is laser treatment works that well or looks that natural.  Offshore RX sells 10 mg tubes (you’d need four tubes) but I wouldn’t try it without a doctor’s supervision.  It’s serious stuff and it burns really bad from about day 10 until about day 17.
  • Fluorouracil Cream 5% - YouTube

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Adiponectin Levels and Risk of Coronary Heart Disease: A Meta-analysis of Prospective Studies - Am J Med Sci. 2012 Nov 1 - "Twelve prospective studies comprising 8 nested case-control studies and 4 cohort studies were included in the meta-analysis ... The pooled RR for CHD was 0.83 (95% CI, 0.69-0.98, P = 0.031). Subgroup analyses showed that the pooled RRs (95% CIs) for CHD risk were 0.78 (0.66-0.92) and 0.75 (0.59-0.94) for men and women, respectively. For studies with mean age less than 65 years, the pooled RR (95% CI) for CHD risk was 0.72 (0.59-0.87). For studies with 100 or more CHD cases, the pooled RR was marginally significant (RR = 0.83, 95% CI, 0.69-1.00; P = 0.051)" - See my adiponectin page for ways to increase it.

Risk factors for intrahepatic cholangiocarcinoma: Association between metformin use and reduced cancer risk - Hepatology. 2012 Oct 11 - "Metformin is purportedly associated with a reduced risk for various cancers ... treatment with metformin was significantly associated with a 60% reduction in ICC risk in diabetic patients" - Note:  The point is that it's one more to the list of cancers reduced by metformin.  See metformin at IAS.

  • Cholangiocarcinoma - Wikipedia, the free encyclopedia - "Cholangiocarcinoma is a medical term denoting a form of cancer that is composed of mutated epithelial cells (or cells showing characteristics of epithelial differentiation) that originate in the bile ducts which drain bile from the liver into the small intestine. Other biliary tract cancers include pancreatic cancer, gallbladder cancer, and cancer of the ampulla of Vater"

Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats - Br J Nutr. 2012 Sep 21:1-7 - "The study evaluates the effects of genistein on blood pressure (BP) and ultrastructural changes in kidney of fructose-fed hypertensive rats ... Genistein administration lowered BP, restored ACE, PKC-βII and eNOS expression and preserved renal ultrastructural integrity. These findings demonstrate that genistein has effects on eNOS activity in renal cells, leading to eNOS activation and NO synthesis. These effects could have been mediated by activation of PKC-βII. The observed benefits of genistein make it a promising candidate for therapy of diabetic kidney disease" - See genistein at Amazon.com.

Titrating lovaza from 4 to 8 to 12 grams/day in patients with primary hypertriglyceridemia who had triglyceride levels >500 mg/dl despite conventional triglyceride lowering therapy - Lipids Health Dis. 2012 Oct 30;11(1):143 - "With TG >500 mg/dl despite Type V diet, hyperinsulinemia and diabetes control, and fibric acids, Lovaza (4 g/d) was added for 1 month, and if TG remained >500 mg/dl, increased to 8 g/d for 1 month, and then to 12 g/d for 1 month, and subsequently reduced to 4 g/day for 4 months ... Titration of Lovaza from 4 to 8 to 12 g/d safely offers an effective way to lower TG beyond conventional 4 g therapy" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Dietary folate and folate vitamers and the risk of prostate cancer in The Netherlands Cohort Study - Cancer Causes Control. 2012 Oct 30 - "Dietary folate was not associated with prostate cancer risk, nor with the risk of advanced prostate cancer, among men in the NLCS cohort"

Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose - Atherosclerosis. 2012 Oct 12 - "Metformin, but not placebo, administered to simvastatin-treated IFG subjects reduced plasma levels of C-reactive protein, soluble intercellular adhesion molecule-1, as well as lymphocyte release of interleukin-2, interferon-γ and tumor necrosis factor-α, which was accompanied by the improvement in insulin sensitivity and a reduction in free fatty acid levels ... The obtained results indicate that metformin potentiates lymphocyte-suppressing and systemic anti-inflammatory effects of simvastatin in subjects with IFG. These effects of statin-metformin combination therapy may play a role in the prevention and treatment of atherosclerosis and its complications in patients with early glucose metabolism abnormalities" - See metformin at IAS.

Low HDL-C predicts risk and PCI outcomes in the Han Chinese population - Atherosclerosis. 2012 Oct 3 - "Low HDL-C was the most powerful lipid parameter for predicting the risk and the clinical outcome of CHD in the Han Chinese population"

Effects of Sun Ginseng on Memory Enhancement and Hippocampal Neurogenesis - Phytother Res. 2012 Oct 29 - "Panax ginseng C.A. Meyer has been used in traditional herb prescriptions for thousands of years. A heat-processing method has been used to increase the efficacy of ginseng, yielding what is known as red ginseng. In addition, recently, a slightly modified heat-processing method was applied to ginseng, to obtain a new type of processed ginseng with increased biological activity; this new form of ginseng is referred to as Sun ginseng (SG) ... These results suggest that SG has memory-enhancing activities and that these effects are mediated, in part, by the increase in the levels of pERK and pAkt and by the increases in cell proliferation and cell survival" - See ginseng at Amazon.com.

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