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Recent Longevity News for the seven days ending 10/24/12.  You should consult your doctor if you are taking any medications.

Aspirin may slow the decline in mental capacity among elderly patients, Swedish study suggests - Science Daily, 10/22/12 - "Of the 681 women, 129 received a low daily dose of acetylsalicylic acid, equivalent to a fourth of an aspirin, to prevent heart disease. The Gothenburg study shows that acetylsalicylic acid also slowed decline in brain capacity among the elderly women ... At the end of the five year examination period mental capacity had declined among all the women and the portion that suffered from dementia was equally large in the entire group. However, the decline in brain capacity was significantly less and occurred at a slower pace among the women who received acetylsalicylic acid"

Crusty foods may worsen heart problems associated with diabetes - Science Daily, 10/22/12 - "We see evidence that cooking methods that create a crust -- think the edge of a brownie or the crispy borders of meats prepared at very high temperatures -- produce advanced glycation end products (AGEs). And AGEs are associated with plaque formation, the kind we see in cardiovascular disease ... people with higher rates of cardiovascular complications ate more of these glycated products. For each unit increase in AGEs intake, a study participant was 3.7 times more likely to have moderate to high risk for cardiovascular disease ... Boiling or stewing meat would reduce your AGEs intake further. And scrambling an egg with cooking spray instead of frying it leads to a significant reduction in AGEs"

Probiotics are secret weapon for fighting symptoms of the common cold in college students, study suggests - Science Daily, 10/22/12 - "randomized 198 college students aged 18 to 25 and living on-campus in residence halls at Framingham State University in Massachusetts. Groups received either a placebo (97 students) or a powder blend containing Chr. Hansen's probiotic strains BB-12® and LGG® (101 students) for 12 weeks. Each day, students completed a survey to assess the effect of the probiotic supplementation ... The study found that while all students caught colds at roughly the same rate, the students who took the probiotic supplementation experienced: ... A duration of colds that was two days shorter (four days vs. six days) ... Symptoms that were 34% less severe and ... A higher quality of life that resulted in fewer missed school days (15 vs. 34 missed by students taking the placebo) ... consumers need to read the label to be sure that the product contains Lactobacillus rhamnosus GG [LGG] and Bifidobacterium animalis lactis BB12 [BB12]. There also are some yogurts that contain LGG and/or BB12 but check the labels, since companies change the probiotics strains often" - See probiotic products at Amazon.com.

Exercise Protects Aging Brains Better - WebMD, 10/22/12 - "The new research included about 700 people living in the United Kingdom who all had brain scans when they reached the age of 73 ... Three years earlier, at age 70, the study participants were questioned about the leisure and physical activities they engaged in ... People in the study who reported being the most physically active tended to have larger brain volumes of gray and normal white matter, and physical activity was linked to less brain atrophy ... Regular exercise also appeared to protect against the formation of white matter lesions, which are linked to thinking and memory decline"

Statins may reduce risk of esophageal cancer - Science Daily, 10/22/12 - "Only 1 in 5 patients with this cancer will still be alive five years after diagnosis ... The Mayo study combined data from 13 studies that included over 1.1 million patients, of which 9,285 had esophageal cancer. The analysis found statins lowered cancer risk by nearly one-third; the longer a patient was on statins, the greater the protective effect ... When researchers looked specifically at Barrett's esophagus, patients taking a statin and aspirin reduced their risk of esophageal cancer by 72 percent"

Metabolic factors may increase men's risk of dying from prostate cancer - Science Daily, 10/22/12 - "Umeå University in Sweden, and their colleagues analyzed information from 289,866 men enrolled in a study called the Metabolic syndrome and Cancer project ... average follow-up time of 12 years ... Men in the highest categories of body mass index and blood pressure had a 36 percent and 62 percent increased risk of dying from prostate cancer, respectively. Also, when comparing a composite score of all metabolic factors, men with a high score were more likely to die from prostate cancer ... The study found no evidence for a link between high levels of metabolic factors and a man's risk of developing prostate cancer but revealed a link between these factors and his risk of dying from the disease"

Diet soda is doing these 7 awful things to your body - Today Health, 10/18/12 - "even just one diet soda a day is linked to a 34% higher risk of metabolic syndrome ... the more diet sodas a person drank, the greater their risk of becoming overweight. Downing just two or more cans a day increased waistlines by 500% ... Cell Damage Diet sodas contain something many regular sodas don't: mold inhibitors. They go by the names sodium benzoate or potassium benzoate, and they're in nearly all diet sodas"

Blood hormone levels predicted long-term breast cancer risk for postmenopausal women - Science Daily, 10/18/12 - "Women with hormone levels in the highest 25 percent for estradiol, testosterone and dehydroepiandrosterone sulfate (DHEAS) had a 50 percent to 107 percent greater chance for developing breast cancer compared with women in the lowest 25 percent. Relative risks for developing breast cancer were similar at one to 10 years versus 11 to 20 years (also 16 to 20 years) after blood collection ... Women in the highest 25 percent of SHBG levels had a 30 percent lower risk for breast cancer compared with women in the lowest 25 percent for SHBG levels"

Green tea reduced inflammation, may inhibit prostate cancer tumor growth, research finds - Science Daily, 10/18/12 - "researchers randomly assigned the men to either six cups of brewed green tea or water daily for three to eight weeks, depending on the timing of their surgery ... The data showed that serum prostate-specific antigen (PSA) concentrations were significantly lower at the end of the study compared with baseline levels in men consuming green tea. In addition, prostate tissue PSA protein expression was lower in men assigned to green tea consumption compared with the control group at the end of the study ... Further, immunostaining analysis revealed that nuclear factor kappa B, a marker of inflammation, was significantly reduced in those men assigned to green tea compared with those in the control group" - See green tea extract at Amazon.com.

Increased flavonoid intake reduced risk for aggressive prostate cancer - Science Daily, 10/17/12 - "Men with the highest total intake of flavonoids had a 25 percent lower risk for aggressive prostate cancer compared with those men with the lowest flavonoid intake ... higher total flavonoid intake was associated with reduced odds for aggressive prostate cancer in both African-American and European-American men, but no individual subclass of flavonoids appeared to be protective independently, suggesting that it is important to consume a variety of plant-based foods in the diet, rather than to focus on one specific type of flavonoid or flavonoid-rich food" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.

Vegetable-derived compound effective in treating triple-negative breast cancer, research suggests - Science Daily, 10/17/12 - "TNBC accounts for approximately 15-20 percent of all breast cancer cases in the U.S. It is one of the most aggressive forms of breast cancer; it grows faster, spreads to other parts of the body earlier, is harder to detect on a mammogram and recurs more often ... Sachdeva's study reveals that these synthetic compounds derived from diindolylmethane (DIM), commonly found in various types of cruciferous vegetables, can be used to treat several types of cancer, including triple-negative breast cancer. C-DIMs are also being investigated for their cancer prevention activity" - See diindolylmethane at Amazon.com.

Multivitamins Cut Cancer Risk in Men, Study Finds - ABC News, 10/17/12 - "a new study of almost 15,000 men over 50 suggests popping that daily supplement could cut cancer rates by 8 percent ... It's unclear whether the results apply to women or men under 50 ... First, the new study randomly assigned men to two groups, one of which took a daily Centrum Silver® while the other took a placebo pill ... Second, it followed the men, who were 65 years old on average, over 11 years – a longer follow-up than previous studies and sufficient time for cancer to develop ...Other trials have tested a single vitamin such as calcium or vitamin A, E or D in large doses, which is very different from how people normally get the vitamins and minerals they need from food" - Yeah but I wouldn't call Centrum Silver a top of the line supplement.  Click here and click on "Product Labeling" for incredients.  Some examples; it's only has the synthetic dl-Alpha Tocopheryl Acetate form of vitamin E plus there are 8 forms of that vitamin.  There are over 600 carotenoids and some claim taking just one of those can cause a deficiency of the others, etc.  See Garden of Life, Vitamin Code, 50 & Wiser Men, 240 UltraZorbe Veggie Caps and Garden of Life, Vitamin Code, 50 & Wiser Women, 240 UltraZorbe Veggie Caps.

Alcohol dependence seems to shorten life more than smoking, especially among women - Science Daily, 10/16/12 - "alcohol dependent (AD) ... John and his colleagues used registration data to gather a random sample of 4,070 respondents between the ages of 18 and 64 years from a region in Germany ... First, we found that annualized death rates were 4.6-fold higher for females and 1.9-fold higher for males compared to the age- and gender-specific general population ... Second, we found that the mean age at death was 60 for females and 58 for males, both of which are about 20 years lower than the mean age at death among the general population. None of those deceased had reached the age of life expectancy"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

The use of dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: A report of gender differences - Eur Neuropsychopharmacol. 2012 Oct 17 - "Data regarding the efficacy of dehydroepiandrosterone (DHEA) in the treatment of hypoactive sexual desire disorder (HSDD) are scarce and inconsistent. We aimed to determine possible gender differences in the efficacy of DHEA as a treatment for HDSS. Postmenopausal women (n=27), and men (n=21) with HSDD, were randomized to receive either DHEA 100mg daily or placebo for 6 weeks in a controlled, double blind study ... In women only, significant interaction effects were observed for sexual arousal (p<0.05), satisfaction (p<0.05), and cognition (trend; p=0.06). For arousal, a significant improvement was observed for the DHEA treated group at 6 weeks (p=0.001). Significant correlations were observed between bioavailable T and sexual cognitions, arousal and orgasm, while DHEAS was correlated with satisfaction. In the men, significant correlations were observed between testosterone and arousal (r=.45), sexual drive (r=.50) and orgasm (r=.55). In women with HSDD, DHEA treatment had a significant beneficial effect on arousal, whereas no efficacy was demonstrated in men, indicating a possible gender difference. This improvement seems to be mediated via DHEA's metabolism to testosterone. Our positive results suggest that the neurosteroid DHEA may be effective as a treatment for women with HSDD if administered at a dose of at least 100mg per day" - See DHEA at Amazon.com.

Regulation of brown adipose tissue development and white fat reduction by L-arginine - Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):529-38 - "Brown adipose tissue (BAT), which is present in humans, plays an important role in oxidation of fatty acids and glucose ... L-arginine increases mammalian BAT growth and development via mechanisms involving gene expression, nitric oxide signaling, and protein synthesis. This enhances the oxidation of energy substrates and, thus, reduces white fat accretion in the body. L-arginine holds great promise in preventing and treating obesity in humans" - See L-arginine products at Amazon.com.

What Next after Metformin? A Retrospective Evaluation of the Outcome of Second-Line, Glucose-Lowering Therapies in People with Type 2 Diabetes - J Clin Endocrinol Metab. 2012 Oct 17 - "Sulfonylurea monotherapy had significantly higher hazard ratios (HRs) for all-cause mortality (HR 1.459, 1.207-1.763); MACE (HR 1.578, 1.187-2.099); stroke (HR 1.444, 1.050-1.987); and the combined end point (HR 1.381, 1.194-1.597). Metformin plus pioglitazone had significantly lower adjusted HRs for all-cause mortality (HR 0.707, 0.515-0.970) and the combined end point (HR 0.747, 0.612-0.911)"

Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study - Am J Clin Nutr. 2012 Oct 17 - "gastric cancer (GC) ...followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline ... average follow-up of 11 y ... We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after log(2) transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). In women, significant inverse associations with GC risk were also observed for intakes of some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols), particularly with intestinal type tumors for total flavonoid and flavanol intakes" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.

Conversion from Mild Cognitive Impairment to Dementia: Influence of Folic Acid and Vitamin B12 Use in the VITA Cohort - J Nutr Health Aging. 2012;16(8):687-94 - "Increased serum homocysteine and low folate levels are associated with a higher rate of conversion to dementia ... The self-reported combined use of folic acid and vitamin B12 for more than one year was associated with a lower conversion rate to dementia. Serum levels of homocysteine and vitamin B12 as measured at baseline or at five years were not associated with conversion. Higher folate levels at baseline in females predicted a lower conversion rate to dementia. The assessment of brain morphological parameters by magnetic resonance imaging revealed higher serum folate at baseline, predicting lower medial temporal lobe atrophy and higher levels of homocysteine at baseline, predicting moderate/severe global brain atrophy at five years. Users of vitamin B12 or folate, independent of time and pattern of use, had lower grades of periventricular hyperintensities and lower grades of deep white matter lesions as compared to non-users" - See folic acid products at Amazon.com and vitamin B12 at Amazon.com.

Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies - Eur J Clin Nutr. 2012 Oct 17 - "We performed a literature search on PubMed database through July 2012 to indentify prospective studies of dietary fiber intake in relation to risk of stroke ... The dose-response analysis suggested a 12% (RR=0.88; 95% CI, 0.79-0.97) reduction in risk of stroke for each 10 g per day increment in dietary fiber intake ... Findings of this meta-analysis indicate a significant inverse dose-response relationship between dietary fiber intake and risk of stroke" - See Garden of Life, RAW Fiber at Amazon.com.

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population - Eur J Clin Nutr. 2012 Oct 17 - "LTL was measured by quantitative real-time polymerase chain reaction in 1942 men and women aged 57-70 years from the Helsinki Birth Cohort Study. We assessed the whole diet by a validated semiquantitative 128-item food-frequency questionnaire ... In general, there were only a few significant results. However, total fat and SFA intake (P=0.04 and 0.01, respectively) were inversely associated with LTL in men adjusting for age and energy intake. In women, vegetable intake was positively associated with LTL (P=0.05). Men consuming the most butter and least fruits had significantly shorter telomeres than those consuming the lowest amounts of butter and highest amounts of fruits (P=0.05). We found no association between LTL and body mass index, waist-hip ratio, smoking, physical activity or educational attainment"

Oxytocin facilitates protective responses to aversive social stimuli in males - Proc Natl Acad Sci U S A. 2012 Oct 16 - "Our results therefore show that OXT can potentiate the protective and mnemonic impact of aversive social information despite reducing amygdala activity, and suggest that the insula may play a role in emotional modulation of memory" - See Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems and Oxytocin Factor.

A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride - Int J Clin Pract. 2012 Nov;66(11):1052-5. doi - "The incidence of erectile dysfunction, ejaculatory dysfunction and decreased libido resulting in discontinuation from therapy was significantly (p<0.01) higher in the dutasteride (5.1%, 2.4%, 2.7% respectively) compared with the finasteride (2.1%, 1.8%, 1.4% respectively) group. In addition, the incidence of self-reported breast tenderness and/or enlargement was significantly (p<0.01) greater in the dutasteride (3.5%) compared with the finasteride (1.2%) group. Conclusions: In this retrospective analysis of data from consecutive patients treated at a single clinic, both finasteride and dutasteride were effective therapies for the management of lower urinary tract symptoms. However, dutasteride resulted in significantly more sexual side effects and breast complications than finasteride" - Note:  I'm not sure that makes sense.  The first sentence says "resulting in discontinuation from therapy"

Ambulatory Blood Pressure Values in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) - Hypertension. 2012 Oct 15 - "Twenty-four-hour systolic BP was similarly reduced by R (-2.0 mm Hg) and T (-2.1 mm Hg), whereas the reduction was more than twice as large in the T+R group (-5.3 mm Hg), which showed a lower on-treatment 24-hour BP also in additional patients (n=408) in whom ambulatory BP was performed only on-treatment. Twenty-four-hour systolic BP was ≈14 mm Hg lower than clinic systolic BP at baseline, whereas during treatment the 2 values became progressively closer as clinic systolic BP was more tightly controlled and superimposable when clinic systolic BP was <120 mm Hg. Similar results were obtained for diastolic BP. These findings provide evidence on the relationship of clinic and ambulatory BP target drug treatment. They also show that in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial, failure of the R+T combination to enhance cardiovascular and renal protection was not because of inability to more effectively control daily life BP" - See my combining ARB with ACE inhibitor section.

Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults - Diabetes Care. 2012 Oct 15 - "Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. Insulin resistance may play a role in Alzheimer disease etiopathogenesis. This longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in Alzheimer disease-sensitive brain regions and 2) worse cognitive performance ... higher insulin resistance was related to medial temporal lobe atrophy. Atrophy itself corresponded to cognitive deficits in the RAVLT. Temporal lobe atrophy that was predicted by higher insulin resistance significantly mediated worse RAVLT encoding performance ... These results suggest that insulin resistance in an asymptomatic, late middle-aged cohort is associated with progressive atrophy in regions affected by early Alzheimer disease. Insulin resistance may also affect the ability to encode episodic information by negatively influencing gray matter volume in medial temporal lobe"

Attenuation of post-myocardial infarction depression in rats by n-3 fatty acids or probiotics starting after the onset of reperfusion - Br J Nutr. 2012 Oct 15:1-7 - "Proinflammatory cytokines play a central role in depression-like behaviour and apoptosis in the limbic system after myocardial infarction (MI). A PUFA n-3 diet or the combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 probiotics, when given before the ischaemic period, reduce circulating proinflammatory cytokines as well as apoptosis in the limbic system ... These results indicate that a high-PUFA n-3 diet or the administration of probiotics, starting after the onset of reperfusion, are beneficial to attenuate apoptosis in the limbic system and post-MI depression in the rat" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com and probiotic products at Amazon.com.

Neat Tech Stuff / "How To's":

Health Focus (Olive Leaf):

Specific Recommendations:

News and Research:

  • Olive oil’s health benefits? It’s a slippery question - The Washington Post, 9/11/12 - "The health benefits of olive oil are 99 percent related to the presence of the phenolic compounds, not the oil itself ... Malik is referring to the polyphenols in olive oil, nutrients also found in wine, tea, cocoa and many fruits and vegetables that have been discovered over the past decade to be the substances responsible for the bulk of olive oil’s health benefits, without which “you might as well use canola oil,” ... when tested, polyphenols were surprisingly low in most commercially available olive oils ... Any exposure of the harvested olives or the oil to heat, light or air will reduce polyphenol content"
  • Olive extract shows benefits for inflammatory bowel disease - Nutra USA, 9/12/11 - "Olive oil and the hydroxytyrosol it contains may reduce inflammation linked with the development of colitis ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil. Previous research has linked the compound to cardiovascular benefits, with reductions in LDL or 'bad' cholesterol. Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... the olive oil-fed animals had an attenuation of the colonic damage, as well as a 50% reduction in the mortality rate caused by DSS. The results were improved further by hydroxytyrosol supplement ... levels of the pro-inflammatory compound interleuking-10 (IL-10) were “significantly improved” in both olive oil-fed groups" - [Abstract]
  • Hydroxytyrosol is key anti-inflammatory compound in olive: DSM study - Nutra USA, 8/25/11 - "Hydroxytyrosol, an ingredient to watch, has been identified as the main anti-inflammatory compound in olives ... hydroxytyrosol was found to inhibit both nitric oxide (NO) and prostaglandin E2 (PGE2), both are pro-inflammatory compounds ... The effects of hydroxytyrosol on NO and chemokine production point to their impact on chronic inflammatory processes in endothelium or arthritis ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil ... Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... Several companies already offer the compound for nutraceutical applications ... Results showed that hydroxytyrosol inhibited the production of both NO and PGE2 in mouse cells, "reflecting strong anti-inflammatory activity"" - [Abstract] - Note:  Trouble is, you usually don't want to inhibit nitric oxide.
  • Olive Oil Linked to Reduced Stroke Risk - WebMD. 6/15/11 - "seniors who regularly used this healthy monounsaturated fat had a 41% lower risk of stroke compared to their counterparts who never used olive oil ... So what exactly is it about olive oil that may lower stroke risk? There are several theories, she says. It may be that people choose olive oil over saturated, artery-clogging fats. “Moreover, previous research found that the polyphenols from virgin olive oil account specifically for its ability to lower oxidized low-density lipoprotein (LDL)” or bad cholesterol. High cholesterol levels are a known risk factor for stroke ... Olive oil is a healthy fat and it can reduce cholesterol and inflammation, and has been shown to help reduce the incidence of heart disease" - Click here for my olive oil mayonnaise recipe.  See olive leaf extract at Amazon.com.
  • DSM builds olive extract IP with energy & exercise performance patent - Nutra USA, 4/7/11 - "According to European Patent EP2009/063492, the invention refers to hydroxytyrosol in combination with at least one other ingredient, including the likes of CoQ10, resveratrol, B vitamins, and EGCG from green tea ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil. Previous research has linked the compound to cardiovascular benefits, with reductions in LDL or 'bad' cholesterol. Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... Hydroxytyrosol significantly increased the running distance to exhaustion in mice and so improved endurance in prolonged exercise ... hydroxytyrosol promotes mitochondrial activity and mitochondrial biogenesis leading to an enhancement of mitochondrial function and cellular defense system" - See olive leaf extract at Amazon.com.  As far as the synergy, I would think that most would be already taking the CoQ-10, resveratrol, B-vitamins and green tea.
  • Olive leaf extract may help hypertension: Frutarom study - Nutra USA, 3/9/11 - "Olive leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5–25 mg twice daily ... after eight weeks of treatment, both treatment groups experienced significant reductions in systolic and diastolic blood pressure from baseline. They added that such reductions were not significantly different between groups ... However, they reported that a significant reduction of triglyceride level was observed for the group receiving olive leaf extract, but not in Captopril group ... the anti-hypertensive activity “lies probably in its content of oleuropein acting synergistically with other active substances to exert both ACE inhibitory and calcium channel blocking activities."" - [Abstract] - See olive leaf extract at Amazon.com.
  • Olive oil protects liver from oxidative stress, rat study finds - Science Daily, 10/29/10 - "researchers separated the rats into a control group, an olive oil group, and 6 groups that were exposed to the herbicide '2,4-Dichlorophenoxyacetic acid' with or without either whole olive oil, or one of two oil extracts -- the hydrophilic fraction or the lipophilic fraction. All rats given the herbicide showed signs of significant liver damage. However, extra virgin olive oil and hydrophilic fraction intake induced a significant increase in antioxidant enzyme activity and a decrease in markers of liver damage ... The hydrophilic fraction of olive oil seems to be the effective one in reducing toxin-induced oxidative stress, indicating that hydrophilic extract may exert a direct antioxidant effect on hepatic cells"
  • Olive oil compounds may boost cardiac fat oxidation: Study - Nutra USA, 10/21/10 - "Obese rats supplemented with olive oil, oleuropein, and cafeic acid had higher oxygen consumption, increased fat-oxidation, and lower carbon dioxide production than non supplemented obese rats" - [Abstract]
  • Science strengthens for olive extract’s bone benefits - Nutra USA, 9/14/10 - “Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis" - [Abstract]
  • Olive oil extract shows brain protecting benefits - Nutra USA, 8/3/10 - "the olive oil compound reduced the cell damaging effects of the oxidative and nitrosative stress in a dose-dependent manner, with higher doses providing increased protection" - [Abstract]
  • Key mechanism links virgin olive oil to protection against breast cancer - Science Daily, 6/30/10 - "virgin olive oil is associated with higher incidences of benign breast tumours and at the same time with a decrease in the activity of the p21Ras oncogene, which spurs uncontrolled cell proliferation and stimulates the growth of tumours. In addition, olive oil suppresses the activity of some proteins, such as the AKT, essential for the survival of cells since they prevent apoptosis, the cell's "suicide" programme. Between proliferation and apoptosis in tumour cells, these effects tip the balance towards cell death, thereby slowing the growth of tumours"
  • Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function - Science Daily, 6/30/10 - "The first group consumed a traditional Mediterranean diet with virgin olive oil rich in polyphenols. The second group consumed a traditional Mediterranean diet with an olive oil low in polyphenols. The third group followed their habitual diet. After three months, the first group had a down-regulation in the expression of atherosclerosis-related genes in their peripheral blood mononuclear cells. Additionally, the olive oil polyphenols made a significant impact on the expression of genetic changes influencing coronary heart disease. Results also showed that the consumption of virgin olive oil in conjunction with a Mediterranean diet can positively impact lipid and DNA oxidation, insulin resistance, inflammation, carcinogenesis, and tumor suppression ... olive oil and a Mediterranean diet affect our bodies in a far more significant way than previously believed"
  • Olive-oil enriched diet helps breast cancer survivors lose more weight - Science Daily, 6/3/10
  • Olive oil component could avert Alzheimer’s - Nutra USA, 10/20/09 - "ADDLs bind within the neural synapses of the brains of Alzheimer's patients and are believed to directly disrupt nerve cell function, eventually leading to memory loss, cell death and global disruption of brain function ... incubation with oleocanthal changed the structure of ADDLs by increasing the protein's size" - [Abstract]
  • Natural Compound In Extra-virgin Olive Oil -- Oleocanthal -- May Help Prevent, Treat Alzheimer's - Science Daily, 9/29/09 - "Measuring ADDL binding with and without oleocanthal, they discovered that small amounts of oleocanthal effectively reduced binding of ADDLs to hippocampal synapses. Additional studies revealed that oleocanthal can protect synapses from structural damage caused by ADDLs ... An unexpected finding was that oleocanthal makes ADDLs into stronger targets for antibodies. This action establishes an opportunity for creating more effective immunotherapy treatments, which use antibodies to bind to and attack ADDLs"
  • Source Of Major Health Benefits In Olive Oil Revealed - Science Daily, 4/1/09 - "Scientists have pinned down the constituent of olive oil that gives greatest protection from heart attack and stroke. In a study of the major antioxidants in olive oil, Portuguese researchers showed that one, DHPEA-EDA, protects red blood cells from damage more than any other part of olive oil"
  • Extra Virgin Olive Oil May Help To Combat Breast Cancer - Science Daily, 2/5/09 - "this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation"
  • New Anti-cancer Components Of Extra-virgin Olive Oil Revealed - Science Daily, 12/17/08 - "Extra-virgin olive oil is the oil that results from pressing olives without the use of heat or chemical treatments. It contains phytochemicals that are otherwise lost in the refining process. Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2"
  • Olive Leaf Extract Can Help Tackle High Blood Pressure And Cholesterol - Science Daily, 8/27/08 - "This works showed that taking a 1000mg dose has substantial effects in people with borderline hypertension"

Abstracts:

  • Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort - Br J Nutr. 2012 Sep 25:1-8 - "we studied the association between olive oil and CHD in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort study. The analysis included 40,142 participants (38 % male), free of CHD events at baseline, recruited from five EPIC-Spain centres from 1992 to 1996 and followed up until 2004 ... Cox proportional regression models were used to assess the relationship between validated incident CHD events and olive oil intake (energy-adjusted quartiles and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for potential confounders. During a 10.4-year follow-up, 587 (79 % male) CHD events were recorded. Olive oil intake was negatively associated with CHD risk after excluding dietary mis-reporters (hazard ratio (HR) 0.93; 95 % CI 0.87, 1.00 for each 10 g/d per 8368 kJ (2000 kcal) and HR 0.78; 95 % CI 0.59, 1.03 for upper v. lower quartile). The inverse association between olive oil intake (per 10 g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 % reduced CHD risk (P = 0.048)), in never/low alcohol drinkers (25 % reduced CHD risk (P < 0.001)) and in virgin olive oil consumers (14 % reduced CHD risk (P = 0.072)). In conclusion, olive oil consumption was related to a reduced risk of incident CHD events"
  • Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial Function in Young Women with Mild Hypertension - Am J Hypertens. 2012 Aug 23 - "We conducted a double-blind, randomized, crossover dietary-intervention study. After a run-in period of 4 months (baseline values), two diets were used, one with polyphenol-rich olive oil (~30 mg/day), the other with polyphenol-free olive oil. Each dietary period lasted 2 months with a 4-week washout between diets ... When compared to baseline values, only the polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91 mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found for serum asymmetric dimethylarginine (ADMA) (-0.09 +- 0.01 µmol/l, P < 0.01), oxidized low-density lipoprotein (ox-LDL) (-28.2 +-28.5 µg/l, P < 0.01), and plasma C-reactive protein (CRP) (-1.9 +- 1.3 mg/l, P < 0.001). The polyphenol-rich olive oil diet also elicited an increase in plasma nitrites/nitrates (+4.7 +- 6.6 µmol/l, P < 0.001) and hyperemic area after ischemia (+345 +- 386 perfusion units (PU)/sec, P < 0.001)" - Note: It goes back to whether it's the polyphenols or the omega-9 or both.  This implies the polyphenols.  See olive leaf extract at Amazon.com.  To me it's a lot better than putting up with the taste of the dark olive oil.
  • Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis - Eur J Nutr. 2012 Aug 8 - "Eighty-two patients with early atherosclerosis (presence of endothelial dysfunction) were enrolled in this double-blind, randomized trial with 52 completing the study. The aim of the study was to compare the effect of a daily intake of 30 ml simple OO, with 30 ml of EGCG-supplemented OO, on endothelial function as well as on inflammation and oxidative stress after a period of 4 months ... After 4 months, when OO and EGCG-supplemented OO groups were combined, OO significantly improved endothelial function (RHI, 1.59 +/- 0.25-1.75 +/- 0.45; p < 0.05). However, there were no significant differences in results between the two olive oil groups. Interestingly, with OO supplementation there was a significant reduction in inflammatory parameters: sICAM (196 to 183 ng/mL, p = < 0.001); white blood cells (WBCs) (6.0 × 10(9)/L-5.8 × 10(9)/L, p < 0.05); monocytes (0.48 × 10(9)/L to 0.44 × 10(9)/L, p = 0.05); lymphocytes (1.85 × 10(9)/L to 1.6 × 10(9)/L, p = 0.01); and platelets (242-229 × 10(9)/L, p = 0.047)" - [Nutra USA] - Click here for my method of making olive oil mayonnaise.  Make sure all the ingredients are at room temperature.  Note:  The so called olive oil mayonnaise you see in the store is mostly omega-6. If you read the ingredients, it might have olive oil near the beginning but then you see about three omega-6 oils after it. For example, if it contained 1/3 cup of olive oil and 1/4 cup soy oil and 1/4 cup of palm oil and 1/4 cup of corn oil you’d have over a cup of oil consisting of 1/3 cup omega-9 oils and 3/4 cup of omega-6 oils. The omega-9 is still the top one.
  • Olive oil intake and mortality within the Spanish population (EPIC-Spain) - Am J Clin Nutr. 2012 May 30 - "In comparison with nonconsumers, the highest quartile of olive oil consumption was associated with a 26% (95% CI: 13%, 36%) reduction in risk of overall mortality and a 44% (95% CI: 21%, 60%) reduction in CVD mortality. For each increase in olive oil of 10 g ⋅ 2000 kcal(-1) ⋅ d(-1), there was a 7% (95% CI: 3%, 10%) decreased risk of overall mortality and a 13% (95% CI: 6%, 20%) decreased risk of CVD mortality. No significant association was observed between olive oil and cancer mortality"
  • Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans - Am J Clin Nutr. 2012 Mar 21 - "Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression ... a randomized, crossover, controlled trial, 18 healthy European volunteers daily received 25 mL olive oil with a low polyphenol content (LPC: 2.7 mg/kg) or a high polyphenol content (HPC: 366 mg/kg) in intervention periods of 3 wk separated by 2-wk washout periods ... In addition to reducing LDL oxidation, the intake of polyphenol-rich olive oil reduces CD40L gene expression, its downstream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans. These findings provide evidence that polyphenol-rich olive oil can act through molecular mechanisms to provide cardiovascular health benefits"
  • Beneficial effects of combined olive oil ingestion and acute exercise on postprandial TAG concentrations in healthy young women - Br J Nutr. 2012 Jan 23:1-7 - "Foods high in monounsaturated fat, such as olive oil, and endurance exercise are both known to independently reduce postprandial TAG concentrations. We examined the combined effects of exercise and dietary fat composition on postprandial TAG concentrations in nine healthy pre-menopausal females (age 26.8 (sd 3.3) years, BMI 22.3 (sd 2.0) kg/m2). Each participant completed four, 2 d trials in a randomised order: (1) butter-no exercise, (2) olive oil-no exercise, (3) butter-exercise, (4) olive oil-exercise. On day 1 of the exercise trials, participants walked or ran on a treadmill for 60 min. On the no-exercise trials, participants rested on day 1. On day 2 of each trial, participants rested and consumed an olive oil meal (saturated fat 15 % and unsaturated fat 85 %) or a butter meal (saturated fat 71 % and unsaturated fat 29 %) for breakfast ... A significant main effect on physical activity (exercise or control) was obtained for plasma TAG concentration (three-way ANOVA, P = 0.043), and the total area under the concentration v. time curve for TAG was 26 % lower on the olive oil-exercise trial (4.40 (sd 0.40) mmol × 6 h/l) than the butter-no exercise trial (5.91 (sd 1.01) mmol × 6 h/l) (one-way ANOVA, P = 0.029). These findings suggest that the combination of exercise and a preference for monounsaturated dietary fat intake in the form of olive oil may be most beneficial for reducing postprandial TAG concentrations"
  • Olive oil, an essential component of the Mediterranean diet, and breast cancer - Public Health Nutr. 2011 Dec;14(12):2323-32 - "Diets rich in extra virgin olive oil (EVOO) exert a negative modulatory effect on experimental breast cancer to a weak promoting effect, much lower than that obtained with a high-corn oil diet. EVOO confers to the mammary adenocarcinomas a clinical behaviour and morphological features compatible with low tumour aggressiveness. This differential effect, in relation to other dietary lipids, may be related to a lower effect on body weight and sexual maturation. In addition, EVOO induced different molecular changes in tumours, such as in the composition of cell membranes, activity of signalling proteins and gene expression. All these modifications could induce lower proliferation, higher apoptosis and lower DNA damage. These results, together with the favourable effect of olive oil reported in the literature when it is consumed in moderate quantities, suggest a beneficial influence of EVOO on breast cancer risk"
  • Olive oil intake is inversely related to cancer prevalence: A systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies - Lipids Health Dis. 2011 Jul 30;10(1):127 - "Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q=47.52, p=0.0002, I-sq=62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR=-0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR=-0,36 95%CI -0.50 to -0.21), compared with the lowest intake.The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects" - Note:  That last sentence has been my question on many of the olive oil studies.  I still use my olive oil mayonnaise made with the extra light plus I take the olive oil extract capsules.  I'm not going to suffer through the taste of the extra virgin olive oil.  See olive leaf extract at Amazon.com.
  • Mechanisms of Olive Leaf Extract-Ameliorated Rat Arthritis Caused by Kaolin and Carrageenan - Phytother Res. 2011 Jul 27 - "Olive leaf extract (OLE) has antioxidant and antiinflammatory actions. However, the role of OLE in mechanical inflammatory arthritis (osteoarthritis, OA) is unclear. This study investigated the effect of OLE on the development of kaolin and carrageenan-induced arthritis, a murine model of OA. Administration of OLE significantly ameliorated paw swelling, the paw Evans blue content and the histopathological scores. In the human monocyte cell line, THP-1, the OLE reduced the LPS-induced TNF-α production and was dose dependent. Croton oil-induced ear edema in mice also revealed that treatment with OLE suppressed ear edema, myeloperoxidase (MPO) production and was dose dependent. These results indicated that OLE is an effective antiarthritis agent through an antiinflammation mechanism. Also OLE may be beneficial for the treatment of OA in humans"
  • Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain) - Br J Nutr. 2011 May 17:1-11 - "Epidemiological studies show that adherence to a Mediterranean diet (MD) increases longevity; however, few studies are restricted to Mediterranean populations or explore the effect of a MD pattern that directly incorporates olive oil. Therefore the relationship between adherence to the MD and mortality was studied within the the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain) ... Risk of all-cause and cause-specific mortality was assessed according to the level of adherence to a relative MD (rMED) score, measured using an 18-unit scale incorporating nine selected dietary components. A high compared with a low rMED score was associated with a significant reduction in mortality from all causes (hazard ratio (HR) 0.79; 95 % CI 0.69, 0.91), from CVD (HR 0.66; 95 % CI 0.49, 0.89), but not from overall cancer (HR 0.92; 95 % CI 0.75, 1.12). A 2-unit increase in rMED score was associated with a 6 % (P < 0.001) decreased risk of all-cause mortality. A high olive oil intake and moderate alcohol consumption contributed most to this association. In this Spanish cohort, following an olive oil-rich MD was related to a significant reduction in all-cause mortality, and reduced the risk of mortality from CVD. These results support the important role that the MD pattern has on reducing mortality in Mediterranean countries" - Click here for my olive oil mayonnaise recipe.
  • Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial - Atherosclerosis. 2011 May 6 - "Apolipoprotein (Apo)B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins ... Participants assigned to a low-fat diet (control) (n=177), or TMDs (TMD+virgin olive oil (VOO), n=181 or TMD+nuts, n=193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30g/day). A 3-month evaluation was performed ... Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD+VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD+VOO versus low-fat diet were -2.9mg/dL (95% CI, -5.6 to -0.08), 3.3mg/dL (95% CI, 0.84 to 5.8), and -0.03mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively ... Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations" - The question is; is it the polyphenols or the omega-9 or both in the virgin olive oil responsible for the benefit? See olive leaf extract at Amazon.com.
  • Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with Captopril - Phytomedicine. 2011 Feb 15;18(4):251-8 - "Mean SBP at baseline was 149.3+/-5.58mmHg in Olive group and 148.4+/-5.56mmHg in Captopril group; and mean DBPs were 93.9+/-4.51 and 93.8+/-4.88mmHg, respectively. After 8 weeks of treatment, both groups experienced a significant reduction of SBP as well as DBP from baseline; while such reductions were not significantly different between groups. Means of SBP reduction from baseline to the end of study were -11.5+/-8.5 and -13.7+/-7.6mmHg in Olive and Captopril groups, respectively; and those of DBP were -4.8+/-5.5 and -6.4+/-5.2mmHg, respectively. A significant reduction of triglyceride level was observed in Olive group, but not in Captopril group. In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25mg twice daily"
  • Fruit, vegetables, and olive oil and risk of coronary heart disease in Italian women: the EPICOR Study - Am J Clin Nutr. 2010 Dec 22 - "aimed to investigate the association between consumption of fruit, vegetables, and olive oil and the incidence of coronary heart disease (CHD) in 29,689 women enrolled between 1993 and 1998 ... A strong reduction in CHD risk among women in the highest quartile of consumption of leafy vegetables (hazard ratio: 0.54; 95% CI: 0.33, 0.90; P for trend = 0.03) and olive oil (hazard ratio: 0.56; 95% CI: 0.31, 0.99; P for trend = 0.04) was found. In contrast, no association emerged between fruit consumption and CHD risk"
  • Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes Nutr J. 2010 Oct 19;9(1):46 - "The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions"
  • Prediction of Extra Virgin Olive Oil Varieties through Their Phenolic Profile. Potential Cytotoxic Activity against Human Breast Cancer Cells - J Agric Food Chem. 2010 Aug 26 - "extra virgin olive oil (EVOO) varieties ...Five different Spanish EVOO varieties were analyzed, and RRLC-ESI-TOF-MS method was applied for qualitative and quantitative identification of most important phenolic compounds. We finally employed MTT-based cell viability protocol to assess the effects of crude EVOO phenolic extracts (PEs) on the metabolic status of cultured SKBR3 human breast cancer cells. MTT-based cell viability assays revealed a wide range of breast cancer cytotoxic potencies among individual crude PE obtained from EVOO monovarietals. Remarkably, breast cancer cell sensitivity to crude EVOO-PEs was up to 12 times higher in secoiridoids enriched-PE than in secoiridoids-low/null EVOO-PE"
  • Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells - Pharmacol Res. 2010 Jun 16 - "Following a short-term exposure (30min) to the compounds of interest, cells were subjected to oxidative or nitrosative stress by adding either ferrous iron or sodium nitroprusside to the cell culture medium for 18h, respectively. Cytotoxicity was assessed by measuring MTT reduction, cellular ATP levels and mitochondrial membrane potential in the absence and presence of HT or HT-rich olive mill wastewater extract. The results we obtained mainly confirm our previous observation of promising cytoprotection of brain cells by HT-rich olive mill wastewater extract in different stressor paradigms"
  • Multiple antimelanoma potential of dry olive leaf extract - Int J Cancer. 2010 Jun 21 - "dry olive leaf extract (DOLE) ... Taken together, the results of this study indicate that DOLE possesses strong anti-melanoma potential. When DOLE was applied in combination with different chemotherapeutics, various outcomes, including synergy and antagonism were observed"
  • Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow - Osteoporos Int. 2010 May 21 - "Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis"
  • Exclusive Olive Oil Consumption Is Associated with Lower Likelihood of Developing Left Ventricular Systolic Dysfunction in Acute Coronary Syndrome Patients: The Hellenic Heart Failure Study - Ann Nutr Metab. 2009 Nov 27;56(1):9-15 - "70% of the LVSD patients and 76% of the non-LVSD patients reported exclusive olive oil consumption. Multi-adjusted analysis revealed that exclusive olive oil consumption in post-ACS patients with a first cardiac episode was associated with a 65% (95% confidence interval 0.14-0.87) lower likelihood of developing LVSD after adjusting for various confounders. No significant association was observed among participants with a previous history of ACS. Conclusions: Exclusive, long-term olive oil consumption seems to offer significant protection against the development of LVSD in post-ACS patients"
  • Olive Oil and Cognition: Results from the Three-City Study - Dement Geriatr Cogn Disord. 2009 Oct 30;28(4):357-36 - "Participants with moderate or intensive use of olive oil compared to those who never used olive oil showed lower odds of cognitive deficit for verbal fluency and visual memory. For cognitive decline during the 4-year follow-up, the association with intensive use was significant for visual memory (adjusted OR = 0.83, 95% CI: 0.69-0.99) but not for verbal fluency (OR = 0.85, 95% CI: 0.70-1.03) in multivariate analysis"
  • Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal - Toxicol Appl Pharmacol. 2009 Oct 15;240(2):189-97 - "results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics"
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