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Recent Longevity News for the seven days ending 10/3/12.  You should consult your doctor if you are taking any medications.

Gum Disease Is Linked to an Increased Risk of Pancreatic Cancer - NYTimes.com, 10/1/12 - "To be sure, the research showed only an association, not a causal relationship. But other studies have also found intriguing results. One at Harvard found that men with poor gum health had a 63 percent higher risk of developing pancreatic cancer than men who did not have gum disease. And a New York University study found that high levels of P. gingivalis were linked to greater risk of dying of pancreatic and colorectal cancer, even in people without overt gum disease"

Omega-3 supplements may slow a biological effect of aging - Science Daily, 10/1/12 - "In the study, lengthening of telomeres in immune system cells was more prevalent in people who substantially improved the ratio of omega-3s to other fatty acids in their diet ... Omega-3 supplementation also reduced oxidative stress, caused by excessive free radicals in the blood, by about 15 percent compared to effects seen in the placebo group ... Study participants took either 2.5 grams or 1.25 grams of active omega-3 polyunsaturated fatty acids ... The supplements were calibrated to contain a ratio of the two cold-water fish oil fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), of seven to one ... the typical American diet tends to be heavy on omega-6 fatty acids and comparatively low in omega-3s that are naturally found in cold-water fish such as salmon and tuna. While the ratio of omega-6 to omega-3 fatty acids averages about 15-to-1, researchers tend to agree that for maximum benefit, this ratio should be lowered to 4-to-1, or even 2-to-1 ... when the researchers analyzed the participants' omega-6 to omega-3 ratio in relationship to telomere lengthening, a lower ratio was clearly associated with lengthened telomeres ... omega-3 supplements lowered IL-6 by 10 to 12 percent, depending on the dose. By comparison, those taking a placebo saw an overall 36 percent increase in IL-6 by the end of the study ... This finding strongly suggests that inflammation is what's driving the changes in the telomeres" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Moderate alcohol consumption may increase risk of atrial fibrillation in people with heart disease - Science Daily, 10/1/12 - "Moderate alcohol consumption was measured as one to 14 drinks a week for women and one to 21 drinks a week for men. Binge drinking was classified as five or more drinks a day ... The incidence rate of atrial fibrillation rose to 6.3% of the low intake group, 7.8% in the moderate and 8.3% in the high intake groups"

Eating cherries lowers risk of gout attacks by 35%, study suggests - Science Daily, 9/28/12 - "Our findings indicate that consuming cherries or cherry extract lowers the risk of gout attack ... The gout flare risk continued to decrease with increasing cherry consumption, up to three servings over two days.” The authors found that further cherry intake did not provide any additional benefit" - See cherry extracts at iHerb.

Largest Study to Date Links Low Vitamin D to CVD Risk - Medscape, 9/26/12 - "The scientists compared the 5% lowest levels of vitamin D (<5 nmol/L) with the 50% highest levels (>50 nmol/L). In Denmark--where foods are not fortified with vitamin D--it is currently recommended to have a vitamin-D status of at least 50 nmol/L, they note ... they found a stepwise increase in risk: those with the lowest levels of vitamin D had a 40% increased risk of ischemic heart disease, a 64% higher chance of an MI, a 57% increased risk of early death, and an 81% higher likelihood of fatal ischemic heart disease/MI" - See vitamin D at Amazon.com.

Thyroxine Therapy Improves QoL in Subclinical Hypothyroidism - Medscape, 9/26/12 - "significant improvements in the domains of physical, affective, and social problems, as well as in overall quality of life in adults with SCH treated with L-thyroxine 50 µg/day for 6 months. The dose of L-thyroxine was titrated to achieve euthyroidism ... The baseline score for quality of life increased significantly at 6 months for patients receiving active therapy, whereas untreated patients tended to deteriorate ... In the treatment group, ankle edema, irritability, and memory loss improved, and patients lost weight. In the control group, dry skin, constipation, irritability, cold intolerance, alopecia, dry hair, myalgia, and sweating abnormalities continued" - Note:  I'm not a doctor but I still worry about the T3/T4 ratio.  I take both:

Gut bacteria could could play key role in development of type 2 diabetes - Science Daily, 9/26/12 - "The 1.5 kilograms of bacteria that we each carry in our intestines have an enormous impact on our health and well being. The bacteria normally live in a sensitive equilibrium but if this equilibrium is disrupted our health could suffer. In the new study, scientists examined the intestinal bacteria of 345 people from China, of which 171 had type 2 diabetes ... The research, which was recently published in the scientific journal Nature, also demonstrated that people with type 2 diabetes have a more hostile bacterial environment in their intestines, which can increase resistance to different medicines ... The big question now is whether the changes in gut bacteria can affect the development of type 2 diabetes or whether the changes simply reflect that the person is suffering from type 2 diabetes" - Follow-up story:

Melatonin and exercise work against Alzheimer's in mice - Science Daily, 9/26/12 - "The mice were divided into one control group and three other groups which would undergo different treatments: exercise -unrestricted use of a running wheel-, melatonin -a dose equivalent to 10 mg per kg of body weight-, and a combination of melatonin and voluntary physical exercise ... After six months, the state of the mice undergoing treatment was closer to that of the mice with no mutations than to their own initial pathological state. From this we can say that the disease has significantly regressed ... The results, which were published in the journal Neurobiology of Aging, show a general improvement in behaviour, learning, and memory with the three treatments ... These procedures also protected the brain tissue from oxidative stress and provided good levels of protection from excesses of amyloid beta peptide and hyperphosphorylated TAU protein caused by the mutations" - Note:  That's a huge amount of melatonin though but then on the other hand it was a short six month period but on the third hand, mice have a much shorter life span so it might interpolate to a much longer time span for humans.  See Source Naturals, Melatonin, 2.5 mg, Peppermint Flavored Sublingual, 60 Tablets which is what I take.

Resveratrol may preserve pain-relieving effects of morphine - Science Daily, 9/25/12 - "If the findings are confirmed in humans, resveratrol might become a useful addition to clinical pain management approaches -- especially in patients with chronic, severe pain who have become tolerant to the effects of morphine ... In morphine-tolerant rats, the pain-relieving response to morphine was about 20 percent of normal. In rats receiving resveratrol, morphine responses were restored to about 60 percent of normal ... resveratrol appeared to work in two ways. It reversed the increase in expression of a type of neurotransmitter (N-methyl D-aspartate, or NMDA) receptors associated with morphine tolerance. Resveratrol also blocked the increase of inflammation-promoting substances, called cytokines, in rats with morphine tolerance" - See resveratrol products at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome - Metabolism. 2012 Sep 26 - "In a randomized, single-blind, parallel design, participants consumed either 3 whole eggs/day (EGG, n=20) or the equivalent amount of yolk-free egg substitute (SUB, n=17), as part of a moderately carbohydrate-restricted diet (25%-30% energy) for 12 weeks ... Atherogenic dyslipidemia improved for all individuals as evidenced by reductions in plasma triglycerides, apoC-III, apoE, oxLDL, VLDL particle diameter, large VDL, total IDL, small LDL, and medium LDL particles (P<0.05). Furthermore, there were increases in HDL-cholesterol, large LDL and large HDL particles (P<0.05) for all individuals. However, there were greater increases in HDL-cholesterol and large HDL particles, and reductions in total VLDL and medium VLDL particles for those consuming EGG compared to SUB (P<0.05). Plasma insulin and insulin resistance (HOMA-IR) were reduced, while LCAT activity, and both HDL and LDL diameters increased over time in the EGG group only (P<0.05)"

In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells - Cancer Lett. 2012 Sep 26 - "Silibinin suppresses the growth of many cancers; however, its efficacy against pancreatic cancer has not been evaluated in established preclinical models. Here, we investigated in vitro and in vivo effects of silibinin against lower and advanced stages of human pancreatic carcinoma cells ... Overall, these findings show both in vitro as well as in vivo anticancer efficacy of silibinin against pancreatic cancer that could involve inhibition of cell proliferation, cell cycle arrest, apoptosis induction and/or decrease in tumor angiogenesis" - See silymarin at Amazon.com.

Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections - Br J Nutr. 2012 Oct 1:1-9 - "College students are susceptible to upper respiratory infections (URI) due to inadequate sleep, stress and close living quarters. Certain probiotic strains modulate immune function and may improve health-related quality of life (HRQL) during URI ... randomised to receive placebo (n 117) or probiotic-containing powder (daily dose of minimum 1 billion colony-forming units of each Lactobacillus rhamnosus LGG® (LGG®) and Bifidobacterium animalis ssp. lactis BB-12® (BB-12®); n 114) for 12 weeks ... The median duration of URI was significantly shorter by 2 d and median severity score was significantly lower by 34 % with probiotics v. placebo (P < 0.001), indicating a higher HRQL during URI. Number of missed work days was not different between groups (P = 0.429); however, the probiotics group missed significantly fewer school days (mean difference = 0.2 d) compared to the placebo group (P = 0.002). LGG® and BB-12® may be beneficial among college students with URI for mitigating decrements in HRQL" - See probiotic products at Amazon.com.

n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species - Br J Nutr. 2012 Oct 1:1-11 - "Increased n-6 and reduced n-3 long-chain PUFA (LC-PUFA) intake in Western diets may contribute to the increased prevalence of allergic diseases ... This suggests that dietary supplementation with EPA and/or DHA may alter the MC phenotype, contributing to a reduced susceptibility to develop and sustain allergic disease" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Associations of intake of antioxidant vitamins and fatty acids with asthma in pre-school children - Public Health Nutr. 2012 Oct 1:1-6 - "Compared with children with the lowest intake tertile for vitamin C and vitamin E, those in the highest were significantly inversely associated with asthma; adjusted OR (95 % CI) were 0.35 (0.14, 0.88) and 0.32 (0.12, 0.85), respectively. A statistically significant trend was also observed. Fruit intake showed an inverse but insignificant association with asthma. There were no associations of any type of fatty acids with asthma" - See vitamin C at Amazon.com and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

The association of red blood cell n-3 and n-6 fatty acids to dietary fatty acid intake, bone mineral density and hip fracture risk in the Women's Health Initiative - J Bone Miner Res. 2012 Sep 27 - "Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) in red blood cells (RBC) are an objective indicator of PUFA status and may be related to hip fracture risk ... A nested case-control study (n=400 pairs) was completed within the Women's Health Initiative (WHI) using 201 incident hip fracture cases from the Bone Mineral Density (BMD) cohort, along with 199 additional incident hip fracture cases randomly selected from the WHI Observational Study ... In adjusted hazard models, lower hip fracture risk was associated with higher RBC a-linolenic acid [Hazard ratio (HR) Tertile 3 (T3): 0.44; 95% CI: 0.23-0.85; p for linear trend 0.0154)], eicosapentaenoic acid (HR T3: 0.46; 95% CI: 0.24-0.87; p for linear trend 0.0181) and total n-3 PUFAs (HR T3: 0.55; 95% CI: 0.30-1.01; p for linear trend 0.0492). Conversely, hip fracture nearly doubled with the highest RBC n-6/n-3 ratio (HR T3: 1.96; 95% CI: 1.03-3.70; p for linear trend 0.0399). RBC PUFAs were not associated with BMD. RBC PUFAs were indicative of dietary intake of marine n-3 PUFAs (Spearman's rho=0.45, p<0.0001), total n-6 PUFAs (rho=0.17, p<0.0001) and linoleic acid (rho= 0.09, p<0.05). These results suggest that higher RBC a-linolenic acid, as well as eicosapentaenoic acid and total n-3 PUFAs, may predict lower hip fracture risk. Contrastingly, a higher RBC n-6/n-3 ratio may predict higher hip fracture risk in postmenopausal women" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Omega-6
polyunsaturated
Omega-3
polyunsaturated
Omega-9
monounsaturated
LA - Linoleic Acid ALA or LNA - Alpha linolenic acid Oleic acid
GLA - Gamma linolenic acid EPA - Eicosapentaenoic acid
DGLA - Dihomo gamma-linolenic Acid DHA - Docosahexaenoic acid  
AA - Arachidonic Acid DPA (omega 3) - Docosapentaenoic acid
DTA - Docosatetraenoic acid    
DPA -  (omega 6) Docosapentaenoic

Effects of omega-3 fatty acids on postprandial triglycerides and monocyte activation - Atherosclerosis. 2012 Sep 13 - "Patients were treated with 4 g n3-FA/day or placebo for 3 weeks in a randomized, placebo-controlled, double-blind, crossover study. Relative postprandial TG increase reached its maximum 4 h after fat intake (185.1 +/- 10.9% of baseline). n3-FA reduced fasting TG from 137.1 +/- 12.9 to 112.2 +/- 8.6 mg/dl (p < 0.05), and maximum ppTG concentrations from 243.6 +/- 24.6 to 205.8 +/- 17.1 mg/dl (p < 0.05), while relative TG increase (192.8 +/- 12.7%) was comparable to placebo" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Tadalafil : In the Treatment of Signs and Symptoms of Benign Prostatic Hyperplasia with or without Erectile Dysfunction - Drugs Aging. 2012 Sep;29(9):771-81 - "Once-daily tadalafil 5 mg was effective in treating the signs and symptoms of benign prostatic hyperplasia (BPH). In phase III trials in men with BPH, the mean change from baseline to week 12 in the total International Prostate Symptom Score (IPSS; primary endpoint) was significantly greater in those treated with once-daily tadalafil 5 mg than with placebo. Improvements in total IPSS that occurred over the initial 12 weeks of tadalafil treatment were maintained with continued treatment over a 1-year period in an open-label extension study. Moreover, tadalafil was effective in treating both erectile dysfunction (ED) and the signs and symptoms of BPH in a phase III trial that specifically enrolled men with both indications. Both the International Index of Erectile Function-Erectile Function domain score and the total IPSS (co-primary endpoints) were significantly improved from baseline to week 12 after treatment with once-daily tadalafil 5 mg compared with placebo" - See tadalafil at OffshoreRx1.com.

Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men - J Clin Endocrinol Metab. 2012 Sep 26 - "our data revealed a U-shaped association between serum IGF-I levels and all-cause mortality. Low as well as high serum IGF-I (quintile 1 or 5 vs. quintiles 2-4) associated with increased cancer mortality [hazard ratio (HR) = 1.86, 95% confidence interval (CI) = 1.34-2.58; and HR = 1.90, 95% CI = 1.37-2.65, respectively]. Only low serum IGF-I associated with increased CVD mortality (quintile 1 vs. quintiles 2-4, HR = 1.48, 95% CI = 1.08-2.04) ... Our findings demonstrate that both low and high serum IGF-I levels are risk markers for increased cancer mortality in older men. Moreover, low IGF-I levels associate with increased CVD mortality"

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people - Nutr J. 2012 Sep 26;11(1):79 - "Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures ... The present study was conducted in healthy middle aged people (40--60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption ... Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities" - See iHerb search of lipidated curcumin.

Serum high-density lipoprotein cholesterol and progression to arterial stiffness in middle-aged and elderly Chinese - Nutr Metab Cardiovasc Dis. 2012 Sep 22 - "participants in the highest quartile of HDL-c had an odds ratio of 0.442 (95% CI 0.268-0.729) for developing high arterial stiffness compared with participants in the lowest quartile" - See niacin at Amazon.com.

Vitamin D, cognition, and dementia: A systematic review and meta-analysis - Neurology. 2012 Sep 25;79(13):1397-405 - "Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D <50 nmol/L to those with values ≥50 nmol/L. There was significant heterogeneity among the studies that compared the WMD for MMSE but an overall positive effect for the higher vitamin D group (1.2, 95% confidence interval [CI] 0.5 to 1.9; I(2) = 0.65; p = 0.002). The small positive effect persisted despite several sensitivity analyses. Six studies presented data comparing Alzheimer disease (AD) to controls but 2 utilized a method withdrawn from commercial use. For the remaining 4 studies the AD group had a lower vitamin D concentration compared to the control group (WMD = -6.2 nmol/L, 95% CI -10.6 to -1.8) with no heterogeneity (I(2) < 0.01; p = 0.53) ... These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD" - See vitamin D at Amazon.com.

Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort - Br J Nutr. 2012 Sep 25:1-8 - "we studied the association between olive oil and CHD in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort study. The analysis included 40,142 participants (38 % male), free of CHD events at baseline, recruited from five EPIC-Spain centres from 1992 to 1996 and followed up until 2004 ... Cox proportional regression models were used to assess the relationship between validated incident CHD events and olive oil intake (energy-adjusted quartiles and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for potential confounders. During a 10.4-year follow-up, 587 (79 % male) CHD events were recorded. Olive oil intake was negatively associated with CHD risk after excluding dietary mis-reporters (hazard ratio (HR) 0.93; 95 % CI 0.87, 1.00 for each 10 g/d per 8368 kJ (2000 kcal) and HR 0.78; 95 % CI 0.59, 1.03 for upper v. lower quartile). The inverse association between olive oil intake (per 10 g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 % reduced CHD risk (P = 0.048)), in never/low alcohol drinkers (25 % reduced CHD risk (P < 0.001)) and in virgin olive oil consumers (14 % reduced CHD risk (P = 0.072)). In conclusion, olive oil consumption was related to a reduced risk of incident CHD events"

Health Focus (Breast Cancer):

Popular Medications:

Popular Supplements:

Alternative News:

  • Use of isoflavone supplements is associated with reduced postmenopausal breast cancer risk - Int J Cancer. 2012 Aug 13 - "Associations between ever use of 28 isoflavone supplements and breast cancer risk in Ontario, Canada were evaluated using cases (n=3101) identified in 2002-2003 from the Ontario Cancer Registry and controls (n=3471) identified through random digit dialing methods ... Several individual supplements were associated with reduced breast cancer risk (e.g. Natural HRT; AOR = 0.39; 95% CI: 0.22, 0.69; n(users) =58). Use of any isoflavone supplements was associated with reduced risk when ≥3 were ever used (AOR = 0.68; 95% CI: 0.54, 0.86; n(users) =332; P(trend) =0.008) or any was taken >5 years (AOR = 0.75; 95% CI: 0.60, 0.94; n(users) =325; P(trend) =0.01); high content supplements were consistently associated with reduced risk. Risk reduction was confined to postmenopausal breast cancer for both individual and combined supplements, and was strongest in the latter among high content users who ever took ≥3 supplements (AOR = 0.55; 95% CI: 0.38, 0.81; n(users) =118; P(trend) =0.04) or any >5 years (AOR = 0.47; 95% CI: 0.27, 0.81; n(users) =60; P(trend) =0.03). Associations did not differ by estrogen-progesterone tumor receptor status" - See soy isoflavones at Amazon.com.
  • Plant-based compound slows breast cancer in a mouse model - Science Daily, 8/2/12 - "The natural plant compound phenethyl isothiocyanate (PEITC) hinders the development of mammary tumors in a mouse model with similarities to human breast cancer progression ... PEITC has shown to be effective as a chemopreventative agent in mice for colon, intestinal, and prostate cancer, by inducing apoptosis ... administering PEITC for 29 weeks was linked with a 56.3% reduction in mammary carcinoma lesions greater than 2mm ... Since chemoprevention trials are both expensive and time-consuming and necessitate years of follow-up, the authors feel that, "The discovery of biomarker(s) associated with exposure and activity is critical for clinical development of promising cancer chemopreventative agents." - See cruciferous vegetables supplement at Amazon.com.
  • Vitamin D May Help Breast Cancer Survivors Stay on Track - Medscape, 6/25/12 - "women taking 30,000 IU of oral vitamin D3 weekly on starting letrozole therapy achieved significant benefits in terms of fatigue, joint pain, and disability from joint pain ... Aromatase inhibitors are one of the most important endocrine treatments for breast cancer, but the problem is that about half of the women have severe musculoskeletal pain from these agents, and 18% to 30% report fatigue, [resulting in] a discontinuation rate of about 10% each year ... pain relievers are the only available treatment option ... Using the Simple Descriptive Pain Intensity scale for analysis, only 37% of women receiving vitamin D3 supplementation reported a musculoskeletal event (joint pain, disability from joint pain, or resulting discontinuation of letrozole) at 6 months compared with 51% of those in the placebo group ... In addition, significantly fewer patients receiving vitamin D3 supplementation reported adverse quality of life events, including worsening of pain, disability, or fatigue (42% vs 72%; P < .001)" - See vitamin D at Amazon.com.
  • Diabetes, Metformin, and Breast Cancer in Postmenopausal Women - J Clin Oncol. 2012 Jun 11 - "assessed associations among diabetes, metformin use, and breast cancer in postmenopausal women participating in Women's Health Initiative clinical trials ... observed over a mean of 11.8 years ... Women with diabetes receiving medications other than metformin had a slightly higher incidence of breast cancer (hazard ratio [HR], 1.16; 95% CI, 0.93 to 1.45), and women with diabetes who were given metformin had lower breast cancer incidence (HR, 0.75; 95% CI, 0.57 to 0.99). The association was observed for cancers positive for both estrogen receptor and progesterone receptor and those that were negative for human epidermal growth factor receptor 2 ... Metformin use in postmenopausal women with diabetes was associated with lower incidence of invasive breast cancer" - See metformin at IAS.
  • Eating cruciferous vegetables may improve breast cancer survival - Science Daily, 4/3/12 - "a prospective study of 4,886 Chinese breast cancer survivors who were diagnosed with stage 1 to stage 4 breast cancer from 2002 to 2006 ... Women who were in the highest quartiles of intake of vegetables per day had a 62 percent reduced risk of total mortality, 62 percent reduced risk of breast cancer mortality, and 35 percent reduced risk of breast cancer recurrence ... cruciferous vegetable consumption habits differ between China and the United States and suggested this fact be considered when generalizing these results to U.S. breast cancer survivors ... Commonly consumed cruciferous vegetables in China include turnips, Chinese cabbage/bok choy and greens, while broccoli and Brussels sprouts are the more commonly consumed cruciferous vegetables in the United States and other Western countries ... Cruciferous vegetables contain phytochemicals known as isothiocyanates and indoles which appear to have a protective effect against some types of cancer" - See cruciferous supplements at Amazon.com.
  • More fiber may reduce breast cancer risk: Meta-analysis - Nutra USA, 1/23/12 - "Every 10 gram per day increase in soluble fiber intake was associated with a 26% reduction in the risk of breast cancer, but no such effect was observed for insoluble fiber" - [Abstract]
    • Dietary Fiber: Insoluble and Soluble Fiber - WebMD - "Soluble fiber dissolves in water. Insoluble fiber does not ... Sources of soluble fiber: oatmeal, oat cereal, lentils, apples, oranges, pears, oat bran, strawberries, nuts, flaxseeds, beans, dried peas, blueberries, psyllium, cucumbers, celery, and carrots ... Sources of insoluble fiber: whole wheat, whole grains, wheat bran, corn bran, seeds, nuts, barley, couscous, brown rice, bulgur, zucchini, celery, broccoli, cabbage, onions, tomatoes, carrots, cucumbers, green beans, dark leafy vegetables, raisins, grapes, fruit, and root vegetable skins"
  • Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status - Nutr Cancer. 2012 Jan 2 - "Legume intake (mostly from black soybeans) was inversely associated with the risk of breast cancer recurrence in HER2 negative cancer patients (HR: 0.27, 95% CI: 0.13-0.57, P for trend < 0.01), whereas legume intake was positively associated in HER2 positive cancer patients (P for trend = 0.02). In HER2 negative cancer patients, isoflavone was inversely associated with breast cancer recurrence (HR: 0.23, 95% CI: 0.06-0.89; P for trend = 0.01). Total soy intake was not associated with an increased risk of cancer recurrence. In conclusion, overall soy food intake might not affect the risk of cancer recurrence, but high intake of soy isoflavones increased the risk of cancer recurrence in HER2-positive breast cancer patients. However, further research is needed to confirm these results due to the small number of cancer recurrence events"
  • ω-3 and ω-6 polyunsaturated fatty acid intakes and the risk of breast cancer in Mexican women: impact of obesity status - Cancer Epidemiol Biomarkers Prev. 2011 Dec 22 - "Overall, there was no significant association between ω-3 PUFA intake and breast cancer risk (p=0.31). An increased risk of breast cancer was associated with increasing ω-6 PUFA intake in pre-menopausal women (OR=1.92, 95% CI=1.13;3.26; p=0.04). A decreased risk of breast cancer was significantly associated with increasing ω-3 PUFA intake in obese women (OR=0.58, 95%CI=0.39;0.87; p=0.008), but not in normoweight nor in overweight women (p for heterogeneity = 0.017)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Low levels of alcohol consumption associated with small increased risk of breast cancer, study finds - Science Daily, 11/1/11 - "Analyses of data indicated that a low level of alcohol consumption (5.0 to 9.9 grams per day, equivalent to 3-6 glasses of wine per week) was modestly but statistically significantly associated with a 15 percent increased risk of breast cancer. In addition, women who consumed at least 30 grams of alcohol daily on average (at least 2 drinks per day) had a 51 percent increased risk of breast cancer compared with women who never consumed alcohol"
  • Inhibitory Effects of Combination of Lycopene and Genistein on 7,12- Dimethyl Benz(a)anthracene-Induced Breast Cancer in Rats - Nutr Cancer. 2011 Sep 29 - "Breast cancer is one of the most common cancers in women. Carotenoids and soy isoflavones have been postulated to have breast cancer preventive effects ... 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogen known to induce breast tumors ... Tumor weight decreased by 48%, 61%, and 67%, and mean tumor volume decreased by 18%, 35%, and 65% with lycopene, genistein, and lycopene + genistein, respectively (P < 0.01 for the combination). The proportions of adenocarcinoma masses decreased with lycopene and genistein combination (P < 0.05). Administration of lycopene and genistein combination suppressed breast cancer development and was associated with a decrease in MDA, 8-isoprostane, and 8-OhdG levels and with an increase in serum lycopene and genistein levels. Animals administered DMBA developed breast cancer, which was associated with increased expression of Bcl-2 and decreased expression of Bax, caspase 3, and caspase 9 in mammary tissues. Administration of genistein and lycopene in combination was more effective in inhibiting DMBA-induced breast tumors and modulating the expression of apoptosis associated proteins than the administration of each agent alone" - See lycopene at Amazon.com and genistein at Amazon.com.
  • Red wine ingredient resveratrol stops breast cancer growth, study suggests - Science Daily, 9/29/11 - "resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of estrogen ... resveratrol is able to counteract the malignant progression since it inhibits the proliferation of hormone resistant breast cancer cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy ... Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy" - See resveratrol products at Amazon.com.
  • Blueberry powder may slow breast tumor growth: Mouse data - Nutra USA, 9/20/11 - "The California-based researchers performed two separate experiments. The first put mice in one of three diet groups: A control diet or the diet supplemented with 5% or 10% blueberry powder ... After two weeks of feeding the mice received injections containing aggressive breast cancer cells. After a further six weeks of observation the researchers reported that the 5 and 10% blueberry groups displayed a 75 and 60% reduction in tumor size, compared to the control group ... In addition, results from molecular analysis revealed that blueberry consumption was associated with an alteration in the expression of genes related to inflammation, cancer, and metastasis in such a way that cancer risk would most likely decline ... This suggests that there may be an optimal level of blueberry intake" - [Abstract] - See blueberry extract at Amazon.com.
  • Plant compound reduces breast cancer mortality, study suggests - Science Daily, 9/13/11 - "The most important type of phytoestrogens in our Western diet are lignans, which are contained in seeds, particularly flaxseeds, as well as in wheat and vegetables. In the bowel, these substances are turned into enterolactone, which is absorbed by the mucous tissue and which was determined by the Heidelberg researchers as a biomarker in the patients' blood ... Compared to the study subjects with the lowest enterolactone levels, the women with the highest blood levels of this biomarker had an approximately 40 percent lower mortality risk ... Another observation that may be interpreted in this direction is that Asian women are less frequently affected by breast cancer. Their soy-rich diet contains large amounts of another type of phytoestrogens, isoflavones. On the other hand, scientists fear that isoflavones might imitate the growth-promoting properties of real hormones and, thus, accelerate hormone-dependent tumors such as breast cancer and prostate cancer. "It has not yet been finally determined whether lignans in the body imitate the hormone effect or, on the contrary, counteract it,""
  • Whole Blueberry Powder Modulates the Growth and Metastasis of MDA-MB-231 Triple Negative Breast Tumors in Nude Mice - J Nutr. 2011 Aug 31 - "In this study, tumor volume was 75% lower in mice fed the 5% BB diet and 60% lower in mice fed the 10% BB diet than in control mice (P ≤ 0.05). Tumor cell proliferation (Ki-67) was lower in the 5 and 10% BB-fed mice and cell death (Caspase 3) was greater in the 10% BB-fed mice compared to control mice (P ≤ 0.05). Gene analysis of tumor tissues from the 5% BB-fed mice revealed significantly altered expression of genes important to inflammation, cancer, and metastasis, specifically, Wnt signaling, thrombospondin-2, IL-13, and IFNγ. To confirm effects on Wnt signaling, analysis of tumor tissues from 5% BB-fed mice revealed lower β-catenin expression and glycogen synthase kinase-3β phosphorylation with greater expression of the β-catenin inhibitory protein adenomatous polyposis coli compared to controls. A second study tested the ability of the 5% BB diet to inhibit MDA-MB-231-luc-D3H2LN metastasis in vivo. In this study, 5% BB-fed mice developed 70% fewer liver metastases (P = 0.04) and 25% fewer lymph node metastases (P = 0.09) compared to control mice. This study demonstrates the oral antitumor and metastasis activity of whole BB powder against TNBC in mice" - See blueberry extract at Amazon.com.
  • Vitamin D relieves joint, muscle pain for breast cancer patients - Science Daily, 7/26/11 - "Rastelli's group recruited 60 patients who reported pain and discomfort associated with anastrozole, one of three FDA-approved aromatase inhibitors. The patients they studied also had low vitamin D levels. Half the group was randomly assigned to receive the recommended daily dose of vitamin D (400 international units) plus a 50,000-unit vitamin D capsule once a week. The other half received the daily dose of 400 units of vitamin D plus a weekly placebo. All subjects received 1,000 milligrams of calcium daily throughout the study ... patients receiving high-dose vitamin D every week reported significantly less musculoskeletal pain and also were less likely to experience pain that interfered with daily living" - See vitamin D at Amazon.com.
  • Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression - Cancer Causes Control. 2011 Jul 15 - "Overall, 51 studies met the inclusion criteria. Comparing the highest with the lowest intake, total vitamin A intake reduced the breast cancer risk by 17% (pooled OR = 0.83, 95% CI: 0.78-0.88). Further subgroup analysis based on study design did not change the significant reduction. Although the dietary vitamin A, dietary vitamin E, and total vitamin E intake all reduced breast cancer risk significantly when data from all studies were pooled, the results became nonsignificant when data from cohort studies were pooled. The significant association between total retinol intake and breast cancer in all studies became nonsignificant in case-control studies but remain significant in cohort studies. No significant dose-response relationship was observed in the higher intake of these vitamins with reduced breast cancer risk"
  • Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies - Am J Clin Nutr. 2011 Jul 20 - "We identified 10 prospective cohort studies of dietary fiber intake and risk of breast cancer involving 16,848 cases and 712,195 participants. The combined RR of breast cancer for the highest compared with the lowest dietary fiber intake was 0.89 (95% CI: 0.83, 0.96), and little evidence of heterogeneity was observed. The association between dietary fiber intake and risk of breast cancer did not significantly differ by geographic region, length of follow-up, or menopausal status of the participants. Omission of any single study little changed the combined risk estimate. Dose-response analysis showed that every 10-g/d increment in dietary fiber intake was associated with a significant 7% reduction in breast cancer risk. Little evidence of publication bias was found"
  • Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status - Br J Nutr. 2011 May 16:1-8 - "Dietary intake information was assessed using a validated FFQ administered through a face-to-face interview ... A significant inverse association was found between dietary folate and vitamin B6 intake and breast cancer risk. The adjusted OR of the highest v. the lowest quartile were 0.32 (95 % CI 0.21, 0.49; Ptrend < 0.001) for dietary folate and 0.46 (95 % CI 0.30, 0.69; Ptrend < 0.001) for vitamin B6. No associations were observed for vitamin B12 and methionine intake. A significant inverse association between dietary folate intake and breast cancer risk was observed in all subtypes of ER and PR status. These findings suggest that dietary folate and vitamin B6 intakes were inversely associated with breast cancer risk. The inverse association did not differ by ER and/or PR status"
  • Low-carbohydrate, high-protein diets may reduce both tumor growth rates and cancer risk - Science Daily, 6/14/11 - "The first diet, a typical Western diet, contained about 55 percent carbohydrate, 23 percent protein and 22 percent fat. The second, which is somewhat like a South Beach diet but higher in protein, contained 15 percent carbohydrate, 58 percent protein and 26 percent fat. They found that the tumor cells grew consistently slower on the second diet ... As well, mice genetically predisposed to breast cancer were put on these two diets and almost half of them on the Western diet developed breast cancer within their first year of life while none on the low-carbohydrate, high-protein diet did. Interestingly, only one on the Western diet reached a normal life span (approximately 2 years), with 70 percent of them dying from cancer while only 30 percent of those on the low-carbohydrate diet developed cancer and more than half these mice reached or exceeded their normal life span ... tumor cells, unlike normal cells, need significantly more glucose to grow and thrive. Restricting carbohydrate intake can significantly limit blood glucose and insulin, a hormone that has been shown in many independent studies to promote tumor growth in both humans and mice"
  • Breast cancer research: Mammary gland development of blueberry-fed lab animals studied - Science Daily, 6/7/11 - "several indicators of rat mammary gland health were improved in the offspring (pups) of mothers (dams) that had been fed 5 percent blueberry powder in their rations during pregnancy and during the weeks that they nursed their pups ... In their analysis of several biochemical indicators, the team found, for instance, that the level of the tumor-suppressing protein PTEN (phosphatase and tensin homolog deleted in chromosome 10) was significantly higher in mammary tissues of offspring of dams on the 5 percent regimen. That's a plus, because PTEN is thought to help protect against cancer" - See blueberry extract at Amazon.com.
  • Magnesium supplements may ease hot flashes for breast cancer patients - Nutra USA, 6/6/11 - "400 mg per day of magnesium oxide for 4 weeks was associated with a 41.4 percent reduction in the frequency of hot flashes ... The intensity of the hot flashes was also reduced as a result of magnesium supplementation by about 50 percent" - [Abstract] - See magnesium supplements at Amazon.com.
  • Coffee reduces breast cancer risk, study suggests - Science Daily, 5/10/11 - "Researchers from Sweden compared lifestyle factors and coffee consumption between women with breast cancer and age-matched women without. They found that coffee drinkers had a lower incidence of breast cancer than women who rarely drank coffee. However they also found that several lifestyle factors affected breast cancer rates, such as age at menopause, exercise, weight, education, and a family history of breast cancer. Once they had adjusted their data to account for these other factors they found that the protective effect of coffee on breast cancer was only measurable for ER-negative breast cancer"
  • Low Vitamin D Linked to Aggressive Breast Cancer - WebMD, 4/29/11 - "Women in the study with triple-negative tumors, which do not respond to hormone treatments, were almost three times more likely to have suboptimal vitamin D levels as women with other breast cancers"
  • Lights in the Bedroom Increase Breast Cancer Risk - Medscape, 1/11/11 - "This is the third study to suggest that women who have lights on in the bedroom are at greater risk for breast cancer than those who sleep in total darkness ... light at night in the sleeping habitat significantly increased the risk for breast cancer (odds ratio, 1.22"
  • High dietary fat, cholesterol linked to increased risk of breast cancer - Science Daily, 1/6/11 - "This mouse model is believed to closely parallel the pathogenesis of human breast cancer. PyMT mice were placed on a diet that contained 21.2 percent fat and 0.2 percent cholesterol, reflective of a typical Western diet. A control group of PyMT mice was fed a normal chow that had only 4.5 percent fat and negligible amounts of cholesterol ... tumors began to develop quickly in mice fed the fat/cholesterol-enriched chow. In this group, the number of tumors was almost doubled, and they were 50 percent larger than those observed in mice that ate a normal diet. "The consumption of a Western diet resulted in accelerated tumor onset and increased tumor incidences, multiplicity, and burden, suggesting an important role for dietary cholesterol in tumor formation," ... There was also a trend towards an increased number of lung metastasis in mice fed the fatty diet"
  • Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study - Cancer Epidemiol Biomarkers Prev. 2010 Dec 21 - "Antioxidants may protect normal cells from the oxidative damage that occurs during radiotherapy and certain chemotherapy regimens, however, the same mechanism could protect tumor cells and potentially reduce effectiveness of cancer treatments ... Vitamin use shortly after breast cancer diagnosis was associated with reduced mortality and recurrence risk, adjusted for multiple lifestyle factors, sociodemographics, and known clinical prognostic factors. Women who used antioxidants (vitamin E, vitamin C, multivitamins) had 18% reduced mortality risk (hazard ratio (HR) = 0.82, 95% confidence interval (CI): 0.65-1.02) and 22% reduced recurrence risk (HR = 0.78, 95% CI: 0.63-0.95). The inverse association was found regardless of whether vitamin use was concurrent or non-concurrent with chemotherapy, but was only present among patients who did not receive radiotherapy"
  • Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling - Cancer Lett. 2010 Dec 16 - "The anti-tumor activity of rapamycin is compromised by the feedback-loop-relevant hyperactive PI3K and ERK-MAPK pathway signaling. In breast cancer cells treated with rapamycin, we observed a moderate increase of AKT phosphorylation (P-AKT) in a rapamycin resistant cell line, MDA-MB-231, as well as a slight increase of P-AKT in a rapamycin sensitive cell line, MCF-7. We found that resveratrol, a natural phytoalexin, suppressed the phosphorylation and activation of the PI3K/AKT pathway in all the three breast cancer cell lines that we tested. It also had a weak inhibitory effect on the activation of the mTOR/p70S6K pathway in two cell lines expressing wildtype PTEN, MCF-7 and MDA-MB-231. The combined use of resveratrol and rapamycin resulted in modest additive inhibitory effects on the growth of breast cancer cells, mainly through suppressing rapamycin-induced AKT activation"
  • Dietary patterns and risk of breast cancer - Br J Cancer. 2010 Dec 14 - "only that characterised by high consumption of fruit and salad was associated with a reduced risk, with stronger associations observed for tumours not expressing oestrogen (ER) and progesterone receptors (PR). Compared with women in the lowest quintile of the factor score, the hazard ratio for women in the highest quintile was 0.92 (95% confidence interval (CI)=0.70-1.21; test for trend, P=0.5) for ER-positive or PR-positive tumours and 0.48 (95% CI=0.26-0.86; test for trend, P=0.002) for ER-negative and PR-negative tumours"
  • Joint effects of dietary vitamin D and sun exposure on breast cancer risk: results from the French E3N cohort - Cancer Epidemiol Biomarkers Prev. 2010 Dec 2 - "Dietary and supplemental vitamin D intakes were not associated with BC risk; however, in regions with the highest UVRd, postmenopausal women with high dietary or supplemental vitamin D intake had a significantly lower BC risk as compared to women with the lowest vitamin D intake (HR = 0.68, 95% CI: 0.54 - 0.85, and HR = 0.55, 95% CI: 0.36 - 0.90 respectively)" - See vitamin D at Amazon.com.
  • Vitamin D Levels Low Even In Breast Cancer Patients Taking Supplements - Medscape, 12/10/10 - "A majority of the women (73%) were taking vitamin D supplements, but even among this group, vitamin D deficiency was found in 25%" - See vitamin D at Amazon.com.
  • Metformin and incident breast cancer among diabetic women: a population-based case-control study in Denmark - Cancer Epidemiol Biomarkers Prev. 2010 Nov 30 - "Metformin users were less likely to be diagnosed with breast cancer (OR=0.77; 95% CI=0.61, 0.99) than non-metformin users. Adjusting for diabetes complications, clinically diagnosed obesity, and important predictors of breast cancer did not substantially alter the association (OR=0.81; 95%CI=0.63, 0.96). CONCLUSION: Our results suggest that metformin may protect against breast cancer in type 2 diabetic peri- or postmenopausal women. Impact: This study supports the growing evidence of a role for metformin in breast cancer chemoprevention"
  • Dietary patterns and breast cancer risk among Chinese women - Cancer Causes Control. 2010 Nov 16 - "a 74% decreased risk was observed among women in the highest quartile of the vegetable-fruit-soy-milk-poultry-fish dietary pattern relative to the lowest quartile (OR = 0.26, 95% CI = 0.17-0.42). The refined grain-meat-pickle pattern was positively associated with breast cancer risk (OR = 2.58, 95% CI = 1.53, 4.34). Women with a high intake of the vegetable-fruit-soy-milk-poultry-fish pattern and a low intake of the refined grain-meat-pickle pattern showed a decreased risk of breast cancer (adjusted OR = 0.26, 95% CI = 0.17-0.41)"
  • Soy isoflavones may modify risk of breast cancer - Science Daily, 11/8/10 - "Those women with the highest isoflavone intake had an approximately 30 percent decreased risk of having an invasive breast tumor, and an approximately 60 percent decreased risk of having a grade 1 tumor ... Among premenopausal women, the highest intake of isoflavones had a 30 percent decreased risk of stage I disease, a 70 percent decreased risk of having a tumor larger than 2 cm, and a 60 percent decreased risk of having stage 2 breast cancer. These connections were not seen among postmenopausal women" - See soy isoflavones at Amazon.com.
  • Soy intake associated with lower recurrence of breast cancer in hormone-sensitive cancers - Science Daily, 10/18/10 - "The recurrence rate of estrogen- and progesterone- positive breast cancer was 12.9% lower among patients in the highest quartile of soy isoflavone intake than among those in the lowest quartile and was 18.7% lower for patients receiving anastrozole therapy in the highest quartile" - See soy isoflavones at Amazon.com.
  • Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: A prospective cohort study - Int J Cancer. 2010 Sep 28 - "We found no association of breast cancer risk to dietary intake of linoleic acid, arachidonic acid, α-linolenic acid, or marine-derived n-3 PUFA. We found a statistically significant interaction between n-6 PUFA intake, marine-derived n-3 PUFA intake and breast cancer risk (p = 0.008). Women with lower intake (the lowest tertile) of marine-derived n-3 PUFA and higher intake (the highest tertile) of n-6 PUFA had an increase risk for breast cancer (RR=2.06; 95% CI=1.27-3.34) compared to women with higher intake (the highest tertile) of marine-derived n-3 PUFAs and lower intake (the lowest tertile) of n-6 PUFAs after adjusting for potential confounders. The relative amounts of n-6 PUFA to marine-derived n-3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort - Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2341-50 - "We found a decreased risk of breast cancer with increasing 25(OH) vitamin D(3) serum concentrations (odds ratio, 0.73; 95% confidence interval, 0.55-0.96; P trend = 0.02) among women in the highest tertile. We also observed a significant inverse association restricted to women under 53 years of age at blood sampling [odds ratio (T(3) versus T(1)), 0.60; 95% confidence interval, 0.37-0.98; P trend = 0.04]. In premenopausal women, the risk was also decreased, although not significantly" - See vitamin D at Amazon.com.
  • Fish oil may reduce risk of breast cancer - Science Daily, 7/8/10 - "asked 35,016 postmenopausal women who did not have a history of breast cancer to complete a 24-page questionnaire about their use of non-vitamin, non-mineral "specialty" supplements in the Vitamins and Lifestyle (VITAL) cohort study ... Regular use of fish oil supplements, which contain high levels of the omega-3 fatty acids, EPA and DHA, was linked with a 32 percent reduced risk of breast cancer. The reduction in risk appeared to be restricted to invasive ductal breast cancer, the most common type of the disease" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Key mechanism links virgin olive oil to protection against breast cancer - Science Daily, 6/30/10 - "virgin olive oil is associated with higher incidences of benign breast tumours and at the same time with a decrease in the activity of the p21Ras oncogene, which spurs uncontrolled cell proliferation and stimulates the growth of tumours. In addition, olive oil suppresses the activity of some proteins, such as the AKT, essential for the survival of cells since they prevent apoptosis, the cell's "suicide" programme. Between proliferation and apoptosis in tumour cells, these effects tip the balance towards cell death, thereby slowing the growth of tumours" - See olive leaf extract at Amazon.com.
  • How dietary supplement may block cancer cells - Science Daily, 6/29/10 - "The research showed that I3C causes the destruction of that molecule and thereby blocks the growth of breast cancer cells ... Cdc25A is present at abnormally high levels in about half of breast cancer cases, and it is associated with a poor prognosis ... The molecule also occurs at abnormally high levels in cancers of the breast, prostate, liver, esophagus, endometrium and colon, and in non-Hodgkin lymphoma, and in other diseases such as Alzheimer's disease ... I3C can have striking effects on cancer cells ... When the substance was given orally to the mice, it reduced tumor size by up to 65 percent. They also showed that I3C had no affect on breast-cell tumors in which the Cdc25A molecule had a mutation in that key location" - See indole-3-carbinol at Amazon.com.
  • Women who choose boiled coffee run lower risk of breast cancer, Swedish study finds - Science Daily, 6/16/10 - "A major difference between boiled and filtered coffee is that the boiled version contains up to 80 times as much coffee-specific fatty acids ... Among women who drank boiled coffee more than four times a day there was a lowered risk of breast cancer compared with women who drank coffee less than once a day. Among women who drank filtered coffee there was an increased risk for early breast cancer (under 49 years old) and a decreased risk for late breast cancer (over 55 years old). Boiled-coffee drinkers, but not filtered-coffee drinkers, also had an increased risk of pancreatic cancer and lung cancer among men"
  • Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York Exposures and Breast Cancer (WEB) Study - Cancer Causes Control. 2010 May 25 - "Recent aspirin use was inversely associated with breast cancer risk (adjusted OR 0.80, 95% CI: 0.68-0.94); the strongest reduction in risk was observed among those who took >/=2 pills/day on days that aspirin was taken (OR 0.74, 95% CI: 0.61-0. 90). Adult lifetime use was also associated with breast cancer risk (>10 days/month, adjusted OR 0.68, 95% CI: 0.46-1.00). Use of ibuprofen or acetaminophen was not associated with breast cancer"
  • Broccoli component limits breast cancer stem cells, study finds - Science Daily, 5/4/10 - "In the current study, researchers took mice with breast cancer and injected varying concentrations of sulforaphane from the broccoli extract. Researchers then used several established methods to assess the number of cancer stem cells in the tumors. These measures showed a marked decrease in the cancer stem cell population after treatment with sulforaphane, with little effect on the normal cells. Further, cancer cells from mice treated with sulforaphane were unable to generate new tumors. The researchers then tested sulforaphane on human breast cancer cell cultures in the lab, finding similar decreases in the cancer stem cells" - See sulforaphane at Amazon.com.
  • Vitamin and calcium supplements may reduce breast cancer risk - Science Daily, 4/18/10 - "It is not an immediate effect. You don't take a vitamin today and your breast cancer risk is reduced tomorrow ... Vitamin supplements appeared to reduce the risk of breast cancer by about 30 percent"
  • Experts allay fears over multivitamins and breast cancer risk - Nutra USA, 4/7/10
  • Bitter melon extract decreased breast cancer cell growth - Science Daily, 2/23/10 - "Bitter melon extract, a common dietary supplement, exerts a significant effect against breast cancer cell growth and may eventually become a chemopreventive agent against this form of cancer ... the mechanism of bitter melon extract significantly decreased proliferation, that is, cell growth and division, and induced death in breast cancer cells" - See bitter melon extract at Amazon.com.
  • Aspirin Intake and Survival After Breast Cancer - J Clin Oncol. 2010 Feb 16 - "Aspirin use was associated with a decreased risk of breast cancer death. The adjusted relative risks (RRs) for 1, 2 to 5, and 6 to 7 days of aspirin use per week compared with no use were 1.07 (95% CI, 0.70 to 1.63), 0.29 (95% CI, 0.16 to 0.52), and 0.36 (95% CI, 0.24 to 0.54), respectively (test for linear trend, P < .001). This association did not differ appreciably by stage, menopausal status, body mass index, or estrogen receptor status. Results were similar for distant recurrence. The adjusted RRs were 0.91 (95% CI, 0.62 to 1.33), 0.40 (95% CI, 0.24 to 0.65), and 0.57 (95% CI, 0.39 to 0.82; test for trend, P = .03) for 1, 2 to 5, and 6 to 7 days of aspirin use, respectively. CONCLUSION: Among women living at least 1 year after a breast cancer diagnosis, aspirin use was associated with a decreased risk of distant recurrence and breast cancer death"
  • DHA omega-3 may improve chemotherapy outcomes: Study - Nutra USA, 2/10/10 - "Our data show for the first time that a dietary intervention targeted on DHA is a feasible approach that has potential to substantially increase survival in metastatic breast cancer patients treated with chemotherapy ... the overall survival of women was 22 months, and reached 34 months in women with the highest DHA levels in their blood" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial - Br J Cancer. 2009 Dec 15;101(12):1978-85 - "The objective response rate was 44%. With a mean follow-up time of 31 months (range 2-96 months), the median TTP was 6 months. Median OS was 22 months and reached 34 months in the sub-population of patients (n = 12) with the highest plasma DHA incorporation. The most common grade 3 or 4 toxicity was neutropaenia (80%). CONCLUSION: DHA during chemotherapy was devoid of adverse side effects and can improve the outcome of chemotherapy when highly incorporated. DHA has a potential to specifically chemosensitise tumours" - See Jarrow Max DHA at Amazon.com.
  • Carotenoids may reduce breast cancer risk in women: Study - Nutra USA, 2/8/10 - "The highest average levels of alpha- and beta-carotene were associated with a 68 and 65 per cent reduction in the risk of ER-PR breast cancer among smokers" - [Abstract] - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Moderate physical activity and breast cancer risk: the effect of menopausal status - Cancer Causes Control. 2010 Jan 19 - "Participating in moderate-intensity physical activity decreased the risk of BC in both pre- and postmenopausal women (OR = 0.96; 95% CI 0.92.-0.99; OR = 0.90; 95% CI 0.86-0.93, respectively) for every 3 h per week of moderate-intensity physical activity. There was a statistically significant modification effect by menopausal status"
  • Pomegranates May Stall Breast Cancer - WebMD, 1/5/10 - "Eating pomegranates or drinking pomegranate juice may help prevent and slow the growth of some types of breast cancer ... Researchers say the ellagitannins in pomegranates work by inhibiting aromatase, which is a key enzyme used by the body to make estrogen and plays a key role in breast cancer growth" - See pomegranate at Amazon.com.
  • Soy food intake and breast cancer survival - JAMA. 2009 Dec 9;302(22):2437-43 - "Soy food intake, as measured by either soy protein or soy isoflavone intake, was inversely associated with mortality and recurrence. The hazard ratio associated with the highest quartile of soy protein intake was 0.71 (95% confidence interval [CI], 0.54-0.92) for total mortality and 0.68 (95% CI, 0.54-0.87) for recurrence compared with the lowest quartile of intake. The multivariate-adjusted 4-year mortality rates were 10.3% and 7.4%, and the 4-year recurrence rates were 11.2% and 8.0%, respectively, for women in the lowest and highest quartiles of soy protein intake. The inverse association was evident among women with either estrogen receptor-positive or -negative breast cancer and was present in both users and nonusers of tamoxifen. CONCLUSION: Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence"
  • Spices may boost breast health: Study - Nutra USA, 12/9/09 - "curcumin, found in turmeric, and piperine, found in black peppers, decreased the number of stem cells while having no effect on normal differentiated cells ... If we can limit the number of stem cells, we can limit the number of cells with potential to form tumours ... normal, non-cancerous stem cells were unaffected by the compounds, which appeared to selectively target the cancer stem cells" - [Abstract] - See curcumin products at Amazon.com and piperine extract at Amazon.com.
  • Targeting breast stem cells with the cancer preventive compounds curcumin and piperine - Breast Cancer Res Treat. 2009 Nov 7 - "Both curcumin and piperine inhibited mammosphere formation, serial passaging, and percent of ALDH+ cells by 50% at 5 muM and completely at 10 muM concentration in normal and malignant breast cells. There was no effect on cellular differentiation. Wnt signaling was inhibited by both curcumin and piperine by 50% at 5 muM and completely at 10 muM. Curcumin and piperine separately, and in combination, inhibit breast stem cell self-renewal but do not cause toxicity to differentiated cells. These compounds could be potential cancer preventive agents. Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials" - See curcumin products at Amazon.com and piperine extract at Amazon.com.
  • Soy Appears Safe for Breast Cancer Survivors - WebMD, 12/8/09
  • Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases" - See resveratrol products at Amazon.com.
  • High Fiber Intake Linked to Reduced Risk of Breast Cancer - Science Daily, 10/2/09 - "Relative to the lowest quintile of total fiber intake, the highest quintile was associated with a 13% decreased risk of breast cancer"
  • Recent, Vigorous Exercise Is Associated With Reduced Breast Cancer Risk - Science Daily, 10/1/09
  • Diabetes Drug Fights Breast Cancer - WebMD, 9/14/09 - "And in mice carrying human breast cancers, metformin made standard chemotherapy vastly more effective. Mice treated with the combination remain cancer-free for four months, unlike mice treated with either drug alone ... A lot of data shows lower cancer risk -- not just breast cancer -- in people taking metformin for diabetes ... This drug at low doses can be considered a very good candidate for cancer prevention before a person has any cancer at all" - Note:  I've been taking metformin for years for anti-aging.  See my Insulin and Aging page.  See metformin at IAS.
  • The Way You Eat May Affect Your Risk For Breast Cancer - Science Daily, 8/4/09
  • Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors - Menopause. 2009 Jul 22 - "Combined hormone therapy (HT) containing estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to increased risk of breast cancer in postmenopausal women, compared with HT regimens containing estrogen alone or placebo ... Treatment with curcumin delayed the first appearance of MPA-accelerated tumors by 7 days, decreased tumor incidence by the end of the experiment, and reduced tumor multiplicity in DMBA-induced MPA-accelerated tumors. Curcumin also prevented many of the gross histological changes seen in the MPA-treated mammary gland. Immunohistochemical analyses of mammary tumors showed that curcumin decreased MPA-induced VEGF induction in hyperplastic lesions, although it did not affect the levels of estrogen and progesterone receptors" - See curcumin products at Amazon.com.
  • Asian Spice Could Reduce Breast Cancer Risk In Women Exposed To Hormone Replacement Therapy - Science Daily, 7/13/09 - "curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy ... curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands" - See curcumin products at Amazon.com.
  • Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study - BMC Cancer. 2009 Jun 30;9(1):216 - "Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, p for trend: 0.19 [0.08 to 0.45], p < 0.001 for premenopausal women, 0.27 [0.11 to 0.66], p = 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of omega-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study - Am J Clin Nutr. 2009 Jun;89(6):1920-6 - "Adult soy food consumption, measured either by soy protein or isoflavone intake, was inversely associated with the risk of premenopausal breast cancer, and the association was highly statistically significant (P for trend < 0.001). The multivariate-adjusted relative risks (RRs) for the upper intake quintile compared with the lowest quintile were 0.41 (95% CI: 0.25, 0.70) for soy protein intake and 0.44 (95% CI: 0.26, 0.73) for isoflavone intake. High intake of soy foods during adolescence was also associated with a reduced risk of premenopausal breast cancer (RR: 0.57; 95% CI: 0.34, 0.97). Women who consumed a high amount of soy foods consistently during adolescence and adulthood had a substantially reduced risk of breast cancer. No significant association with soy food consumption was found for postmenopausal breast cancer"
  • Teen soy intake linked to lower breast cancer risk - Nutra USA, 6/1/09 - "Adolescent intakes of soy foods were associated with a 43 per cent reduction in pre-menopausal breast cancer risk, while high intakes of soy protein and isoflavones were associated with 59 and 56 per cent reductions in the risk of breast cancer before the menopause" - [Abstract]
  • Walnuts Fight Breast Cancer - WebMD, 4/21/09 - "Standard testing showed that eating walnuts cut the risk of developing breast tumors in half ... If mice did get breast tumors, the growth rate was also slowed, by 50% ... Extrapolating to humans, this would be about a nine-year delay"
  • Relationship between selenium and breast cancer: a case-control study in the Klang Valley - Singapore Med J. 2009 Mar;50(3):265-9 - "Breast cancer risk decreased with the increasing quartiles of selenium intake, with odds ratios (95 percent confidence interval) of 2.95 (1.22-7.12), 2.17 (1.13-4.19) and 1.71 (0.84-3.52), respectively. However, the association diminished after adjustment for confounding factors ... it is essential for Malaysian women to achieve a good selenium status by consuming good food sources of selenium as a chemopreventive agent"
  • Dietary carotenoids and the risk of invasive breast cancer - Int J Cancer. 2009 Feb 3 - "An inverse association observed among premenopausal women was for high levels of vitamin A (OR: 0.82, 95% CI: 0.68-0.98, p for trend = 0.01), beta-carotene (OR: 0.81, 95% CI 0.68-0.98, p for trend = 0.009), alpha-carotene (OR: 0.82, 95% CI: 0.68-0.98, p for trend = 0.07) and lutein/zeaxanthin (OR: 0.83, 95% CI 0.68-0.99, p for trend = 0.02). An inverse association was not observed among postmenopausal women. Among premenopausal women who reported ever smoking, these results were stronger than among never smokers, although tests for interaction were not statistically significant. Results from this study are comparable to previous prospective studies, and suggest that a high consumption of carotenoids may reduce the risk of premenopausal but not postmenopausal breast cancer, particularly among smokers" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Early soy intake may slash breast cancer risk later in life - Nutra USA, 3/30/09 - "By comparing the highest and lowest soy intake values for soy-based foods such as tofu, miso and natto, Korde and co-workers calculated that women with the highest soy intake during childhood (ages 5 to 11) had a 58 per cent lower risk of breast cancer as adults as the women with the lowest soy intake as children" - [Abstract]
  • Childhood Soy Intake and Breast Cancer Risk in Asian American Women - Cancer Epidemiol Biomarkers Prev. 2009 Mar 24 - "Comparing highest with lowest tertiles, the multivariate relative risks (95% confidence interval) for childhood, adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively"
  • Extra Virgin Olive Oil May Help To Combat Breast Cancer - Science Daily, 2/5/09 - "this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation"
  • Glycemic load, glycemic index and breast cancer risk in a prospective cohort of Swedish women - Int J Cancer. 2009 Feb 3 - "In analyses stratified by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumors, we observed statistically significant positive associations of carbohydrate intake, glycemic index and glycemic load with risk of ER+/PR- breast cancer; the multivariate relative risks comparing extreme quintiles were 1.34 [95% confidence interval (CI) = 0.93-1.94; p for trend = 0.04] for carbohydrate intake, 1.44 (95% CI = 1.06-1.97; p for trend = 0.01) for glycemic index and 1.81 (95% CI = 1.29-2.53; p for trend = 0.0008) for glycemic load. No associations were observed for ER+/PR+ or ER-/PR- breast tumors. These findings suggest that a high carbohydrate intake and diets with high glycemic index and glycemic load may increase the risk of developing ER+/PR- breast cancer"
  • Vitamin D Found To Stimulate A Protein That Inhibits The Growth Of Breast Cancer Cells - Science Daily, 2/5/09 - "Calcitrol, the active form of vitamin D, has been found to induce a tumor suppressing protein that can inhibit the growth of breast cancer cells" - See vitamin D at Amazon.com.
  • Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity - Int J Cancer. 2008 Dec 15 - "Using chemotaxis and fluorescent-bead cell motility assays, we demonstrated that I3C significantly decreased the in vitro migration of MDA-MB-231 cells, a highly invasive breast cancer cell line" - See indole-3-carbinol at Amazon.com.
  • Green tea may protect against breast cancer: Study - Science Daily, 1/27/09 - "Regular consumption of the beverage was associated with a “slightly decreased risk for breast cancer” of 12 per cent" - [Abstract] - See green tea extract at Amazon.com.
  • Drinking green tea modestly reduces breast cancer risk - J Nutr. 2009 Feb;139(2):310-6 - "Compared with nondrinkers, regular drinking of green tea was associated with a slightly decreased risk for breast cancer (OR, 0.88; 95% CI, 0.79-0.98)" - See green tea extract at Amazon.com.
  • Breast cancer cell response to genistein is conditioned by BRCA1 mutations - Biochem Biophys Res Commun. 2009 Jan 3 - "We showed that growth of BRCA1 mutant cells was strongly inhibited by genistein whereas it only had a weak effect in cells expressing wild-type BRCA1 protein. BRCA1 mutant cells hypersensitivity could be linked to higher expression of ERbeta gene, which suggests that genistein may be an efficient inhibitor of cancer development in BRCA1 mutant breast cancer cells"
  • Prospective cohort study of lifetime physical activity and breast cancer survival - Int J Cancer. 2008 Nov 17 - "A decreased risk of breast cancer death and all deaths was observed among women in the highest versus the lowest quartiles of recreational activity"
  • Urinary melatonin levels and postmenopausal breast cancer risk in the nurses' health study cohort - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9 - "An increased concentration of urinary aMT6s was statistically significantly associated with a lower risk of breast cancer (odds ratio for the highest versus lowest quartile of morning urinary aMT6s, 0.62 ... Results from this prospective study add substantially to the growing literature that supports an inverse association between melatonin levels and breast cancer risk" - see melatonin at Amazon.com.
  • Tea consumption and risk of breast cancer - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):341-5 - "Tea consumption was not related to breast cancer risk overall (P for trend = 0.18). However, when stratified by age, an inverse association was observed among women less than 50 years: those consuming three or more cups per day had a 37% reduced breast cancer risk when compared with women reporting no tea consumption (age and study site-adjusted odds ratios, 0.63; 95% confidence intervals, 0.44-0.89; P = 0.01) with a significant test for trend (P = 0.01). The inverse association noted among younger women was consistent for in situ and invasive breast cancer, and for ductal and lobular breast cancer ... We observed evidence to support a potential beneficial influence for breast cancer associated with moderate levels of tea consumption (three or more cups per day) among younger women. Further research is needed to confirm this association"
  • Conjugated Linoleic Acid (CLA) Inhibits Expression of the Spot 14 (THRSP) and Fatty Acid Synthase Genes and Impairs the Growth of Human Breast Cancer and Liposarcoma Cells - Nutr Cancer. 2009;61(1):114-22 - "We conclude that as in bovine mammary and mouse adipose cells, CLA suppresses S14 and FAS gene expression in human breast cancer and liposarcoma cells. Rescue from the antiproliferative effect of CLA by palmitic acid indicates that reduced tumor lipogenesis is a major mechanism for the anticancer effects of CLA" - See conjugated linoleic acid at Amazon.com.
  • Breast Cancer: Diet High In Vegetables, Fruit And Fiber May Cut Risk Of Cancer Recurrence In Women Without Hot Flashes - Science Daily, 12/30/08 - "A secondary analysis of a large, multicenter clinical trial has shown that a diet loaded with fruits, vegetables and fiber and somewhat lower in fat compared to standard federal dietary recommendations cuts the risk of recurrence in a subgroup of early-stage breast cancer survivors – women who didn't have hot flashes – by approximately 31 percent. These patients typically have higher recurrence and lower survival rates than breast cancer patients who have hot flashes"
  • How Certain Vegetables Combat Cancer - Science Daily, 12/23/08 - "Breast cancer, the second leading cause of cancer deaths in women, can be protected against by eating cruciferous vegetables such as cabbage and near relatives of cabbage such as broccoli and cauliflower ... Our paper focuses on the anti-cancer activity of one of these compounds, called sulforaphane, or SFN ... SFN inhibits the proliferation of human tumor cells by a mechanism similar to the way that the anticancer drugs taxol and vincristine inhibit cell division during mitosis ... SFN, like the more powerful anticancer agents, interferes with microtubule functioning during mitosis in a similar manner to the more powerful anticancer drugs ... SFN may be an effective cancer preventive agent because it inhibits the proliferation and kills precancerous cells"
  • New Anti-cancer Components Of Extra-virgin Olive Oil Revealed - Science Daily, 12/17/08 - "Extra-virgin olive oil is the oil that results from pressing olives without the use of heat or chemical treatments. It contains phytochemicals that are otherwise lost in the refining process. Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2"
  • Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression To Attenuate Migration and Invasion of Breast Cancer Cells - J Agric Food Chem. 2008 Dec 5 - "Indole-3-carbinol (I3C), a major indole metabolite in cruciferous vegetables, has been shown to inhibit invasion of breast cancer cells ... Migration, invasion, and MMP-2 activity of MCF-7 breast cancer cells were dose-dependently inhibited by I3C. In addition, the MMP-2 mRNA level was also reduced by I3C ... In addition, I3C inhibited the extracellular signal-regulated kinase (ERK) signaling pathway in MCF-7 cells. The results suggest that I3C inhibits MMP-2 expression by blocking the ERK/Sp1-mediated gene transcription to attenuate migration and invasion of breast cancer cells" - See indole-3-carbinol at Amazon.com.
  • Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women - Int J Cancer. 2008 Oct 1 - "Compared with nonconsumers, the Odds ratios (Ors) were 0.36 (95% CI = 0.25-0.51) and 0.53 (0.38-0.73) for daily intake of >/=10 g fresh mushrooms and >/=4 g dried mushrooms, based on multivariate logistic regression analysis adjusting for established and potential confounders. There were dose-response relationships with significant tests for trend (p < 0.001). The inverse association was found in both pre- and postmenopausal women. Compared with those who consumed neither mushrooms nor green tea, the ORs were 0.11 (0.06-0.20) and 0.18 (0.11-0.29) for daily high intake of fresh and dried mushrooms combined with consuming beverages made from >/=1.05 g dried green tea leaves per day"
  • Canola Oil May Affect Breast Cancer Risk - WebMD, 11/18/08 - "Could the type of oil a woman consumes during pregnancy influence her daughter's breast cancer risk years later? ... pregnant women may be better off choosing canola oil over most other vegetable oils ... Corn oil has 50% omega-6 and almost no omega-3, while canola oil has 20% omega-6 and 10% omega-3,""
  • Vigorous Exercise Cuts Breast Cancer Risk - WebMD, 10/30/08 - "When we evaluated the relation of vigorous activity to breast cancer among women who were of normal weight ... the risk among women reporting the highest amount of vigorous activity decreased by about 30% compared with women with no vigorous activity"
  • Caffeine Consumption Not Associated With Breast Cancer Risk In Most Women, Study Suggests - Science Daily, 10/13/08 - "Consumption of caffeine and caffeinated beverages and foods was not statistically significantly associated with overall risk of breast cancer"
  • Vitamin D again linked to breast cancer protection - Nutra USA, 9/26/08 - "Increased intakes of the vitamin were associated with a 24 per cent reduction in the risk of developing ER+ and PR+ tumours" - [Abstract] - See vitamin D at Amazon.com.
  • Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer - Int J Cancer. 2008 Sep 9 - "Breast cancer risk was not related to any dietary PUFA overall; however, opposite associations were seen according to food sources, suggesting other potential effects than PUFA per se. Breast cancer risk was inversely associated with alpha-linolenic acid (ALA) intake from fruit and vegetables [highest vs. lowest quintile, hazard ratio (HR) 0.74; 95% confidence interval (CI) 0.63, 0.88; p trend < 0.0001], and from vegetable oils (HR 0.83; 95% CI 0.71, 0.97; p trend 0.017). Conversely, breast cancer risk was positively related to ALA intake from nut mixes (p trend 0.004) and processed foods (p trend 0.068), as was total ALA intake among women in the highest quintile of dietary vitamin E (p trend 0.036). A significant interaction was also found between omega-6 and long-chain omega-3 PUFAs, with breast cancer risk inversely related to long-chain omega-3 PUFAs in women belonging to the highest quintile of omega-6 PUFAs (p interaction 0.042). These results emphasize the need to consider food sources, as well as interactions between fatty acids and with antioxidants, when evaluating associations between PUFA intakes and breast cancer risk" - Note:  Alpha-linolenic acid is the vegetable form of omega-3.
  • Vitamin D intake and breast cancer risk: a case-control study in Italy - Ann Oncol. 2008 Aug 18 - "The OR for subjects in the three highest deciles of consumption compared with those in the lowest ones combined was 0.79 (95% CI 0.70-0.90). Intake of vitamin D >3.57 mug or 143 IU appeared to have a protective effect against breast cancer. The inverse association was consistent across strata of menopausal status ... This study adds to the existing evidence that vitamin D intake in inversely associated with breast cancer risk" - See vitamin D at Amazon.com.
  • Resveratrol May Prevent Breast Cancer - WebMD, 7/7/08 - "when the body's system for processing estrogen gets out of balance, dangerous estrogen metabolites appear. These toxic compounds react with DNA in breast cells and jump-start the growth of tumors ... resveratrol decreases the processing of estrogen into these dangerous compounds. Perhaps more importantly, it also blocks interactions between estrogen metabolites and cellular DNA ... And that's not all. Rogan's team finds that resveratrol increases production of an enzyme that destroys dangerous estrogen metabolites" - [Science Daily] - See resveratrol products at Amazon.com.
  • Genistein protects against polycyclic aromatic hydrocarbon-induced oxidative DNA damage in non-cancerous breast cells MCF-10A - Br J Nutr. 2008 Jun 23:1-6 - "These enzymes, in turn, will metabolise the PAH into their ultimate carcinogenic forms. Genistein can significantly suppress the expressions within 5 mum. The comet assay indicated that DMBA introduced DNA damage to these cells, and co-treatment with genistein at 5 or 10 mum could alleviate the damage. In addition to the chelation of DMBA metabolites to DNA, flow cytometry results revealed that oxidation was also a factor of DNA damage. The oxidative DNA damage could be removed by co-treating with 10 mum-genistein. Because no increased oxidative DNA repair was observed, suppression on the cytochrome enzymes appeared to be the underlying mechanism"
  • A Mixture of trans, trans Conjugated Linoleic Acid Induces Apoptosis in MCF-7 Human Breast Cancer Cells with Reciprocal Expression of Bax and Bcl-2 - J Agric Food Chem. 2008 Jun 21 - "These findings suggest that incorporation of t, t CLA in the membrane induces a mitochondria-mediated apoptosis that can enhance the antiproliferative effect of t, t CLA in MCF-7 cells" - See conjugated linoleic acid at Amazon.com.
  • Genistein reduced the invasive activity of human breast carcinoma cells as a result of decreased tight junction permeability and modulation of tight junction proteins - Cancer Lett. 2008 Jun 14 - "Taken together our results indicate a possible role of genistein as an inhibitor of cancer cell invasion through the tightening of TJs, which may counteract the up-regulation of claudins. In addition, our results indicate that may be beneficial for the inhibition of tumor metastasis"
  • Low Melatonin Associated with Increased Risk of Breast Cancer in Postmenopausal Women - Science Daily, 6/15/08 - "women with the lowest levels of melatonin had a statistically significantly higher incidence of breast cancer than those with the highest levels" - See melatonin at Amazon.com.
  • Link Between Vitamin D Status And Breast Cancer Illuminated - Science Daily, 5/15/08 - "This is the first study, to our knowledge, to show that higher serum levels of vitamin D are associated with reduced incidence rates of breast cancer worldwide" - See vitamin D at Amazon.com.
  • Stay Fit, Avoid Breast Cancer? - WebMD, 5/12/08 - "the women whose activity equaled 13 walking hours a week or 3.25 running hours per week had a 23% lower risk of premenopausal breast cancer compared with the less active women. The strongest association was seen with increased exercise during adolescent and young adult years (ages 12-22)"
  • Daily Aspirin May Cut Breast Cancer Risk - WebMD, 4/30/08 - "Overall, NSAID use wasn't associated with breast cancer risk. But women who reported taking daily aspirin were 16% less likely to develop estrogen-receptor positive breast cancer. Those tumors are fueled by estrogen; most breast cancers are estrogen-receptor positive"
  • Dietary Lignans Improve Breast Cancer Survival - Medscape, 4/25/08 - "a high intake of lignans was associated with about a 50% reduction in mortality from all causes. This included cardiovascular disease and other cancers" - See flax seed at Amazon.com.
  • Coffee May Protect Against Breast Cancer, Study Shows - Science Daily, 4/24/08 - "Depending on which variant of a certain gene a woman has, a coffee consumption rate of at least two-three cups a day can either reduce the total risk of developing breast cancer or delay the onset of cancer"
  • High Blood Levels Of Vitamin D Protect Women From Breast Cancer, Study Suggests - Science Daily, 4/22/08 - "Women with a very low blood level of 25(OH)D have a considerably increased breast cancer risk. The effect was found to be strongest in women who were not taking hormones for relief of menopausal symptoms" - See vitamin D at Amazon.com.
  • Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 - "Overall, women who engaged in recreational exercise 30 to 150 minutes per week were 50% less likely to have breast cancer than women who exercised less than a half hour per week"
  • Green Tea Ingredient, EGCG, Significantly Inhibits Breast Cancer Growth In Female Mice - Science Daily, 4/7/08 - "Green tea is high in the antioxidant EGCG (epigallocatechin-3- gallate) which helps prevent the body’s cells from becoming damaged and prematurely aged ... At the end of the five week period the researchers found that oral consumption of EGCG caused significant decreases in TCSA (66%), tumor weight (68%), IM density 155+/-6 vs.111+/-20 IM#mm^2) and VEGF protein levels (59.0+/-3.7 vs. 45.7+/-1.4 pg/mg) in the breast tumors vs. the control mice, respectively (N=8; P<0.01). Further, VEGF plasma levels were lower in EGCG mice than in control mice (40.8+/-3.5 vs. 26.5+/-3.8 pg/ml P< 0.01)" - [WebMD] - See green tea extract at Amazon.com.
  • CXCR4 and CXCL12 down-regulation: A novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers - Cancer Lett. 2008 Mar 28 - "Our data suggest that one mechanism whereby DIM protects against breast, ovarian, and possibly other cancers is through the repression of CXCR4 and/or CXCL12, thereby lowering the invasive and metastatic potential of these cells" - See diindolylmethane at Amazon.com.
  • Aspirin Could Reduce Breast Cancer And Help Existing Sufferers, Review of Studies Suggests - Science Daily, 3/6/08 - "Anti-inflammatory drugs like aspirin may reduce breast cancer by up to 20 per cent"
  • Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group - J Clin Oncol. 2008 Mar 3 - "We found a statistically significant inverse association between plasma genistein and risk of breast cancer, but no association for plasma daidzein. Adjusted odds ratios for the highest versus lowest quartile of plasma level were 0.34 for genistein (95% CI, 0.16 to 0.74; P for trend, .02) and 0.71 for daidzein (95% CI, 0.35 to 1.44; P for trend, .54). Median plasma genistein values in the control group were 31.9 ng/mL for the lowest and 353.9 ng/mL for the highest quartile groups" - See soy isoflavones at Amazon.com.
  • Vitamin D Appears to Cut Breast and Colorectal Cancer Risk - Medscape, 2/12/08 - "Compared with a serum 25-hydroxyvitamin D level less than 10 ng/mL, a level of 50 ng/mL reduced the risk for breast cancer by 50%. This level of serum 25-hydroxyvitamin D would require an average intake of 4000 IU of vitamin D per day, although the authors note that intake of 2000 IU per day combined with sun exposure of approximately 12 minutes per day with 50% of the skin exposed could also help patients achieve a serum 25-hydroxyvitamin D level of 50 ng/mL" - See vitamin D at Amazon.com.
  • Dietary Fiber Intake Inversely Associated With Breast Cancer Risk - Medscape, 2/8/08 - "Among ever-users of postmenopausal hormones, a significant inverse association was observed between intake of dietary fiber, especially from cereal products, and breast cancer risk for overall, ER+PR+, and ER-PR- tumors. The adjusted relative risk for all invasive tumors was 0.50"
  • Coffee, tea, caffeine and risk of breast cancer: A 22-year follow-up - Int J Cancer. 2008 - "our results suggested a weak inverse association between caffeine-containing beverages and risk of postmenopausal breast cancer"
  • The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast cancer cell growth in vitro and in vivo - Int J Cancer. 2007 Dec 20 - "Tumor volume in the EGCG + curcumin treated mice decreased 49% compared to vehicle control mice (p < 0.05), which correlated with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the tumors. Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment. Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERalpha- breast cancer and that regulation of VEGFR-1 may play a key role in this effect"
  • Isoflavones may stop benign breast lumps: study - Nutra USA, 12/18/07 - "the highest plasma levels of genistein (more than 76.95 nanograms per millilitre) were 74 per cent less likely to have breast cancer, and 60 per cent less likely to have benign conditions, relative to women with the lowest average levels (less than 9.42 ng/mL)" - See soy isoflavones at Amazon.com.
  • Green Tea Shown To Possess Antitumor Effect In Breast Cancer - Science Daily, 12/8/07 - "green tea has antitumor effect in breast cancer cells ... Dr. Maheshwari’s study observed that green tea can inhibit the invading capacity of these breast cancer cells and have also identified the mechanisms involved in death inducing and invasion inhibiting effects of green tea" - See green tea extract at Amazon.com.
  • Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study - Nutr Cancer. 2007;57(1):20-7 - "Increasing consumption of grapes was linked to a significant protective effect against risk of breast cancer (OR=0.66; 95% CI=0.41-0.86; P<0.01). Among the vegetables, reduced risk was observed with high tomato intake (OR=0.62; 95% CI=0.38-0.81; P<0.01). Among soy foods, high consumption of cooked soybeans, including yellow and black soybeans, had an association with reduced breast cancer (OR=0.67; 95% CI=0.45-0.91; P<0.02)"
  • Differential expression of genes induced by resveratrol in human breast cancer cell lines - Nutr Cancer. 2006;56(2):193-203 - "The phytoalexin, trans-resveratrol (RES), is a polyphenolic compound found in plants and fruits that seems to have a wide spectrum of biological activities. It has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumor initiation, promotion, and progression. RES is also a phytoestrogen, which binds to and activates estrogen receptors (ERs) that regulate the transcription of estrogen-responsive target genes" - See resveratrol products at Amazon.com.
  • Low Calcium May Spur Breast Cancer Spread - oncologystat.com, 10/19/07 - "The study involved implanting breast cancer cells into mice and feeding them a low-calcium diet. The mice experienced a high bone turnover and showed a 43% increase in bone destruction, a 24% increase in tumor area, and a 24% increase in tumor cell proliferation compared to a control group"
  • A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean women - Int J Cancer. 2007 Oct 17 - "Both the daily intake (5th vs. 1st quintile, OR = 0.48, 95% CI = 0.30-0.78, p for trend 0.030) and the average consumption frequency of mushrooms (4th vs. 1st quartile, OR = 0.54, 95% CI = 0.35-0.82, p for trend 0.008) were inversely associated with breast cancer risk" - See maitake at Amazon.com and shiitake mushroom supplements at Amazon.com.
  • Weight Gain Ups Breast Cancer Risk - WebMD, 10/22/07 - "If you had a weight gain early in life in the absence of weight gain later, it would not be risky in terms of breast cancer ... But weight gain any time after 35 is very predictive of postmenopausal breast cancer"
  • Exposure To Sunlight May Decrease Risk Of Advanced Breast Cancer By Half - Science Daily, 10/18/07 - "We believe that sunlight helps to reduce women's risk of breast cancer because the body manufactures the active form of vitamin D from exposure to sunlight ... It is possible that these effects were observed only among light- skinned women because sun exposure produces less vitamin D among women with naturally darker pigmentation" - See vitamin D at Amazon.com.
  • Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study - Breast Cancer Res Treat. 2007 Oct 5 - "a 20% reduction in breast cancer risk was observed with vitamin E supplement use among women with low-dietary vitamin E intake ... A non-significant 20% risk reduction was observed among vitamin B supplement users with low B dietary intake (OR = 0.8; 95% CI, 0.6-1.1). Frequent use of a vitamin B supplement was adversely associated with breast cancer risk among those with high dietary vitamin B intake (OR = 1.4"
  • Breast Cancer Risk May Decrease With Increasing Duration of NSAID Use -  Medscape, 10/1/07 - "Use of NSAIDs was associated with a lower risk for breast cancer (odds ratio [OR], 0.76"
  • Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study - Cancer Causes Control. 2007 Sep;18(7):775-82 - "The adjusted RR of breast cancer for women consuming >800 IU/day versus <400 IU/day total vitamin D was 0.89 (95% CI: 0.77-1.03). RRs were stronger among women with negative than positive ER or PR status. The association of high vitamin D intake with breast cancer was strongest in the first 5 years after baseline dietary assessment (RR = 0.66; 95% CI: 0.46-0.94 compared with lowest-intake group), and diminished over time"
  • Vitamin D for Cancer Prevention? - WebMD, 9/5/07 - "The 2,000-IU daily dose of vitamin D suggested by the reviewers is currently considered the "tolerable upper limit" for vitamin D ... a projected 50% reduction in colon cancer incidence would require a universal intake of 2,000 IU per day of vitamin D3 ... A similar reduction in breast cancer incidence would require 3,500 IU per day"
  • Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status-A prospective cohort study among Swedish women - Int J Cancer. 2007 Aug 31 - "estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk ... When comparing the highest to the lowest quintile, we observed non-significant inverse associations between total fiber intake and the risk of all tumor subtypes; the multivariate-adjusted RRs were 0.85 (95% CI: 0.69-1.05) for overall, 0.85 (0.64-1.13) for ER+PR+, 0.83 (0.52-1.31) for ER+PR- and 0.94 (0.49-1.80) for ER-PR-. For specific fiber, we observed statistically significant risk reductions for overall (34%) and for ER+PR+ (38%) for the highest versus lowest quintile of fruit fiber, and non-significant inverse associations for other subtypes of cancer and types of fiber. Among ever-users of postmenopausal hormone (PMH), total fiber intake and especially cereal fiber were statistically significantly associated with approximately 50% reduced risk for overall and ER+PR+ tumors when comparing the highest to the lowest quartile, but no association was observed among PMH never users"
  • Study Shines More Light On Benefit Of Vitamin D In Fighting Cancer - Science Daily, 8/21/07 - "For the first time, we are saying that 600,000 cases of breast and colorectal cancer could be prevented each year worldwide, including nearly 150,000 in the United States alone ... The serum level recommended by the study would correspond to intake of 2000 International Units per day of vitamin D3 for a meaningful reduction in colorectal cancer" - See vitamin D at Amazon.com.
  • Increased folate may slash breast cancer risk - Nutra USA, 8/9/07 - "women in the highest average intake group (456 micrograms of folate per day) had a 44 per cent lower risk of invasive breast cancer than women in the lowest average intake group (160 micrograms of folate per day)" - See folic acid at Amazon.com.
  • High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort - Am J Clin Nutr. 2007 Aug;86(2):434-43 - "Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59" - See folic acid at Amazon.com.
  • Breast Cancer: More Veggies Not Better - WebMD, 7/17/07 - "eating more than five daily servings of fruits and vegetables doesn't offer extra benefit"
  • Diet And Exercise Key To Surviving Breast Cancer, Regardless Of Obesity, Study Suggests - Science Daily, 6/9/07 - "even if a woman is overweight, if she eats at least five servings of vegetables and fruits a day and walks briskly for 30 minutes, six days a week, her risk of death from her disease goes down by 50 percent"
  • Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study - Cancer Causes Control. 2007 Jun 5 - "Vitamin D intake of >800 IU/day appears to be associated with a small decrease in risk of breast cancer among postmenopausal women" - See vitamin D at Amazon.com.
  • Preventing Breast Cancer? - Dr. Weil, 5/3/07 - "Take 2 grams of fish oil a day. High omega-3 fatty acid intake significantly reduces your risk of breast cancer" - See Mega Twin EPA at Amazon.com or Jarrow Max DHA at Amazon.com.
  • Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China - Am J Clin Nutr. 2007 Apr;85(4):1090-7 - "Our results support a protective effect of n-3 fatty acids on breast cancer risk" - See Mega Twin EPA at Amazon.com.
  • Vitamin d and reduced risk of breast cancer: a population-based case-control study - Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):422-9 - "We found strong evidence to support the hypothesis that vitamin D could help prevent breast cancer. However, our results suggest that exposure earlier in life, particularly during breast development, maybe most relevant"
  • Dietary carotenoids and risk of breast cancer in Chinese women - Asia Pac J Clin Nutr. 2007;16 Suppl:437-42 - "higher intake of lycopene, beta-carotene and beta-cryptoxanthin is associated to a lower risk of breast cancer among Chinese women"
  • Plant Estrogen May Cut Breast Cancer - WebMD, 3/20/07 - "A diet rich in estrogen-like compounds found in flaxseed, tea, and many plants may help curb breast cancer after menopause ... Women with the highest lignan intake were 17% less likely to be diagnosed with breast cancer during the study than those with the lowest intake"
  • Exercise Helps Prevent Breast Cancer - WebMD, 2/16/07 - "women who get more than six hours of strenuous exercise a week, and have no family history of breast cancer, may be 23% less likely to develop the disease than women who don't exercise at all"
  • Vitamin D Appears to Cut Breast and Colorectal Cancer Risk - Medscape, 2/12/07 - "Compared with a serum 25-hydroxyvitamin D level less than 10 ng/mL, a level of 50 ng/mL reduced the risk for breast cancer by 50%. This level of serum 25-hydroxyvitamin D would require an average intake of 4000 IU of vitamin D per day, although the authors note that intake of 2000 IU per day combined with sun exposure of approximately 12 minutes per day with 50% of the skin exposed could also help patients achieve a serum 25-hydroxyvitamin D level of 50 ng/mL" - See vitamin D at Amazon.com.
  • Vitamin D Backed For Cancer Prevention In Two New Studies - Science Daily, 2/8/07 - "Two new vitamin D studies using a sophisticated form of analysis called meta-analysis, in which data from multiple reports is combined, have revealed new prescriptions for possibly preventing up to half of the cases of breast cancer and two-thirds of the cases of colorectal cancer in the United States ... The serum level associated with a 50 percent reduction in risk could be maintained by taking 2,000 international units of vitamin D3 daily plus, when the weather permits, spending 10 to 15 minutes a day in the sun" - See vitamin D at Amazon.com.
  • Phytoestrogens and indicators of breast cancer prognosis - Nutr Cancer. 2006;56(1):3-10 - "In women with higher intakes of phytoestrogens, there was a 32% reduction in the odds of being diagnosed with any stage of cancer other than stage 1 (95% confidence interval, CI = 0.49-0.93; P = 0.02), a 38% reduction in odds of being diagnosed with positive lymphovascular invasion (95% CI = 0.40-0.95; P = 0.03), and a 66% increase in the odds of being diagnosed with a positive progesterone receptor"
  • Low-Fat Diet May Help Breast Cancer - WebMD, 12/16/06
  • Pro-vitamin E Shown To Be Active Against Breast Cancer Cells - Science Daily, 12/9/06 - "pro-vitamin E or alpha-tocopheryl succinate can reduce tumour volume in experimental animals with high levels of HER2"
  • Soy, Fish May Cut Cancer Risk - WebMD, 11/14/06 - "Women who ate the most soy as teens or adults were about 25% less likely to have breast cancer than those who skimped on it"
  • Control hormones to stop breast cancer - MSNBC, 10/27/06
  • Vitamin D May Slow Breast Cancer - WebMD, 10/17/06 - "women with early-stage breast cancer had much higher levels of vitamin D in their blood than women with more advanced disease"
  • Regular Exercise, Keeping Weight In Check Reduces Breast-cancer Risk In Postmenopausal Women - Science Daily, 10/12/06 - "women with high BMI and low physical-activity had mean estrogen concentrations that were 50 percent to 100 percent higher than that of women with low BMI and high activity levels"
  • Idleness, Weight Up Breast Cancer Risk - WebMD, 10/10/06 - "postmenopausal women who exercise and keep their weight down substantially reduce their risk of breast cancer"
  • Indole-3: A Broccoli Cure? - Dr. Weil, 9/15/07 - see my I3C page.
  • Exercise May Up Breast Cancer Survival - WebMD, 9/11/06
  • Ginseng linked to improved breast cancer outcomes - Nutra USA, 8/17/06
  • Weight Gain May Increase Risk of Breast Cancer in Postmenopausal Women - Doctor's Guide, 7/12/06 - "Women who gained about 55 pounds or more since age 18 were at a 45% increased risk of breast cancer, compared with those who maintained their weight ... Women who gained about 22 pounds or more since menopause were at an 18% increased risk of breast cancer ... Those who lost about 22 pounds or more since menopause (and kept the weight off) and had never used postmenopausal hormones were at a 57% lower risk of breast cancer than those who simply maintained their weight"
  • Veggies may keep breast cancer from returning - MSNBC, 4/14/06 - "After about seven years, women who began with the highest levels of carotenoids in their blood showed 43 percent less risk of developing breast cancer again when compared to women with the lowest carotenoid levels"
  • Food Antioxidants, Vitamin D Fight Breast Cancer - HealthDay, 4/7/06 - "postmenopausal women who consumed high levels of flavonoids, a class of antioxidants found in plants, had a 45 percent lower risk of breast cancer ... Those who had the highest levels of intake of kaempferol had a 38 percent decrease in the incidence of ovarian cancer compared to women with the lowest levels of this flavonoid ... those with the highest blood levels of a vitamin D metabolite known as 25-hydroxyvitamin D had a 50 percent reduced risk of breast cancer" - [Science Daily]
  • Tea May Fight Ovarian, Breast Cancers - WebMD, 4/5/06 - "women who increase their consumption of kaempferol, a type of flavonoid, can lower their risk of ovarian cancer by nearly 40% ... women who consume a diet rich in other types of flavonoids - specifically, flavones, flavan-3-ols, and lignans -- can reduce their chance of developing breast cancer by 26% to 39%" - See green tea extract at Amazon.com.
  • Vitamin D linked to lower breast cancer risk - Nutra USA, 4/4/06 - "a serum vitamin D level of 52 nanograms per milliliter was associated with a 50 percent reduction in breast cancer risk. To have such a serum vitamin level would require a daily intake of about 1,000 International Units (IU)" - See vitamin D at Amazon.com.
  • Researchers Find Ginseng May Improve Breast Cancer Outcomes - Science Daily, 3/16/06 - "They also found significant improvements in both survival and quality of life measures in patients who used ginseng" - See ginseng at Amazon.com.
  • Soy Phytoestrogens May Block Estrogen Effects - Science Daily, 1/16/06 - "the addition of high levels of dietary soy isoflavones tended to block estrogen effects in breast tissue. This finding suggests that postmenopausal women with higher levels of estrogen may derive the greatest benefit from soy"
  • Consumption of coffee, but not black tea, is associated with decreased risk of premenopausal breast cancer - J Nutr. 2006 Jan;136(1):166-71 - "Among premenopausal women, consumption of regular coffee was associated with linear declines in breast cancer risk (P for trend = 0.03); consumers of >/=4 cups/d experienced a 40% risk reduction"
  • Eat Dairy Foods, Avoid Breast Cancer? - WebMD, 12/14/05 - "Women who had the highest dietary calcium intake were 20% less likely to have been diagnosed with breast cancer than those whose diets were lowest in dietary calcium"
  • Turmeric for Breast Cancer Prevention? - Dr. Weil, 12/2/05
  • Breast cancer and dietary factors in Taiwanese women - Cancer Causes Control. 2005 Oct;16(8):929-37 - "Cases also consumed statistically significant less supplements such as vitamins and mineral than controls ... Our results indicate a strong protective effect of dietary supplements and a harmful effect of dietary fats on the risk of breast cancer among women in Taiwan"
  • Primrose Oil Component Cuts Levels Of Cancer-causing Gene Her-2/neu - Science Daily, 11/4/05 - "Gamma-linolenic acid (GLA), a substance in evening primrose oil and several other plant oils used in herbal medicine, inhibits action of Her-2/neu, a cancer gene that is responsible for almost 30 percent of all breast cancers" - See borage oil at Amazon.com.
  • Plant oil 'acts like cancer drug' - BBC News, 11/2/05 - "It is down to a substance in the oil called gamma-linolenic acid that acts on the same receptor in tumours as the powerful breast cancer drug Herceptin" - See borage oil at Amazon.com.
  • Spice Ingredient May Cut Breast Cancer Spread - WebMD, 10/17/05
  • Eat wisely to reduce breast cancer risk - MSNBC, 7/22/05 - "The women who followed a low-fat diet in this study reduced their risk of a recurrence during the next five years by 24 percent ... Keep in mind that omega-3 fats may be protective"
  • Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 - "Less than a quarter of the mice in the curcumin-plus-Taxol group had cancer that spread to the lungs. So did half of the curcumin group. In comparison, cancer spread to the lungs in three-fourths of the Taxol group and almost all (95%) mice that got no treatment" - See curcumin supplements at Amazon.com.
  • Omega-3 Offers Hope For New Anti-breast Cancer Drugs - Science Daily, 6/8/05 - "Compounds of Omega-3 fatty acids and propofol reduce the ability of breast cancer cells to develop into malignant tumours, inhibiting cancer cell migration by 50% and significantly reducing their metastatic activity ... Propofol is a potent anti-oxidant known to inhibit cancer cell migration by only 5-10%"
  • Weight Gain Affects Breast Cancer Survival - Physician's Weekly, 5/16/05
  • Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 - "During a six-year period, women who used statins reduced their risk of breast cancer by more than half (51%) compared with nonusers" - See Zocor at International Anti-aging Systems or SuperSaverMeds.com.
  • Breast Cancer Protection Starts in the Womb - WebMD, 4/20/05 - "Mothers who choose foods packed with omega-3 fatty acids during pregnancy and while nursing and then feed their kids such a diet after weaning may reduce the risk of breast cancer in their daughters by nearly 90%, early research in mice indicates"
  • Soy protein could protect against breast cancer, say researchers - Nutra USA, 4/13/05 - "Eating soy protein on a regular basis may reduce a woman’s chance of developing breast cancer by up to 22 percent"
  • Disease-fighting Chemicals In Apples Could Reduce The Risk Of Breast Cancer, Cornell Study In Rats Suggests - Science Daily, 3/12/05 - "tumor incidence was reduced by 17, 39 and 44 percent in rats fed the human equivalent of one, three or six apples a day, respectively, over 24 weeks ... Studies increasingly provide evidence that it is the additive and synergistic effects of the phytochemicals present in fruits and vegetables that are responsible for their potent antioxidant and anticancer activities"
  • An Apple a Day May Cut Breast Cancer Risk - WebMD, 3/2/05 - "For humans, the doses equaled eating one, three, or six apples per day ... After 24 weeks, breast tumor rates were 17% lower in the rats receiving the low dose of the apple extract, 39% lower with the medium dose, and 44% lower with the high dose"
  • Seaweed May Lower Breast Cancer Risk - WebMD, 2/2/05
  • Calcium, Vitamin D Intake Low among Breast Cancer Patients - Doctor's Guide, 12/14/04
  • Anticancer Diet - Time, 11/15/04 - "eating at least 35 servings of fruits and vegetables a week can cut the risk of developing hormone-stimulated breast-cancer tumors by 35% in postmenopausal women ... leafy greens and colorful vegetables like carrots, squash, tomatoes and peppers, which are rich in lycopene and beta carotene, are especially potent cancer fighters"
  • Exercise Boosts Recovery From Breast Cancer - Science Daily, 10/18/04
  • Eating More Soy-rich Foods Could Reduce Spread Of Breast Cancer - Science Daily, 9/29/04 - "eating a soy rich products such as soy milk, soy drinks and desserts, could have an important role in preventing the spread of cancer cells in the body"
  • Fish Oil's Breast Cancer Benefits May Vary - WebMD, 9/23/04
  • How To Prevent Breast Cancer Anti-Cancer Power of Coenzyme Q10 - Life Extension Magazine, 1/96
  • Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer Cell Growth - Science Daily, 9/1/04 - "The compound, in broccoli and other cruciferous vegetables ... sulforaphane (SUL) ... We were surprised and pleased to find that SUL could block the growth of breast cells that were already cancerous ... SUL's actions appear similar to a group of anticancer drugs currently in use, such as Taxol"
  • Overweight? Good Cholesterol May Fight Cancer - WebMD, 8/3/04 - "overweight, postmenopausal women with high levels of good HDL cholesterol have 67% less breast cancer than similar women with low HDL levels"
  • Aspirin May Protect Against Breast Cancer - WebMD, 5/25/04 - "taking aspirin at least once a week for six months or longer reduced the risk of breast cancer by 20%, compared with women who never took aspirin. Taking a daily aspirin reduced risk by more than 25%"
  • Role of vitamins in the risk, prevention, and treatment of breast cancer - Curr Opin Obstet Gynecol. 2004 Feb;16(1):19-25 - "High intake of folate or adequate circulating levels of folate may reduce the risk of breast cancer. Adequate folate levels may be particularly important for women who are at higher risk of breast cancer because of high alcohol consumption. The inverse association between vitamin D and risk of breast cancer needs to be evaluated in more studies" - See folic acid at Amazon.com.
  • Exercise Helps Breast Cancer Fight - Intelihealth, 3/29/04
  • Diet has impact on breast cancer, say scientists - Nutra USA, 3/25/04
  • Vitamin D to protect women - Nutra USA, 3/23/04 - "Now the researchers believe that a contributing factor to high rates of the cancer may be low levels of vitamin D" - See vitamin D at Amazon.com.
  • Does tea really fight cancer? - MSNBC, 11/21/03 - "A new study of the potential link of green tea consumption with lower risk of breast cancer does suggest a protective benefit. Asian-American women who averaged at least three six-ounce cups of green tea per week were about half as likely to develop breast cancer as those who drank none ... One of the strengths of this study is that researchers statistically adjusted for the effects of many other influences on breast cancer risk"  - See green tea extract at Amazon.com. - Ben
  • Cutting Genetic Breast Cancer Risk - WebMD, 10/23/03
  • Walking Away from Breast Cancer? - Dr. Weil, 10/20/03
  • Is Breast Cancer Treatment Shorter Today? - Dr. Weil, 10/6/03
  • Modest Exercise Lowers Breast Cancer Risk - WebMD, 9/9/03 - "exercising a mere 1 1/4 to 2 1/2 hours each week -- walking briskly or similar exercise -- reduced the risk of breast cancer by 18% compared with inactive women. That protective effect is only slightly less than the 22% reduced risk observed in women who exercise at least 10 hours a week"
  • Burger Diet Raises Breast Cancer Risk - WebMD, 7/15/03 - "The increase was most closely linked with animal fat -- specifically from animal fat -- and, more specifically, red meat and high-fat dairy foods"
  • High Cysteine Levels Linked to Lower Rates of Breast Cancer - Doctor's Guide, 7/15/03 - "Women in the highest quintile for measured cysteine levels in this study had a 56% lower risk of invasive or in situ breast cancer than women in the lowest quintile ... The findings were more pronounced when only invasive cancer was considered ... Cysteine or its precursors might have the potential to be chemoprotective against breast cancer" - See iHerb cysteine products.
  • NSAID Use Linked to Lower Rates of Breast Cancer - Doctor's Guide, 7/15/03 - "Ten years or more of ibuprofen use reduced a patient's risk nearly in half (RR=0.51, P<0.04), and just 1 to 4 years of regular use was associated with a 29% reduction in risk. The effect of acetylsalicylic acid (Aspirin) was weaker, with 10 years of use of full-strength Aspirin associated with a 21% risk reduction that did not achieve significance ... Neither acetaminophen nor low-dose Aspirin was associated with a reduction in breast-cancer risk ... he found the evidence of a chemoprotective effect compelling enough to treat himself with 200 mg of ibuprofen per day" - See ibuprofen at Amazon.com.
  • Best Bet for Breast Cancer Survivors? - Dr. Weil, 7/15/03
  • Hormone Melatonin Slows Breast Cancer - WebMD, 7/14/03 - "The nighttime hormone melatonin puts breast cancer cells to sleep. It also slows breast cancer growth by 70%" - See melatonin at Amazon.com.
  • Chemical in Miso and Other Soy Foods Believed to Block Certain Tumors - WebMD, 6/17/03 - "identified 21,852 women between the ages of 40 and 59 and surveyed them about various lifestyle issues ... They traced the women 10 years later ... Women with the most isoflavones in their diet had the lowest risk of breast cancer. This was especially true of postmenopausal women"
  • Selenium Supplements May Reduce Breast Cancer Risk in Some - WebMD, 6/16/03 - "a certain version of the gene was associated with a higher breast cancer risk. That same gene was also less responsive to selenium stimulation ... that means people with this genetic variation may benefit from selenium supplements but they require a higher dose to achieve selenium's protective effect against cancer"
  • Night Shifts May Raise Cancer Risk - WebMD, 6/3/03 - "Data from an ongoing study of almost 80,000 nurses already suggest that working nights increases a woman's risk of breast cancer ... a new analysis points to a similar association for colorectal cancer ... "The peak production of melatonin occurs at about 1 or 2 a.m." Exposure to light at night stops the production of melatonin" - See melatonin at Amazon.com.
  • Yoga Helps Breast Cancer Patients - WebMD, 6/3/03
  • Breast Cancer: Beating the Odds? - Dr. Weil, 5/8/03
  • Breast Cancer Survivors: Get Moving - WebMD, 5/7/03
  • Dietary intake and risk of postmenopausal breast cancer - Cancer Causes Control 2003 Feb;14(1):19-27 - "Red meat intake was significantly associated with an increased breast cancer risk (p for trend = 0.002) and fish (including fried fish) and dairy product intake was inversely associated with breast cancer risk (p for trend = 0.04 and 0.05, respectively). No significant associations were noted betwen fruit or vegetable intake and breast cancer risk"
  • Cholesterol Drugs: Breast Cancer Treatment? - WebMD, 4/10/03 - "One reason cancer cells grow so fast is that they lack biochemical brakes that slow cell growth ... Mevacor -- and, likely, other statins -- lets these growth-brakes build up inside cancer cells -- making them a potentially useful breast cancer treatment down the road" - Note: Red yeast rice is a non-prescription statin but you should still check with your physician.
  • Painkillers Help Prevent Breast Cancer - WebMD, 4/9/03
  • Use of Non-steroidal Anti-inflammatory Drugs Dramatically Reduces Risk of Breast Cancer - Doctor's Guide, 4/8/03
  • Folate, Vitamin B6 Reduce Breast Cancer Risk Among Moderate Drinkers - WebMD, 3/4/04 - "They found women with the highest folate levels were 27% less likely to have breast cancer than those with the lowest folate levels. And the reduction in breast cancer risk was much greater among women who drank about one glass of wine or a cocktail per day. These moderate drinkers with high folate levels were 89% less likely to develop breast cancer than those who drank less than one drink per day ... Women with high levels of vitamin B6 also had about a 30% lower risk of breast cancer than those with low levels of this nutrient. Although high levels of vitamin B12 seemed to protect premenopausal women against breast cancer, the effect was not found among postmenopausal women" - See folic acid at Amazon.com.
  • Eggs May Lower Breast Cancer Risk - WebMD, 2/20/03 - "eating about three eggs a week during adolescence decreased the risk of breast cancer by 18%. Diets rich in vegetable oils and dietary fiber had similar effects. But eating roughly one pat of butter a day increased risk by 6% ... eggs may be protective because they are high in essential amino acids, vitamins, and minerals. And studies suggest that fiber-rich foods reduce estrogen levels"
  • Exercise Cuts Breast Cancer Risk - WebMD, 2/10/03 - "women who reported high levels of physical activity from as young as age 16 in some cases cut their risk of developing breast cancer after menopause in half, compared to women who reported no strenuous activity ... The study has a drawback, though, that all such studies face, which is what's called a "healthy patient bias." In this case, women who exercise often might be more apt to take care of themselves in other ways, so that a decrease in breast cancer later in life may not be due to the exercise itself, but rather some other associated factor. The researchers accounted for this by factoring in subjects such as smoking history and weight. "After adjusting for all these factors we're pretty confident that what we see is the effect of exercise,""
  • Breast Cancer Answers: Strategies Show Promise In Mice - Intelihealth, 10/23/02 - "Another study found that young female mice who ate lots of fish oil had lower breast cancer rates"
  • Eating Lots of Tofu May Prevent Breast Cancer - WebMD, 10/2/02
  • Got Milk - WebMD, 9/27/02 - "A combination of soy and cow's milk could have some beneficial, anti-cancer nutrients ... She explains that conjugated linoleic acid, or CLA, is the key to the cow's role in cancer prevention. CLA is a minor fatty acid found in milk and milk products and beef ... He says he thinks the most potent cancer-fighting component of soy is a compound called genistein ... He demonstrated that by feeding rats a diet containing genistein before exposing them to a cancer-causing drug. The number of breast tumors was reduced by 50%" - See conjugated linoleic acid at Amazon.com.
  • Diet Rich In Soy Protein Lowers Estrogens Associated With Breast Cancer - Intelihealth, 9/24/02 - "Consuming tofu and other soy-based foods significantly lowers levels of a class of estrogens normally associated with breast cancer risk in postmenopausal women ... The study found a link between soy-rich diets consumed by Asian women in Singapore and reduced levels of an estrogen called estrone, the predominant form of estrogen in women following menopause ... estrone levels did not decline in a linear manner with increasing soy intake; an apparent reduction was only seen among those in the top 25 percent of soy protein consumers ... The study also showed that hormone levels remained unaffected by other dietary and lifestyle choices. These included consumption of alcohol, coffee, tea, fat, fiber and various micronutrients, including vitamins A, C and E, along with calcium and carotenoids ... There is a suggestion that weight change (particularly weight increase) has a profound influence on breast cancer rates in Asian-American women"
  • New Broccoli Compound Appears Promising Against Breast Cancer - Intelihealth, 8/19/02 - "Called oxomate, the synthetic compound works like its natural counterpart, sulforaphane, which was recently identified as a cancer-preventive agent in broccoli and other cruciferous vegetables (such as cabbage and Brussels sprouts). Both compounds boost the body's production of phase II enzymes, which can detoxify cancer-causing chemicals and reduce cancer risk ... But the natural broccoli compound, sulforaphane, can be toxic in high doses ... It is also difficult and expensive to synthesize ... oxomate was seven times less toxic than sulforaphane ... In tests on female rats, those that were fed oxomate after exposure to cancer-inducing chemicals had up to a 50 percent reduction in the number of breast tumors"
  • Breast Cancer May Be Thwarted By Carotenoids - Doctor's Guide, 5/23/02 - "These results suggest carotenoids may protect against development of breast cancer" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Does Vitamin E Prevent Breast Cancer? - Life Extension Magazine, 5/02 - "premenopausal women with a family history who consumed the highest quantity of vitamin E enjoyed a 43% reduction in breast cancer incidence compared to only a 16% risk reduction for women without a family history of breast cancer.[11] Based on this study, vitamin E appears to protect against genetic- predisposed breast cancer better than environmental-induced breast cancer. (Note that nutrients like indole-3-carbinol may specifically protect against environmental breast carcinogens.)"
  • What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 - "Tocotrienols and breast cancer ..." - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
  • Some Herbs Boost Breast Cancer Risk - WebMD, 3/26/02 - "Our studies show that dong quai and ginseng stimulate the growth of [breast cancer] cells"
  • Serum Levels of Micronutrients, Antioxidants and Total Antioxidant Status Predict Risk of Breast Cancer in a Case Control Study - The American Society for Nutritional Sciences J. Nutr. 132:303-306, 2002 - "Blood samples were collected from 153 breast cancer cases and 151 controls. Serum samples were analyzed for retinol, -tocopherol, lycopene, - and ß-carotene by HPLC, and total antioxidant status by the Trolox-equivalent antioxidant assay ... After adjustment for age at menarche, parity, dietary fat and alcohol intake, we observed the following reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles: 0.47 [95% confidence interval (CI) 0.24, 0.91] for ß-carotene; 0.53 (CI 0.28, 1.01) for retinol; 0.50 (CI 0.26, 0.97) for bilirubin and 0.47 (CI 0.24, 0.94) for total antioxidant status. We conclude that increased serum levels of ß-carotene, retinol, bilirubin and total antioxidant status are associated with reductions in breast cancer risk"
  • Estrogen's Two-Way Street - Nutrition Science News, 11/01 - "Studies show that when 2-hydroxylation increases, the body resists cancer, and that when 2-hydroxylation decreases, cancer risk increases ... Cell-culture studies and human clinical trials have shown that I3C at doses of 200­400 mg/day can influence estrogen metabolism and promote formation of 2-OH-estrone, and therefore may be useful in breast cancer prevention"
  • Green Tea, Glycine May Slow Tumor Growth - WebMD, 11/2/01 - "high levels of glycine reduced breast tumor growth rates by 15% in rats by blocking the growth of new tumor-feeding blood vessels. The special diet also reduced wound-healing by 30% ... Tumors and wounds have one very important thing in common -- they both produce new blood vessels through the same mechanism, known as angiogenesis ... If you can block one response, you can block the other"
  • Acupuncture Relieves Nausea And Pain Following Major Breast Surgery - Intelihealth, 10/18/01
  • Breast Cancer and the Night Shift: Is There A Link? - WebMD, 10/17/01
  • Drink To Breast Health - Intelihealth, 10/9/01 - "Possible anti-cancer factors found in milk include calcium, vitamin D and CLA (conjugated linoleic acid). A recent Finnish study found that women with breast cancer had significantly lower levels of CLA in their diets and blood, compared with women without breast cancer. CLA has been shown to block the local growth and spread of breast cancer in animal studies"
  • Activity Could Lower Cancer Risk - Intelihealth, 10/1/01
  • Physical activity Over Lifetime Could Reduce Breast Cancer Risk - Doctor's Guide, 9/27/01
  • Flaxseed May Fight Breast Cancer In Postmenopausal Women - Intelihealth, 8/30/01
  • Can Flax Beat Soy as Breast Cancer Buster? - WebMD, 8/30/01
  • Keeping Weight Down Can Save You From Breast Cancer - WebMD, 8/20/01
  • Curcumin protects against mammary tumors in rats - Life Extension Magazine, 8/01
  • Dr. Weil: Chemo OK, but other treatments needed - CNN, 4/13/01
  • I3C and DIM: Keys to Cancer Prevention? - Nutrition Science News, 4/01 - "Increased 16-alpha-hydroxyestrone production has been linked to an increase in breast cancer. Based on estrogen metabolism's influence on breast-cancer risk, researchers speculate that reducing hydroxylation of estrone's 16th carbon and increasing hydroxylation of the second carbon would be a wise, protective measure ... The minimum effective dose to increase the ratio of 2-hydroxyestrone to 16-alpha-hydroxyestrone was 300 mg/day ... Most of the research thus far has focused on I3C, a phytonutrient converted by stomach acid to DIM, indolylcarbazole, and other metabolites ... A 350­500 mg dose of I3C is roughly equal to 300­500 mg of raw cabbage or brussels sprouts or about 3 cups of broccoli"
  • Newer Agents Offer Better Hot Flash Control In Breast Cancer Patients - Doctor's Guide, 4/4/01 - "If hot flashes are mild and/or the patient is risk averse, vitamin E (800 IU/day) is reasonable to try, because it is safe, inexpensive, and has some demonstrated efficacy. A reasonable next step is to use other non-hormonal agents that may have more efficacy than vitamin E, but also have the associated drawbacks of higher cost and worse side effects"
  • Somers' cancer treatment worries some experts - CNN, 3/30/01 - see my Iscador page.
  • Exercise Benefits Patients Being Treated For Early Stage Breast Cancer - Doctor's Guide, 1/31/01
  • Women Battling Breast Cancer Should Stay in Fighting Shape, Exercise Important During Breast Cancer Treatment - WebMD, 1/30/01
  • Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows Lower Breast Cancer Risk - WebMD, 12/21/00
  • A Muffin a Day for Breast Cancer? If It Contains Flaxseed Oil, May Have Benefits Similar to Potent Drug - WebMD, 12/8/00 - "the investigators found that flaxseed oil's ability to reduce tumor growth is comparable to tamoxifen." - See flaxseed
  • Researchers Find Phytochemicals In Apples May Fight Off Cancer - Intelihealth, 8/22/00
  • Know Your Breast Cancer Prevention Options - WebMD, 7/20/00
  • I3C Indole 3 carbinol The Tamoxifen Substitute - Life Extension Foundation, 10/99
  • Exercise May Reduce Breast Cancer - Intelihealth, 10/26/99
  • Elevated Prolactin Linked To Breast Cancer - Life Extension Magazine, 6/99
  • Using natural therapies for the prevention of breast and other forms of cancer - Life Extension Magazine, 6/99
  • Co-Q10 and Cancer - Nutrition Science News, 4/99
  • Natural Sugar-Phosphate Compound Shows Promise In Cancer - Doctor's Guide, 3/30/98 (see my IP-6 page)
  • Chalk Up Another One For Broccoli! Chemical In Vegetable Shown To Halt Growth Of Breast Cancer Cells - Science Daily, 2/16/98
  • Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk - Cancer Res. 1997 Nov 15;57(22):5067-72 (See my CLA page)
  • Study: Grapes inhibit cancer growth - CNN, 1/10/97 (see my grape seed extract page)
  • Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10 -  Biochem Biophys Res Commun 1994 Mar 30;199(3):1504-8 - see my coenzyme Q10 page.

Other News:

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