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Recent Longevity News for the
seven days ending 8/29/12. You should consult your doctor if you are
taking any medications.
the side effects of treatment for prostate cancer - Science Daily, 8/24/12 -
reduced the risk of both gynecomastia and
breast pain at 3, 6, 9, and 12 months of treatment compared to men who received
no treatment. Overall, treatment with tamoxifen was more successful in reducing
breast symptoms than treatment with an aromatase inhibitor (anastrazole)
or radiotherapy" - Note: They left out
Adolescent pot use leaves lasting mental deficits; Developing brain susceptible
to lasting damage from exposure to marijuana - Science Daily, 8/27/12 -
"The persistent, dependent use of
marijuana before age 18 has been shown to
cause lasting harm to a person's intelligence, attention and memory ...
individuals who started using cannabis in adolescence and used it for years
afterward showed an average decline in IQ of 8 points when their age 13 and age
38 IQ tests were compared. Quitting pot did not appear to reverse the loss"
weight individuals with belly fat at highest CVD risk - Science Daily,
8/27/12 - "The subjects with normal BMI but central
obesity as defined by a high waist-to-hip ratio had the highest cardiovascular
death risk and the highest death risk from all causes among the six subgroups.
The risk of cardiovascular death was 2.75 times higher and the risk of death
from all causes was 2.08 times higher in normal weight obese people as compared
with subjects with normal BMI and normal waist-to-hip ratio ... The high risk of
death may be related to a higher visceral fat
accumulation in this group, which is associated with insulin resistance and
other risk factors, the limited amount of fat located on the hips and legs,
which is fat with presumed protective effects and to the relatively limited
amount of muscle mass"
from self-luminous tablet computers can affect evening melatonin, delaying sleep
- Science Daily, 8/27/12 - "To produce white light,
these electronic devices must emit light at short wavelengths, which makes them
potential sources for suppressing or delaying the onset of
in the evening, reducing sleep duration and
disrupting sleep. This is particularly worrisome in populations such as young
adults and adolescents, who already tend to be night owls ... Melatonin
suppression after a one-hour exposure to the tablet was not significantly
affected. However, after a two-hour exposure there was significant suppression"
Source Naturals, Melatonin, 2.5
mg, Peppermint Flavored Sublingual, 60 Tablets.
cancer survival rates improved since introduction of PSA testing - Science
Daily, 8/23/12 - "Median survival in trial S8494, which
enrolled patients from 1985 to 1986, was 30 months, and median survival in trial
S8894, which enrolled patients from 1989 to 1994, was 33 months. In contrast,
median survival in trial S9346, which enrolled patients from 1995 to 2009, was
49 months. A 30% decreased risk of death was found in the most recent trial
(S9346) from the previous trial (S8894)"
should shed excess weight before fathering children, study suggests -
Science Daily, 8/22/12 - "a father's
obesity negatively impacts sperm, resulting in
smaller fetuses, poor pregnancy success and reduced placental development"
Antibiotic use in infants before six months associated with being overweight in
childhood - Science Daily, 8/21/12 - "on average,
children exposed to antibiotics from birth to
5 months of age weighed more for their height than children who weren't exposed.
Between the ages of 10 to 20 months, this translated into small increases in
body mass percentile, based on models that incorporated the potential impacts of
diet, physical activity, and parental obesity. By 38 months of age, exposed
children had a 22% greater likelihood of being overweight. However, the timing
of exposure mattered: children exposed from 6 months to 14 months did not have
significantly higher body mass than children who did not receive antibiotics in
that same time period"
teeth! Dental health linked to dementia risk - MSNBC, 8/21/12 -
"Inflammation stoked by gum
disease-related bacteria is implicated in a host of conditions including
heart disease, stroke and diabetes ... It's thought that gum disease bacteria
might get into the brain, causing inflammation and brain damage ... followed
5,468 residents of a Californian retirement community from 1992 to 2010. Most
people in the study were white, well-educated and relatively affluent. When the
study began, participants ranged in age from 52 to 105, with an average age of
81 ... All were free of dementia at the outset, when they answered questions
about their dental health habits, the condition of their teeth and whether they
wore dentures ... followed up 18 years later ... Of 78 women who said they
brushed their teeth less than once a day in 1992, 21 had dementia by 2010, or
about one case per 3.7 women ... In comparison, among those who brushed at least
once a day, closer to one in every 4.5 women developed dementia which translates
to a 65-percent greater chance of dementia among those who brushed less than
counteracts oxidative stress, lengthens lifespan in fruit flies - Science
Daily, 8/21/12 - "a commercially available
acai berry product can lengthen the lives
of fruit flies, when the flies' lives are made short through additional
oxidative stress. Under certain conditions (a simple sugar diet) acai
supplementation could triple flies' lifespans,
from eight to 24 days. Acai could also counteract the neurotoxic effects of the
herbicide paraquat on the flies ... Acai berries contain a variety of
antioxidant and anti-inflammatory compounds, such as anthocyanins" - See
acai berry products at Amazon.com.
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
effects on astrocyte function: Relevance to neurodegenerative diseases -
Biochem Biophys Res Commun. 2012 Aug 14 - "Inflammatory
molecules have been implicated in the pathogenesis of neurodegenerative diseases
such as Parkinson's disease, Alzheimer's
disease, and multiple sclerosis. Resveratrol
is an anti-fungal compound found in the skins of red grapes and other fruits and
nuts. We examined the ability of resveratrol to inhibit lipopolysaccharide
(LPS)-induced production of inflammatory molecules from primary mouse
astrocytes. Resveratrol inhibited LPS-induced production of nitric oxide (NO);
the cytokines tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β),
and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play
critical roles in innate immunity, by astrocytes. Resveratrol also suppressed
astrocyte production of IL-12p40 and IL-23, which are known to alter the
phenotype of T cells involved in adaptive immunity. Finally resveratrol
inhibited astrocyte production of C-reactive protein (CRP), which plays a role
in a variety of chronic inflammatory disorders. Collectively, these studies
suggest that resveratrol may be an effective therapeutic agent in
neurodegenerative diseases initiated or maintained by inflammatory processes"
resveratrol products at Amazon.com.
100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus
- Clin Nutr. 2012 Aug 13 - "A total of 484 men and 340
women reported newly diagnosed diabetes during10 years. High soft drink intake
was associated with increased risk of type 2 diabetes in women but not men; odds
ratio (95% CI) for women with almost daily consumption versus non-consumers was
2.10 (1.23-3.59; P-trend = 0.004) and 1.79 (1.11-2.89; P-trend = 0.01) at 5 and
10 years, respectively. The association was evident in overweight, highly
educated and premenopausal women, and women with blue collar job. Intakes of
100% fruit juice and vegetable juice were not associated with risk of type 2
diabetes for either gender (P-trend >0.05)"
importance of vitamins D and K for the bone health and immune function in
inflammatory bowel disease - Curr Opin Clin Nutr Metab Care. 2012 Aug 20 -
"The levels of vitamins D and K are lower than normal in
patients with IBD, especially in Crohn's disease. Although vitamins D and K are
important for the maintenance of bone mineral density in non-IBD patients, an
association between vitamins D or K and bone metabolism is not apparent in IBD
patients. Recent studies showed that vitamins D and K are suggested to have
immune-suppressive effects, both in animal models of colitis and human trials.
In particular, vitamin D suppresses dendritic and T-cell functions by inhibiting
the production of proinflammatory cytokines. Insufficiency of vitamin D is
associated with the activated phenotype of IBD ... Vitamins D and K potentially
contribute to the maintenance of bone health in IBD, but this effect may be
diminished by other factors such as steroid use, reduced exposure to sunlight,
and inflammatory cytokines. Vitamin D and possibly vitamin K are suggested to be
involved in the suppression of immune-mediated inflammation and modulation of
Polyphenols Decrease Blood Pressure and Improve Endothelial Function in Young
Women with Mild Hypertension - Am J Hypertens. 2012 Aug 23 -
"We conducted a double-blind, randomized, crossover
dietary-intervention study. After a run-in period of 4 months (baseline values),
two diets were used, one with
polyphenol-rich olive oil (~30 mg/day), the
other with polyphenol-free olive oil. Each dietary period lasted 2 months with a
4-week washout between diets ... When compared to baseline values, only the
polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91
mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found
for serum asymmetric dimethylarginine (ADMA) (-0.09 +- 0.01 µmol/l, P < 0.01),
oxidized low-density lipoprotein (ox-LDL) (-28.2 +-28.5 µg/l, P < 0.01), and
plasma C-reactive protein (CRP) (-1.9 +- 1.3 mg/l, P < 0.001). The
polyphenol-rich olive oil diet also elicited an increase in plasma
nitrites/nitrates (+4.7 +- 6.6 µmol/l, P < 0.001) and hyperemic area after
ischemia (+345 +- 386 perfusion units (PU)/sec, P < 0.001)" - Note: It
goes back to whether it's the polyphenols or the omega-9 or both. This
implies the polyphenols. See
olive leaf extract at Amazon.com. To me it's a lot better than putting up with the taste of
the dark olive oil.
Beneficial effects of
polyphenol-rich olive oil in patients with early atherosclerosis - Eur J
Nutr. 2012 Aug 8 - "Eighty-two patients with early
atherosclerosis (presence of
endothelial dysfunction) were enrolled in this double-blind, randomized trial
with 52 completing the study. The aim of the study was to compare the effect of
a daily intake of 30 ml simple OO, with 30 ml
of EGCG-supplemented OO, on endothelial function as well as on inflammation and
oxidative stress after a period of 4 months ... After 4 months, when OO and
EGCG-supplemented OO groups were combined, OO significantly improved endothelial
function (RHI, 1.59 +/- 0.25-1.75 +/- 0.45; p < 0.05). However, there were no
significant differences in results between the two olive oil groups.
Interestingly, with OO supplementation there was a significant reduction in
inflammatory parameters: sICAM (196 to 183 ng/mL, p = < 0.001); white blood
cells (WBCs) (6.0 × 10(9)/L-5.8 × 10(9)/L, p < 0.05); monocytes (0.48 × 10(9)/L
to 0.44 × 10(9)/L, p = 0.05); lymphocytes (1.85 × 10(9)/L to 1.6 × 10(9)/L, p =
0.01); and platelets (242-229 × 10(9)/L, p = 0.047)" - [Nutra
USA] - Click here for my method of making
olive oil mayonnaise. Make sure all the ingredients are at room
temperature. Note: The so called olive oil mayonnaise you see in the
store is mostly omega-6. If you read the ingredients, it might have olive oil
near the beginning but then you see about three omega-6 oils after it. For
example, if it contained 1/3 cup of olive oil and 1/4 cup soy oil and 1/4 cup of
palm oil and 1/4 cup of corn oil you’d have over a cup of oil consisting of 1/3
cup omega-9 oils and 3/4 cup of omega-6 oils. The omega-9 is still the top one.
Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate
depression: A randomized, double-blind, placebo-controlled trial - Eur
Neuropsychopharmacol. 2012 Aug 18 - "Eighty-one
mild-to-moderately depressed outpatients were randomly assigned to receive
either 1g/d of EPA or DHA or placebo (coconut oil) for 12 weeks ... Although
there was no significant difference between groups at baseline, patients in the
EPA group showed a significantly lower mean HDRS score at study endpoint
compared with those in the DHA (p<0.001) or placebo (p=0.002) groups.
Furthermore, response to treatment (defined as a ≥50% decrease from the baseline
HDRS score) was only observed in 6 patients receiving EPA, while no one in any
of DHA or placebo groups responded to treatment" - See
Mega Twin EPA at Amazon.com.
Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral
Blood Monocytes in Obese Patients With Dyslipidemia - Diabetes Care. 2012
Aug 21 - "Peripheral blood monocytes were prepared from
26 obese patients without and 90 obese patients with dyslipidemia. Of the latter
90 obese patients with dyslipidemia, 82 patients were treated with or without
EPA treatment (1.8 g daily) for 3 months ...
This study is the first to show that EPA increases the monocyte IL-10 expression
in parallel with decrease of arterial
stiffness, which may contribute to the antiatherogenic effect of EPA in
obese dyslipidemic patients" - See
Mega Twin EPA at Amazon.com.
Health Focus (Cruciferous
News & Research:
Eating cruciferous vegetables may improve breast cancer survival -
Science Daily, 4/3/12 - "a prospective study of
4,886 Chinese breast cancer survivors who were diagnosed with stage 1 to
stage 4 breast cancer from 2002 to 2006 ... Women who were in the highest
quartiles of intake of vegetables per day had a 62 percent reduced risk of
total mortality, 62 percent reduced risk of breast cancer mortality, and 35
percent reduced risk of breast cancer recurrence ... cruciferous vegetable
consumption habits differ between China and the United States and suggested
this fact be considered when generalizing these results to U.S. breast
cancer survivors ... Commonly consumed cruciferous vegetables in China
include turnips, Chinese cabbage/bok choy and greens, while broccoli and
Brussels sprouts are the more commonly consumed cruciferous vegetables in
the United States and other Western countries ... Cruciferous vegetables
contain phytochemicals known as isothiocyanates and indoles which appear to
have a protective effect against some types of cancer"
your broccoli: Another mechanism discovered by which sulforaphane prevents
cancer - Science Daily, 2/28/12 - "it provides
not just one, but two ways to prevent cancer through the complex mechanism
of epigenetics ... Epigenetics, an increasing focus of research around the
world, refers not just to our genetic code, but also to the way that diet,
toxins and other forces can change which genes get activated, or
"expressed." This can play a powerful role in everything from cancer to
heart disease and other health issues ... HDAC inhibitors, such as
sulforaphane, can help restore proper balance and prevent the development of
cancer. This is one of the most promising areas of much cancer research. But
the new OSU studies have found a second epigenetic mechanism, DNA
methylation, which plays a similar role" - See
sulforaphane at Amazon.com.
evidence that spicing up broccoli boosts its cancer-fighting power -
Science Daily, 9/13/11
Broccoli extract can ‘target’ cancer cells: Study - Nutra USA, 6/15/11 -
"The research, published in Molecular Nutrition and
Food Research, reports for the first time that sulforaphane – one of the
primary phytochemicals in broccoli and other cruciferous vegetables – is
able to selectively target and kill cancer cells, while leaving normal cells
healthy and unaffected ... Here we show for the first time that sulforaphane
selectively targets benign hyperplasia cells and cancerous prostate cells
while leaving the normal prostate cells unaffected"
Study confirms safety, cancer-targeting ability of nutrient in broccoli,
other vegetables, researchers say - Science Daily, 6/9/11 -
"Sulforaphane, one of the primary phytochemicals in
broccoli and other cruciferous vegetables that helps them prevent cancer,
has been shown for the first time to selectively target and kill cancer
cells while leaving normal prostate cells healthy and unaffected ... Here we
show for the first time that sulforaphane selectively targets benign
hyperplasia cells and cancerous prostate cells while leaving the normal
prostate cells unaffected" - See
sulforaphane at Amazon.com.
Sprouts? Supplements? Team them up to boost broccoli's cancer-fighting power
- Science Daily, 1/27/11 - "To get broccoli's
benefits, though, the enzyme myrosinase has to be present; if it's not
there, sulforaphane, broccoli's cancer-preventive and anti-inflammatory
component, doesn't form ... There was almost a twofold increase in
sulforaphane absorption when sprouts and powder were eaten together. It
changed the way the subjects metabolized the powder. We saw plasma and urine
metabolites much earlier and at much higher levels than when either was
eaten alone ... Steaming broccoli for two to four minutes is the perfect way
to protect both the enzyme and the vegetable's nutrients"
Discovery of a biochemical basis for broccoli's cancer-fighting ability
- Science Daily, 1/26/11
Eating broccoli could guard against arthritis - Science Daily, 9/15/10 -
"a compound in broccoli called sulforaphane blocks
the enzymes that cause joint destruction in osteoarthritis -- the most
common form of arthritis" - See
sulforaphane at Amazon.com.
Anti-cancer effects of broccoli ingredient explained - Science Daily,
7/12/10 - "sulforaphane, a chemical found in
broccoli, interacts with cells lacking a gene called PTEN to reduce the
chances of prostate cancer developing"
sulforaphane at Amazon.com.
Plant extract may be effective against inflammatory bowel disease -
Science Daily, 7/7/10 - "PEITC is found in the
Brassica genus of plants, which includes cabbage, cauliflower, watercress
and broccoli ... it not only alleviates several clinical signs of ulcerative
colitis -- for example, it attenuates the damage that occurs in the colon
tissues and colon epithelium, as well as the clinical signs like diarrhea
and blood in stool. The weight loss is a major sign in colitis and that was
combination effective against pancreatic cancer: Substance in broccoli
supports cancer therapy, study finds - Science Daily, 6/15/10 -
"Sorafenib is used for advanced liver and kidney
cancer and also appears to be effective against cancer stem cells in
pancreatic cancer ... It inhibits resistant tumor stem cells and is also
especially effective in combination with sulforaphane, an organic compound
found in broccoli ... vegetables from the cruciferous family such as
broccoli and cauliflower possess a high content of sulforaphane, an
anti-cancer compound. The experiments show that sulforaphane prevents the
activation of the NF-kB pathway by sorafenib. The combination treatment
reinforces the effect of sorafenib without causing additional side effects"
Broccoli component limits breast cancer stem cells, study finds -
Science Daily, 5/4/10 - "In the current study,
researchers took mice with breast cancer and injected varying concentrations
of sulforaphane from the broccoli extract. Researchers then used several
established methods to assess the number of cancer stem cells in the tumors.
These measures showed a marked decrease in the cancer stem cell population
after treatment with sulforaphane, with little effect on the normal cells.
Further, cancer cells from mice treated with sulforaphane were unable to
generate new tumors. The researchers then tested sulforaphane on human
breast cancer cell cultures in the lab, finding similar decreases in the
cancer stem cells"
Broccoli-extract may protect skin from harmful UV - Nutra USA, 4/9/10 -
"Hairless mice developed 25 per cent fewer skin
tumours following exposure to UV radiation and fed a the broccoli extract
for 13 weeks, compared with mice receiving a standard protective agent ...
In addition, the tumours the broccoli-fed mice did develop were 70 per cent
smaller" - [Abstract]
Antioxidant found in vegetables has implications for treating cystic
fibrosis - 11/20/09 - "a dietary antioxidant
found in such vegetables as broccoli and cauliflower protects cells from
damage caused by chemicals generated during the body's inflammatory response
to infection and injury. The finding has implications for such
inflammation-based disorders as cystic fibrosis (CF), diabetes, heart
disease, and neurodegeneration ... the antioxidant thiocyanate normally
existing in the body protects lung cells from injuries caused by
accumulations of hydrogen peroxide and hypochlorite, the active ingredient
in household bleach. These potentially harmful chemicals are made by the
body as a reaction to infection and injury. In addition, thiocyanate also
protects cells from hypochlorite produced in reactions involving MPO, an
enzyme released from germ-fighting white blood cells during inflammation"
Broccoli extract’s heart health benefits pinpointed? - Nutra USA, 9/7/09
- "Researchers from Imperial College London (ICL)
report that sulforaphane, a compound most widely associated with broccoli,
may activate a protein called Nrf2 in arteries ... the natural compound
sulforaphane reduced inflammation at the high-risk areas by 'switching on'
Nrf2 ... Atherosclerosis, known as hardening or furring of the arteries is a
key risk factor for cardiovascular disease, the cause of over 50 per cent of
deaths in Europe and the US ... When these cells were exposed to
sulforaphane, a re-activation of Nrf2 in the disease-prone regions of the
artery was observed. This indicated that the cells’ ability to protect
themselves from becoming inflamed was restored" - [Abstract]
sulforaphane at Amazon.com.
Naturally Occurring Compounds Selectively Deplete Mutant P53 In Tumor Cells
- Science Daily, 4/20/09 - "This study demonstrates
for the first time that phenethyl isothiocyante (PEITC), a
naturally-occurring compound, can selectively deplete mutant p53. The
authors also made an intriguing observation that the depletion of mutant p53
in human cancer cells is accompanied by restoration of the wild type p53.
PEITC is a member of the isothiocyanate family compounds found in
cruciferous vegetables, such as watercress, broccoli and cabbage. PEITC has
been shown to have cancer preventive activity"
Broccoli May Help Protect Against Respiratory Conditions Like Asthma -
Science Daily, 3/2/09 - "a naturally occurring
compound found in broccoli and other cruciferous vegetables may help protect
against respiratory inflammation that causes conditions like asthma,
allergic rhinitis and chronic obstructive pulmonary disease ...
sulforaphane, a chemical in broccoli, triggers an increase of antioxidant
enzymes in the human airway that offers protection against the onslaught of
free radicals that we breathe in every day in polluted air, pollen, diesel
exhaust and tobacco smoke" - See
sulforaphane at Amazon.com.
Broccoli And Cabbage-based Drug Could Inhibit Melanoma - Science Daily,
3/1/09 - "We have developed drugs from naturally
occurring compounds that can inhibit the growth of tumors in mice by 50 to
60 percent with a very low dose ... Robertson and his colleagues previously
showed the therapeutic potential of targeting the Akt3 protein in inhibiting
the development of melanoma. The search for a drug to block the protein led
them to a class of compounds called isothiocyanates ... These naturally
occurring chemicals found in cruciferous vegetables are known to have
certain cancer-fighting properties ... Selenium deficiency is common in
cancer patients ... the selenium-enhanced compounds significantly reduced
the production of Akt3 protein and shut down its signaling network"
Certain Vegetables Combat Cancer - Science Daily, 12/23/08 -
"Breast cancer, the second leading cause of cancer
deaths in women, can be protected against by eating cruciferous vegetables
such as cabbage and near relatives of cabbage such as broccoli and
cauliflower ... Our paper focuses on the anti-cancer activity of one of
these compounds, called sulforaphane, or SFN ... SFN inhibits the
proliferation of human tumor cells by a mechanism similar to the way that
the anticancer drugs taxol and vincristine inhibit cell division during
mitosis ... SFN, like the more powerful anticancer agents, interferes with
microtubule functioning during mitosis in a similar manner to the more
powerful anticancer drugs ... SFN may be an effective cancer preventive
agent because it inhibits the proliferation and kills precancerous cells"
Broccoli May Help Smokers' Lungs - WebMD, 11/18/08 -
"asked 948 lung cancer patients and 1,743 people
without lung cancer about their smoking history and consumption of fruits,
cruciferous vegetables, and other vegetables ... Among smokers -- and
especially among former smokers -- higher intake of cruciferous vegetables
was linked to lower risk of lung cancer"
Unpopular veggies vital for cancer protection: Study - Nutra USA,
10/7/08 - "Significant inhibition of all the cancer
cell lines tested – stomach, lung, breast, kidney, skin, pancreas, prostate,
and brain – was observed for all the extracts from cruciferous vegetables,
such as broccoli, kale, Brussels sprouts, and curly cabbage, and vegetables
of the genus Allium, such as garlic ... These chemopreventive effects are
likely related to the formation of organosulfur compounds following
mechanical disruption of these vegetables, namely isothiocyanates from
cruciferous and a series of allyl sulfur molecules from Allium vegetables"
COPD? Eat Your Veggies - Science Daily, 9/12/08 -
"Sulforapane has been shown to be able to restore
antioxidant gene expression in human epithelial tissue in which DJ-1 has
been reduced. Isothicyanate compounds such as that found in broccoli inhibit
KEAP1, and thus prevent it from degrading NRF2"
Broccoli Could Reverse The Heart Damaging Effects Of Diabetes - Science
Daily, 8/26/08 - "Our study suggests that compounds
such as Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes"
Broccoli can reverse diabetic heart damage, say researchers - Nutra USA,
8/8/08 - "Our study suggests that compounds such as
Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes ... Published in the journal
Diabetes Care, the epidemiological study of 71,346 female nurses found for
every additional serving of green leafy vegetables, the risk of developing
diabetes may be reduced by almost 10 per cent" - [Abstract]
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of
endothelial cells induced by hyperglycemia linked to vascular disease -
Diabetes. 2008 Aug 4 - "Sulforaphane (SFN) is an
activator of transcription factor NF-E2-related factor-2 (nrf2) that
regulates gene expression through the promoter antioxidant response element
(ARE). Nrf2 regulates the transcription of a battery of protective and
metabolic enzymes ... We conclude that activation of nrf2 may prevent
biochemical dysfunction and related functional responses of endothelial
cells induced by hyperglycemia in which increased expression of
transketolase has a pivotal role" - [Nutra
Broccoli May Cut Prostate Cancer Risk - WebMD, 7/1/08 - [Science
Daily] - "men who regularly ate broccoli showed
more changes in gene expression suggestive of a reduced risk of cancer"
Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 -
"Foods rich in plant chemicals called
isothiocyanates and quercetin appeared to offer the best protection against
lung cancer ... Isothiocyanates are found in cruciferous vegetables such as
broccoli, cabbage, cauliflower, brussels sprouts, and turnips"
foods prevent ovarian cancer? - MSNBC, 3/14/08 -
"Kaempferol — a flavonoid found in tea, broccoli, kale and spinach — and
luteolin — which is provided by peppers, carrots, cabbage and celery — were
both identified as cancer protective. Women who consumed the most of these
two flavonoids were 40 percent and 34 percent less likely, respectively, to
develop ovarian cancer compared to women who consumed the least ... A 2007
study published in the British Journal of Nutrition linked greater
consumption of carotenoid phytochemicals with a 67 percent lower risk of
ovarian cancer. This included not only beta-carotene, the oft-cited
carotenoid in deep-orange vegetables and fruits, but also alpha-carotene,
beta-cryptoxanthin, lutein and zeaxanthin — carotenoids found in a wide
range of red, orange, yellow and green vegetables" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
Broccoli May Help Boost Aging Immune System - Science Daily, 3/6/08 -
"As we age, the ability of the immune system to
fight disease and infections and protect against cancer wears down as a
result of the impact of oxygen radicals on the immune system ... our study
shows that a chemical present in broccoli is capable of stimulating a wide
range of antioxidant defense pathways and may be able to interfere with the
age-related decline in immune function ... The UCLA team not only found that
the direct administration of sulforaphane in broccoli reversed the decline
in cellular immune function in old mice, but they witnessed similar results
when they took individual immune cells from old mice, treated those cells
with the chemical outside the body and then placed the treated cells back
into a recipient animal"
Extract Of Broccoli Sprouts May Protect Against Bladder Cancer - Science
Daily, 2/28/08 - "A concentrated extract of freeze
dried broccoli sprouts cut development of bladder tumors in an animal model
by more than half" - [WebMD]
Finding the Right Prostate Cancer Diet - WebMD, 2/15/08 -
"poultry and eggs double the risk of prostate cancer
progression ... orange and yellow vegetables, such as squash, yams, and
carrots, and cruciferous vegetables, such as broccoli, cut the risk of
recurrence by about half ... If you eat chicken or poultry, eat it without
the skin ... the men's overall PSA doubling time was nearly four times
slower after they began drinking pomegranate juice"
Vegetables- and antioxidant-related nutrients, genetic susceptibility, and
non-Hodgkin lymphoma risk - Cancer Causes Control. 2008 Jan 17 -
"For the GSTM3 3-base insertion and higher total
vegetable intake, the risk was 0.56 (0.35-0.92, p interaction = 0.03); for
GSTP1 A114V and higher cruciferous vegetable intake, the risk was 0.52
(0.34-0.81, p interaction = 0.02); for OGG1 S326C and higher daily zinc
intake, the risk was 0.71 (0.47-1.08, p interaction = 0.04) and for XRCC3
T241M and higher green leafy vegetable intake, the risk was 0.63"
Broccoli Good for the Heart - WebMD, 1/18/08 -
"The rats that had eaten the broccoli extract had three heart advantages
over the other rats: ... Better blood-pumping ability ... Less heart damage
during oxygen deprivation ... Higher levels of heart-health chemicals during
oxygen deprivation ... Broccoli's key nutrients include selenium and
sulforaphane, which may also curb cancer"
Is There an Anticancer Diet? - WebMD, 12/6/07 -
"Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and
cauliflower seem to reduce bladder cancer risk by about 40%"
Natural Chemical Found In Broccoli Helps Combat Skin Blistering Disease
- Science Daily, 8/20/07
Broccoli May Help Cut Prostate Cancer - WebMD, 7/24/07 -
"Men who reported eating cauliflower more than once
per week were 52% less likely to be diagnosed with aggressive prostate
cancer than men who reported eating cauliflower less than once a month ...
Men who reported eating broccoli more than once per week were 45% less
likely to be diagnosed with aggressive prostate cancer than men who reported
eating broccoli less than once a month"
Your Broccoli: Study Finds Strong Anti-Cancer Properties In Cruciferous
Veggies - Science Daily, 5/17/07 -
"if you’re at all worried about cancer or at high
risk of cancer, especially of prostate or colon cancer, then increasing your
dietary intake of broccoli and other vegetables could be a good idea"
Boiling Broccoli Ruins Its Anti-cancer Properties, According To Study -
Science Daily, 5/15/07 - "Boiling appeared to have a
serious impact on the retention of those important glucosinolate within the
vegetables. The loss of total glucosinolate content after boiling for 30
minutes was: broccoli 77%, Brussel sprouts 58%, cauliflower 75% and green
Nutrients In Certain Vegetables May Provide Cancer-fighting Benefit -
Science Daily, 4/17/07 - "Dr. Singh's study is based
on phytochemicals, called isothiocyanates (ITCs), found in several
cruciferous vegetables and generated when vegetables are either cut or
chewed. His laboratory has found that phenethyl-ITC, or PEITC, is highly
effective in suppressing the growth of human prostate cancer cells at
concentrations achievable through dietary intake"
Worried About Prostate Cancer? Tomato-broccoli Combo Shown To Be Effective
- Science Daily, 1/16/07 - "fed a diet containing 10
percent tomato powder and 10 percent broccoli powder to laboratory rats that
had been implanted with prostate cancer cells ... The tomato/broccoli combo
outperformed all other diets in shrinking prostate tumors ... The only
treatment that approached the tomato/broccoli diet's level of effectiveness
was castration ... To get these effects, men should consume daily 1.4 cups
of raw broccoli and 2.5 cups of fresh tomato, or 1 cup of tomato sauce, or ½
cup of tomato paste"
Broccoli, Cauliflower May Fight Cancer - WebMD, 5/19/06
Broccoli, Cauliflower And Genetic Cancer - Science Daily, 5/18/06 -
"cruciferous vegetables ... are abundant in
sulforaphane (SFN) ... those mice fed with an SFN-supplemented diet
developed significantly fewer and smaller tumors"
Crunchy Veggies Fight Cancer - WebMD, 4/5/06 -
"focused on a substance found in cruciferous
vegetables called phenethyl-ITC, or PEITC ... After 31 days of treatment,
the size of the tumors in the treated animals was about half that of the
Curry And Cauliflower Could Halt Prostate Cancer - Science Daily,
1/15/06 - "The bottom line is that PEITC and
curcumin, alone or in combination, demonstrate significant cancer-preventive
qualities in laboratory mice, and the combination of PEITC and curcumin
could be effective in treating established prostate cancers"
Eat Your Veggies and Fight Cancer, Too - WebMD, 10/31/05
Broccoli May Protect Some Against Lung Cancer - WebMD, 10/27/05 -
"consumption of cruciferous vegetables was
associated with a 33%-37% reduction in lung cancer risk among people with an
inactive form of one of the two genes. Among those with an inactive form of
both genes, the reduction in risk provided by eating cruciferous vegetables
was doubled to more than 70%"
Broccoli May Fight Lung Cancer - WebMD, 9/15/05
Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression
- Science Daily, 9/15/05 - "A family of compounds
found in cruciferous vegetables, such as broccoli, cauliflower, and
watercress, blocked lung cancer progression in both animal studies and in
tests with human lung cancer cells"
Broccoli Ingredient May Fight Bladder Cancer - WebMD, 8/3/05
Broccoli Packs Powerful Punch To Bladder Cancer Cells - Science Daily,
7/29/05 - "men who ate two or more half-cup servings
of broccoli per week had a 44 percent lower incidence of bladder cancer
compared to men who ate less than one serving each week ... The plant's kin,
which include cabbage, cauliflower, Brussels sprouts and kale, may all
contain similar disease-fighting phytochemicals"
Cruciferous veg, chili could slow or stop cancer cell growth - Nutra
Maximizing The Anti-Cancer Power Of Broccoli - Science Daily, 4/5/05 -
"For the consumer, who cannot readily hold the
temperature as low as 140 degrees, that means the best way to prepare
broccoli is to steam it lightly about 3 or 4 minutes--until the broccoli is
off cancer with a Japanese diet - MSNBC, 12/17/04 -
"Cruciferous vegetables make a unique contribution to good health. They
contain natural substances called glucosinolates that break down in the body
to form indoles and other compounds that fight cancer development in several
An Apple a Day for Cancer Prevention - WebMD, 10/18/04 -
"Those who ate both green leafy and cruciferous vegetables got "particularly
strong" cancer prevention protection"
Crunchy Veggies May Crush Breast Cancer - WebMD, 9/3/04
Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer
Cell Growth - Science Daily, 9/1/04 - "The
compound, in broccoli and other cruciferous vegetables ... sulforaphane
(SUL) ... We were surprised and pleased to find that SUL could block the
growth of breast cells that were already cancerous ... SUL's actions appear
similar to a group of anticancer drugs currently in use, such as Taxol"
Broccoli compound may protect against AMD - Nutra USA, 7/15/04
Broccoli May Prevent Blindness - WebMD, 7/13/04 -
"sulforaphane, the naturally occurring antioxidant
in broccoli and broccoli sprouts, protects the eye from damage caused by the
sun's ultraviolet light"
Cabbage to fight cancer? - Nutra USA, 5/11/04
Broccoli Blocks Prostate Cancer Cells - WebMD, 5/20/03
New Broccoli Compound Appears Promising Against Breast Cancer
- Intelihealth, 8/19/02 - "Called oxomate, the
synthetic compound works like its natural counterpart, sulforaphane, which
was recently identified as a cancer-preventive agent in broccoli and other
cruciferous vegetables (such as cabbage and Brussels sprouts). Both
compounds boost the body's production of phase II enzymes, which can
detoxify cancer-causing chemicals and reduce cancer risk ... But the natural
broccoli compound, sulforaphane, can be toxic in high doses ... It is also
difficult and expensive to synthesize ... oxomate was seven times less toxic
than sulforaphane ... In tests on female rats, those that were fed oxomate
after exposure to cancer-inducing chemicals had up to a 50 percent reduction
in the number of breast tumors"
Broccoli Pill Prevents Breast Cancer - WebMD, 8/19/02
Broccoli Beats Ulcers, Cancer - WebMD, 5/28/02
Broccoli Tea: Can't Find Enough Of A Good Thing - Natural Foods
Broccoli Finally Gets Respect - Intelihealth, 2/4/02
New research shows how broccoli beats cancer - Life Extension Magazine,
11/01 - "Sulforaphane is most highly concentrated in
broccoli, as well as in other cruciferous vegetables, such as Brussels
sprouts, cabbage and cauliflower ... animal studies to date have shown that
sulforaphane can dramatically reduce the number of malignant tumors,
reproduction, growth rate and size, as well as delay cancer onset"
Veggies Not Created Equal In Fighting Cancer - Intelihealth, 1/18/01 -
"But the Agriculture Department studied 71 types of
broccoli plants and found a 30-fold difference in the amounts of
glucoraphanin. Some had virtually none of it."
Impairs Radiation-Induced Survival Pathways Independently of Androgen Receptor
Expression and Augments Radiation Efficacy in Prostate Cancer - Cancer Lett.
2011 Dec 9 - "Increased consumption of cruciferous
vegetables is associated with decreased risk in prostate cancer (PCa). The
active compound in cruciferous vegetables appears to be the self dimerized
product [3,3'-diindolylmethane (DIM)] of indole-3-carbinol (I3C). Nutritional
grade B-DIM (absorption-enhanced) has proven safe in a Phase I trial in PCa ...
B-DIM inhibited cell growth in a dose-dependent manner in both PC-3 (AR-) and
C4-2B (AR+) cell lines. B-DIM was effective at increasing radiation-induced cell
killing in both cell lines, independently of AR expression. B-DIM inhibited
NF-κB and HIF-1α DNA activities and blocked radiation-induced activation of
these transcription factors in both PC-3 and C4-2B cells. In C4-2B (AR+) cells,
AR expression and nuclear localization were significantly increased by
radiation. However, B-DIM abrogated the radiation-induced AR increased
expression and trafficking to the nucleus, which was consistent with decreased
PSA secretion. In vivo, treatment of PC-3 prostate tumors in nude mice with
B-DIM and radiation resulted in significant primary tumor growth inhibition and
control of metastasis to para-aortic lymph nodes. These studies demonstrate that
B-DIM augments radiation-induced cell killing and tumor growth inhibition. B-DIM
impairs critical survival signaling pathways activated by radiation, leading to
enhanced cell killing. These novel observations suggest that B-DIM could be used
as a safe compound to enhance the efficacy of radiotherapy for
castrate-resistant PCa" - See
diindolylmethane at Amazon.com.
vegetable consumption is associated with a reduced risk of total and
cardiovascular disease mortality - Am J Clin Nutr. 2011 May 18 -
"Overall, fruit and vegetable intake was inversely
associated with risk of total mortality in both women and men, and a
dose-response pattern was particularly evident for cruciferous vegetable intake.
The pooled multivariate hazard ratios (95% CIs) for total mortality across
increasing quintiles of intake were 1 (reference), 0.91 (0.84, 0.98), 0.88
(0.77, 1.00), 0.85 (0.76, 0.96), and 0.78 (0.71, 0.85) for cruciferous
vegetables (P < 0.0001 for trend) and 0.88 (0.79, 0.97), 0.88 (0.79, 0.98), 0.76
(0.62, 0.92), and 0.84 (0.69, 1.00) for total vegetables (P = 0.03 for trend).
The inverse associations were primarily related to cardiovascular disease
mortality but not to cancer mortality"
Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl
Isothiocyanate in a Mouse Model of Prostate Cancer - J Natl Cancer Inst.
2011 Feb 17 - "This study was undertaken to determine
the chemopreventative efficacy of phenethyl isothiocyanate (PEITC), a bioactive
constituent of many edible cruciferous vegetables, in a mouse model of prostate
cancer, and to identify potential biomarker(s) associated with PEITC response
... Administration of PEITC (3 μmol/g diet) decreased incidence (PEITC diet vs
control diet, mean = 21.65 vs 57.58%, difference = -35.93%, 95% confidence
interval = -45.48% to -13.10%, P = .04) as well as burden (affected area) (PEITC
diet vs control diet, mean = 18.53% vs 45.01%, difference = -26.48%, 95%
confidence interval = -49.78% to -3.19%, P = .02) of poorly differentiated
tumors in the dorsolateral prostate of transgenic mice compared with control
mice, with no toxic effects. PEITC-mediated inhibition of prostate
carcinogenesis was associated with induction of autophagy and overexpression of
E-cadherin in the dorsolateral prostate. However, PEITC treatment was not
associated with a decrease in cellular proliferation, apoptosis induction, or
inhibition of neoangiogenesis. Plasma proteomics revealed distinct changes in
the expression of several proteins (eg, suppression of clusterin protein) in the
PEITC-treated mice compared with control mice. Conclusions In this transgenic
model, dietary PEITC suppressed prostate cancer progression by induction of
autophagic cell death. Potential biomarkers to assess the response to PEITC
treatment in plasma were identified"
Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and
vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4
pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep
27 - "Chronic inflammation plays pivotal roles in both
cancer and cardiovascular diseases. A large body of evidence suggests that high
intake of cruciferous vegetables is closely related with low risk of these
disorders ... Taken all together, adhesion molecules are confirmed to be the
novel targets of sulphoraphane in preventing inflammatory insult to endothelial
cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors
such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the
subsequent expression of adhesion molecules. These data suggested a novel
inflammatory pathway mediated by sulphoraphane" - See
sulforaphane at Amazon.com.
Cruciferous Vegetables Modifies Bladder Cancer Survival - Cancer Epidemiol
Biomarkers Prev. 2010 Jun 15 - "After an average of 8
years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder
cancer. After adjustment for other prognostic factors, a strong and significant
inverse association was observed between bladder cancer mortality and broccoli
intake, in particular raw broccoli intake (>/=1 versus <1 serving per month; HR
for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43;
95% CI, 0.25-0.74). There were no significant associations for total vegetables,
total fruits, or other individual cruciferous vegetables" - See
sulforaphane at Amazon.com.
of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and
apoptosis in LNCaP human prostate cancer cells - Int J Food Sci Nutr.
2010 May;11(7):324-36 - "Cruciferous vegetable
consumption is associated with decreased risk of several cancers, including
prostate cancer. Gluconasturtiin, one of the predominant glucosinolates in
cruciferous vegetables, is hydrolyzed to yield phenylethyl isothiocyanate
(PEITC). PEITC absorption and metabolism in humans involves glutathione
conjugation followed by conversion via the mercapturic acid pathway to an
N-acetylcysteine (NAC) conjugate that is excreted in the urine. We observed
an inhibitory effect of PEITC and its metabolite, NAC-PEITC, on cancer cell
proliferation, cell-cycle progression, and apoptosis in LNCaP human prostate
cancer cells. PEITC and NAC-PEITC suppressed LNCaP cell proliferation in a
dose-dependent manner, and exposure to 5 microM PEITC or NAC-PEITC reduced
cell proliferation by 25% and 30%, respectively. Cell-cycle analysis
revealed that cells treated with 5 microM PEITC or NAC-PEITC arrested at the
G(2)/M phase. In addition, the percentage of cells in the S phase decreased
from 46% to 25% following 48 h of incubation with PEITC or NAC-PEITC. The
G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC
or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1)
protein expression. Apoptosis was observed at the later stages of 24-h and
48-h treatments with 5 microM PEITC and NAC-PEITC. In conclusion, PEITC and
NAC-PEITC are potential chemopreventive/chemotherapeutic agents against
LNCaP human prostate cancer cells"
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a
Proinflammatory State - Arterioscler Thromb Vasc Biol. 2009 Sep 3 -
"Treatment with sulforaphane, a dietary antioxidant,
activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site
in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC
activation via Nrf2 ... Nrf2 prevents ECs at the atheroprotected site from
exhibiting a proinflammatory state via the suppression of p38-VCAM-1
signaling. Pharmacological activation of Nrf2 reduces EC activation at
atherosusceptible sites and may provide a novel therapeutic strategy to
prevent or reduce atherosclerosis" - See
sulforaphane at Amazon.com.
Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression
To Attenuate Migration and Invasion of Breast Cancer Cells - J Agric
Food Chem. 2008 Dec 5 - "Indole-3-carbinol
(I3C), a major indole metabolite in cruciferous vegetables, has been shown
to inhibit invasion of breast cancer cells ... Migration, invasion, and
MMP-2 activity of MCF-7 breast cancer cells were dose-dependently inhibited
by I3C. In addition, the MMP-2 mRNA level was also reduced by I3C ... In
addition, I3C inhibited the extracellular signal-regulated kinase (ERK)
signaling pathway in MCF-7 cells. The results suggest that I3C inhibits
MMP-2 expression by blocking the ERK/Sp1-mediated gene transcription to
attenuate migration and invasion of breast cancer cells" - See
indole-3-carbinol at Amazon.com.
Consumption of Raw Cruciferous Vegetables is Inversely Associated with
Bladder Cancer Risk - Cancer Epidemiol Biomarkers Prev. 2008
Apr;17(4):938-44 - "We observed a strong and
statistically significant inverse association between bladder cancer risk
and raw cruciferous vegetable intake (adjusted OR for highest versus lowest
category = 0.64; 95% CI, 0.42-0.97), with a significant trend (P = 0.003);
there were no significant associations for fruit, total vegetables, or total
cruciferous vegetables ... These data suggest that cruciferous vegetables,
when consumed raw, may reduce the risk of bladder cancer, an effect
consistent with the role of dietary isothiocyanates as chemopreventive
agents against bladder cancer"
Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the
Redox Cycling of the Thioredoxin Superfamily - J Agric Food Chem. 2007
Dec 29 - "the results of the present study indicate
that the consumption of broccoli triggers cardioprotection by generating a
survival signal through the activation of several survival proteins and by
redox cycling of thioredoxins"
Cruciferous vegetables, genetic polymorphisms in glutathione s-transferases
m1 and t1, and prostate cancer risk - Nutr Cancer. 2004;50(2):206-13 -
"two or more servings per month of cruciferous vegetables may reduce risk of
Breast Cancer Risk in Premenopausal Women Is Inversely Associated with
Consumption of Broccoli, a Source of Isothiocyanates, but Is Not Modified by
- J Nutr. 2004 May;134(5):1134-1138 - "These data
indicate that cruciferous vegetables may play an important role in
decreasing the risk of premenopausal breast cancer"
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