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Recent Longevity News for the seven days ending 12/28/11.  You should consult your doctor if you are taking any medications.

IQ isn't fixed at birth, can increase - USATODAY.com, 12/27/11 - "the average increased by 0.6 points, which correlated with an increase in IQ of 3.7 points for an addition year of schooling"

Curcumin and Piperine Prevent Remodeling of Aorta - Medscape, 12/26/11 - "N-nitro-L-arginine-methylester (L-NAME) is a nonspecific inhibitor of all three NO synthase (NOS) isoforms (neuronal - nNOS; inducible - iNOS; endothelial - eNOS) and causes an increase of blood pressure in a dose-dependent manner when administered to the experimental animals ... Administration of piperine or curcumin to animals with L-NAME-induced hypertension lead to a decrease of blood pressure, curcumin causing a more significant drop. Similar hypertension reducing effect of curcumin has been reported recently by Nakmreong et al.[34] Another study[25] registered a significant decrease of blood pressure after intravenous piperine administration. Piperine treatment was effective also in lowering blood pressure in rats with L-NAME-induced experimental hypertension described by Kumar et al.[36] The combination of curcumin and piperine in our experiment did not cause a statistically significant blood pressure decrease (with the exception of the third week) but it is apparent that it copies the course of the piperine graph curve. These differences in the results are probably related to different mechanisms of effect by the spices on blood pressure" - See curcumin products at Amazon.com and piperine at Amazon.com.

Eau de DNA: Do genes determine our perfume preference? - MSNBC, 12/23/11 - "A perfume that one person loves may be repulsive to another. The difference is in our genes" - Tell me about it.  There are at least two that are so offensive to me that I have to leave the room.  Someone said one might be the "Poison" brand perfume.  To me it smells like flea spray.

Possible cure for leukemia found in fish oil - Science Daily, 12/22/11 - "The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice ... The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil ... During the experiments, the researchers injected each mouse with about 600 nanograms of D12-PGJ3 each day for a week. Tests showed that the mice were completely cured of the disease. The blood count was normal, and the spleen returned to normal size. The disease did not relapse ... The researchers focused on D12-PGJ3 because it killed the leukemia stem cells, but had the least number of side effects" - See Mega Twin EPA at Amazon.com.

Statin Prescriptions and Breast Cancer Recurrence Risk - Medscape, 12/22/11 - "It is possible that some past incidence studies did not observe an association because a high proportion of statin users took hydrophilic drugs. For instance, Cauley et al.[16] observed a lower risk of breast cancer among lipophilic statin users, 82% of whom took either simvastatin or lovastatin (HR = 0.82, 95% CI = 0.70 to 0.97); and Boudreau et al.[17] observed an inverse association with overall statin use, when approximately 48% of the study participants were simvastatin or lovastatin users (odds ratio = 0.7, 95% CI = 0.4 to 1.0).[17] However, Woditschka et al.[14] observed no association between statin use and breast cancer incidence in which most users were exposed to the lipophilic drugs simvastatin and lovastatin (odds ratio = 1.02, 95% CI = 0.97 to 1.08);[52] and Friis et al.[12] studied statin use and breast cancer incidence in a Danish population that overlaps with the population analyzed in our study (so simvastatin is expected to have accounted for a large proportion of the overall statin exposure) and also observed no association; (relative risk = 1.02, 95% CI = 0.76 to 1.36).[12] Although the apparent discordance between the statin associations with breast cancer incidence and recurrence may be explained by inadequate exposure characterization with respect to solubility, it is also important to realize that factors which prevent recurrence are not necessarily expected to also prevent incidence"

Menopause pill may boost sex life - USATODAY.com, 12/20/11 - "This is the first evidence that low doses of DHEA (dehydroepiandrosterone), a hormone secreted by the adrenal glands, can help sexual function as well as menopausal symptoms ... women taking DHEA had a statistically significant increase in sexual interest and activity, with similar results for women in the HRT group. Sexual activity was also higher among the women taking tiboline, but the increase was not statistically significant" - See DHEA at Amazon.com.

Scientists identify an innate function of vitamin E - Science Daily, 12/20/11 - "Everyday activities such as eating and exercise can tear the plasma membrane and the new research shows that vitamin E is essential to repair. Without repair of muscle cells, for example, muscles eventually waste away and die in a process similar to what occurs in muscular dystrophy ... Vitamin E appears to aid repair in several ways. As an antioxidant, it helps eliminate destructive byproducts from the body's use of oxygen that impede repair. Because it's lipid-soluble, vitamin E can actually insert itself into the membrane to prevent free radicals from attacking. It also can help keep phospholipids, a major membrane component, compliant so they can better repair after a tear" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Mediterranean diet gives longer life, Swedish study suggests - Science Daily, 12/20/11 - "A Mediterranean diet with large amounts of vegetables and fish gives a longer life. This is the unanimous result of four studies to be published by the Sahlgrenska Academy ... The results show that those who eat a Mediterranean diet have a 20% higher chance of living longer"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study - Eur J Clin Nutr. 2011 Dec 21 - "There were no adverse events. Compliance was high. This suggests that 300 000 IU vitamin D3 orally 6-monthly may safely and effectively correct vitamin D deficiency in adolescents" - See vitamin D at Amazon.com.

ω-3 and ω-6 polyunsaturated fatty acid intakes and the risk of breast cancer in Mexican women: impact of obesity status - Cancer Epidemiol Biomarkers Prev. 2011 Dec 22 - "Overall, there was no significant association between ω-3 PUFA intake and breast cancer risk (p=0.31). An increased risk of breast cancer was associated with increasing ω-6 PUFA intake in pre-menopausal women (OR=1.92, 95% CI=1.13;3.26; p=0.04). A decreased risk of breast cancer was significantly associated with increasing ω-3 PUFA intake in obese women (OR=0.58, 95%CI=0.39;0.87; p=0.008), but not in normoweight nor in overweight women (p for heterogeneity = 0.017)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

COFFEE, TEA AND SUGAR-SWEETENED CARBONATED SOFT DRINK INTAKE AND PANCREATIC CANCER RISK: A POOLED ANALYSIS OF 14 COHORT STUDIES - Cancer Epidemiol Biomarkers Prev. 2011 Dec 22 - "Sugar-sweetened carbonated soft drink (abbreviated as SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous ... pooled analysis from 14 prospective cohort studies ... No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR=1.10, 95% CI=0.81-1.48 comparing >900 to <0g/day; 237g≈8oz), tea (MVRR=0.96, 95% CI=0.78-1.16 comparing >400 to 0g/day; 237g≈8oz) or SSB (MVRR=1.19, 95% CI=0.98-1.46 comparing >250 to 0g/day; 355g≈12oz) (p-value, test for between-studies heterogeneity >0.05). These associations were consistent across levels of sex, smoking status and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR=1.06, 95% CI=1.02-1.12)" - Big change compared to this study:

A Low-Glycemic Load Diet Reduces Serum C-Reactive Protein and Modestly Increases Adiponectin in Overweight and Obese Adults - J Nutr. 2011 Dec 21 - "Among participants with high-body fat mass (>32.0% for males and >25.0% for females), the low-GL diet reduced CRP (P = 0.02) and marginally increased adiponectin (P = 0.06). In conclusion, carbohydrate quality, independent of energy, is important. Dietary patterns emphasizing low-GL foods may improve the inflammatory and adipokine profiles of overweight and obese individuals"

Diet Quality Is Associated with All-Cause Mortality in Adults Aged 65 Years and Older - J Nutr. 2011 Dec 21 - "Three measures of diet quality were used: the Healthy Diet Score (HDS), the Recommended Food Score (RFS), and the Mediterranean Diet Score (MDS) ... After adjustment for confounders, the MDS was significantly associated with mortality [highest vs. lowest quartile; HR = 0.78 (95% CI = 0.62-0.98)]. Similarly, the RFS was also associated with mortality [HR = 0.67 (95 % CI = 0.52-0.86)]; however, there were no significant associations for the HDS [HR = 0.99 (95% CI = 0.79-1.24)]"

Effect of vitamin d supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis - J Am Geriatr Soc. 2011 Dec;59(12):2291-300 - "Supplemental vitamin D with daily doses of 800 to 1,000 IU consistently demonstrated beneficial effects on strength and balance. An effect on gait was not demonstrated, although further evaluation is recommended" - See vitamin D at Amazon.com.

Testosterone therapy decreased subcutaneous fat and adiponectin in ageing men - Eur J Endocrinol. 2011 Dec 21 - "Our data showed that testosterone therapy decreased subcutaneous fat on the abdomen and lower extremities, but had no significant effect on visceral fat. Moreover, adiponectin levels were significantly decreased during testosterone therapy"

Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma - Br J Nutr. 2011 Dec 20:1-9 - "Intake of vegetables was associated with a decreased risk of RCC (OR 0.5; 95 % CI 0.3, 0.7; Ptrend = 0.002), (top compared to the bottom quartile of intake). When intake of individual nutrients was investigated, vegetable fibre intake was associated with decreased risks (OR 0.4; 95 % CI 0.2, 0.6; P < 0.001), but this was not the case with fruit fibre (OR 0.7; 95 % CI 0.4, 1.1) or grain fibre (OR 1.0; 95 % CI 0.6, 1.5). β-Cryptoxanthin and lycopene were also associated with decreased risks, but when both were included in a mutually adjusted backwards stepwise regression model, only β-cryptoxanthin remained significant (OR 0.5; 95 % CI 0.3, 0.8). When other micronutrients and types of fibre were investigated together, only vegetable fibre and β-cryptoxanthin had significant trends (P < 0.01) (OR 0.6; 95 % CI 0.3, 0.9) (OR 0.5; 95 % CI 0.3, 0.9), respectively. These findings were stronger in those aged over 65 years (Pinteraction = 0.001). Among non-smokers, low intake of cruciferous vegetables and fruit fibre was also associated with increased risk of RCC (Pinteraction = 0.03); similar inverse associations were found for β-cryptoxanthin, lycopene and vitamin C. When nutrients were mutually adjusted by backwards regression in these subgroups, only β-cryptoxanthin remained associated with lower RCC risk"

Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran - Nutr J. 2011 Dec 20;10(1):137 - "ESCC cases consumed significantly more hot foods and beverages and fried and barbecued meals, compared to the controls (p<0.05). After adjusting for potential confounders, the risk of ESCC increased significantly in the highest tertiles of saturated fat [OR:2.88,95%CI:1.15-3.08], cholesterol [OR:1.53, 95%CI: 1.41-4.13], discretionary calorie [OR:1.51, 95%CI: 1.06-3.84], sodium [OR:1.49,95%CI:1.12-2.89] and total fat intakes [OR:1.48, 95%CI:1.09-3.04]. In contrast, being in the highest tertile of carbohydrate, dietary fiber and (n-3) fatty acid intake reduced the ESCC risk by 78%, 71% and 68%, respectively. The most cancer-protective effect was observed for the combination of high folate and vitamin E intakes (OR: 0.02, 95%CI: 0.00-0.87; p<0.001). Controls consumed 623.5 times higher selenium, 5.48 times as much beta-carotene and 1.98 times as much alpha-tocopherol as the amount ESCC cases consumed"

Curcumin Attenuates TNF-α-induced Expression of Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1 and Proinflammatory Cytokines in Human Endometriotic Stromal Cells - Phytother Res. 2011 Dec 20 - "These findings suggest that curcumin may have potential therapeutic uses in the prevention and treatment of endometriosis" - See curcumin products at Amazon.com.

Neat Tech Stuff / "How To's":

Health Focus (BPH/Prostate Cancer):

Related Topics:

Popular Supplements:

Alternative News:

  • B-DIM Impairs Radiation-Induced Survival Pathways Independently of Androgen Receptor Expression and Augments Radiation Efficacy in Prostate Cancer - Cancer Lett. 2011 Dec 9 - "Increased consumption of cruciferous vegetables is associated with decreased risk in prostate cancer (PCa). The active compound in cruciferous vegetables appears to be the self dimerized product [3,3'-diindolylmethane (DIM)] of indole-3-carbinol (I3C). Nutritional grade B-DIM (absorption-enhanced) has proven safe in a Phase I trial in PCa ... B-DIM inhibited cell growth in a dose-dependent manner in both PC-3 (AR-) and C4-2B (AR+) cell lines. B-DIM was effective at increasing radiation-induced cell killing in both cell lines, independently of AR expression. B-DIM inhibited NF-κB and HIF-1α DNA activities and blocked radiation-induced activation of these transcription factors in both PC-3 and C4-2B cells. In C4-2B (AR+) cells, AR expression and nuclear localization were significantly increased by radiation. However, B-DIM abrogated the radiation-induced AR increased expression and trafficking to the nucleus, which was consistent with decreased PSA secretion. In vivo, treatment of PC-3 prostate tumors in nude mice with B-DIM and radiation resulted in significant primary tumor growth inhibition and control of metastasis to para-aortic lymph nodes. These studies demonstrate that B-DIM augments radiation-induced cell killing and tumor growth inhibition. B-DIM impairs critical survival signaling pathways activated by radiation, leading to enhanced cell killing. These novel observations suggest that B-DIM could be used as a safe compound to enhance the efficacy of radiotherapy for castrate-resistant PCa" - See diindolylmethane at Amazon.com.
  • You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests - Science Daily, 10/25/11 - "Men who ate a low-fat diet with fish oil supplements for four to six weeks before having their prostate removed had slower cancer-cell growth in their prostate tissue than men who ate a traditional, high-fat Western diet ... The short-term study also found that blood obtained from patients after the low-fat, fish oil diet slowed the growth of prostate cancer cells in a test tube, while blood from men on the Western diet did not slow cancer growth ... Preclinical studies suggest that lowering dietary omega-6 fatty acids from corn oil and increasing omega-3 fatty acids from fish oil decreases the risk of prostate cancer development and progression," the study states. "We found this diet intervention resulted in a decrease in omega-6 vs. omega-3 fatty acid ratios in benign and malignant prostate tissue and a decrease in malignant cell proliferation" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT) - JAMA. 2011 Oct 12;306(14):1549-56 - "Oral selenium (200 μg/d from L-selenomethionine) with matched vitamin E placebo, vitamin E (400 IU/d of all rac-α-tocopheryl acetate) with matched selenium placebo, both agents, or both matched placebos for a planned follow-up of a minimum of 7 and maximum of 12 years ... This report includes 54,464 additional person-years of follow-up and 521 additional cases of prostate cancer since the primary report. Compared with the placebo (referent group) in which 529 men developed prostate cancer, 620 men in the vitamin E group developed prostate cancer (hazard ratio [HR], 1.17; 99% CI, 1.004-1.36, P = .008); as did 575 in the selenium group (HR, 1.09; 99% CI, 0.93-1.27; P = .18), and 555 in the selenium plus vitamin E group (HR, 1.05; 99% CI, 0.89-1.22, P = .46). Compared with placebo, the absolute increase in risk of prostate cancer per 1000 person-years was 1.6 for vitamin E, 0.8 for selenium, and 0.4 for the combination" - Note:  The study used rac-α-tocopheryl acetate.  See my vitamin E page for several articles regarding taking only one of the  eight forms of vitamin E.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Zyflamend Reduces the Expression of Androgen Receptor in a Model of Castrate-Resistant Prostate Cancer - Nutr Cancer. 2011 Sep 29 - "These results demonstrated that Zyflamend inhibited IGF-1-stimulated cell growth, IGF-1R expression, and androgen receptor expression and its nuclear localization, but these effects were not dependent upon phosphatidylinositol 3-kinase/pAKT signaling. In conclusion, Zyflamend decreased cell proliferation and inhibited IGF-1R and androgen receptor expression in a phosphatidylinositol 3-kinase/pAKT independent manner" - See Zyflamend at Amazon.com.
  • Calcium intake and prostate cancer among African Americans: Effect modification by vitamin D receptor calcium absorption genotype - J Bone Miner Res. 2011 Sep 1 - "Compared to men in the lowest quartile of calcium intake, men in the highest quartile had an approximately two-fold increased risk of localized and advanced prostate cancer (odds ratio [OR]= 2.20, 95% confidence interval [CI]= 1.40, 3.46), with a significant dose-response. Poor absorbers of calcium (VDR Cdx2 GG genotype) had a significantly lower risk of advanced prostate cancer (OR= 0.41, 95% CI = 0.19, 0.90). The gene-calcium interaction was statistically significant (p = 0.03). Among men with calcium intake below the median (680 mg/day), carriers of the G allele had an approximately 50% decreased risk compared to men with the AA genotype. These findings suggest a link between prostate cancer risk and high intestinal absorption of calcium"
  • Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection among US men - Cancer Causes Control. 2011 Jul 29 - "Associations of serum vitamin A and carotenoid levels with markers of prostate cancer detection were evaluated among 3,927 US men, 40-85 years of age, who participated in the 2001-2006 National Health and Nutrition Examination Surveys. Five recommended definitions of prostate cancer detection were adopted using total and free prostate-specific antigen (tPSA and fPSA) laboratory measurements. Men were identified as high risk based on alternative cutoffs, namely tPSA > 10 ng/ml, tPSA > 4 ng/ml, tPSA > 2.5 ng/ml, %fPSA < 25%, and %fPSA < 15%. %fPSA was defined as (fPSA÷tPSA)× 100%. Serum levels of vitamin A (retinol and retinyl esters) and carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein + zeaxanthin, lycopene) were defined as quartiles and examined as risk/protective factors for PSA biomarkers. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using binary logistic models. After adjustment for known demographic, socioeconomic, and lifestyle confounders, high serum levels of retinyl esters (tPSA > 10 ng/ml: Q4 vs. Q1 → OR = 0.38, 95% CI: 0.14-1.00) and α-carotene (%fPSA < 15%: Q4 vs. Q1 → OR = 0.49, 95% CI: 0.32-0.76) were associated with a lower odds, whereas high serum level of lycopene (tPSA > 2.5 ng/ml: Q4 vs. Q1 → OR = 1.49, 95% CI: 1.01-2.14) was associated with a greater odds of prostate cancer detection. Apart from the three significant associations observed, no other exposure-outcome association was significant. Monitoring specific antioxidant levels may be helpful in the early detection of prostate cancer"
  • Impact of Consumption of Vegetable, Fruit, Grain, and High Glycemic Index Foods on Aggressive Prostate Cancer Risk - Nutr Cancer. 2011 Jul 20 - "Here we further investigate such potential relationships with a case-control study of 982 men (470 more aggressive prostate cancer cases and 512 control subjects). Comparing the highest to lowest quartiles of intake, we found that increasing intakes of leafy vegetables were inversely associated with risk of aggressive prostate cancer [adjusted odds ratio (OR) = 0.66, 95% CI: 0.46, 0.96; P trend = 0.02], as was higher consumption of high carotenoid vegetables (OR = 0.71, 95% CI: 0.48, 1.04; P trend = 0.04). Conversely, increased consumption of high glycemic index foods were positively associated with risk of aggressive disease (OR = 1.64, 95% CI: 1.05, 2.57; P trend = 0.02). These results were driven by a number of specific foods within the food groups. Our findings support the hypothesis that diets high in vegetables and low in high glycemic index foods decrease risk of aggressive prostate cancer"
  • Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells - Urology. 2011 Jun 13 - "Radiotherapy is effective in inducing apoptosis in DU145 cells, but its effect was significantly reduced in the presence of EGCG, and this was associated with an increase in the induction of manganese superoxide dismutase"
  • Androgen-independent Effects of Serenoa repens Extract (Prostasan®) on Prostatic Epithelial Cell Proliferation and Inflammation - Phytother Res. 2011 Jun 8 - "Prostasan® inhibited epidermal growth factor (EGF) and lipopolysaccharide (LPS) induced proliferation of the prostatic epithelial, androgen independent cell line PC-3. At effective concentrations of 50 µg/mL, Prostasan® partly displaced EGF from EGF receptor (EGFR) but fully blocked EGF-induced cell proliferation of PC-3 cells. Similarly, Prostasan® inhibited LPS-induced proliferation of PC-3 cells without affecting LPS activation of the NFĸB pathway via toll-like receptor-4 (TLR-4). Additionally, Prostasan® reduced the constitutive secretion of monocyte chemotactic protein-1 (MCP-1), the LPS-induced secretion of IL-12 and inhibited MCP-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) production in the presence of LPS on PC-3 cells. Taken together, our results suggest that S. repens extracts, in addition to other reported effects on BPH development and prostatitis, inhibits EGF-dependent growth and proinflammatory responses of the prostate epithelial cells" - See Prostasan at Amazon.com.
  • Omega-3 Fatty Acid Inhibition of Prostate Cancer Progression to Hormone Independence Is Associated With Suppression of mTOR Signaling and Androgen Receptor Expression - Nutr Cancer. 2011 Jun 10:1-7 - "We used an in vitro model of androgen ablation to determine the effect of treatment with omega-3 fatty acids on the progression to an androgen-independent state. The omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were able to prevent progression of LNCaP cells while the omega-6 fatty acid arachidonic acid (AA) actually promoted cell growth under conditions of hormone depletion. These results correlated with a decrease in the expression of the androgen receptor as well as suppression of the Akt/mTOR signaling pathway. Connecting the mechanisms by which omega-3 fatty acids affect phenotypic outcome is important for effective exploitation of these nutrient agents as a therapeutic approach" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Broccoli extract can ‘target’ cancer cells: Study - Nutra USA, 6/15/11 - "The research, published in Molecular Nutrition and Food Research, reports for the first time that sulforaphane – one of the primary phytochemicals in broccoli and other cruciferous vegetables – is able to selectively target and kill cancer cells, while leaving normal cells healthy and unaffected ... Here we show for the first time that sulforaphane selectively targets benign hyperplasia cells and cancerous prostate cells while leaving the normal prostate cells unaffected" - [Abstract] - See sulforaphane at Amazon.com.
  • Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables, researchers say - Science Daily, 6/9/11 - "Sulforaphane, one of the primary phytochemicals in broccoli and other cruciferous vegetables that helps them prevent cancer, has been shown for the first time to selectively target and kill cancer cells while leaving normal prostate cells healthy and unaffected ... Here we show for the first time that sulforaphane selectively targets benign hyperplasia cells and cancerous prostate cells while leaving the normal prostate cells unaffected" - See sulforaphane at Amazon.com.
  • Mushroom compound suppresses prostate tumors - Science Daily, 5/22/11 - "A mushroom used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumour development in mice during early trials ... The compound, polysaccharopeptide (PSP), which is extracted from the 'turkey tail' mushroom, was found to target prostate cancer stem cells and suppress tumour formation in mice ... The findings are quite significant ... Importantly, we did not see any side effects from the treatment ... He said PSP had been previously shown to possess anti-cancer properties, and 'turkey tail' mushrooms (known as Coriolus versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits" - See PSP supplement at Amazon.com.
  • Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study - J Natl Cancer Inst. 2011 May 17 - "Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels ... The average intake of coffee in 1986 was 1.9 cups per day. Men who consumed six or more cups per day had a lower adjusted relative risk for overall prostate cancer compared with nondrinkers (RR = 0.82, 95% confidence interval [CI] = 0.68 to 0.98, P(trend) = .10). The association was stronger for lethal prostate cancer (consumers of more than six cups of coffee per day: RR = 0.40, 95% CI = 0.22 to 0.75, P(trend) = .03). Coffee consumption was not associated with the risk of nonadvanced or low-grade cancers and was only weakly inversely associated with high-grade cancer. The inverse association with lethal cancer was similar for regular and decaffeinated coffee (each one cup per day increment: RR = 0.94, 95% CI = 0.88 to 1.01, P = .08 for regular coffee and RR = 0.91, 95% CI = 0.83 to 1.00, P = .05 for decaffeinated coffee). The age-adjusted incidence rates for men who had the highest (≥6 cups per day) and lowest (no coffee) coffee consumption were 425 and 519 total prostate cancers, respectively, per 100 000 person-years and 34 and 79 lethal prostate cancers, respectively, per 100 000 person-years"
  • Coffee may reduce risk of lethal prostate cancer in men - Science Daily, 5/17/11 - "The researchers chose to study coffee because it contains many beneficial compounds that act as antioxidants, reduce inflammation, and regulate insulin, all of which may influence prostate cancer. Coffee has been associated in prior studies with a lower risk of Parkinson's disease, type 2 diabetes, gallstone disease, and liver cancer or cirrhosis ... Men who consumed the most coffee (six or more cups daily) had nearly a 20% lower risk of developing any form of prostate cancer ... Men who drank the most coffee had a 60% lower risk of developing lethal prostate cancer ... Even drinking one to three cups of coffee per day was associated with a 30% lower risk of lethal prostate cancer"
  • Aspirin reduces the risk of cancer recurrence in prostate cancer patients, study suggests - Science Daily, 5/2/11 - "After 10-years from completion of treatment, 31% of the men who took aspirin developed recurrence compared with 39% of non-aspirin users (p=0.0005). There was also a 2% improvement in 10-year prostate cancer related survival associated with aspirin use with a trend toward statistical significance"
  • Thiazolidenediones induce tumour-cell apoptosis through the Akt-GSK3β pathway - J Clin Pharm Ther. 2011 Mar 16 - "Prostate cancer is a major health threat for men. Thiazolidenediones (TZDs) are synthetic ligands of the peroxisome proliferator-activated receptor γ (PPARγ), and previous studies have shown that TZDs induce apoptosis of prostate cancer cells independently of PPARγ activation. However, the exact mechanism of these effects remains unknown ... The apoptosis-inducing effect of TZDs on prostate cancer cells involves the inhibition of Akt phosphorylation. Furthermore, TZDs induce inactivation of GSK3β, a multifunctional kinase that mediates essential events promoting prostate cancer development and acquisition of androgen independence. In addition, the GSK3β inhibitor lithium chloride sensitizes prostate cancer cells to TZDs cytotoxicity. What is new and Conclusion:  Our data suggest that modulation of Akt-GSK3β pathway is involved in the cell death pathway engaged by TZDs in prostate cancer cells. This reveals another possible mechanism of TZDs on apoptosis in prostate cancer. Inhibition of the Akt-GSK3β cascade may be a useful approach in prostate cancer" - Got that because I'm going to give a test on it in next weeks newsletter.  The point is that TZDs such as pioglitazone may help prevent or slow prostate cancer.  See Pioglitazone at OffshoreRx1.com.
  • Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide - Int J Cancer. 2011 Mar 11 - "Although cell-based studies have shown that γ-tocotrienol (γTE) exhibits stronger anticancer activities than other forms of vitamin E including γ-tocopherol (γT), the molecular bases underlying γTE-exerted effects remains to be elucidated ... In agreement with these cell-based studies, γTE inhibited LNCaP xenograft growth by 53% (P<0.05), compared with 33% (P = 0.07) by γT, in nude mice. These findings provide a molecular basis of γTE-stimulated cancer-cell death and support the notion that elevation of intracellular dihydroceramide and dihydrosphingosine is likely a novel anticancer mechanism" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Selenium may reduce prostate cancer markers: Study - Nutra USA, 2/23/11 - "The new study tested whether a 6-week supplementation of 200 micrograms of selenium (in the form of glycinate) affected the activities of 2 blood selenium enzymes (erythrocyte and plasma GPx) and a marker of prostate cancer risk (plasma PSA) ... selenium supplementation, but not placebo, raised both plasma and erythrocyte GPx activities ... selenium glycinate, but again not placebo, lowered the cancer risk marker of serum PSA" - See selenium at Amazon.com.
  • Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer - J Natl Cancer Inst. 2011 Feb 17 - "This study was undertaken to determine the chemopreventative efficacy of phenethyl isothiocyanate (PEITC), a bioactive constituent of many edible cruciferous vegetables, in a mouse model of prostate cancer, and to identify potential biomarker(s) associated with PEITC response ... Administration of PEITC (3 μmol/g diet) decreased incidence (PEITC diet vs control diet, mean = 21.65 vs 57.58%, difference = -35.93%, 95% confidence interval = -45.48% to -13.10%, P = .04) as well as burden (affected area) (PEITC diet vs control diet, mean = 18.53% vs 45.01%, difference = -26.48%, 95% confidence interval = -49.78% to -3.19%, P = .02) of poorly differentiated tumors in the dorsolateral prostate of transgenic mice compared with control mice, with no toxic effects. PEITC-mediated inhibition of prostate carcinogenesis was associated with induction of autophagy and overexpression of E-cadherin in the dorsolateral prostate. However, PEITC treatment was not associated with a decrease in cellular proliferation, apoptosis induction, or inhibition of neoangiogenesis. Plasma proteomics revealed distinct changes in the expression of several proteins (eg, suppression of clusterin protein) in the PEITC-treated mice compared with control mice. Conclusions In this transgenic model, dietary PEITC suppressed prostate cancer progression by induction of autophagic cell death. Potential biomarkers to assess the response to PEITC treatment in plasma were identified" - See cruciferous supplements at Amazon.com.
  • Dietary zinc and prostate cancer survival in a Swedish cohort - Am J Clin Nutr. 2011 Jan 12 - "High dietary zinc intake was associated with a reduced risk of prostate cancer-specific mortality (HR(Q4 vs Q1): 0.64; 95% CI: 0.44, 0.94; P for trend = 0.05) in the study population. The association was stronger in men with localized tumors (HR: 0.24; 95% CI: 0.09, 0.66; P for trend = 0.005). Zinc intake was not associated with mortality from other causes" - See Jarrow Zinc Balance at Amazon.com (some studies show that taking zinc can cause a difficiency of copper).
  • 'Longevity' protein SIRT1 may ward off precursor to prostate cancer - Science Daily, 1/13/11 - "prostatic intraepithelial neoplasia (PIN) ... deletion of the Sirt1 gene in mice resulted in PIN lesion formation associated with reduced autophagy, which is the necessary degradation of a cell's own components and most likely essential for tumor suppression ... it tells you that this 'longevity' gene is normally blocking prostate cancer" - Note: Resveratrol increases Sirt1.  See resveratrol products at Amazon.com:
    • Sirtuin1 may boost memory and learning ability; Discovery could lead to new drugs to fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 - "Resveratrol, found in wine, has been touted as a life-span enhancer because it activates a group of enzymes known as sirtuins, which have gained fame in recent years for their ability to slow the aging process. Now MIT researchers report that Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also promotes memory and brain flexibility ... We have now found that SIRT1 activity also promotes plasticity and memory"
    • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging"
    • Wine Compound Spurs Diabetes Research - WebMD, 11/29/07 - "In October, Chinese researchers reported that resveratrol curbs insulin resistance in mice. Insulin is a hormone that controls blood sugar. Insulin resistance can lead to type 2 diabetes ... Like resveratrol, the lab-made chemicals activate a gene called SIRT1, making the diabetic mice more sensitive to insulin ... the newly developed chemicals are 1,000 times more potent than resveratrol"
  • Lycopene and Apo-12'-Lycopenal Reduce Cell Proliferation and Alter Cell Cycle Progression in Human Prostate Cancer Cells - Nutr Cancer. 2011 Jan 3:1 - "Apo-lycopenals or other lycopene metabolites, whether produced by cleavage enzymes within the body or consumed with tomato products, can be found in tissues at concentrations equivalent to physiological retinoid concentrations ... The present data indicate that lycopene and apo-12'-lycopenal reduce the proliferation of prostate cancer cells, in part, by inhibiting normal cell cycle progression" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Exercise may lower risk of death for men with prostate cancer - Science Daily, 1/5/11 - "Compared with men who walked less than 90 minutes per week at an easy pace, those who walked 90 or more minutes per week at a normal to very brisk pace had a 46% lower risk of dying from any cause ... Only vigorous activity -- defined as more than three hours per week -- was associated with reduced prostate cancer mortality. Men who did vigorous activity had a 61% lower risk of prostate cancer-specific death compared with men who did less than one hour per week of vigorous activity"
  • Pomegranate juice components could stop cancer from spreading - Science Daily, 12/12/10 - "Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone ... the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids" - See pomegranate at Amazon.com.
  • Dihydrotestosterone May Not Affect Prostate Growth But May Reduce BMD - Medscape, 11/16/10
  • Soy may stop prostate cancer spread: Experimental soy-based drug shows benefits in men with localized prostate cancer - Science Daily, 11/8/10 - "A recent phase II randomized study of 38 men with localized prostate cancer found that genistein, when given once a day as a pill, one month prior to surgery, had beneficial effects on prostate cancer cells ... genistein increased the expression of genes that suppress the invasion of cancer cells and decreased the expression of genes that enhance invasion" - See genistein at Amazon.com.
  • Rye Whole Grain and Bran Intake Compared with Refined Wheat Decreases Urinary C-Peptide, Plasma Insulin, and Prostate Specific Antigen in Men with Prostate Cancer - J Nutr. 2010 Oct 27 - "Seventeen participants were provided with 485 g rye whole grain and bran products (RP) or refined wheat products with added cellulose (WP), corresponding to ~50% of daily energy intake, in a randomized controlled, crossover design ... We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion"
  • Vitamin E in front line of prostate cancer fight - Science Daily, 10/23/10 - "the research team have discovered a particular form of T3, called gamma-tocotrienol (γ-T3), can successfully kill off the prostate cancer CSCs ... Other research has found γ-T3 is also effective in suppressing other types of cancer, including breast, colon, liver and gastric ... not all vitamin E preparations had the active constituent" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer - Nutr Cancer. 2010 Oct;62(7):996-1000 - "Soy isoflavones sensitize prostate cancer cells to radiation therapy by inhibiting cell survival pathways activated by radiation. At the same time, soy isoflavones have significant antioxidant and anti-inflammatory activity, which may help prevent the side effects of radiation ... Adverse effects of radiation therapy on bladder, bowel, and sexual function were assessed by a self-administered quality of life questionnaire at 3 and 6 mo. Only 26 and 27 patients returned completed questionnaires at 3 and 6 mo, respectively. At each time point, urinary, bowel, and sexual adverse symptoms induced by radiation therapy were decreased in the soy isoflavone group compared to placebo group. At 3 mo, soy-treated patients had less urinary incontinence, less urgency, and better erectile function as compared to the placebo group. At 6 mo, the symptoms in soy-treated patients were further improved as compared to the placebo group. These patients had less dripping/leakage of urine (7.7% in Group 1 vs. 28.4% in Group 2), less rectal cramping/diarrhea (7.7% vs. 21.4%), and less pain with bowel movements (0% vs. 14.8%) than placebo-treated patients. There was also a higher overall ability to have erections (77% vs. 57.1%). The results suggest that soy isoflavones taken in conjunction with radiation therapy could reduce the urinary, intestinal, and sexual adverse effects in patients with prostate cancer" - See soy isoflavones at Amazon.com.
  • The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms Br J Nutr. 2010 Aug 31:1-9 - "In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study" - [Nutra USA] - See Jarrow Formulas, Cran Clearance at Amazon.com.
  • Nutrients and risk of prostate cancer - Nutr Cancer. 2010 Aug;62(6):710-8 - "Intake of trans fat was associated with the risk of PCa; the OR for the highest vs. the lowest quartile was 1.45 (95% CI = 1.16-1.81); the association was apparently stronger in subjects aged less than 65, normal weight men, and ever smokers. An increased risk was also observed with increasing intake of sucrose and disaccharides. In contrast, men in the highest quartile of cholesterol intake were at lower risk of PCa. No association was found with intake of total proteins, total fat, monounsaturated fats, polyunsaturated fats, monosaccharides, and total carbohydrates. The findings provide evidence that a diet low in trans fat could reduce PCa risk"
  • Mixed Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice - Nutr Cancer. 2010 Aug;62(6):789-94 - "mixed-tocotrienol-fed groups had a lower incidence of tumor formation along with a significant reduction in the average wet weight of genitourinary apparatus. Furthermore, mixed tocotrienols significantly reduced the levels of high-grade neoplastic lesions as compared to the positive controls. This decrease in levels of high-grade neoplastic lesions was found to be associated with increased expression of proapoptotic proteins BAD (Bcl(2) antagonist of cell death) and cleaved caspase-3 and cell cycle regulatory proteins cyclin dependent kinase inhibitors p21 and p27. In contrast, the expression of cyclins A and E were found to be decreased in mixed-tocotrienol groups. Taken together, our results show that by modulating cell cycle regulatory proteins and increasing expression of proapoptotic proteins, mixed tocotrienols suppress prostate tumorigenesis in the TRAMP mice" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Anti-cancer effects of broccoli ingredient explained - Science Daily, 7/12/10 - "sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing" - See sulforaphane at Amazon.com.
  • Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population - Int J Cancer. 2010 Jul 8 - "Emerging evidence supports that prostate cancer originates from a rare sub-population of cells, namely prostate cancer stem cells (CSCs). Conventional therapies for prostate cancer are believed to mainly target the majority of differentiated tumor cells but spare CSCs, which may account for the subsequent disease relapse after treatment. Therefore, successful elimination of CSCs may be an effective strategy to achieve complete remission from this disease. Gamma-tocotrienols (gamma-T3) is one of the vitamin-E constituents which have been shown to have anticancer effects against a wide-range of human cancers. Recently, we have reported that gamma-T3 treatment not only inhibits prostate cancer cell invasion but also sensitizes the cells to docetaxel-induced apoptosis, suggesting that gamma-T3 may be an effective therapeutic agent against advanced stage prostate cancer. Here, we demonstrate for the first time that gamma-T3 can down-regulate the expression of prostate CSC markers (CD133/CD44) in androgen independent (AI) prostate cancer cell lines (PC-3 & DU145), as evident from western blotting analysis. Meanwhile, the spheroid formation ability of the prostate cancer cells was significantly hampered by gamma-T3 treatment. In addition, pre-treatment of PC-3 cells with gamma-T3 was found to suppress tumor initiation ability of the cells. More importantly, while CD133-enriched PC-3 cells were highly resistant to docetaxel treatment, these cells were as sensitive to gamma-T3 treatment as the CD133-depleted population. Our data suggest that gamma-T3 may be an effective agent in targeting prostate CSCs, which may account for its anticancer and chemosensitizing effects reported in previous studies" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Polyphenols in red wine and green tea halt prostate cancer growth, study suggests - Science Daily, 6/9/10 - "The profound impact that the antioxidants in red wine and green tea have on our bodies is more than anyone would have dreamt just 25 years ago," Weissmann added. "As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent 'health foods' we know." - See resveratrol products at Amazon.com and green tea extract at Amazon.com.
  • Calcium consumption may cause prostate cancer in Chinese, research suggests - Science Daily, 6/1/10 - "Results showed a 25 percent increased risk of prostate cancer when comparing those who consumed, on average, 659 mg vs. 211 mg of total calcium a day ... Major food sources of calcium in this population consisted of: vegetables (19.3 percent), dairy (17.3 percent), grain products (14.7 percent), soyfoods (11.8 percent), fruit (7.3 percent) and fish (6.2 percent). However, the researchers stress that there was no positive association with prostate cancer risk and any one particular food source ... Among men with less than average BMI (median BMI was 22.9 kg/m2), the researchers found a twofold increased risk of prostate cancer"
  • Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells - Int J Food Sci Nutr. 2010 May;11(7):324-36 - "Cruciferous vegetable consumption is associated with decreased risk of several cancers, including prostate cancer. Gluconasturtiin, one of the predominant glucosinolates in cruciferous vegetables, is hydrolyzed to yield phenylethyl isothiocyanate (PEITC). PEITC absorption and metabolism in humans involves glutathione conjugation followed by conversion via the mercapturic acid pathway to an N-acetylcysteine (NAC) conjugate that is excreted in the urine. We observed an inhibitory effect of PEITC and its metabolite, NAC-PEITC, on cancer cell proliferation, cell-cycle progression, and apoptosis in LNCaP human prostate cancer cells. PEITC and NAC-PEITC suppressed LNCaP cell proliferation in a dose-dependent manner, and exposure to 5 microM PEITC or NAC-PEITC reduced cell proliferation by 25% and 30%, respectively. Cell-cycle analysis revealed that cells treated with 5 microM PEITC or NAC-PEITC arrested at the G(2)/M phase. In addition, the percentage of cells in the S phase decreased from 46% to 25% following 48 h of incubation with PEITC or NAC-PEITC. The G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1) protein expression. Apoptosis was observed at the later stages of 24-h and 48-h treatments with 5 microM PEITC and NAC-PEITC. In conclusion, PEITC and NAC-PEITC are potential chemopreventive/chemotherapeutic agents against LNCaP human prostate cancer cells"
  • Dietary supplements discouraged for prostate cancer patients - Science Daily, 3/8/10
  • Lycopene effects contributing to prostate health - Nutr Cancer. 2009 Nov;61(6):775-83 - "Epidemiological evidence links lycopene consumption with decreased prostate cancer risk ... Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication. Lycopene's influence on these pathways likely contributes to the observed cell growth inhibition and apoptosis induction by lycopene. A substantial part of the lycopene effects can be explained by its antioxidant action, but other mechanisms might also be involved" - See lycopene at Amazon.com.
  • Fats of any kind may boost prostate cancer risk: Study - Nutra USA, 1/29/10 - "Last year, a study from Harvard reported that increased intakes of trans-fatty acids may increase the risk of non-aggressive prostate tumors by about 100 per cent ... the highest blood levels of trans oleic acid and linoleic acids (18:1n-9t and 18:2t) were associated with a 116 and 97 per cent increase in the risk of non-aggressive prostate tumors, respectively, compared to the lowest levels. The study followed almost 15,000 men over 13 years"
  • Dietary fat and early-onset prostate cancer risk - Br J Nutr. 2010 Jan 19:1-6 - "A nutritional database was used to calculate daily fat intake. A positive, statistically significant risk estimate for the highest v. lowest quintile of intake of total fat, SFA, MUFA and PUFA was observed when adjusted for confounding variables: OR 2.53 (95 % CI 1.72, 3.74), OR 2.49 (95 % CI 1.69, 3.66), OR 2.69 (95 % CI 1.82, 3.96) and OR 2.34 (95 % CI 1.59, 3.46), respectively, with all P for trend < 0.001. In conclusion, there was a positive statistically significant association between prostate cancer risk and energy-adjusted intake of total fat and fat subtypes. These results potentially identify a modifiable risk factor for early-onset prostate cancer"
  • Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression - Am J Clin Nutr. 2009 Dec 30 - "Intakes of processed and unprocessed red meat, fish, total poultry, and skinless poultry were not associated with prostate cancer recurrence or progression. Greater consumption of eggs and poultry with skin was associated with 2-fold increases in risk in a comparison of extreme quantiles: eggs [hazard ratio (HR): 2.02; 95% CI: 1.10, 3.72; P for trend = 0.05] and poultry with skin (HR: 2.26, 95% CI: 1.36, 3.76; P for trend = 0.003). An interaction was observed between prognostic risk at diagnosis and poultry. Men with high prognostic risk and a high poultry intake had a 4-fold increased risk of recurrence or progression compared with men with low/intermediate prognostic risk and a low poultry intake (P for interaction = 0.003). CONCLUSIONS: Our results suggest that the postdiagnostic consumption of processed or unprocessed red meat, fish, or skinless poultry is not associated with prostate cancer recurrence or progression, whereas consumption of eggs and poultry with skin may increase the risk"
  • Hops compound may prevent prostate cancer - Science Daily, 12/9/09 - "xanthohumol blocks the action of estrogen by binding to its receptor, which may lead to prevention of breast cancer ... Since testosterone receptors act similarly to that of estrogen -- by binding, then stimulating hormone-dependent effects, such as gene expression and cell growth ... Xanthohumol prevented the receptor from translocating to the cell nucleus, thus inhibiting its potential to stimulate the secretion of PSA and other hormone-dependent effects" - See hops supplements at Amazon.com.
  • Exercise reduces death rate in prostate cancer patients - Science Daily, 12/7/09 - "men who walked four or more hours a week had a 23 percent lower risk of all-cause mortality compared to men who walked less than 20 minutes per week. Men who walked 90 or more minutes at a normal to brisk pace had a 51 percent lower risk of death from any cause than men who walked less than 90 minutes at an easy walking pace"
  • Coffee May Cut Risk of Prostate Cancer - WebMD, 12/7/09 - "men who drank the most coffee were nearly 60% less likely to develop advanced prostate cancer than non-coffee drinkers ... men who drank decaffeinated coffee also had a similar reduction in aggressive prostate cancer risk ... coffee also contains many other potentially beneficial compounds such as antioxidants and minerals that may play a role in preventing prostate cancer ... Coffee has effects on insulin and glucose metabolism as well as sex hormone levels, all of which play a role in prostate cancer"
  • Coffee consumption associated with reduced risk of advanced prostate cancer - Science Daily, 12/7/09
  • Aspirin May Prevent Prostate Cancer Recurrence - WebMD, 11/6/09 - "use of anti-clotting drugs, including aspirin, appears to lower the odds that cancer will recur in men undergoing radiation treatment for prostate cancer ... taking an anticoagulant lowers the risk [of recurrence] by almost half"
  • Pomegranate’s prostate protection potential grows - Nutra USA, 10/27/09 - "Pomegranate juice consumption, thus, may be of considerable advantage in prostate cancer chemoprevention, not only in patients with a genetic predisposition toward prostate cancer but also in patients undergoing cancer therapy" - See pomegranate at Amazon.com.
  • Folate intake and prostate cancer risk: a case-control study - Nutr Cancer. 2009;61(5):617-28 - "Folate deficiency has been implicated in the carcinogenesis of several tumor types ... Dietary folate intake was inversely associated with overall risk of prostate cancer as compared to clinic controls (P for a linear trend = 0.003). When stratified by disease severity, dietary folate and folate from natural sources were associated with reduced risk of high-grade cancer as compared to both clinic controls (P for a linear trend = 0.0009 and 0.02, respectively) and biopsy negative controls (P for a linear trend = 0.03 and 0.05, respectively) ... These analyses support an inverse association between dietary folate intake and prostate cancer risk and primarily risk of high-grade prostate cancer"
  • Gamma Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells - Nutr Cancer. 2009;61(5):649-62 - "These data demonstrate that the growth arrest mediated by gamma-tocopherol follows a PPAR-gamma-dependent mechanism" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex - Int J Cancer. 2009 Oct 6 - "Our study identifies MTA1 as a new molecular target of Res that may have important clinical applications for PCa chemoprevention and therapy, and points to the combination of Res with HDAC inhibitors as an innovative therapeutic strategy for the treatment of PCa" - See resveratrol products at Amazon.com.
  • Zinc Deficiencies A Global Concern - Science Daily, 9/17/09 - "One new study has found DNA damage in humans caused by only minor zinc deficiency ... Zinc deficiency is quite common in the developing world ... studies have shown that zinc is essential to protecting against oxidative stress and helping DNA repair – meaning that in the face of zinc deficiency, the body's ability to repair genetic damage may be decreasing even as the amount of damage is going up ... When prostate glands become cancerous, their level of zinc drops precipitously, and some studies have suggested that increasing zinc in the prostate may at least help prevent prostate cancer and could potentially be a therapeutic strategy. There are concerns about the relationship of zinc intake to esophageal, breast, and head and neck cancers. And the reduced zinc status that occurs with aging may also contribute to a higher incidence of infection and autoimmune diseases" - See Jarrow Zinc Balance at Amazon.com.
  • Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study - Cancer Causes Control. 2009 Aug 4 - "In Caucasian men, metformin use was more common in controls than in cases (4.7 vs. 2.8%, p = 0.04), resulting in a 44% risk reduction for PCa (adjusted OR = 0.56; 95% CI 0.32-1.00). No association was seen in African-American men" - See metformin at IAS.
  • Selenium Intake May Worsen Prostate Cancer In Some, Study Reports - Science Daily, 6/26/09
  • Green Tea May Slow Prostate Cancer Progression - Science Daily, 6/19/09 - "According to results of a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, men with prostate cancer who consumed the active compounds in green tea demonstrated a significant reduction in serum markers predictive of prostate cancer progression ... Findings showed a significant reduction in serum levels of HGF, VEGF and PSA after treatment, with some patients demonstrating reductions in levels of greater than 30 percent" - See green tea extract at Amazon.com.
  • Diet May Reduce Risk Of Prostate Cancer - Science Daily, 6/3/09 - "a diet low in fat, high in vegetables and fruit, and avoiding high energy intake, excessive meat, and excessive dairy products and calcium intake may be helpful in preventing prostate cancer, and for patients diagnosed with prostate cancer ... Specifically, consumption of tomatoes, cauliflower, broccoli, green tea, and vitamins including Vitamin E and selenium seemed to propose a decreased risk of prostate cancer. Consumption of highly processed or charcoaled meats, dairy products, and fats seemed to be correlated with prostate cancer"
  • Carbohydrate Restriction May Slow Prostate Tumor Growth - Science Daily, 5/26/09 - "The researchers believe that insulin and insulin-like growth factor contribute to the growth and proliferation of prostate cancer, and that a diet devoid of carbohydrates lowers serum insulin levels in the bodies of the mice, thereby slowing tumor growth"
  • Vitamin D deficiency and insufficiency among patients with prostate cancer - BJU Int. 2009 Apr 4 - "The frequency of vitamin D deficiency (<20 ng/mL) and insufficiency (20-31 ng/mL) was 40% and 32% in men with recurrent prostate; 28% had vitamin D levels that were normal (32-100 ng/mL). Among men with localized prostate cancer, 18% were deficient, 50% were insufficient and 32% were normal. Among controls, 31% were deficient, 40% were insufficient and 29% were normal" - See vitamin D at Amazon.com.
  • Pomegranate Juice May Slow Prostate Cancer - WebMD, 4/26/09 - "All of the men drank 8 ounces of pomegranate juice daily, and that slowed down the time it took for their PSA levels to double ... Fifteen of the patients stayed with the study for up to 64 months (a little more than five years), and it typically took four times longer for their PSA levels to double when they were drinking pomegranate juice, compared to their PSA doubling time at the study's start" - See pomegranate at Amazon.com.
  • Serum calcium and the risk of prostate cancer - Cancer Causes Control. 2009 Apr 18 - "These data do not support the hypothesis that high serum calcium levels is a risk factor for prostate cancer. On the contrary, the data suggest that high serum levels of calcium in young overweight men may be a marker for a decreased risk of developing prostate cancer"
  • Serum Retinol and Prostate Cancer Risk: a Nested Case-Control Study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial - Cancer Epidemiol Biomarkers Prev. 2009 Mar 31 - "Vitamin A (retinol) plays a key role in the regulation of cell growth and differentiation, and has been studied as a potential chemopreventive agent for prostate cancer ... the highest versus lowest concentrations of serum retinol were associated with a 42% reduction in aggressive prostate cancer risk (Ptrend = 0.02), with the strongest inverse association for high-grade disease (Gleason sum >7; odds ratio, 0.52; 95% confidence interval, 0.32-0.84; Ptrend = 0.01)"
  • Vitamin K and prostate cancer – study supports benefits - Nutra USA, 3/31/09 - "increased intakes of vitamin K2, but not K1, were associated with a 35 per cent reduction in prostate cancer risk. The potential benefits of K2 were more pronounced for advanced prostate cancer ... A higher ratio of undercarboxylated osteocalcin (ucOC) to intact total osteocalcin (iOC) is indicative of poorer vitamin K status ... of ucOC and iOC were analysed from serum samples, and every 0.1 increment in the ratio was associated with a 38 per cent increase in advanced-stage prostate cancer, and a 21 per cent increase in high-grade prostate cancer" - [Abstract] - See vitamin K at Amazon.com.
  • Fatty Fish May Cut Prostate Cancer Risk - WebMD, 3/24/09 - "Men in the study who ate one or more servings of fatty fish a week were found to have a 63% lower risk for developing aggressive prostate cancer than men who reported never eating fish" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Folic Acid May Raise Prostate Cancer Risk - WebMD, 3/10/09 - "Men in the study who took high doses of the vitamin had a more than twofold increase in prostate cancer risk, compared to men who did not take folic acid supplements"
  • Differential Effects of Selenium on Benign and Malignant Prostate Epithelial Cells: Stimulation of LNCaP Cell Growth by Noncytotoxic, Low Selenite Concentrations - Nutr Cancer. 2009;61(2):251-64 - "Thus, noncytotoxic selenite concentrations did not induce growth inhibition or apoptosis selectively in prostate cancer cells. Growth stimulation of LNCaP cells by low concentrations suggests the possibility of adverse effects of selenium supplementation on hormone sensitive prostate cancer, whereas inhibition of PC-3 cell proliferation at noncytotoxic concentrations suggests potential benefit of selenium in advanced prostate cancer"
  • Intake of plant foods and associated nutrients in prostate cancer risk - Nutr Cancer. 2009;61(2):216-24 - "Plant foods and associated nutrients may impact prostate cancer (PC) risk and survival ... Reduced PC risk was associated with the highest tertile of cryptoxanthin (OR = 0.51; 95% CI = 0.35-0.75), fiber (OR = 0.56; 95% CI = 0.35-0.89), vitamin C (OR = 0.60; 95% CI = 0.41-0.88), and fruits and/or fruit juices (OR = 0.46; 95% CI = 0.31-0.68), with significant linear trends. Increased risk of PC was associated with the highest tertile of protein (OR = 1.99; 95% CI = 1.05-3.79) and daily servings of grains (OR = 1.99; 95% CI = 1.23-3.22) with significant linear trends"
  • Zinc intake from supplements and diet and prostate cancer - Nutr Cancer. 2009;61(2):206-15 - "Ten-year average intake of supplemental zinc was not associated with a reduced prostate cancer risk overall (adjusted hazard ratio (HR) = 0.82 (95% confidence interval (CI) 0.58-1.14) for >15mg/day vs. nonuse, P for trend = 0.44); however, risk of advanced prostate cancer (regionally invasive or distant metastatic, n = 123) decreased with greater intake of supplemental zinc (adjusted HR = 0.34, 95% CI = 0.13-1.09 for 10-yr average intake > 15 mg/day vs. nonuse, P for trend = 0.04). Dietary zinc was not associated with prostate cancer. In this prospective cohort, long-term supplemental zinc intake was associated with reduced risk of clinically relevant advanced disease"
  • New Lab Evidence Suggests Preventive Effect Of Herbal Supplement In Prostate Cancer - Science Daily, 2/23/09 - "Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen protein secretion two to four-fold and gene expression up to 50-fold in the cancer cells. When these cell cultures were treated with red clover isoflavones, the androgenic effects of DHEA were reversed" - See Trinovin at Amazon.com.
  • Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis - Am J Clin Nutr. 2009 Feb 11 - "Our analysis of studies on soy intake yielded a combined RR/OR of 0.74"
  • Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells - Br J Pharmacol. 2009 Jan 16 - "Treatment with EPA inhibited I(Na) directly and also indirectly, by down-regulation of Na(v) mRNA expression in prostate cancer cells, thus inhibiting their metastatic potential" - See Mega Twin EPA at Amazon.com.
  • Serum undercarboxylated osteocalcin as biomarker of vitamin k intake and risk of prostate cancer: a nested case-control study in the heidelberg cohort of the European prospective investigation into cancer and nutrition - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):49-56 - "From cell studies, Vitamin K is known to exert anticancer effects on a variety of cancer cell lines, including prostate cancer cells. Recently, we reported an inverse association between dietary intake of menaquinones (vitamin K(2)), but not phylloquinone (vitamin K(1)), and risk of prostate cancer ... There was indication of a lower prostate cancer risk in carriers of the A allele (compared with GG carriers) of the +2255 VKORC1 polymorphism with increasing menaquinone intake (P(interaction) = 0.14) whereas no distinct effect modification was observed for the ucOC/iOC ratio (P(interaction) = 0.37). The increased risks of advanced-stage and high-grade prostate cancer with higher serum ucOC/iOC ratio strengthen the findings for dietary menaquinone intake" - See vitamin K at Amazon.com.
  • Study supports pomegranate’s anti-prostate cancer potential - Nutra USA, 1/6/09 - "the average doubling time increased from an average of 15 months to 54 months for the men drinking the pomegranate juice" - [Abstract] - See pomegranate at Amazon.com.
  • Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor - J Nutr Biochem. 2008 Dec;19(12):848-55 - "A twofold suppression of gene expression was considered statistically significant. Pomegranate polyphenols inhibited gene expression and AR most consistently in the LNCaP-AR cell line (P=.05). Therefore, inhibition by pomegranate polyphenols of gene expression involved in androgen-synthesizing enzymes and the AR may be of particular importance in androgen-independent prostate cancer cells and the subset of human prostate cancers where AR is up-regulated" - See pomegranate at Amazon.com.
  • gamma-Tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice - Int J Cancer. 2008 Oct 27 - "8 week old TRAMP males were fed 0.1% gamma-T-enriched mixed tocopherol diet that contained 20-fold higher levels of gamma-tocopherol, and roughly 3-fold higher levels of alpha-tocopherol ... Treatment with gamma-T-enriched mixed tocopherols significantly suppressed the incidence of palpable tumor and Prostate Intraepithelial Neoplasia (PIN) development without affecting the expression of the transgene (SV-40) ... gamma-T-enriched mixed tocopherols significantly up-regulated the expression of Nrf2 and its related detoxifying and antioxidant enzymes thereby suppressing PIN and tumor development" - Note:  One previous study was done with alpha-tocopherol.  I cannot understand why they did that when the previous research also supported the gamma unless they didn't do any homework at all before planning the study.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Vitamin and mineral use and risk of prostate cancer: the case-control surveillance study - Cancer Causes Control. 2008 Dec 18 - "For use of multivitamins that did not contain zinc, the multivariable odds ratios of prostate cancer were 0.6 for 1-4 years, 0.8 for 5-9 years, and 1.2 for 10 years or more, respectively (p for trend = 0.70). Men who used zinc for ten years or more, either in a multivitamin or as a supplement, had an approximately two-fold (OR = 1.9"
  • Flaxseed Supplementation (Not Dietary Fat Restrict...[Cancer Epidemiol Biomarkers Prev. 2008] - PubMed Result - Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3577-3587 - "Men were on protocol an average of 30 days. Proliferation rates were significantly lower (P < 0.002) among men assigned to the flaxseed arms. Median Ki-67-positive cells/total nuclei ratios (x100) were 1.66 (flaxseed-supplemented diet) and 1.50 (flaxseed-supplemented, low-fat diet) versus 3.23 (control) and 2.56 (low-fat diet) ... Findings suggest that flaxseed is safe and associated with biological alterations that may be protective for prostate cancer"
  • Characterizing components of the Saw Palmetto Berry Extract (SPBE) on prostate cancer cell growth and traction - Biochem Biophys Res Commun. 2008 Dec 4 - "Saw Palmetto Berry Extract (SPBE) ... The results show for the first time the potential of SPBE, beta-sitosterol and stigmasterol as potential anti-tumor agents" - See beta sitosterol at Amazon.com and saw palmetto at Amazon.com.
  • Oily fish may boost prostate cancer survival rate: Study - Nutra USA, 11/24/08 - "The prospective cohort study with 20,167 men also found that men who ate five portions of fish per week had a 48 per cent improved survival rate from the disease than men who consumed only one portion per week" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality - Am J Clin Nutr. 2008 Nov;88(5):1297-303 - "Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish >or=5 times/wk had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05]. A similar association was found between seafood n-3 fatty acid intake and prostate cancer mortality (RR(Q5 versus Q1) = 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Men Who Take Aspirin Have Significantly Lower PSA Levels - Science Daily, 11/16/08 - "PSA levels were 9 percent lower in men taking aspirin (the NSAID most commonly used) compared with men who did not use aspirin"
  • Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells - Cancer Lett. 2008 Oct 31 - "EGCG suppressed cell proliferation, prostate specific antigen (PSA) expression, and AR transcriptional activity in the different LNCaP sublines. Intraperitoneal administration of EGCG also suppressed the growth of relapsing R1Ad tumors and decreased tumor-derived serum PSA. Effects of EGCG on tumor PSA expression have the potential to affect accurate monitoring of patient tumor burden by serum PSA measurement" - See green tea extract at Amazon.com.
  • Prostate Cancer: Vitamin E, Selenium No Help - WebMD, 10/28/08 - "That evidence included a 1998 Finnish study of whether vitamin E could prevent lung cancer in some 30,000 smokers. It didn't, but men taking vitamin E had 32% fewer prostate cancers ... I am afraid it will be the end of the story for large trials of vitamin E and selenium to prevent prostate cancer" - Note:  Most of the vitamin E studies I've read on prostate cancer indicated that only the gamma-tocopherol worked yet they spent $114 million on this study and used the cheapest synthetic dl-alpha-tocopherol acetate form.  How dumb was that?  I don't know what the story on the selenium was.  Some say it's because people in the U.S. aren't deficient in selenium.  See my comments in my 10/29/08 newsletter.
  • Too Much Calcium In Blood May Increase Risk Of Fatal Prostate Cancer - Science Daily, 9/3/08 - "Comparing men in the top third with men in the bottom third, we found a significantly increased hazard for fatal prostate cancer"
  • Broccoli May Cut Prostate Cancer Risk - WebMD, 7/1/08 - [Science Daily] - "men who regularly ate broccoli showed more changes in gene expression suggestive of a reduced risk of cancer"
  • New Treatment for Prostate Cancer? - Dr. Weil, 7/1/08
  • Dietary Agents for Chemoprevention of Prostate Cancer - oncologystat.com, 6/16/08 - "In this review, we have summarized the findings from clinical and preclinical studies on dietary agents including green tea, pomegranate, lupeol, fisetin, and delphinidin that are currently being investigated in our laboratory for their chemopreventive potential against CaP" - Click here for the review but it is 172 pages in the .pdf format.
  • Legume and isoflavone intake and prostate cancer risk: The Multiethnic Cohort Study - Int J Cancer. 2008 Jun 2 - "legume intake is associated with a moderate reduction in prostate cancer risk and that the isoflavones in soy products are probably not responsible for this effect"
  • Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells - Int J Cancer. 2008 Jun 15;122(12):2699-706 - "1,25-VD can protect nonmalignant prostate cells from oxidative stress-induced cell death by elimination of ROS-induced cellular injuries through transcriptional activation of G6PD activity. The antioxidative effect of vitamin D strengthens its roles in cancer chemoprevention and adds to a growing list of beneficial effects of vitamin D against cancer" - Seevitamin D at Amazon.com.  I've gone to the vitamin D 2000 IU at Amazon.com.
  • Reducing Intake Of Dietary Fat Prevents Prostate Cancer In Mice - Science Daily, 5/15/08 - "focused on fat from corn oil, which is made up primarily of omega-6 fatty acids, or the polyunsaturated fat commonly found in the Western diet ... Researchers fed one group of mice a diet with about 40 percent of calories coming from fat, a percentage typical in men eating a Western diet. The other group received 12 percent of their calories from fat, a figure considered to be a very low fat diet. Researchers found there was a 27 percent reduced incidence of prostate cancer in the low-fat diet group. Aronson also studied cells in the prostate that were precancerous, or would soon become cancer, and found that the cells in the mice eating the low-fat diet were growing much more slowly than those in the high-fat group"
  • Prostates protected by vitamin D: study - Nutra USA, 5/14/08 - "In this study, we have demonstrated that 1,25-(OH)2D can protect nonmalignant human prostate epithelial cells against H2O2-induced cell death through modulating the ROS defense systems, suggesting a possible role of 1,25-(OH)2D in prostate cancer prevention" - See vitamin D at Amazon.com.
  • Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro - Mol Nutr Food Res. 2008 Apr 8;52(5):567-580 - "The capacity of a pure mammalian lignan, enterolactone (ENL) ... the antiproliferative activity of ENL is a consequence of altered expression of cell cycle associated genes and provides novel molecular evidence for the antiproliferative properties of a pure lignan in prostate cancer" - I take one of the Flax Essence at iHerb everyday for hair loss.
  • Vitamin D Protects Cells From Stress That Can Lead To Cancer - Science Daily, 5/13/08 - "By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer" - See vitamin D at Amazon.com.
  • In vivo and in vitro regulation of syndecan 1 in prostate cells by N-3 polyunsaturated fatty acids - J Biol Chem. 2008 Apr 30 - "These findings indicate that syndecan 1 is upregulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. This mechanism may contribute to the chemopreventive properties of n-3 fatty acids in prostate cancer" - See Mega Twin EPA at Amazon.com.
  • A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy - Int J Med Sci. 2008 Mar 24;5(2):62-7 - "oral Apatone (Vitamin C and Vitamin K3) administration in the treatment of prostate cancer ... 5,000 mg of VC and 50 mg of VK3 each day ... At the conclusion of the 12 week treatment period, PSAV decreased and PSADT increased in 13 of 17 patients (p < or = 0.05). There were no dose-limiting adverse effects. Of the 15 patients who continued on Apatone after 12 weeks, only 1 death occurred after 14 months of treatment"
  • Exercise May Lead To Faster Prostate Tumor Growth - Science Daily, 4/13/08
  • Vitamin K2 linked to lower prostate cancer risk - Nutra USA, 4/9/08 - "While no reduction in the risk of prostate cancer was observed for vitamin K1 (phylloquinone), an increased intake of all menaquinones (vitamin K2) was associated with a 35 per cent reduction in risk" - See vitamin K at Amazon.com.
  • Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity - J Bone Miner Res. 2007 Dec;22 Suppl 2:V74-80 - "Calcitriol, the hormonally active form of vitamin D, inhibits the growth and development of several cancers ... We conclude that calcitriol exerts several anti-inflammatory actions in prostate cells, which contribute to its potential as a chemopreventive and therapeutic agent in PCa" - See vitamin D at Amazon.com.
  • Soy Compound May Halt Spread Of Prostate Cancer - Science Daily, 3/14/08 - "the amount of the chemical, an antioxidant known as genistein, used in the experiments was no higher than what a human would eat in a soybean-rich diet ... genistein decreased metastasis of prostate cancer to the lungs by 96 percent compared with mice that did not eat the compound in their chow" - See soy isoflavones at Amazon.com.
  • Effects of One-Year Treatment with Isoflavone Extract from Red Clover on Prostate, Liver Function, Sexual Function, and Quality of Life in Men with Elevated PSA Levels and Negative Prostate Biopsy Findings - Urology. 2008 Feb;71(2):185-90 - "isoflavonoid extract from red clover ... daily 60-mg dose of an isoflavone extract for 1 year ... The average PSA level was 10.16 ng/mL at baseline versus 7.15 ng/mL after 12 months, for a statistically significant reduction of 33% ... The sexual hormone levels did not change throughout the study. We registered a significant increase in all three liver transaminases after 3 months"
  • Finding the Right Prostate Cancer Diet - WebMD, 2/15/08 - "poultry and eggs double the risk of prostate cancer progression ... orange and yellow vegetables, such as squash, yams, and carrots, and cruciferous vegetables, such as broccoli, cut the risk of recurrence by about half ... If you eat chicken or poultry, eat it without the skin ... the men's overall PSA doubling time was nearly four times slower after they began drinking pomegranate juice"
  • Men Who Are Continually Active At Work May Have Decreased Prostate Cancer Risk, Study Suggests - Science Daily, 2/13/08 - "The message from this study for today is that if you’re more active, you may be able to prevent this cancer from happening"
  • Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo - Int J Oncol. 2008 Feb;32(2):475-80 - "pomegranate extract standardized to ellagitannin content (POMx) ... POMx decreased prostate cancer xenograft size, tumor vessel density, VEGF peptide levels and HIF-1alpha expression after 4 weeks of treatment in SCID mice. These results demonstrate that an ellagitannin-rich pomegranate extract can inhibit tumor-associated angiogenesis as one of several potential mechanisms for slowing the growth of prostate cancer in chemopreventive applications" - See pomegranate at Amazon.com.
  • More support for lycopene's prostate benefits - Nutra USA, 1/9/08 - "At the end of the six month intervention period ... levels of prostate-specific antigen (PSA), a marker of prostate health, were reduced in the lycopene group showing improvements in health of the tissue. However, no changes were recorded in the placebo group ... Moreover, no enlargement of the prostate occurred in the lycopene group, whereas growth was observed in the placebo group" - [Abstract] - See Jarrow Lyco-Sorb at Amazon.com.
  • Lycopene inhibits disease progression in patients with benign prostate hyperplasia - J Nutr. 2008 Jan;138(1):49-53 - "Whereas progression of prostate enlargement occurred in the placebo group as assessed by trans-rectal ultrasonography (P < 0.05) and digital rectal examination (P < 0.01), the prostate did not enlarge in the lycopene group. Symptoms of the disease, as assessed via the International Prostate Symptom Score questionnaire, were improved in both groups with a significantly greater effect in men taking lycopene supplements" - See Jarrow Lyco-Sorb at Amazon.com.
  • Nonfat Milk Linked to Prostate Cancer - Medscape, 1/2/08 - "Intake of calcium and vitamin D has little or no impact on the risk of prostate cancer, but consumption of low fat or nonfat milk may increase the risk of the malignancy ... low fat or nonfat milk increased the risk of localized or low-grade tumors, while whole milk decreased this risk"
  • J Nutr. 2008 Jan;138(1):49-53Lycopene Inhibits Disease Progression in Patients with Benign Prostate Hyperplasia - J Nutr. 2008 Jan;138(1):49-53 - "Symptoms of the disease, as assessed via the International Prostate Symptom Score questionnaire, were improved in both groups with a significantly greater effect in men taking lycopene supplements. In conclusion, lycopene inhibited progression of BPH" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Green tea may cut prostate cancer risk - USATODAY.com, 12/20/07 - "those who drank five or more cups of green tea a day reduced their risk of having progressive prostate cancer by half, compared with those who drank a cup or less" - See green tea extract at Amazon.com.
  • Dietary patterns and surgically treated benign prostatic hyperplasia: a case control study in Western Australia - BJU Int. 2007 Dec 5 - "BPH risk was not associated with the 'Health Conscious' or 'Western' patterns, but there was a lower risk with an increasing score for the 'Vegetable' pattern (odds ratio 0.78, 95% confidence interval 0.63-0.98). BPH risk was significantly and inversely related to the intake of total vegetables, dark yellow vegetables, other vegetables, tofu and red meat. There was a higher risk of BPH with increasing intake of high-fat dairy products"
  • High Carb Diet Linked to Prostate Tumor Growth - Science Daily, 11/27/07 - "A diet high in refined carbohydrates, like white rice or white bread, is associated with increased prostate tumor growth in mice ... Having too much insulin in the blood, a condition called hyperinsulinemia, is associated with poorer outcomes in patients with prostate cancer"
  • Lycopene and soy isoflavones in the treatment of prostate cancer - Nutr Cancer. 2007;59(1):1-7 - "The data suggest that lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer"
  • Plasma carotenoids and prostate cancer: a population-based case-control study in Arkansas - Nutr Cancer. 2007;59(1):46-53 - "This study added to the emerging evidence that high circulating levels of lycopene, lutein/zeaxanthin, and beta-cryptoxanthin are associated with a low risk of prostate cancer" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status - Nutr Cancer. 2007;58(2):178-87 - "Taken together, these findings suggest DHA is the primary tumor suppressive omega-3 fatty acid in vivo and in vitro and inhibits cancer growth by p53 dependent and independent pathways, while the marginal inhibition by EPA is p53 independent" - See Jarrow Max DHA at Amazon.com.
  • Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells - Nutr Cancer. 2007;58(2):171-7 - "These studies are consistent with epidemiological studies that show inverse relationships of these carotenoids with prostate cancer" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • A Low-carb Diet May Stunt Prostate Tumor Growth - Science Daily, 11/13/07
  • Onion and garlic intake and the odds of benign prostatic hyperplasia - Urology. 2007 Oct;70(4):672-6 - "Compared with nonusers, the multivariate ORs for the highest category of onion and garlic intake were 0.41 ... This uniquely large data set from European populations showed an inverse association between allium vegetable consumption and BPH"
  • Green tea may halve prostate cancer risk - Nutra USA, 10/12/07 - "Drinking five or more cups a day was associated with a 48 per cent reduction in advanced prostate cancer risk, compared to drinking less than one cup per day" - [Abstract] - See green tea extract at Amazon.com.
  • Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study - Am J Epidemiol. 2007 Sep 29 - "The multivariate relative risk was 0.52 (95% confidence interval: 0.28, 0.96) for men drinking 5 or more cups/day compared with less than 1 cup/day (p(trend) = 0.01). Green tea may be associated with a decreased risk of advanced prostate cancer" - See green tea extract at Amazon.com.
  • Full-fat dairy may protect prostates from cancer - Nutra USA, 10/10/07 - "when the researchers considered intakes of specific dairy products they noted a significant 12 per cent reduction in total prostate cancer risk by increased whole milk consumption. On the other hand, low-/nonfat milk was related to 16 per cent increased risk"
  • Prostate Cancer Survival Varies by Season - washingtonpost.com, 10/7/07 - "Summer and autumn months correspond to times when vitamin D is highest (in Norway). Although the study does not prove vitamin D is the determining factor, it does suggest that this possibility should be studied further ... Compared with men diagnosed in the summer and fall, those diagnosed in the winter and spring were 20 percent more likely to die within three years after diagnosis" - See vitamin D at Amazon.com.
  • Diet And Medications May Assist Prevention Of Prostate Cancer - Science Daily, 9/24/07 - "dutasteride, has reduced by 50 percent the number of cancerous biopsies among men with benign prostatic hypertrophy ... In one study of selenium, the incidence of prostate cancer was reduced by 49 percent over ten years ... Data already suggests novel uses of statins, commonly prescribed cholesterol-lowering agents, and insulin modulating drugs, such as metformin or the glitazones" - See dutasteride at OffshoreRx1.com.
  • Pomegranate Juice vs. Prostate Cancer? - WebMD, 9/20/07 - "The prostate tumors grew more slowly in the mice that got the pomegranate juice orally or by injection, compared with mice that got the placebo"
  • Pomegranate extracts may inhibit prostate cancer growth - Nutra USA, 9/3/07
  • Red Wine Compound Shown To Prevent Prostate Cancer - Science Daily, 8/31/07 - "n the study resveratrol-fed mice showed an 87 percent reduction in their risk of developing prostate tumors that contained the worst kind of cancer-staging diagnosis ... Other mice in the study, those fed resveratrol but still developed a less-serious form of prostate cancer, were 48 percent more likely to have their tumor growth halted or slowed when compared to mice who did not consume the compound ... A cancer prevention researcher lives for these days when they can make that kind of finding" - See resveratrol products at Amazon.com.
  • Pectin shows potential against prostate cancer - Nutra USA, 8/22/07 - "The new study looked at the effect of different forms of pectin - commercially available fractionated pectin powder (FPP), citrus pectin (CP), and pH-modified CP (PectaSol) - on hormone- (androgen) responsive and androgen-independent human prostate cancer cells ... the FPP induced apoptosis (programmed cell death) by about 40 fold, compared to non-treated cells, for both types of cancer cell"  - [Abstract] - See pectin supplements at Amazon.com.
  • The Effect of High Calcium Levels on Prostate Cancer - Physician's Weekly, 8/13/07 - "the relative risk of prostate cancer for 2,000 mg/day or more of calcium intake was 1.63. Conversely, a 1.26 relative risk calculation was observed for ingestion of less than 1,000 mg/day of calcium"
  • Broccoli May Help Cut Prostate Cancer - WebMD, 7/24/07 - "Men who reported eating cauliflower more than once per week were 52% less likely to be diagnosed with aggressive prostate cancer than men who reported eating cauliflower less than once a month ... Men who reported eating broccoli more than once per week were 45% less likely to be diagnosed with aggressive prostate cancer than men who reported eating broccoli less than once a month" - See indole-3-carbinol at Amazon.com.
  • Dietary Isoflavones May Protect against Prostate Cancer in Japanese Men - J Nutr. 2007 Aug;137(8):1974-1979 - "Isoflavones and their aglycones (genistein and daidzein) were significantly associated with decreased risk. The odds ratio for the highest category (>/=89.9 mg/d) compared with the lowest category (<30.5 mg/d) of isoflavone intake was 0.42 (95% CI = 0.24-0.72) and the linear trend was significant"
  • Omega-3 Fatty Acids May Help Slow Prostate Cancer Growth - Science Daily, 6/21/07
  • Omega-3 Fatty Acids May Lower Genetic Risk for Prostate Cancer - Medscape, 6/21/07 - "Overall, diets rich in omega-3 fatty acids reduced prostate tumor growth, slowed histopathological progression, and increased survival, the researchers write. The 12-month survival rate was 60% for mice fed a diet high in omega-3, 10% on the low–omega-3 diet, and 0% on the high–omega-6 diet. The ideal ratio of omega-6 to omega-3 fatty acids is 1:1, and mice fed diets with this ratio of fatty acids were able to delay both the formation and progression of prostate tumors and prolong their survival" - See Twinlab Mega Twin EPA at Amazon.com or Jarrow Max DHA at Amazon.com.
  • Prostate Cancer Confusion? - Dr. Weil, 6/18/07 - "while these investigators concluded that on the basis of their retrospective analytical methods lycopene and other carotenoids had no effect on prostate cancer, we have very good evidence from other studies that lycopene does in fact lower the risk"
  • Supplemental and dietary vitamin e intakes and risk of prostate cancer in a large prospective study - Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1128-35 - "dietary gamma-tocopherol, the most commonly consumed form of vitamin E in the United States, was significantly inversely related to the risk of advanced prostate cancer (for highest versus lowest quintile: RR, 0.68" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Flaxseed May Curb Prostate Tumor Growth - WebMD, 6/4/07 - "As measured by how fast their cancer cells were dividing, tumors grew about 30% to 40% slower in the men taking flaxseed"
  • Red Wine Protects The Prostate - Science Daily, 5/25/07 - "men who drink an average of four to seven glasses of red wine per week are only 52% as likely to be diagnosed with prostate cancer as those who do not drink red wine ... when white wine was compared with red, red had the most benefit ... But much of the speculation focuses on chemicals—including various flavonoids and resveratrol—missing from other alcoholic beverages"
  • Mega Multivitamins and Prostate Cancer - WebMD, 5/15/07
  • Study: Vitamins tied to prostate cancer - USA Today, 5/15/07 - "Overall, the researchers found no link between multivitamin use and early-stage prostate cancer ... perhaps high-dose vitamins had little effect until a tumor appeared, and then could spur its growth"
  • Nutrients In Certain Vegetables May Provide Cancer-fighting Benefit - Science Daily, 4/17/07 - "Dr. Singh's study is based on phytochemicals, called isothiocyanates (ITCs), found in several cruciferous vegetables and generated when vegetables are either cut or chewed. His laboratory has found that phenethyl-ITC, or PEITC, is highly effective in suppressing the growth of human prostate cancer cells at concentrations achievable through dietary intake"
  • Tea and lycopene protect against prostate cancer - Asia Pac J Clin Nutr. 2007;16 Suppl:453-7 - "The protective effect of green tea was significant (odds ratio 0.14, 95% CI: 0.06-0.35) for the highest quartile relative to the lowest after adjusting for total vegetables and fruits intakes and other potential confounding factors. Intakes of vegetables and fruits rich in lycopene were also inversely associated with prostate cancer risk (odds ratio 0.18 ... habitual drinking tea and intakes of vegetables and fruits rich in lycopene could lead to a reduced risk of prostate cancer in Chinese men. Together they have a stronger preventive effect than either component taken separately"
  • Report: Advances In Prostate Cancer Chemoprevention And Treatment - Life Extension Magazine, 4/07
  • The relationship between daily calcium intake and bone mineral density in men with prostate cancer - BJU Int. 2007 Apr;99(4):812-816 - "To analyse the relationship between daily calcium intake (DCI) and bone mineral density (BMD) in patients with prostate cancer ... androgen-deprivation therapy (ADT) ... a low DCI was an independent risk factor for osteoporosis in men with prostate cancer ... Urologists should recommend a DCI of >1000 mg in patients with prostate cancer, especially in those under ADT"
  • Soy Found Protective Against Localized Prostate Cancer - Science Daily, 3/15/07 - "intake of genistein, daidzein, miso soup and soy food had no overall link to diagnosis of prostate cancer. However, they calculated that the risk of developing localized prostate cancer was 50 percent lower in men who ate the most isoflavones compared to men who ate the least meaning that men in the top category ate between two and three times as much isoflavone-rich food"
  • Soy isoflavones linked to lower prostate cancer risk - Nutra USA, 3/8/07 - "The highest intake of soy isoflavones (at least 32.8 milligrams of genistein per day) had a 40 per cent reduced risk compared to those with the lowest intake (less than 13.2 mg/d)"
  • Green Tea And COX-2 Inhibitors Combine To Slow Growth Of Prostate Cancer - Science Daily, 3/1/07 - "In mice that were not treated with either substance, the tumor volume averaged 1,300 cubic millimeters, whereas mice given either the tea or celecoxib had tumors averaging 835 cubic millimeters and 650 cubic millimeters, respectively. Tumors taken from mice given both agents, however, measured on average a volume of 350 cubic millimeters" - See Jarrow Green Tea at Amazon.com.
  • Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy - Eur Urol. 2007 Feb 5 - "In this large study we found a direct association between high zinc intake and prostate cancer risk, particularly for advanced cancers"
  • Veggies for Enlarged Prostate Risk - WebMD, 2/14/07 - "Data came from more than 32,000 male health care workers enrolled in a long-term health study that began in 1986 ... The men who consumed the most vegetables were 11% less likely to have BPH surgery or moderate to high BPH symptoms by 2000"
  • Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men - Am J Clin Nutr. 2007 Feb;85(2):523-9 - "Vegetable consumption was inversely associated with BPH (fifth compared with first quintile-OR: 0.89; 95% CI: 0.80, 0.99; P for trend = 0.03), whereas fruit intake was not. Consumption of fruit and vegetables rich in beta-carotene (P for trend = 0.004), lutein (P for trend = 0.0004), or vitamin C (P for trend = 0.05) was inversely related to BPH. With increasing vitamin C intake from foods, men were less likely to have BPH (P for trend = 0.0009). Neither alpha- nor gamma-tocopherol intake from foods was associated with BPH"
  • On The Cover: Eating Your Way To Prostate Cancer - Life Extension Magazine, 2/07 - "Boswellia extracts have been thoroughly studied as natural remedies for inflammatory disorders. A patented extract from boswellia called 5-LOXIN® has potent ability to inhibit the enzyme 5-LOX, preventing the formation of protein-degrading enzymes, and protecting against inflammation-induced events that can promote tumor angiogenesis" - See 5-LOXIN at Amazon.com.
  • Worried About Prostate Cancer? Tomato-broccoli Combo Shown To Be Effective - Science Daily, 1/16/07 - "fed a diet containing 10 percent tomato powder and 10 percent broccoli powder to laboratory rats that had been implanted with prostate cancer cells ... The tomato/broccoli combo outperformed all other diets in shrinking prostate tumors ... The only treatment that approached the tomato/broccoli diet's level of effectiveness was castration ... To get these effects, men should consume daily 1.4 cups of raw broccoli and 2.5 cups of fresh tomato, or 1 cup of tomato sauce, or ½ cup of tomato paste"
  • Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer - J Nutr. 2007 Jan;137(1):205S-10S - "the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa"
  • Dietary Fatty acids correlate with prostate cancer biopsy grade and volume in jamaican men - J Urol. 2007 Jan;177(1):97-101 - "Omega6 polyunsaturated fatty acids stimulate and Omega3 polyunsaturated fatty acids inhibit prostate cancer growth"
  • Aspirin 'blocks prostate problem' - BBC News, 12/9/06 - "taking NSAIDs was found to prevent or delay enlargement of the prostate"
  • Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies? - Curr Opin Clin Nutr Metab Care. 2006 Nov;9(6):722-7 - "Increasing evidence suggests that a single serving of tomatoes or tomato products ingested daily may contribute to protect from DNA damage. As DNA damage seems to be involved in the pathogenesis of prostate cancer, the regular ingestion of tomatoes or tomato products might prevent the disease"
  • NSAID Use May Prevent or Delay Development of Benign Prostate Hyperplasia - Medscape, 9/6/06 - "NSAIDs reduced the incidence rates of moderate-severe urinary symptoms (HR, 0.73), low maximum urinary flow rate (HR, 0 .51), increased prostate volume (HR, 0.53), elevated serum PSA level (HR, 0.52), and treatment of BPH (HR, 0.79)"
  • Aspirin May Cut Enlarged Prostate Risk - WebMD, 8/30/06 - "Men who reported daily use of aspirin or other anti-inflammatory drugs, such as ibuprofen and naproxen, were 25% less likely to develop moderate to severe enlarged prostate symptoms"
  • Decrease In Progression Of Prostate Cancer With Plant-based Diet And Stress Reduction - Science Daily, 8/29/06 - "The plant-based diet and stress reduction intervention was effective in significantly reducing the PSA rate, indicating a reduction in the rate of progression of the prostate cancer"
  • Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer - Prostate. 2006 Aug 18 - "Our study provides strong evidence that high intake of phytoestrogens substantially reduce prostate cancer risk among men with specific polymorphic variation in the promoter region of the estrogen receptor-beta gene"
  • Altering Fatty Acid Levels In Diet May Reduce Prostate Cancer Growth Rate - Science Daily, 8/1/06 - "tumor cell growth rates decreased by 22 percent and PSA levels were 77 percent lower in the group receiving a healthier balance of fatty acids compared with the group that received predominantly omega-6 fatty acids"
  • Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer - Clin Cancer Res. 2006 Jul 1;12(13):4018-4026 - "Mean PSA doubling time significantly increased with treatment from a mean of 15 months at baseline to 54 months posttreatment ... In vitro assays comparing pretreatment and posttreatment patient serum on the growth of LNCaP showed a 12% decrease in cell proliferation and a 17% increase in apoptosis (P = 0.0048 and 0.0004, respectively), a 23% increase in serum nitric oxide (P = 0.0085), and significant (P < 0.02) reductions in oxidative state and sensitivity to oxidation of serum lipids after versus before pomegranate juice consumption"
  • Pomegranate Slows Prostate Cancer - WebMD, 7/5/06
  • Pomegranate Juice Helps Keep PSA Levels Stable In Men With Prostate Cancer - Science Daily, 7/2/06 - "Drinking an eight ounce glass of pomegranate juice daily increased by nearly four times the period during which PSA levels in men treated for prostate cancer remained stable"
  • Juice 'can slow prostate cancer' - BBC News, 7/1/06 - "measured how long it took for PSA levels to double in individual patients ... The average doubling time is about 15 months, but in patients who drank pomegranate juice this increased to an average of 54 months"
  • Starch Intake May Increase Risk for Benign Prostatic Hyperplasia - Medscape, 6/27/06 - "Starch intake was directly associated with increased risk for BPH with an OR of 1.51 ... The main sources of starch in the subjects were white bread, pasta, and rice ... An inverse relationship was observed for polyunsaturated fats (OR, 0.72; 95% CI, 0.55 - 0.93), linoleic acid (OR, 0.73; 95% CI, 0.56 - 0.94), and linolenic acid (OR, 0.71"
  • Soy-rich diet cuts prostate cancer marker - Nutra USA, 6/22/06 - "Two servings of soy a day reduced levels of the prostate cancer marker PSA in free-living men by 14 percent, but didn’t affect testosterone levels"
  • Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice - J Nutr. 2006 May;136(5):1287-93 - "lycopene combined with vitamin E may inhibit the growth of prostate cancer"
  • More support for lycopene protection against prostate cancer - Nutra USA, 5/3/06 - "half of these men to receive a daily supplement of eight milligrams of lycopene (LycoRed's Lyc-O-Mato) for one year and followed for a futher year ... blood levels of prostate-specific antigen (PSA), a protein that is used as a marker for the disease, decreased by 42 per cent after supplementation" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Pondering Prostate Problems? - Dr. Weil, 4/28/06 - "All told, this study shouldn't discourage men with mild-to-moderate BPH from using saw palmetto. I still recommend taking 160 mg of a standardized extract twice a day; this should help reduce the size of the gland in about four to six weeks"
  • Prostate tumours shrunk by lycopene, vitamin E combo - Nutra USA, 4/14/06 - "Compared with the control, the combined mixture of lycopene and vitamin E, at five mg/kg BW each, suppressed the growth of the prostate xenograft by 73 per cent at day 42 ... the mice receiving the combined supplement also lived 40 per cent longer" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Crunchy Veggies Fight Cancer - WebMD, 4/5/06 - "focused on a substance found in cruciferous vegetables called phenethyl-ITC, or PEITC ... After 31 days of treatment, the size of the tumors in the treated animals was about half that of the untreated animals"
  • Pygeum - An Extract from This Native African Tree Reduces Symptoms of Benign Prostatic Hyperplasia - Life Extension Magazine, 4/06
  • Oily fish may fight prostate cancer spread - MSNBC, 3/21/06 - "Omega-6 fats, found in vegetable oils, nuts and seeds, increased the spread of tumor cells into bone marrow. This invasion was blocked by omega 3 fats -- the ones found in oily fish" - See Mega Twin EPA at Amazon.com or Vitacosticon.
  • Pepper Component Hot Enough To Trigger Suicide In Prostate Cancer Cells - Science Daily, 3/19/06 - "Capsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecular pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in non-treated mice"
  • Pepper extract could stop prostate cancer growth - Nutra USA, 3/15/06 - "capsaicin has a profound inhibiting effect on the growth of prostate cancer cells in vitro and in vivo , inducing apoptosis [programmed cell death] of prostate cancer cell lines"
  • Prostate Cancer: No Antioxidant Help? - WebMD, 2/14/06 - "Vitamin E, vitamin C, and beta-carotene consumption didn't appear to affect prostate cancer risk, the study shows"
  • More support for soy's protection against prostate cancer - Nutra USA, 2/13/06 - "High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The odds ratio (OR) [the risk compared to a standard of 1.00] comparing the highest to the lowest quartile of intake was 0.74"
  • Vitamin D Inhibits Progression Of Some Prostate Cancers - Science Daily, 2/8/06 - "vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing the activity of two enzymes -- proteases called matrix metalloproteinase and cathepsin" [WebMD] - See iHerb or Vitacosticon vitamin D products.
  • Dietary Factors May Affect Risk for Benign Prostatic Hyperplasia - Medscape, 2/7/06 - "Citrus fruit, but not total fruit, consumption was associated with a significantly reduced risk for BPH"
  • Corn oil, omega-6 could speed up prostate cancer, study - Nutra USA, 2/1/06 - "After we added omega-6 fatty acids to the growth medium in the dish, and only omega-6, we observed that tumors grew twice as fast as those without omega-6" - [HealthDay] [WebMD]
  • Herbal extract may treat prostate cancer - MSNBC, 11/27/05 - "Zyflamend has the ability, in culture at least, to reduce prostate cancer cell growth by as much as 78 percent and induce cancer cell death or “apoptosis,”" - See Zyflamend at Amazon.com.
  • Too much calcium may raise prostate cancer risk - Nutra USA, 11/15/05 - "men who consumed more than 2000mg of calcium per day nearly doubled their risk of developing prostate cancer"
  • Columbia Study Suggests Benefits Of Herbal Extract In Early Treatment Of Prostate Cancer - Science Daily, 11/13/05 - "Zyflamend®, a unique herbal extract preparation, suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called “apoptosis" - See Zyflamend at Amazon.com.
  • Randomized, Double-Blind, Placebo-Controlled Crossover Study in Men with Prostate Cancer and Rising PSA: Effectiveness of a Dietary Supplement - Eur Urol. 2005 Oct 17 - "The supplement consisted of soy, isoflavones, lycopene, silymarin and antioxidants as main ingredients ... The soy-based dietary supplement utilised in this study was shown to delay PSA progression after potentially curative treatment in a significant fashion"
  • A New Weapon to Fight Prostate Cancer - Life Extension Magazine, 11/05 - "Scientists have shown that milk thistle extracts possess anti-cancer actions on human prostate carcinoma in vitro and in vivo. Many of the mechanisms by which silymarin compounds interfere with prostate cancer progression have been identified. The scientists who conducted the most recent study stated that, in addition to isosilybin B, there might be other silymarin compounds that are effective as well"
  • Can Green Tea Protect Against Prostate Cancer? - Life Extension Magazine, 11/05 - "Thirty-two subjects received 200 mg of green tea catechins (50% EGCG) three times daily, while the other 30 men received a placebo. Biopsies were conducted at six months and one year later. Remarkably, only one man in the treatment group was diagnosed with prostate cancer, compared to nine men in the control group who developed the disease"
  • Vitamin D Compounds May Fight Prostate Cancer - WebMD, 11/1/05 - "Vitamin D compounds may help slow or prevent prostate cancer ... Calcitriol "markedly reduced tumor burden over time,""
  • Anticancer Agent in Veggies Shows Promise - WebMD, 10/21/05
  • Flavonoids May Inhibit Prostate Cancer - Science Daily, 10/21/05 - "Our findings suggest that apigenin could be developed as a promising agent against prostate cancer"
  • Pomegranates May Prevent Prostate Cancer - WebMD, 9/28/05 - "the dose of pomegranate juice given to the mice equates to about one or two pomegranates -- or 8 to 16 ounces of pomegranate juice ... mice who drank the higher concentration of pomegranate extract experienced a significant slowing in their cancer progression and a decrease in prostate-specific antigen (PSA) levels"
  • Impact of diet on prostate cancer: a review - Prostate Cancer Prostatic Dis. 2005 Aug 30 - "Much interest currently lies in the potential of HMG-CoA reductase inhibitors (statins) to play a chemopreventative role in prostate cancer. Lycopene, a potent antioxidant found in tomatoes, may exert a protective effect in the prostate. Selenium and vitamin E have also been shown to decrease the risk of prostate cancer in some men. Calcium may support vitamin D-related antiproliferative effects in prostate cancer. Certain soy proteins, common in the Asian diet, have been shown to inhibit prostate cancer cell growth. Finally, green tea may also have a chemopreventive effect by inducing apoptosis"
  • Vitamin D, NSAIDS Provide Double Whammy Against Prostate Cancer, Stanford Study Finds - Science Daily, 9/1/05 - "The growth of prostate cancer cells can be halted by combining a form of vitamin D, available only by prescription, with low doses of an over-the-counter painkiller ... The combination reduced prostate cancer cell growth in a laboratory dish by up to 70 percent, according to the findings"
  • Nutrients that fight prostate cancer - Dr. Murray's Natural Facts, 8/24/05
  • Lifestyle And Diet May Stop Or Reverse Prostate Cancer Progression - Science Daily, 8/11/05 - "Participants in the lifestyle-change group were placed on a vegan diet consisting primarily of fruits, vegetables, whole grains, and legumes supplemented with soy, vitamins and minerals. They participated in moderate aerobic exercise, yoga/meditation, and a weekly support group session" - [Doctor's Guide]
  • Aspirin May Cut Prostate Cancer Risk - WebMD, 7/5/05 - "Those who had taken aspirin regularly for a long time were 15% less likely to be diagnosed with prostate cancer. Other anti-inflammatory drugs were associated with an 18% lower risk of prostate cancer"
  • Beta-Sitosterol and the Aging Prostate Gland - Life Extension Magazine, 6/05 - "A study using the prostate cancer cell line LNCaP (an androgen-dependent tumor) showed that beta-sitosterol decreased cancer cell growth by 24% and induced apoptosis (programmed cell death) fourfold ..." - See iHerb or Vitacosticon beta sitosterol products.
  • Lycopene, Saw Palmetto Fail in Prostate Health Trials - Doctor's Guide, 5/26/05
  • Pomegranate Juice May Curb Prostate Cancer - WebMD, 5/23/05 - "Drinking pomegranate juice significantly lengthened the amount of time it took for the men's average PSA levels to double (from 14 to 26 months, on average) ... Pomegranate juice contains antioxidant chemicals that may have cancer-preventing benefits"
  • Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 - "statin use reduces the rate of prostate cancer by 54%" - See Zocor at International Anti-aging Systems.
  • Exercise May Fight Prostate Cancer - WebMD, 5/9/05 - "men over age 65 who engaged in at least three hours of vigorous physical activity, such as running, biking, or swimming, per week had a nearly 70% lower risk of being diagnosed with advanced prostate cancer or dying from the disease"
  • Is There a Link Between Macronutrient Intake and Prostate - Medscape, 5/5/05 - "In this sample of Italian men, intake of monounsaturated fatty acids and starch was directly related to an increased risk of prostate cancer. Polyunsaturated fatty acid consumption was associated with a significantly lower risk of the disease"
  • Purified Green Tea Polyphenol Capsules Taken Daily Appear to Substantially Reduce Prostate Cancer in High Risk Patients - Doctor's Guide, 4/22/05 - "researchers reported a 90% decrease in the rate of prostate cancer in men who received 200 mg doses of the polyphenol capsules three times a day for 1 year" - See iHerb or Vitacosticon green tea products.  My favorite is Jarrow Green Tea at Amazon.com.
  • Antioxidant levels key to prostate cancer risk in some men - Nutra USA, 3/15/05 - "Greater levels of selenium, vitamin E and the tomato carotenoid lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males, or those who inherit a specific genetic variation that is particularly sensitive to oxidative stress"
  • Pilot Study: Potential Role of Vitamin D (Cholecalciferol) in Patients With PSA Relapse After Definitive Therapy - Nutr Cancer. 2005;51(1):32-6 - "Fifteen patients were given 2,000 IU (50 mug) of cholecalciferol daily and monitored prospectively every 2-3 mo. In 9 patients, PSA levels decreased or remained unchanged after the commencement of cholecalciferol. This was sustained for as long as 21 mo. Also, there was a statistically significant decrease in the rate of PSA rise after administration of cholecalciferol (P = 0.005) compared with that before cholecalciferol. The median PSA doubling time increased from 14.3 mo prior to commencing cholecalciferol to 25 mo after commencing cholecalciferol. Fourteen of 15 patients had a prolongation of PSA doubling time after commencing cholecalciferol. There were no side effects reported by any patient"
  • Vitamin E: Which Type Best for Prostate Cancer? - WebMD, 3/1/05 - "the men with the highest blood levels of alpha and gamma tocopherol had lower prostate cancer risk. Men with the highest levels of both forms of the vitamin were 30%-40% less likely to develop prostate cancer as those with the lowest levels"
  • Vitamin D May Cut Prostate Cancer Risk - CBS 2 Chicago, 2/17/05 - "men with higher levels vitamin D in their blood were half as likely to develop aggressive forms of the disease than those with lower amounts"
  • Can Prostate Cancer Be Prevented? - Medscape, 2/8/05 - "The Prostate Cancer Prevention Trial (PCPT) demonstrated that finasteride can prevent prostate cancer, albeit with an apparently increased risk of high-grade disease. A substantial amount of epidemiologic, molecular, and clinical evidence suggests that both selenium and vitamin E might also prevent prostate cancer ... vitamin D exerts an antiproliferative effect on prostate cancer cells"
  • Green tea for a healthy prostate? - MSNBC, 1/21/05 - "phytochemicals called polyphenols attack growth factors and proteins, interrupting processes that increase the size of tumors, thus preventing them from spreading to other parts of the body ... green tea in mice with an aggressive form of cancer can decrease the spread or metastasis of prostate cancer to liver, bone and other sites ... the phytochemicals in green tea could inhibit the early stages of prostate cancer development" - See iHerb or Vitacosticon green tea products.  My favorite is Jarrow Green Tea at Amazon.com.
  • Vitamin D may slow prostate tumour growth - CTV.ca, 1/16/05 - "the vitamin D seemed to cut the rise in PSA rates by more than half. Without vitamin D, PSA rates rose by about five per cent. With vitamin D, PSA rates only rose by two per cent"
  • Vitamin E In Plant Seeds Could Halt Prostate, Lung Cancer, Says Purdue Scientist - Science Daily, 12/30/04 - "gamma-tocopherol, which occurs naturally in walnuts, pecans, sesame seeds, and in corn and sesame oils, inhibits the proliferation of lab-cultured human prostate and lung cancer cells"  - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Vitamin E in Food May Fight Cancer - WebMD, 12/15/04 - "Most supplements provide a different form of the vitamin, alpha-tocopherol ... Gamma-tocopherol aced its lab tests. It inhibited the spread of prostate and lung cancer cells without hurting the healthy cells ... Mixing several forms of vitamin E -- including gamma-tocopherol -- was even better at blocking cancer's spread"  - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Gamma-tocopherol halts cancer cells in lab study - Nutra USA, 12/15/04 - "Gamma-tocopherol, found naturally in walnuts, sesame seeds and corn, was found to hold back the proliferation of lab-cultured human prostate and lung cancer cells, reports the team from Purdue University in the 13 December online edition of the Proceedings of the National Academy of Sciences ... This could indicate that the vitamin Could be used to target lung and prostate cancer cells without the damaging side effects of chemotherapy" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Green Tea Polyphenols Thwart Prostate Cancer Development At Multiple Levels - Science Daily, 12/15/04 - "The polyphenols present in green tea help prevent the spread of prostate cancer by targeting molecular pathways that shut down the proliferation and spread of tumor cells, as well as inhibiting the growth of tumor nurturing blood vessels" - See iHerb or Vitacosticon green tea products.  My favorite is Jarrow Green Tea at Amazon.com.
  • Flower Pollen, Powerful Protection for Prostate Health - Life Extension Magazine, 12/04
  • Green Tea May Stall Prostate Cancer Growth - WebMD, 12/1/04 - "the green tea antioxidant appeared to stall cell growth by decreasing production of several proteins that promote cell survival. In addition, it reduced the production of proteins that are known to be associated with the spread of cancer cells ... the study also suggests that the antioxidant in green tea appeared to starve prostate cancer tumor cells by inhibiting the formation of blood vessels, thereby suppressing the flow of nutrients to the cancerous cells" - See iHerb or Vitacosticon green tea products.  My favorite is Jarrow Green Tea at Amazon.com.
  • Soy: Good for Men’s Health, Too - Healthwell, 11/11/04 - "There was a significant PSA-level drop in the men eating the soy bread compared with the control group"
  • Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer - Functional Foods and Nutraceuticals, 11/04 - "a genistein-rich extract as the sole treatment for prostate cancer does not appear to be an effective treatment for prostate cancer when given alone. However, eight of 13 evaluated patients in the active surveillance group had either no rise or a decline in PSA levels of less than 50 per cent"
  • Nonsteroidal Anti-inflammatory Drugs May Improve Survival among Prostate Cancer Patients - Doctor's Guide, 10/4/04
  • Aspirin May Delay Prostate Cancer, Extend Life - WebMD, 10/4/04 - "more than nine in 10 men who took aspirin or another NSAID were alive 10 years later compared with fewer than seven in 10 men who didn't take the painkillers ... evidence is mounting that prostate cancer may develop in areas with chronic inflammation"
  • Vitamin E + Lycopene Fights Prostate Cancer - WebMD, 9/30/04 - "a combination treatment with low-dose lycopene and vitamin E had the strongest effect at slowing tumor growth -- a 73% slowing of growth on the 42nd day of the test ... The next best results came from the low dose of lycopene alone, which slowed tumor growth by 53% in the same time frame"
  • Soy Improves Prostate Cancer Outlook - WebMD, 9/24/04 - "adding about 2 ounces of soy each day for one month results in a 13% drop in total PSA and a 27% increase in the free-to-total PSA ratio in men with prostate cancer"
  • Daily Glass of Red Wine May Cut Risk of Developing Prostate Cancer - Doctor's Guide, 9/23/04 - "men who consumed four or more glasses of red wine per week reduced their risk of prostate cancer by 50 percent ... That compound, Stanford and colleagues believe, may be an antioxidant called resveratrol, which is abundant in the skins of red grapes but much less so in the skins of white grapes"
  • Relieve Common Men’s Condition with Saw Palmetto Extract - Healthwell Exchange Daily News, 9/16/04 - "Comparison trials found its effects to be similar to those of finasteride and tamsulosin ... however, while some men using the standard medications experienced sexual dysfunction as a side effect, men using the herbal extract did not" - See iHerb or Vitacosticon saw palmetto products.
  • Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer - Urology. 2004 Sep;64(3):510-5 - "Statistically significant differences were detected between the HT [heat-treated] soy grits group and the control wheat group for the percentage of change in total PSA (-12.7% versus 40% ... The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer"
  • Update on Lycopene - Dr. Murray's Natural Facts, 8/25/04 - "men who consumed the highest levels of lycopene (6.5 mg per day) in their diet showed a 21 percent decreased risk of prostate cancer compared with those eating the lowest levels. When the researchers looked at only advanced prostate cancer, the high lycopene eaters had an 86% decreased risk" - See iHerb or Vitacosticon lycopene products.
  • Omega-3s appear to protect against prostate cancer - Nutra USA, 6/23/04 - "alpha-linolenic acid (ALA), an omega-6 fat, may raise the risk of advanced prostate cancer ... Men with the highest quintiles of EPA and DHA combined had an 11 per cent lower total prostate cancer risk and advanced prostate cancer risk was 26 per cent lower" - See Mega Twin EPA at Amazon.com or Vitacosticon.
  • Flaxseed Helps Prevent Common Men’s Condition - Healthwell Exchange Daily News, 6/10/04
  • Selenium and Prostate Cancer - Physician's Weekly, 6/14/04 - "higher levels of selenium may slow prostate cancer tumor progression"
  • Tea Slows Prostate Cancer - WebMD, 4/20/04
  • Tea polyphenols to combat prostate cancer - Nutra USA, 4/20/04
  • Breakthrough research on lycopene - Nutra USA, 4/15/04 - "Men eating four to five tomato based-dishes per week were found to be protected by 25 per cent compared to men eating tomatoes only rarely" - See iHerb or Vitacosticon lycopene products.
  • Fibre for prostate protection - Nutra USA, 4/15/04 - "total fibre intake only slightly reduced prostate cancer risk. However when the study examined soluble fibre only, the reduced risk was greater at 11 per cent, while vegetable fibre cut risk by 18 per cent"
  • Frequent Ejaculation May Be Good for Prostate - WebMD, 4/6/04
  • Resveratrol, Powerful Protection Against Prostate Cancer - Life Extension Magazine, 4/04 - "Resveratrol works through more than a dozen different anticancer mechanisms and selectively targets cancer cells. This single supplement modulates hormones, has several mechanisms that stop cancer cells from multiplying, and even has the ability to destroy cancer cells" - See iHerb or Vitacosticon resveratrol products.
  • Soy: Prevent Prostate Cancer, Male Baldness? - WebMD, 3/30/04 - "A little-known molecule called equol ... is showing promise as a powerful blocker of a potent male hormone involved in prostate cancer, male baldness, even acne ... Actually, the protective effects occur when two chemicals in soy protein -- genistin and daidzin -- reach the digestive system, Setchell explains. There, they are metabolized to form genistein and daidzein. Daidzein is metabolized once again, to form equol" - See iHerb or Vitacosticon isoflavone products.
  • Soy blocks prostate cancer? - Nutra USA, 3/30/04 - "Equol, the major metabolite of the phytoestrogen daidzein - one of the main isoflavones found abundantly in soybeans - completely stops in its tracks the male hormone dihydrotestosterone (DHT), which normally stimulates prostate growth and causes male pattern baldness"
  • Higher Serum Vitamin E Levels Linked to Lower Prostate Cancer Risk - Doctor's Guide, 3/30/04 - "Compared with men in the lowest tertile of alpha-tocopherol levels, men in the highest tertile were 53% less likely to develop prostate cancer (P = .05). Men in the highest tertile of gamma-tocopherol were 39% less likely to develop the cancer than those in the lowest tertile" - See iHerb or Vitacosticon vitamin E products.  My favorite is Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • MCP for Prostate Cancer - Life Extension Magazine, 3/04
  • Treating Prostate Cancer? - Dr. Weil, 2/3/04
  • Selenium Reduces Prostate Cancer Risk - Natural Foods Merchandiser, 1/04
  • Citrus Nutrient Helps Slow Prostate Cancer - WebMD, 12/16/03 - "Every day, patients took 18 capsules of pectin: Each contained 14 grams of pectin, equaling 800 mg a day ... Fourteen months later, 70% of the men had significant increases in the time it took to produce PSA -- it took longer for prostate cells to produce a doubling of blood PSA levels" - See iHerb or Vitacosticon pectin products.
  • Vitamin D and prostate cancer prevention and treatment - Trends Endocrinol Metab. 2003 Nov;14(9):423-30 - "The association between either decreased sun exposure or vitamin D deficiency and the increased risk of prostate cancer at an earlier age, and with a more aggressive progression, indicates that adequate vitamin D nutrition should be a priority for men of all ages"
  • The Prostate Cancer-Fighter - WebMD, 11/4/03 - "in rats made to develop prostate cancer in the laboratory, those who were fed a diet containing tomato powder experienced a longer survival prior to developing cancer and were 26% less likely to die from prostate cancer compared with those on a "control" diet containing no tomato or lycopene foods ... In rats fed a diet of lycopene alone, the death rates from prostate cancer were similar to those rats fed a control diet"
  • Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer - Eur J Cancer Prev. 2003 Oct;12(5):407-15 - "In the rye group, there was a significant increase in plasma enterolactone, and the apoptotic index increased significantly from 2.1% (SD 1.3) to 5.9% ... High intake of rye bran bread is suggested to increase apoptosis in prostate tumours"
  • Does Masturbation Protect Men’s Health? - Dr. Weil, 9/18/03 - "A team of scientists in Australia found that men who ejaculate more frequently between the ages of 20 and 50 are less likely to develop prostate cancer. The protective effect seems greatest for those in their 20s"
  • Botox Treatment Aids Enlarged Prostate - WebMD, 8/4/03
  • Too Much Zinc Linked to Prostate Cancer - WebMD, 7/1/03 - "although taking zinc supplements of up to 100 mg per day did not increase men's overall risk of prostate cancer, men who took more than 100 mg of supplemental zinc per day were more than twice as likely to develop advanced prostate cancer than nonusers ... they can't rule out the fact that some other factor may account for the increase in advanced prostate cancer risk associated with excessive zinc supplementation found by the study" - See my zinc page.  Zinc interferes with copper absorption so maybe the cause is low copper.
  • Sunny Carotenoids for Better Health - Health Supplement Retailer 06/03 - "Comparing 65 patients with prostate cancer to 132 cancer-free controls, they found an inverse association between lycopene, zeaxanthin, lutein and cryptoxanthin levels and prostate cancer incidence ... "In vitro studies have shown that sometimes isolated, synthetic lycopene does not work as well as tomatoes or natural tomato extract," said Diane Fremont, sales director for Lycored, the Beer-Sheva, Israel-based supplier of Lyc-O-Mato® natural lycopene complex. "There is a synergistic effect with a combination of phytonutrients."" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Reducing Prostate Cancer Deaths Through Prevention and Early Diagnosis - Life Extension Magazine, 6/03
  • Broccoli Blocks Prostate Cancer Cells - WebMD, 5/20/03
  • Soy Lowers PSA Levels in Some Men - WebMD, 5/1/03
  • Saw Palmetto Extract Effective in Treating Chronic Prostatitis - Medscape, 4/28/03 - "Permixon, a compound extracted from the fruit of the American dwarf palm tree Serona repens, also known as saw palmetto, appears to improve symptoms of chronic prostatitis/chronic pelvic pain syndrome ... Seventy-five percent of the patients who received Permixon had at least mild improvement in symptoms compared with 20% of the control group. Similarly, 55% of patients who received Permixon reported moderate or marked improvement compared with 16% of the control group ... In the control group, PSA did not differ from baseline. However, the group taking Permixon experienced median decreases from baseline PSA of 22% after 6 weeks" - See iHerb or Vitacosticon saw palmetto products.
  • Low-Fat Diet, Exercise, Less Stress Help Prostate Cancer - WebMD, 4/28/03
  • Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See iHerband Vitacosticon selenium products.
  • Garlic may reduce risk of prostate cancer - Life Extension Magazine, 3/03 - "The study indicated that eating just a tenth of an ounce of scallions daily lowers prostate cancer risk by about 70%; that same amount of garlic reduces the risk by about 53%. The study authors suggest that one clove of garlic daily can achieve desired preventive effects"
  • Green Tea Doesn't Help Prostate Cancer - WebMD, 3/5/03
  • Herbal Remedies Can Aid Prostate Health - WebMD, 2/4/03 - "One in three men are treated for BPH with surgery or, more commonly, prescription drugs such as Flomax or Proscar. But growing research suggests that some symptoms may be treated as effectively with over-the-counter herbal remedies -- sometimes less expensively and thus far, with no reported side effects. What's more, some of these treatments claim they may help prevent prostate cancer, the second leading cause of cancer death in men"
  • Selenium May Fight Prostate Damage - WebMD, 2/4/03 - "About 80% of the prostate cells in dogs fed a normal diet had extensive DNA damage compared with only about 57% in the selenium-treated dogs ... dogs fed the enriched diet also had a twofold increase in the number of prostate cells that had undergone a process that removes damaged cells, called apoptosis, which is associated with a lower risk of cancer" - See iHerb or Vitacosticon selenium products.
  • Vitamin D for Advanced Prostate Cancer - Physician's Weekly, 1/27/03 - "Calcitriol is an active form of vitamin D. Results from a phase II clinical trial suggest that the combination of calcitriol and the chemotherapy agent docetaxel may be twice as effective as the use of docetaxel alone in men with androgen-independent prostate cancer"
  • Wow, You Coulda Had Some Lycopene! - Cancer Decisions Newsletter , 1/7/03 - "Men who received the lycopene supplement had lower prostate-specific antigen (PSA) levels and less aggressive tumors than the non-supplemented control group. Their tumors were smaller (80 percent of the tumors were under 4 milliliters (ml) in volume, compared to 45 percent in the control group). Their cancer was much more likely to be within the surgical margins and/or confined to the prostate gland (73 percent, compared to 18 percent of the control group). And the invasion of the prostate gland by cancer-like "PIN" cells was completely prevented in this group, compared to a 33 percent incidence of "PIN" cells in the control group" - See iHerb or Vitacosticon lycopene products.  My favorite is Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Bad Breath, Healthy Prostate - New Hope Natural Media, 12/20/02 - "Men who consumed more than 10 grams per day of Allium vegetables had almost a 50% reduction in risk of developing prostate cancer, compared with those who consumed less than 2.2 grams per day. Garlic was the most commonly consumed Allium vegetable, followed by scallions and chives"
  • Herbal Treatment Shows Promise Against Prostate Cancer - USA Today, 12/20/02
  • Herb Mix Nixes Prostate Cancer in Lab - WebMD, 12/13/02 - "A number of recent studies point to COX-2 as an important factor in cancer-cell growth. In the Columbia studies, Zyflamend decreased COX-2 activity about as well as a potent COX-2-inhibiting drug ... The herbal mix is called Zyflamend, from New Chapter Inc., and has 10 herbs: holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano, and Scutellaria biacalensis" - See Zyflamend at Amazon.com.
  • Watermelon for Prostate Cancer? - Dr. Weil, 12/10/02 - "Lycopene is a powerful antioxidant that a number of large studies have shown is particularly good at protecting against prostate, colon and rectal cancer, as well as heart disease ... contains 40 percent more lycopene than an equivalent weight of tomatoes ... The body converts about 500 different carotenoids into vitamin A ... If you don’t get enough of these foods in your diet, you may want to use an antioxidant supplement. I recommend a mixed carotenoid supplement containing lycopene, lutein, alpha-carotene, and zeaxanthin, as well as beta-carotene"
  • Flaxseed Might Block Prostate Cancer - WebMD, 11/11/02 - "A study of mice shows that flaxseed in the diet helped improve prostate tumors (reducing their size and severity), and even prevented some of the mice from developing the disease ... men who ate ground flaxseed for 34 days had a drop in levels of testosterone, which helps prostate cancers grow, and in prostate specific antigen (PSA) levels, a marker for prostate cancer"
  • Garlic May Prevent Cancer - Intelihealth, 11/6/02
  • Garlic, Chives Reduce Prostate Cancer - WebMD, 11/5/02 - "filling your diet with garlic and scallions can help reduce the chance of this potentially deadly cancer ... Garlic and scallions, along with onions, leeks, chives, and shallots, are rich in flavonols, substances in plants that have been shown to have antitumor effects. All of these vegetables have previously been linked to lower risks of cancers of the stomach, colon, esophagus, and perhaps breast ... although fruits and vegetables slightly reduced prostate cancer, the lower risk associated with allium vegetables was much more pronounced"
  • Study Of Low-Fat, High-Fiber Diet Finds No Effect On PSA Levels In Men Over A Four-Year Period - Doctor's Guide, 8/30/02
  • Novel Method of Enhancing Anti-Fat Effects of CLA - Life Extension Magazine, 8/02 - "CLA is not just for fat-loss. Studies show it may help protect against many diseases including atherosclerosis and cancer ... CLA is also able to inhibit the growth of prostate cancer. CLA, as the article went on to say, can be considered a powerful prostate cancer preventative, as well as a partial treatment " - See iHerb and Vitacosticon CLA products.
  • Vasectomy: A Prostate Cancer Risk? - Dr. Weil, 7/2/02
  • Profile: Prostate Cancer Success - Life Extension Magazine, 7/02
  • Diet and Lifestyle Changes Slow Progression of Prostate Cancer - New Hope Natural Media Online, 6/13/02 - "The recommendations included a low-fat vegetarian diet, smoking cessation, stress management training and moderate exercise ... The men who received no treatment showed no change in their PSA levels. In contrast, men who followed the Ornish protocol had an average PSA decrease of 6.5%, a finding suggestive of disease regression"
  • Omega 3: Implications in human health and disease - PowerPak (39 page CME course for Registered Dietitians), exp. 8/1/03 - "The results of this study support the association of a reduced risk of prostate cancer with higher levels of long-chain omega 3 fatty acids in red blood cells and the hypothesis that eicosanoid processes are involved in the progression or initiation of prostate cancer" - See Mega Twin EPA at Amazon.com or Vitacosticon.
  • Prostate Cancer and I3C - Life Extension Magazine, 5/02 - "Studies show that I3C changes not only estrogen metabolism, but testosterone and androsterone as well. Its hormone-altering action may help protect against hormone mimickers such as the drugs implanted in food animals. It has been confirmed that whether a hormone is the real thing, a drug facsimilie or a chemical, I3C will neutralize it"
  • What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 - "Gamma tocopherol and prostate cancer ... " - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
  • Role Seen For Oxidative Stress In Benign Prostatic Hyperplasia - Doctor's Guide, 4/1/02
  • Diet Linked to Prostate Enlargement - WebMD, 3/25/02 - "diet had the strongest link with prostate problems ... The men who had prostate disease ate more meat and more fats, specifically polyunsaturated vegetable fats and fish oils ... This is a perplexing association, but Suzuki suggests it may be due to these fatty acids igniting a process called oxidation in the body. Oxidation damages DNA, cells, and tissues, eventually contributing to heart disease, cancer, and other illnesses ... Fruit, vegetables, and whole grains are known to counter oxidation"
  • Painkillers Reduce Prostate Cancer Risk - WebMD, 3/13/02
  • Daily Aspirin May Help Ward Off Prostate Cancer - Doctor's Guide, 3/12/02
  • Tomatoes Lower Prostate Cancer Risk - WebMD, 3/4/02 - "This newest investigation "confirmed our previous findings," ... "Frequent tomato or lycopene intake was associated with a reduced risk of prostate cancer. Intake of tomato sauce, the primary source of [ready available] lycopene, was associated with an even greater reduction in prostate cancer risk." ... Although all evidence points to lycopene as the beneficial ingredient, that remains to be proved" - See iHerb or Vitacosticon lycopene products.  My favorite is Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Lycopene lowers PSA - Life Extension Magazine, 1/02 - "32 mostly African American patients who had been diagnosed with prostate cancer and were awaiting radical prostatectomy were put on diets that included enough tomato sauce to provide 30 mg/day of lycopene for three weeks. Prostate cancer is more frequent and serious among African Americans than among Caucasians ... Mean serum PSA concentrations fell by 17.5%, while a measure of oxidative status fell by 21.3%. DNA damage in the cancer cells fell by 40% after three weeks, of which author Phyllis E. Bowen says, “We don’t know whether that’s good or bad.” Most important, high concentration of lycopene in prostate tissues resulted in a nearly three-fold increase in programmed cell damage among cancer cells, which is a good thing"
  • Green tea polyphenols inhibit prostate cancer in mouse model - Life Extension Magazine, 12/01 - "According to study findings published in the August 28, 2001 issue of the Proceedings of the National Academy of Sciences [PNAS 2001 Aug;98(18):10350-10355], green tea polyphenols—the equivalent found in about six cups of green tea per day in humans—helped to significantly reduce the risk of prostate cancer in a mouse model"
  • Low Selenium Levels Linked With Increased Prostate Cancer Risk - Intelihealth, 12/6/01
  • Selenium May Help Prevent Prostate Cancer - Doctor's Guide, 11/30/01 - "Men with low blood levels of selenium -- a trace element supplied in certain foods and supplements -- are four to five times more likely to contract prostate cancer ... the researchers concluded that the results support the hypothesis that supplemental selenium may reduce the risk of prostate cancer. Because selenium in blood decreases with patient age, supplementation may be beneficial to older men"
  • Green Tea, Glycine May Slow Tumor Growth - WebMD, 11/2/01 - "polyphenols reduced the level of Bcl-XL protein in prostate cancer cell lines. Bcl-XL has been shown to protect cancer cells from death -- known scientifically as apoptosis ... The higher the concentration [of polyphenols] the more apoptosis"
  • Chemical Derived From Hawaiian Mollusk Show Activity Against Prostate Cancer - Doctor's Guide, 10/31/01
  • Vitamin D Prevents Prostate Cancer - drmirkin.com, 9/1/01
  • First Direct Evidence Shows Diet and Exercise Slow Cancer Growth - WebMD, 8/13/01
  • Study Provides New Evidence That Chemical In Tomato Sauce May Help Fight Prostate Cancer, Particularly In Black Men - Intelihealth, 8/30/01 - "Researchers at the University of Illinois in Chicago fed 32 volunteers with newly diagnosed prostate cancer three-fourths cup of tomato sauce daily for three weeks ... the treatment resulted in reduced blood levels of prostate specific antigen (PSA), a protein whose increased levels are strongly linked to a higher prostate cancer risk ...Researchers believe that lycopene, a red pigment with high antioxidant potential, is the most likely agent involved in this effect"
  • Small Study Supports Flaxseed As Cancer Fighter - Intelihealth, 8/15/01
  • Tomato Extract May Have Role in Slowing Prostate Cancer - WebMD, 8/10/01 - "So when the results came in, Kucuk and colleagues were startled: the men who used the lycopene supplement actually had smaller tumors than the men who did not. Even more intriguing, the tumors taken from the men who used lycopene supplement were more likely to be confined to the prostate, and less likely to have advanced beyond it."
  • A Grain of Hope for Prostate Cancer - WebMD, 7/11/01 - "Ground flaxseed -- a grain that was a dietary staple in the 19th century -- may prevent the growth of prostate cancer and speed the death of tumor cells when combined with a low-fat diet"
  • Quercetin Relieves Prostate Pain - Nutrition Science News, 7/01
  • An Aspirin a Day to Keep Prostate Cancer Away? - WebMD, 6/7/01 - "A growing body of research has suggested that people who regularly take aspirin and other NSAIDs have a lower risk for cancers, including breast cancer and colon cancer. And though the definitive word is not in, new research presented at the annual meeting of the American Urological Association suggests that regular NSAID use can reduce the risk of prostate cancer too"
  • Go Fish! Types High in Fatty Acids May Prevent Prostate Cancer, Herring, Mackerel, and Salmon Recommended - WebMD, 6/1/01 - "Eating fatty fish reduces risk of prostate cancer by about 70%, compared to not eating it, and reduces the risk for death from the disease by about 50%."
  • Red Wine, Coffee, and Almonds May Lower Prostate Cancer Risk, Protective Effect Linked to Dietary Boron - WebMD, 4/5/01 - "men who consumed the greatest amount of boron were 64% less likely to develop prostate cancer, when compared with men who consumed the least amount of boron"
  • Canceling Cancer: New Cancer Prevention Strategies on the Horizon - WebMD, 3/26/01 - "Xing has shown that quercetin blocks androgen receptors when applied to cancer cells in the laboratory ... We are very excited by our finding that the new approach quercetin [can be used] in the fight against prostate cancer"
  • Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer - J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23 - "For gamma-tocopherol, men in the highest fifth of the distribution had a fivefold reduction in the risk of developing prostate cancer than men in the lowest fifth" - [Full Article]
  • New Dimensions in the Pharmacologic Treatment of Benign Prostatic... - Medscape, 12/00
  • Saw Palmetto: Effective BPH Symptom Relief - Nutrition Science News, 9/00
  • Herbal Mixture May Protect Against Prostate Cancer, Clinical Trial of 'PC-SPES' Moving Forward - WebMD, 8/31/00
  • Prostate Cancer and Cruciferous Vegetables - Life Extension Magazine, 7/00
  • Vitamin D prevents bone loss in men undergoing treatment for prostate cancer - Doctor's Guide, 5/2/00
  • Saw Palmetto Helps Prostate Enlargement - A Little, New Study Shows Widely Used Herb Does Work - WebMD, 4/21/00
  • Induction of apoptosis in human prostatic cancer cells with beta-glucan - Mol Urol 2000;4(1):7-13 - "this unique mushroom polysaccharide may have great a potential as an alternative therapeutic modality for prostate cancer"
  • CLA Inhibits Prostate Cancer Growth and Metastasis - Life Extension Magazine, 10/99 - see my CLA page
  • Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice - Anticancer Res 1998 May;18(3A):1429-1434, 6/99
  • Vitamin E May Prevent Prostate Cancer - Doctor's Guide, 3/18/98 - "long-term use of a moderate-dose vitamin E supplement substantially reduced prostate cancer incidence and deaths in male smokers"
  • Evidence for a local action of melatonin on the rat prostate - J Urol 1998 Mar;159(3):1069-1073 - "The results demonstrate putative melatonin receptors in the rat prostate and suggest a direct suppression by melatonin of testosterone-dependent prostate growth" - See my melatonin page
  • Evidence Mounting: Beta-Carotene Supplements Reduce Prostate Cancer Risk - Doctor's Guide, 5/23/97
  • Is Herbal Therapy Useful in the Treatment of Men with Symptomatic Benign Prostatic Hyperplasia? - Urological Sciences Research Foundation, Spring 1997
  • Animal Study Finds Vitamin D Inhibits Prostate Cancer Growth - Doctor's Guide, 4/10/97

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