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Recent Longevity News for the seven days ending 11/2/11.  You should consult your doctor if you are taking any medications.

Live longer with fewer calories? Key enzyme involved in aging process found - Science Daily, 10/31/11 - "We are able to show that caloric restriction slows down aging by preventing an enzyme, peroxiredoxin, from being inactivated. This enzyme is also extremely important in counteracting damage to our genetic material ... Prx1 is damaged during aging and loses its activity. Caloric restriction counteracts this by increasing the production of another enzyme, Srx1, which repairs Prx1. Interestingly, the study also shows that aging can be delayed without caloric restriction by only increasing the quantity of Srx1 in the cell. Repair of the peroxiredoxin Prx1 consequently emerges as a key process in aging ... Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, we can now speculate whether increased repair of Prx1 during aging can counteract, or at least delay, the development of cancer" - Note:  I didn't think "fishes" was a word but I researched it and it's used to refer to different species of fish.

CoQ10 may boost antioxidant defenses in people with atherosclerosis - Nutra USA, 10/28/11 - "A daily CoQ10 dose of 150 mg was associated with 29% lower levels of malondialdehyde (MDA - a reactive carbonyl compound and a well-established marker of oxidative stress) after eight weeks, compared with the placebo group ... In addition, after 12 weeks of supplementation, the CoQ10 supplement appeared to stimulate the body’s antioxidant defenses and levels of the antioxidant enzymes catalase and superoxide dismutase (SOD) were 230% and 78% higher than the placebo group, respectively ... blood levels increased of CoQ10 increased in the high dose group by 189% after 12 weeks, but no significant increases were observed in the 60 mg group" - [Abstract] - See ubiquinol products at Amazon.com.

Childhood diet lower in fat and higher in fiber may lower risk for chronic disease in adulthood - Science Daily, 10/28/11 - "In this study, researchers evaluated 230 women between the ages of 25 and 29 years, who nine years before the current study participated in the Dietary Intervention Study in Children (DISC). DISC was a randomized controlled clinical trial of a reduced-fat dietary intervention that strived to limit fat intake to 28 percent of daily caloric intake and increase dietary fiber intake by encouraging consumption of fruits, vegetables and whole grains. The current study was conducted among females who had participated in the DISC trial to determine the longer-term effects of the DISC intervention ... Few participants in our follow-up study met the criteria for metabolic syndrome, however the intervention group had statistically significant lower mean systolic blood pressure and fasting plasma glucose levels compared to the control group ... Longer follow-up studies of DISC participants are needed to determine if the differences found in this study persist or widen with increasing age"

Older men with higher testosterone levels lose less muscle mass as they age - Science Daily, 10/27/11 - "Our study finds that men, aged 65 years and older, with higher testosterone levels lost less muscle mass, especially in their arms and legs, than men this age who had lower testosterone levels" - Note:  My testosterone has been slightly above the normal range.  I believe it's because of the quarter tablet of letrozole I take every third day.  See letrozole at OffshoreRX.

‘Pink Glove Dance’ Take 3: Winning Video Announced - ABC News, 10/27/11 - "The company received 139 submissions from 40 states and Canada ... Medline asked visitors to its website to vote for the Top 3 videos. And this evening, the company shared its three winners with ABC News. Lexington Medical Center in West Columbia, S.C., took first place"

CoQ10 may reduce muscle damage during intensive exercise - Nutra USA, 10/27/11 - "Twenty ultra-runners participated in the study and were divided into two equal groups. One group received one 30 mg capsule of CoQ10 two days before the test, three 30 mg capsules the day before the test, and one capsule one hour before the test. The other group received placebo at the same time. The test involved a 50 km distance run across Europe’s highest road in the Sierra Nevada ... Results showed that the placebo group displayed a 100% increase in levels of 8-OHdG, which <i>“a sensitive indicator of DNA damage as a result of oxidative stress”,</i> said the researchers, compared with an increase of 37.5% in the runners taking the CoQ10 supplements ... The data also indicated that CoQ10 countered the over-expression of certain pro-inflammatory compounds after exercise ... a reduction in levels of creatinine in the urine was observed in the CoQ10 group, compared with the placebo group. Creatinine is produced from creatine and high levels are a marker of muscle break down (or kidney damage) ... CoQ10 supplementation reduces creatinine excretion and therefore decrease muscle damage during physical performance" - [Abstract] - See ubiquinol products at Amazon.com.

Resveratrol may boost oral health: Cell study - Nutra USA, 10/26/11 - "If additional studies support the Hong Kong findings then oral health may also be added to the list of potential benefits of resveratrol ... Results showed that levels of both A. actinomycetemcomitans and P. gingivalis were significantly decreased after 1 hour and that no viable bacterial cells were observed after 24 hours ... Resveratrol had no effect on the other non-periodontitis promoting oral microorganisms, said the researchers ... the researchers note that periodontal disease involves an inflammatory process, and that a recent study has suggested that resveratrol may block this process by preventing the binding of a pro-inflammatory compound called nuclear factor kappaB" - [Abstract] - See resveratrol products at Amazon.com.

The multiple nutrient needs of bones: Review - Nutra USA, 10/26/11 - "According to the new review of the literature, the majority of studies concerning bone health have shown that “vitamin B complex and vitamins C, E, and K correlated positively with bone mineral density (BMD) at multiple skeletal sites and/or were associated with reduced risk of fracture, independent of BMD” ... Animal data has “confirmed” that vitamin E, and particularly the tocotrienol form of vitamin E, had anti-osteoporotic activities ... Biological plausibility does exist for vitamin K, since osteocalcin is a vitamin K-dependent protein and it is essential for the body to use calcium in bone tissue. Without adequate vitamin K, the osteocalcin remains inactive, and this not effective" - [Abstract]

How cannabis causes 'cognitive chaos' in the brain - Science Daily, 10/25/11 - "While the effects of the drug on individual brain regions were subtle, the drug completely disrupted co-ordinated brain waves across the hippocampus and prefrontal cortex, as though two sections of the orchestra were playing out of synch. Both these brain structures are essential for memory and decision-making and heavily implicated in the pathology of schizophrenia ... Marijuana abuse is common among sufferers of schizophrenia and recent studies have shown that the psychoactive ingredient of marijuana can induce some symptoms of schizophrenia in healthy volunteers"

You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests - Science Daily, 10/25/11 - "Men who ate a low-fat diet with fish oil supplements for four to six weeks before having their prostate removed had slower cancer-cell growth in their prostate tissue than men who ate a traditional, high-fat Western diet ... The short-term study also found that blood obtained from patients after the low-fat, fish oil diet slowed the growth of prostate cancer cells in a test tube, while blood from men on the Western diet did not slow cancer growth ... Preclinical studies suggest that lowering dietary omega-6 fatty acids from corn oil and increasing omega-3 fatty acids from fish oil decreases the risk of prostate cancer development and progression," the study states. "We found this diet intervention resulted in a decrease in omega-6 vs. omega-3 fatty acid ratios in benign and malignant prostate tissue and a decrease in malignant cell proliferation" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Korean Red Ginseng (Panax ginseng) Improves Insulin Sensitivity in High Fat Fed Sprague-Dawley Rats - Phytother Res. 2011 Oct 28 - "Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for 18 weeks ... A significant weight reduction, especially fat mass reduction, was observed in the KRG treated group. Increased insulin sensitivity was found in the KRG treated group. We observed increased insulin signalling, increased phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects due to partly increased insulin sensitivity by increased adipokine and partly enhanced insulin signalling" - See ginseng at Amazon.com.

Beneficial effects of catechin-rich green tea and inulin on the body composition of overweight adults - Br J Nutr. 2011 Oct 28:1-6 - "The aim of the present study was to investigate whether the effect of catechin-rich green tea in combination with inulin affects body weight and fat mass in obese and overweight adults. A total of thirty subjects were divided into a control group and an experimental group who received 650 ml tea or catechin-rich green tea plus inulin. A reduction of body weight ( - 1.29 (sem 0.35) kg) and fat mass (0.82 (sem 0.27) kg) in the experimental group was found after 6 weeks, and no adverse effects were observed. After refraining from consumption for 2 weeks, sustained effects on body weight and fat mass were observed. We conclude that continuous intake of catechin-rich green tea in combination with inulin for at least 3 weeks may be beneficial for weight management" - Note: 1.29 kg is 2.8 pounds.  See inulin products at Amazon.com and green tea extract at Amazon.com.

Lower concentrations of serum phosphorus within the normal range could be associated with less calcification of the coronary artery in Koreans with normal renal function - Am J Clin Nutr. 2011 Oct 26 - "Serum phosphorus concentrations are associated with an increased risk of cardiovascular disease (CVD) and mortality in patients with renal insufficiency. This association has also been reported in Western individuals without chronic kidney disease (CKD) ... Compared with the group with a serum phosphorus concentration ≤3.3 mg/dL, the OR of an Agatston score >100 in individuals with a serum phosphorus concentration >3.6 to ≤3.9 mg/dL was 3.89 (95% CI: 1.43, 10.63; P = 0.008) and in those with a serum phosphorus concentration >3.9 mg/dL was 3.17 (95% CI: 1.19, 8.41; P = 0.021) ... A lower concentration of serum phosphorus within the normal range could be associated with less calcification of the coronary artery in Koreans with normal renal function"

Atorvastatin increases exercise leg blood flow in healthy adults - Atherosclerosis. 2011 Oct 4 - "High-dose atorvastatin augments exercising leg hyperemia. Statins may mitigate reductions in the exercise vasodilatory response in humans that are associated with aging and disease"

Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial - Menopause. 2011 Oct 24 - "The aim of this study was to evaluate the effects of red ginseng (RG) on menopausal symptoms and cardiovascular risk factors in postmenopausal women ... either an RG group (supplemented with 3 g of RG, including 60 mg of ginsenosides, per day) or a placebo group for 12 weeks ... Significant improvements in the Kupperman index (P = 0.032) and in the menopause rating scale (P = 0.035) scores were observed in the RG group compared with the placebo group. Total cholesterol (P = 0.009) and low-density lipoprotein cholesterol (P = 0.015) significantly decreased in the group receiving RG. The RG group also showed a significant decrease in carotid intima-media thickness (P = 0.049). Serum estradiol levels were not influenced by RG supplementation" - See ginseng at Amazon.com.

Dietary Fiber and Nutrient Density Are Inversely Associated with the Metabolic Syndrome in US Adolescents - J Am Diet Assoc. 2011 Nov;111(11):1688-95 - "The overall prevalence of MetS was 6.4% (n=138). There was a graded inverse association between the fiber index and MetS (P<0.001) with a threefold difference between the lowest and highest quintiles (9.2% vs 3.1%). Each quintile increase in the fiber index was associated with a 20% decrease in MetS (adjusted odds ratio 0.83, 95% confidence interval 0.68-1.00; P0.043). Neither the saturated fat index (P=0.87) nor the cholesterol index (P=0.22) was significantly associated with MetS ... Higher intakes of dietary fiber, but not low intakes of saturated fat or cholesterol are related to the MetS in adolescents. These findings suggest that to reduce the risks for MetS in adolescents, it is more important to emphasize a paradigm that promotes the inclusion of fiber-rich, nutrient-dense, plant-based foods vs what foods to restrict or exclude as is commonly done when the focus is on total fat, cholesterol, or saturated fat intake"

Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis - J Am Diet Assoc. 2011 Nov;111(11):1720-9 - "Twenty trials (N=1,415) met all inclusion criteria. Upon meta-analysis, GTCs at doses ranging from 145 to 3,000 mg/day taken for 3 to 24 weeks reduced total (-5.46 mg/dL [-0.14 mmol/L]; 95% CI -9.59 to -1.32) and LDL cholesterol (-5.30 mg/dL [-0.14 mmol/L]; 95% CI -9.99 to -0.62) compared to control. GTCs did not significantly alter HDL cholesterol (-0.27 mg/dL [-0.007 mmol/L]; 95% CI -1.62 to 1.09) or triglyceride (3.00 mg/dL [-0.034 mmol/L]; 95% CI -2.73 to 8.73) levels. The consumption of GTCs is associated with a statistically significant reduction in total and LDL cholesterol levels; however, there was no significant effect on HDL cholesterol or triglyceride levels" - See green tea extract at Amazon.com.

Effects of added PGX®, a novel functional fibre, on the glycaemic index of starchy foods - Br J Nutr. 2011 Oct 10:1-4 - "Healthy subjects (n 10) consumed glucose sugar (50 g in water × 3) and six starchy foods with a range of GI values (52-72) along with 0 (inert fibre), 2.5 or 5 g granular PGX® dissolved in 250 ml water ... PGX® significantly reduced the GI of all six foods (P < 0.001), with an average reduction of 19 % for the 2.5 g dose and 30 % for the 5 g dose, equivalent to a reducing the GI by 7 and 15 units, respectively. Consuming small quantities of the novel functional fibre PGX®, mixed with water at the start of a meal, is an effective strategy to reduce the GI of common foods" - See Natural Factors, WellBetX PGX with Mulberry, 180 Capsules at iHerb.

Leukocyte telomere length and physical ability among Danish Twins age 70+ - Mech Ageing Dev. 2011 Oct 12 - "Leukocyte telomere length (LTL) shortens with age and is potentially a biomarker of human aging. We examined the relation of LTL with physical ability and cognitive function in 548 same-sex twins from the Longitudinal Study of Aging Danish Twins ... A random intercept model revealed a positive, significant association between LTL and physical ability. For every unit increase in physical ability score, LTL increased by 0.066kb (p=0.01), equal to approximately three years of age-dependent LTL shortening. A matched case-co-twin design showed that the group consisting of the twins from each pair with the longer LTL also displayed better physical ability (p<0.01). Moreover, the intra-pair difference in LTL was associated with intra-pair difference in physical ability (p<0.01), confirming the association. However, we found no association between cognitive function and LTL. The LTL-physical ability association in the elderly provides further support to the premise that LTL is an index of somatic fitness in the narrow context of human physical health"

Neat Tech Stuff / "How To's":

Health Focus (Resveratrol):

Specific Recommendations:

News & Research:

  • Red wine ingredient resveratrol stops breast cancer growth, study suggests - Science Daily, 9/29/11 - "resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of estrogen ... resveratrol is able to counteract the malignant progression since it inhibits the proliferation of hormone resistant breast cancer cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy ... Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy"
  • Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests, study finds - Science Daily, 9/2/11 - "administering resveratrol to the young offspring of lab rats after weaning actually prevented the development of a metabolic syndrome, which is characterized by glucose intolerance, insulin resistance and higher deposits of abdominal fat"
  • Resveratrol bioavailability boosted by piperine: Study - Nutra USA, 8/16/11 - "Using mice, Prof Ahmad and his co-workers analyzed the level of exposure and maximum blood levels of resveratrol achieved by combining 100 milligrams of resveratrol per kilogram of animal with 10 mg/kg of piperine ... Compared to resveratrol alone, combination with piperine was found to increase the degree of exposure to 229 percent, and the maximum levels in the blood by a whopping 1,544 percent" - [Abstract] - See piperine at Amazon.com.
  • Curry spice could offer treatment hope for tendinitis - Science Daily, 8/9/11 - "Tendons, the tough cords of fibrous connective tissue that join muscles to bones, are essential for movement because they transfer the force of muscle contraction to bones. However, they are prone to injury, particularly in athletes who may overstretch themselves and overuse their joints. Tendinitis (or tendonitis) is a form of tendon inflammation, which causes pain and tenderness near to joints and is particularly common in shoulders, elbows, knees, hips, heels or wrists. Other examples of common tendon disease include tennis and golfer's elbow and Achilles tendinitis ... introducing curcumin in the culture system inhibits NF-kB and prevents it from switching on and promoting further inflammation ... The results follow on from another study by the Nottingham-Munich collaboration, published in the Journal of Biological Chemistry earlier this year, demonstrating that a compound found in red wine could have therapeutic potential for osteoporosis related bone loss in elderly patients, post-menopausal women and patients with rheumatoid arthritis ... The research found that resveratrol, a naturally occurring phytoestrogen found in the skin of red grapes, vines and various other fruits and nuts, inhibits inflammation in bone cells. Its effects extended to inhibiting the formation of osteoclasts, giant congregations of blood-derived cells responsible for bone degeneration, especially in osteoporosis in later life. Resveratrol prevented NF-kB from switching on to trigger inflammation"
  • Red wine: Exercise in a bottle? - Science Daily, 6/30/11 - "a new research study published in the FASEB Journal, suggests that the "healthy" ingredient in red wine, resveratrol, may prevent the negative effects that spaceflight and sedentary lifestyles have on people ... Scientists studied rats that underwent simulated weightlessness by hindlimb tail suspension and were given a daily oral load of resveratrol. The control group showed a decrease in soleus muscle mass and strength, the development of insulin resistance, and a loss of bone mineral density and resistance to breakage. The group receiving resveratrol showed none of these complications ... This study also suggests that resveratrol may be able to prevent the deleterious consequences of sedentary behaviors in humans"
  • Resveratrol studies confirms potential health boost - Science Daily, 6/21/11 - "A comprehensive review of human clinical research on resveratrol has found it has "anti-aging, anti-carcinogenic, anti-inflammatory and antioxidant properties," ...this polyphenol -- an antibiotic substance produced by plants as a defense against microorganisms -- prevents the growth of some cancers in mice, inhibits enzymes that cause inflammation, shrinks tumors and increases blood flow, thus reducing cardiovascular diseases. In many cases, it also extends the life of obese animals. Some evidence also shows that resveratrol could one day be used to help regulate insulin sensitivity in diabetic patients"
  • Study unlocks resveratrol’s fat fighting potential - Nutra USA, 5/11/11 - "It is important to point out that the effective dose in our experimental design, as well as those used by other authors, is far greater than the amount usually ingested by humans (100-930 micrograms per day), meaning that the positive effects of this molecule on body fat would only be achieved by the intake of resveratrol pills or functional foods enriched with this molecule ... resveratrol could activate a gene called sirtuin1 (Sirt1 – the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys ... divided 16 rats into two equal groups ... After six weeks of study, the researchers found that both groups had similar body weight, but that the resveratrol fed animals has significantly lower fat tissue levels"
  • Resveratrol may be useful tool for reducing body fat - Science Daily, 3/4/11 - "This thesis shows, on the one hand, the results obtained after treatment with CLA in hamsters subjected to energy restriction and, on the other, the effect of resveratrol on accumulated fat and lipolytic activity in cell cultures of adipocytes of murinae and humans. The results obtained show that CLA does not foment weight or body fat loss, induced by an energy restriction diet. Neither does it induce greater lipolysis, nor improvement in serum parameters, in glucose homeostasis or insulin function to any greater extent than with the slimming diet itself. On the contrary, resveratrol reduces the accumulation of triglycerides, in part by activation of lipolysis, in both the adipocytes of mice and of humans ... For all these reasons, it can be concluded that, while CLA may not be a molecule useful in treating obesity, when resveratrol is included in hypocaloric diet, it could well be a useful tool for reducing body fat" - See resveratrol products at Amazon.com and conjugated linoleic acid at Amazon.com.
  • Young rats given polyphenols show less endothelial function deterioration with aging - Science Daily, 1/31/11 - "The endothelium is the inner lining of our blood vessels and normal functions of endothelial cells include enabling coagulation, platelet adhesion and immune function. Endothelial dysfunction is associated with reduced anticoagulant properties and the inability of arteries and arterioles to dilate fully ... The gradual decrease in endothelial function over time is a key factor in the development of diseases associated with ageing, especially cardiovascular disease (CVD).  Many epidemiologic studies suggest protection against CVD from moderate intake of alcoholic beverages, especially those rich in antioxidants, such as red wine, which is high in polyphenols (RWPs) ... RWPs and apocynin improved the endothelial dysfunction, normalized oxidative stress and the expression of the different proteins. RWPs also improved ageing-related decline in physical exercise. Thus, intake of RWPs protects against ageing-induced endothelial dysfunction and decline in physical performance ... RWPs intake had also a physiological beneficial effect since it improved the physical exercise capacity of old rats"
  • 'Longevity' protein SIRT1 may ward off precursor to prostate cancer - Science Daily, 1/13/11 - "prostatic intraepithelial neoplasia (PIN) ... deletion of the Sirt1 gene in mice resulted in PIN lesion formation associated with reduced autophagy, which is the necessary degradation of a cell's own components and most likely essential for tumor suppression ... it tells you that this 'longevity' gene is normally blocking prostate cancer" - Note: Resveratrol increases Sirt1:
    • Sirtuin1 may boost memory and learning ability; Discovery could lead to new drugs to fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 - "Resveratrol, found in wine, has been touted as a life-span enhancer because it activates a group of enzymes known as sirtuins, which have gained fame in recent years for their ability to slow the aging process. Now MIT researchers report that Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also promotes memory and brain flexibility ... We have now found that SIRT1 activity also promotes plasticity and memory"
    • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging"
    • Wine Compound Spurs Diabetes Research - WebMD, 11/29/07 - "In October, Chinese researchers reported that resveratrol curbs insulin resistance in mice. Insulin is a hormone that controls blood sugar. Insulin resistance can lead to type 2 diabetes ... Like resveratrol, the lab-made chemicals activate a gene called SIRT1, making the diabetic mice more sensitive to insulin ... the newly developed chemicals are 1,000 times more potent than resveratrol"
  • Resveratrol’s health benefits linked to fat hormone control - Nutra USA, 1/11/11 - "adiponectin has a wide range of beneficial effects on obesity-related medical complications, and noted that both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties" - [Abstract]
  • Resveratrol shows metabolic benefits for obese: Study - Nutra USA, 10/11/10 - "When human fat cells were exposed to IL-1B, the researchers noted increases in the secretion of pro-inflammatory compounds, including IL6, IL8, MCP-1. However, when the cells were simultaneously exposed to resveratrol, a 16 to 36 percent reduction in the expression of these cytokines was observed" - [Abstract]
  • Resveratrol May Slow Aging in Humans - Medscape, 8/6/10 - "the popular plant extract has been shown to prolong life and reduce the rate of aging in roundworms, fruit flies, and yeast, apparently because resveratrol affects a gene associated with longevity ... resveratrol suppressed the generation of “free radicals” -- unstable molecules known to cause oxidative stress and release pro-inflammatory substances into the blood, resulting in damage to the blood vessel lining ... resveratrol also showed suppression of the inflammatory protein tumor necrosis factor, or TNF, and other compounds that increase blood vessel inflammation and interfere with insulin action, causing insulin resistance and the risk of developing diabetes"
  • Resveratrol’s anti-inflammatory power gets human data boost - Nutra USA, 8/3/10 - "The results demonstrated in the research are the first time that such findings have been seen in humans, but are consistent with potential antiatherogenic and antiaging effects of resvertatrol. Concluding that PCE “has a comprehensive suppressive effect on oxidative and inflammatory stress.”" -[Abstract]
  • Plant compound resveratrol shown to suppresses inflammation, free radicals in humans - Science Daily, 7/29/10 - "Resveratrol, a popular plant extract shown to prolong life in yeast and lower animals due to its anti-inflammatory and antioxidant properties, appears also to suppress inflammation in humans ... resveratrol has been shown to prolong life and to reduce the rate of aging in yeast, roundworms and fruit flies, actions thought to be affected by increased expression of a particular gene associated with longevity ... The compound also is thought to play a role in insulin resistance as well, a condition related to oxidative stress, which has a significant detrimental effect on overall health ... resveratrol suppressed the generation of free radicals, or reactive oxygen species, unstable molecules known to cause oxidative stress and release proinflammatory factors into the blood stream, resulting in damage to the blood vessel lining ... Blood samples from persons taking resveratrol also showed suppression of the inflammatory protein tumor necrosis factor (TNF) and other similar compounds that increase inflammation in blood vessels and interfere with insulin action, causing insulin resistance and the risk of developing diabetes"
  • Aging and longevity tied to specific brain region in mice - Science Daily, 7/28/10 - "mice with increased brain SIRT1 have internal mechanisms that make them use energy more efficiently, which helps them move around in search of food even after a long fast. This increased energy-efficiency could help delay aging and extend lifespan ... SIRT1 is at the center of a network that connects metabolism and aging"
  • Sirtuin1 may boost memory and learning ability; Discovery could lead to new drugs to fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 - "Resveratrol, found in wine, has been touted as a life-span enhancer because it activates a group of enzymes known as sirtuins, which have gained fame in recent years for their ability to slow the aging process. Now MIT researchers report that Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also promotes memory and brain flexibility ... We have now found that SIRT1 activity also promotes plasticity and memory"
  • Ingredient in red wine may prevent some blinding diseases - Science Daily, 6/26/10 - "Resveratrol -- found in red wine, grapes, blueberries, peanuts and other plants -- stops out-of-control blood vessel growth in the eye ... There are three major eye diseases that resveratrol treatment may help: age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity"
  • Compound found in red wine neutralizes toxicity of proteins related to Alzheimer's - Science Daily, 6/22/10 - "An organic compound found in red wine -- resveratrol -- has the ability to neutralize the toxic effects of proteins linked to Alzheimer's disease ... this molecule can target some of these packing arrangements that are toxic and rearrange them into packing arrangements that are not toxic. For those forms that are non-toxic, it doesn't change them"
  • Lemurs lose weight with 'life-extending' supplement resveratrol - Science Daily, 6/22/10 - "The anti-obesity properties of resveratrol have been demonstrated for the first time in a primate ... lemurs eating a diet supplemented with the compound decreased their energy intake by 13% and increased their resting metabolic rate by 29% ... a four-week resveratrol supplementation was associated with a decrease in food intake and a reduction in seasonal body-mass gain. The response to resveratrol supplementation also involved significant changes in the animals' body temperatures" - [Nutra USA]
  • Polyphenols in red wine and green tea halt prostate cancer growth, study suggests - Science Daily, 6/9/10 - "The profound impact that the antioxidants in red wine and green tea have on our bodies is more than anyone would have dreamt just 25 years ago," Weissmann added. "As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent 'health foods' we know." - See resveratrol products at Amazon.com and green tea extract at Amazon.com.
  • Chronic colitis patients could benefit from resveratrol, says Spanish study - Nutra USA 5/4/10 - "dietary administration of resveratrol reduced the severity and extension of progressive chronic colonic damage and also significantly counteracted the clinical signs reducing the inflammatory process" - [Abstract]
  • How red wine may shield brain from stroke damage: researchers discover pathway in mice for resveratrol's apparent protective effect - Science Daily, 4/21/10 - "Two hours after feeding mice a single modest dose of resveratrol, a compound found in the skins and seeds of red grapes, the scientists induced an ischemic stroke by essentially cutting off blood supply to the animals' brains. They found that the animals that had preventively ingested the resveratrol suffered significantly less brain damage than the ones that had not been given the compound ... his study suggests that resveratrol increases levels of an enzyme (heme oxygenase) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke"
  • Resveratrol could prove HRT alternative, study - Nutra USA, 11/23/09 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein ... Because it (resveratrol) stimulated the transcription of endogenous estrogen receptor (ER) and proapoptotic effects, this phytoestrogen is the most promising candidate as an HRT alternative and chemopreventive reagent for breast cancer ... The researchers added that their results indicated that daidzein causes a slight cell-stimulating effect in the absence of E2, which may lead to an increased risk of breast cancer in postmenopausal women taking supplements containing these phytoestrogens" - [Abstract] - See resveratrol products at Amazon.com.
  • Click here for Dr. Isadore Rosenfeld on resveratrol on 9/20/09 - 1:32 - Note:  He's recommending 200 mg per day.  See resveratrol products at Amazon.com.  I take two of them, one in the morning and one in the evening.
  • 'Red Wine' Chemical May One Day Treat Diabetes - WebMD, 10/9/09 - "Resveratrol, found in red wine, was found to lower blood sugar levels and improve insulin levels when injected directly into the brains of mice fed very high-calorie diets in a study conducted by researchers at the University of Texas Southwestern Medical Center (UTSW) ... resveratrol does not cross the blood-brain barrier very efficiently"
  • Future Diabetes Treatment May Use Resveratrol To Target The Brain - Science Daily, 10/6/09 - "the brain plays a key role in mediating resveratrol's anti-diabetic actions, potentially paving the way for future orally-delivered diabetes medications that target the brain ... Resveratrol activates sirtuins, a class of proteins that are thought to underlie many of the beneficial effects of calorie restriction"
  • Science: Resveratrol’s miraculous promise - Nutra USA, 9/14/09
  • Study adds to DSM's resveratrol safety rep - Nutra USA, 8/7/09
  • Scientists Uncork Potential Secret Of Red Wine's Health Benefits - Science Daily, 7/30/09 - "researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation. The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective"
  • Red-wine Polyphenol Called Resveratrol Demonstrates Significant Health Benefits - Science Daily, 6/11/09 - "The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more ... Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection ... The simplest explanation is that resveratrol turns on the cell's own survival pathways, preventing damage to individual cells ... Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells ... Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death"
  • Two Glasses Of Wine A Day Helps To Reduce Quantity Of Fat In Liver - Science Daily, 5/12/09 - "Alter four weeks, samples of liver and blood were taken from individuals of the three different groups for their subsequent analysis. It was shown that in the third group - the one treated with resveratrol -, infiltration of liver fat dropped in comparison with group two. After this and a number of other analyses, the researcher concluded that resveratrol reduces the severity of ESNA in models with rats because, in the animals treated with resveratrol, the percentage of the cells of affected liver cells was notably less in non-treated animals"
  • Grape Extracts May Be Effective Against Harmful Gut Bacteria - Science Daily, 3/4/09 - "H. pylori is the bacterial agent most commonly associated with peptic ulcers, gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric cancer ... The antibacterial effects of extracts from red, white, black and muscadine grapes as well as the pure compounds resveratrol, ellagic acid, and myricetin were tested for anti-H. pylori activity using agar dilution, laser scanning microscopy and cell proliferation. Following 24 hour treatment, results showed that muscadine grape skin extract had the highest anti-H. pylori effect, followed by muscadine grape synergy and seed extract. Additionally, two of the three compounds, resveratrol and ellagic acid, also inhibited H. pylori" - See grape seed extract at Amazon.com and resveratrol products at Amazon.com.
  • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging"
  • Scientists Find a Possible Cause of Aging - NYTimes.com, 11/26/08 - "A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health ... Dr. Sinclair has been taking large daily doses of resveratrol since he and others discovered five years ago that it activated sirtuin. “I’m still taking it and I feel great,” he said, “but it’s too early to say if I’m young for my age.""
  • Drug 'tricks body to lose weight' - BBC News, 11/5/08 - "The drug SRT1720 - a chemical cousin of red wine extract resveratrol - targets the protein SIRT1, which is thought to combat ageing ... The French team from the University Louis Pasteur became interested in the SIRT1 protein after earlier studies showing resveratrol countered some effects of a high-calorie diet via SIRT1" - See resveratrol products at Amazon.com.
  • Resveratrol Prevents Fat Accumulation In Livers Of 'Alcoholic' Mice - Science Daily, 10/14/08 - "The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice. The research found that resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and, at the same time, increased the rate at which fat within the liver is broken down" - [WebMD]
  • Red Wine May Lower Lung Cancer Risk - Science Daily, 10/7/08 - "there was on average a two percent lower lung cancer risk associated with each glass of red wine consumed per month ... Red wine is known to contain high levels of antioxidants. There is a compound called resveratrol that is very rich in red wine because it is derived from the grape skin. This compound has shown significant health benefits in preclinical studies" - [WebMD]
  • Plant Antioxidant May Protect Against Radiation Exposure - Science Daily, 9/23/08 - "Resveratrol, the natural antioxidant commonly found in red wine and many plants, may offer protection against radiation exposure ... Currently there are no drugs on the market that protect against or counteract radiation exposure"
  • Resveratrol May Prevent Breast Cancer - WebMD, 7/7/08 - "when the body's system for processing estrogen gets out of balance, dangerous estrogen metabolites appear. These toxic compounds react with DNA in breast cells and jump-start the growth of tumors ... resveratrol decreases the processing of estrogen into these dangerous compounds. Perhaps more importantly, it also blocks interactions between estrogen metabolites and cellular DNA ... And that's not all. Rogan's team finds that resveratrol increases production of an enzyme that destroys dangerous estrogen metabolites" - [Science Daily] - See resveratrol products at Amazon.com.
  • Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle - Science Daily, 7/3/08 - "This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals"
  • Fountain of youth? Red wine gives up secrets - MSNBC, 7/3/08 - "Most of mice given resveratrol did not live longer than other mice but were far more healthy in several important measures"
  • Can Red Wine Help You Live Longer? - WebMD, 6/6/08
  • Red Wine's Resveratrol May Help Battle Obesity - Science Daily, 6/16/08 - "resveratrol inhibited the pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrol hindered fat storage. Most interesting, according to Fischer-Posovszky, was that resveratrol reduced production of certain cytokines (interleukins 6 and 8), substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries. Also, resveratrol stimulated formation of a protein known to decrease the risk of heart attack. Obesity decreases this substance, called adiponectin" - [WebMD]
  • Substance In Red Wine, Resveratrol, Found To Keep Hearts Young - Science Daily, 6/4/08 - "Resveratrol is active in much lower doses than previously thought and mimics a significant fraction of the profile of caloric restriction at the gene expression level ... In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study's authors, were associated with prevention of the decline in heart function associated with aging" - See resveratrol products at Amazon.com.
  • Low-dose resveratrol may slow ageing: for mice at least - Nutra USA, 6/4/08 - "animals in the calorie-restriction and low-dose resveratrol groups had altered gene expression profiles in 90 and 92 per cent, respectively, in the heart ... In short, a glass of wine or food or supplements that contain even small doses of resveratrol are likely to represent "a robust intervention in the retardation of cardiac ageing,"" - See Jarrow Resveratrol 100 at iHerb.
  • Red wine may protect heart from aging’s toll - MSNBC - 6/3/08 - "Resveratrol at low doses can retard some aspects of the aging process, including heart aging, and it may do so by mimicking some of the effects of caloric restriction, which is known to retard aging in several tissues and extend life span"
  • Red Wine Could Benefit Patients With Diabetes - Medscape, 5/16/08 - "New research suggests that resveratrol, a chemical commonly found in red wine, has the ability to lower blood-sugar levels, but it might also produce certain unpleasant adverse effects ... The concern is that you could lower glucose in diabetics but at the same time. . . [lower] glucose levels in the brain or in other important tissues" - Does that last part make sense?  Is there anything that selectively lowers blood-sugar, i. e., lowers the blood without the brain?  And isn't it the high blood sugar in the brain that they believe is the reason the Alzheimer's rate is so high in diabetics?  And isn't it the advance glycation end products that are partly responsible for damage to important tissues?  Sounds like a biased article to me.
  • Mounting Evidence Shows Red Wine Antioxidant Kills Cancer - Science Daily, 3/25/08 - "Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function ... The new study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated with the antioxidant, resveratrol, and irradiated -- the combination induced a type of cell death called apoptosis, an important goal of cancer therapy" - [WebMD]
  • Grape Skin Compound Fights The Complications Of Diabetes - Science Daily, 3/20/08 - "resveratrol, a compound present naturally in grape skin, can protect against the cellular damage to blood vessels caused by high production of glucose in diabetes"
  • Chemical In Red Wine, Fruits And Vegetables Counters Unhealthy Effects Of High-fat Foods - Science Daily, 1/2/08 - "consuming polyphenols (natural compounds in red wine, fruits, and vegetables) simultaneously with high-fat foods may reduce health risks associated with these foods"
  • Wine Compound Spurs Diabetes Research - WebMD, 11/29/07 - "In October, Chinese researchers reported that resveratrol curbs insulin resistance in mice. Insulin is a hormone that controls blood sugar. Insulin resistance can lead to type 2 diabetes ... Like resveratrol, the lab-made chemicals activate a gene called SIRT1, making the diabetic mice more sensitive to insulin ... the newly developed chemicals are 1,000 times more potent than resveratrol"
  • Report: Two resveratrol supplements mislabeled - USATODAY.com, 11/14/07 - "Life Extension Resveratrol Caps are supposed to contain 20 milligrams of resveratrol per capsule but have about 5 milligrams, the report says. Resvert, distributed by SupplementSpot (formerly known as Young Again Nutrients), had only 58% of its promised 25 milligrams of resveratrol per capsule"
  • Resveratrol review - ConsumerLab.com, 11/13/07 - "But ConsumerLab.com found two supplements to provide only 27% and 58% of their listed amounts of resveratrol. A third product boasted several hundred milligrams of a red wine grape complex but actually contained only two milligrams of resveratrol. Across thirteen products, daily doses ranged from just 1 milligram to as much as 1,000 milligrams of resveratrol. Prices ranged several fold" - Note:  I get the paid version and Life Extension® Resveratrol Caps and Resvert™ 100 mg proanthrocyanadins with 25 mg resveratrol were not approved. Jarrow Resveratrol 100™ is what I take and it was approved.
  • Red Wine And Grape Juice Help Defend Against Food-borne Diseases, Study Suggests - Science Daily, 10/11/07
  • Red Wine Compound May Curb Diabetes - WebMD, 10/2/07 - "Resveratrol curbs insulin resistance in mice ... According to our findings, people might need to drink about three liters of red wine each day to get sufficient resveratrol -- about 15 milligrams -- for its biological effects"
  • Red Wine Compound Shown To Prevent Prostate Cancer - Science Daily, 8/31/07 - "n the study resveratrol-fed mice showed an 87 percent reduction in their risk of developing prostate tumors that contained the worst kind of cancer-staging diagnosis ... Other mice in the study, those fed resveratrol but still developed a less-serious form of prostate cancer, were 48 percent more likely to have their tumor growth halted or slowed when compared to mice who did not consume the compound ... A cancer prevention researcher lives for these days when they can make that kind of finding" - See resveratrol products at iHerb.
  • Red Wine Protects The Prostate - Science Daily, 5/25/07 - "men who drink an average of four to seven glasses of red wine per week are only 52% as likely to be diagnosed with prostate cancer as those who do not drink red wine ... when white wine was compared with red, red had the most benefit ... But much of the speculation focuses on chemicals—including various flavonoids and resveratrol—missing from other alcoholic beverages"
  • Resveratrol Content Varies Among Red Wines - Science Daily, 4/19/07
  • Life-extending compound may be great news -- for mice - CNN, 12/21/06 - "In one study, scientists provided mice a high-calorie, high-fat diet and then gave half of the animals resveratrol. At 114 weeks -- old age for mice -- less than a third of the mice taking resveratrol died. More than half of the mice who did not take resveratrol died. In another study, mice who took resveratrol lost weight, increased metabolism and doubled their exercise endurance"
  • Resveratrol could counter metabolic diseases, animal study - Nutra USA, 12/15/06
  • Review Article: Resveratrol - Consumerlab.com, 11/30/06
  • Red Wine Ingredient Increases Endurance, Study Shows - New York Times, 11/16/06 - "Resveratrol makes you look like a trained athlete without the training"
  • Healthy Life Prolonged in Mice - Medscape, 11/3/06 - "In addition to extending their lives, resveratrol also kept the mice fit and healthy in their old age"
  • Wine Ingredient May Nix Fat's Effects - WebMD, 11/1/06 - "A new study shows obese, middle-aged mice fed a fatty diet supplemented with resveratrol, an antioxidant found in red wine, seemed to be spared most of the unhealthy effects of their extra weight and lived longer than those fed the same fat-laden diet without resveratrol"
  • One for the Ages: A Prescription That May Extend Life - New York Times, 10/31/06 - "One leading candidate, a newly synthesized form of resveratrol — an antioxidant present in large amounts in red wine — is already being tested in patients. It may eventually be the first of a new class of anti-aging drugs. Extrapolating from recent animal findings, Dr. Richard A. Miller, a pathologist at the University of Michigan, estimated that a pill mimicking the effects of calorie restriction might increase human life span to about 112 healthy years"
  • Red Wine vs. Colon Cancer - WebMD, 10/24/06 - "3% of red wine drinkers had such abnormal growths, compared with nearly 9% of white wine drinkers and almost 10% of teetotalers ... they suggest that a compound found in grapes and red wine – the antioxidant resveratrol -- may cut the odds of getting abnormal colon growths that can become cancerous"
  • Resveratrol in red wine could cut colorectal cancer risk - Nutra USA, 10/23/06 - "Drinking more than three glasses of red wine a week could cut the risk of colorectal cancer by almost 70 per cent ... the active component in wine that may be behind the apparent benefits is most likely resveratrol"
  • Longevity Genes and Caloric restriction - Life Extension Magazine, 7/06 - "Humans seeking to slow aging and reduce degenerative disease risk may consider reducing food intake and ingesting 20-40 mg of resveratrol and 250-850 mg of metformin each day"
  • Red Wine Ingredient May Delay Aging - WebMD, 2/10/06 - "Researchers found adding resveratrol, an organic compound found in grapes and particularly in red wine, to the daily diet of short-lived fish prolonged their lifespan and delayed the onset of age-related memory and other problems"
  • Natural Compound Prolongs Lifespan And Delays Onset Of Aging-related Traits In A Short-lived Vertebrate - Science Daily, 2/7/06 - "The researchers added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance"
  • Compound In Wine Reduces Levels Of Alzheimer's Disease-causing Peptides - Science Daily, 11/4/05 - "resveratrol, a compound found in grapes and red wine, lowers the levels of the amyloid-beta peptides which cause the telltale senile plaques of Alzheimer's disease ... Resveratrol in grapes may never reach the concentrations required to obtain the effect observed in our studies"
  • Resveratrol could prevent ‘flu epidemics - Nutra USA, 5/24/05
  • Red Wine Lovers, Take Heart: More Evidence Points To The Drink's Cardiac Health Benefits - Science Daily, 12/10/04 - "a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis"
  • Resveratrol linked to longer life - Nutra USA, 7/19/04
  • Daily Glass of Red Wine May Cut Risk of Developing Prostate Cancer - Doctor's Guide, 9/23/04 - "men who consumed four or more glasses of red wine per week reduced their risk of prostate cancer by 50 percent ... That compound, Stanford and colleagues believe, may be an antioxidant called resveratrol, which is abundant in the skins of red grapes but much less so in the skins of white grapes"
  • Does red wine hold the secret to long life? - MSNBC, 7/15/04 - "resveratrol acted on fruit flies and worms in the same way as a method known to extend the life of animals ... We found this chemical that can extend the life span of every organism we give it to"
  • Study Identifies Genetics Of Fat Metabolism, Red Wine Link - Science Daily, 7/9/04 - "When cells were exposed to resveratrol, our studies showed a pretty dramatic reduction in the conversion to fat cells and a lesser but still significant increase in the mobilization of existing fat, or the rate at which the cells metabolized stored fat"
  • Fruits Offer Powerful Protection From Skin Cancer - Intelihealth, 10/30/03 - "Resveratrol significantly inhibited UVB-mediated increases in skin thickness and edema; epidermal cyclooxygenase (COX-2); ornithine decarboxylase (ODC) enzyme and protein levels; and protein levels of proliferating cell nuclear antigen (PCNA), all of which are established markers of tumor promotion. Resveratrol also further stimulated a UVB-mediated increase in p53 protein levels and was found to inhibit UVB exposure-mediated increases in cell cycle promoting signals including the activation of cell division"
  • Red Wine Ingredient May Fight COPD - WebMD, 10/27/03 - "resveratrol, a compound found in the skins of red fruits such as grapes, may slow down the inflammatory process involved in the lung disease COPD (chronic obstructive pulmonary disease)"
  • “Grape Expectations”: Lengthen Lifetime with Red Wine? - Physician's Weekly, 9/15/03 - "Resveratrol, a molecule that exists naturally in grapes and red wine, was shown to extend the life span of yeast cells (polyphenols) by up to 80%. The researchers plan to examine resveratrol's effect in multi-cellular organisms such as worms, fruit flies, and eventually humans"
  • Drinking Red Wine May Slow Aging - WebMD, 8/25/03 - "resveratrol mimics calorie restriction in yeast -- activating enzymes that slow aging, increasing the stability of DNA, hence extending lifespan by as much as 70% ... Researchers now hope to eventually test how resveratrol works in other subjects, including humans"

Abstracts:

  • Low-Dose Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in Adiponectin Knockout and Wild-Type Mice - Nutr Cancer. 2011 Sep 29 - "Obesity is associated with a decrease in the antiinflammatory hormone, adiponectin, and increases in the circulating concentrations of multiple proinflammatory cytokines. These changes contribute to colon tumorigenesis. Resveratrol increases adiponectin production in adipocytes and attenuates the development of colon cancer. Thus, we hypothesized that adiponectin is an integral component of the mechanism by which resveratrol antagonizes colorectal tumorigenesis. To investigate this, we induced tumorigenesis in adiponectin knockout (KO) and wild-type (Wt) C57BL/6 mice through combined azoxymethane and dextran sodium sulfate treatment during which mice were fed a high-fat, lard-based diet, or the same diet containing 20 mg/kg resveratrol. After 14 wk on diet, Wt mice gained more weight and, on a percentage basis, had higher fat mass and lower lean mass than KO mice. Resveratrol tended to attenuate this response in male Wt mice. Resveratrol also tended to reduce aberrant crypt foci development and decrease circulating interleukin 6 and insulin concentrations in male but not female Wt mice. Taken together, resveratrol improved overall health of obese Wt but not KO mice as hypothesized with a differential sex response"
  • Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells - Br J Nutr. 2011 Jul 27:1-7 - "Repeated treatment with resveratrol for 5 d resulted in an increase in endothelial NO synthase (eNOS) protein content and NO production in human umbilical vein endothelial cell (HUVEC) in a concentration-dependent manner. A significant increase in functional eNOS protein content was observed with resveratrol, even at 50 nm. In contrast, eNOS phosphorylation was not stimulated and inducible NO synthase (iNOS) was not detected after resveratrol treatment. Both eNOS protein and mRNA expression were promoted by 50 nm-resveratrol in a time-dependent manner. Increased eNOS mRNA expression in response to resveratrol was not decreased by an oestrogen receptor (ER) antagonist ICI182780, a PPARα inhibitor MK886 or a sirtuin inhibitor Salermide. However, a combination of ICI182780 and MK886 significantly inhibited resveratrol-induced eNOS mRNA expression. Salermide had no effect even in the presence of ICI182780 or MK886. These results demonstrate that resveratrol within the physiological range increases eNOS mRNA and protein expression through ER and PPARα activation, thereby promoting NO production in endothelial cells. eNOS induction might result from the accumulative effect of nanomolar concentrations of resveratrol. The present study results can account in part for the observation that cardiovascular benefits of red wine are experienced with routine consumption, but not with acute consumption"
  • Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress - Br J Nutr. 2011 Jun 28:1-9 - "Resveratrol reduced liver weight and TAG content. It did not modify the activity of lipogenic enzymes but it did increase CPT-Ia and ACO activities. NEFA and ALP were reduced in both resveratrol-treated groups. AST/GOT was reduced only by the lowest dose. ALT/GPT, TAG and adiponectin remained unchanged. Resveratrol reduced liver oxidative stress. This study demonstrates that resveratrol can protect the liver from NAFLD by reducing fatty acid availability. Moreover, resveratrol also protects liver from oxidative stress"
  • Resveratrol Induces p53-Independent, XIAP-Mediated Bax Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation - J Biol Chem. 2011 Jun 28 - "Together, our findings characterize the molecular mechanisms of resveratrol-induced caspase activation, and subsequent apoptosis in cancer cells"
  • Resveratrol promotes osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis - J Bone Miner Res. 2011 Jun 28 - "Taken together, our results describe a novel mechanism of resveratrol on promoting osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis"
  • Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells - Cancer Lett. 2011 Jun 15 - "Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL"
  • Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo - Nutr Cancer. 2011 Jun 8:1 - "The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα, and IL-1. These cytokines interact with their cognate receptors on muscle to activate the downstream transcription factor NF-κB and induce sarcomere proteolysis. Experimentally, inhibiting NF-κB signaling largely prevents cancer-induced muscle wasting, indicating its prominent role in muscle atrophy. Resveratrol, a natural phytoalexin found in the skin of grapes, has recently been shown to inhibit NF-κB in cancer cells, which led us to hypothesize that it might have a protective role in cancer cachexia. Therefore, we investigated whether daily oral resveratrol could protect against skeletal muscle loss and cardiac atrophy in an established mouse model. We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-κB (p65) activity in skeletal muscle and heart. These studies demonstrate for the first time the utility of oral resveratrol therapy to provide clinical benefit in cancer-induced atrophy through the inhibition of NF-κB in muscle. These findings may have application in the treatment of diseases with parallel pathophysiologies such as muscular dystrophy and heart failure"
  • Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells - Nutr Cancer. 2011 Apr 14:1 - "There were synergistic cytotoxic and apoptotic effects of resveratrol with coadministration of C8:ceramide, PDMP, and SK-1 inhibitor. Interestingly, there were also significant increases in expression levels of LASS genes and decreases in expression levels of GCS and SK-1 in K562 cells in response to resveratrol. Our data, in total, showed for the first time that resveratrol might kill CML cells through increasing intracellular generation and accumulation of apoptotic ceramides"
  • A Dietary Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E and C Reduces Atherosclerosis in Transgenic Mice - J Nutr. 2011 Mar 16 - "Chronic inflammation and proatherogenic lipids are important risk factors of cardiovascular disease (CVD). Specific dietary constituents such as polyphenols and fish oils may improve cardiovascular risk factors and may have a beneficial effect on disease outcomes ... AIDM was evaluated in an inflammation model, male human C-reactive protein (CRP) transgenic mice, and an atherosclerosis model, female ApoE*3Leiden transgenic mice. Two groups of male human-CRP transgenic mice were fed AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 6 wk. The effects of AIDM on basal and IL-1β-stimulated CRP expression were investigated. AIDM reduced cytokine-induced human CRP and fibrinogen expression in human-CRP transgenic mice. In the atherosclerosis study, 2 groups of female ApoE*3Leiden transgenic mice were fed an atherogenic diet supplemented with AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 16 wk. AIDM strongly reduced plasma cholesterol, TG, and serum amyloid A concentrations compared with placebo. Importantly, long-term treatment of ApoE*3Leiden mice with AIDM markedly reduced the development of atherosclerosis by 96% compared with placebo. The effect on atherosclerosis was paralleled by a reduced expression of the vascular inflammation markers and adhesion molecules inter-cellular adhesion molecule-1 and E-selectin. Dietary supplementation of AIDM improves lipid and inflammatory risk factors of CVD and strongly reduces atherosclerotic lesion development in female transgenic mice" - See resveratrol products at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com, Jarrow Formulas, CarotenALL at Amazon.com, green tea extract at Amazon.com and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients - Br J Nutr. 2011 Mar 9:1-7 - "After an initial general examination (including blood chemistry), nineteen patients enrolled in the 4-week-long double-blind study were randomly assigned into two groups: a resveratrol group receiving oral 2 × 5 mg resveratrol and a control group receiving placebo. Before and after the second and fourth weeks of the trial, insulin resistance/sensitivity, creatinine-normalised ortho-tyrosine level in urine samples (as a measure of oxidative stress), incretin levels and phosphorylated protein kinase B (pAkt):protein kinase B (Akt) ratio in platelets were assessed and statistically analysed. After the fourth week, resveratrol significantly decreased insulin resistance (homeostasis model of assessment for insulin resistance) and urinary ortho-tyrosine excretion, while it increased the pAkt:Akt ratio in platelets. On the other hand, it had no effect on parameters that relate to β-cell function (i.e. homeostasis model of assessment of β-cell function). The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway"
  • Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells - Biol Pharm Bull. 2011;34(3):354-9 - "Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially the hippocampus, in chronic fatigue syndrome (CFS) patients. However, its pathophysiologic mechanisms are unclear in part due to the lack of an applicable animal model. We established a chronic fatigue murine model by six repeated injections of Brucella abortus antigen to mice, which was manifested as reduced daily running activity and hippocampal atrophy. Thereafter, resveratrol, a polyphenolic activator of sirtuin 1, was used for treatment in this model. Daily running activity was increased by more than 20%, and the hippocampus was enlarged after 4-week resveratrol therapy. Furthermore, resveratrol inhibited neuronal apoptosis and expression of hippocampal acetylated p53 in the fatigue mice. Resveratrol also improved neurogenesis and expression of brain-derived neurotrophic factor mRNA in the hippocamous. We concluded that repeated injection of B. abortus antigen could induce hypoactivity and hippocampal atrophy in mice. Resveratrol may be effective for improving fatigue symptoms and enlarging the atrophic hippocampus by repressing apoptosis and promoting neurogenesis"
  • Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway - J Agric Food Chem. 2011 Feb 28 - "Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously, resveratrol (RS) and pterostilbene (PS) had been reported to prevent chemical-induced colon carcinogenesis by anti-inflammatory and pro-apoptotic properties ... Administrations of PS can be more effective than RS in reducing AOM-induced formation of aberrant crypt foci (ACF), lymphoid nodules (LNs), and tumors. We also find that PS is functioning more effectively than RS to reduce nuclear factor-κB (NF-κB) activation by inhibiting the phosphorylation of protein kinase C-β2 (PKC-β2) and decreasing downstream target gene expression, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and aldose reductase (AR) in mouse colon stimulated by AOM. Moreover, administration of RS and PS for 6 weeks significantly enhanced expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR), via activation of NF-E2-related factor 2 (Nrf2) signaling. When the above findings are taken together, they suggest that both stilbenes block cellular inflammation and oxidative stress through induction of HO-1 and GR, thereby preventing AOM-induced colon carcinogenesis. In comparison, PS was a more potent chemopreventive agent than RS for the prevention of colon cancer. This is also the first study to demonstrate that PS is a Nrf2 inducer and AR inhibitor in the AOM-treated colon carcinogenesis model" - See pterostilbene at iHerb.
  • A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal - J Clin Endocrinol Metab. 2011 Feb 2 - "High-fat, high-carbohydrate (HFHC) meals are known to induce oxidative and inflammatory stress, an increase in plasma endotoxin concentrations, and an increase in the expression of suppressor of cytokine signaling-3 (SOCS-3) ... A supplement containing resveratrol and muscadine polyphenols suppresses the increase in oxidative stress, lipopolysaccharide and LBP concentrations, and expression of TLR-4, CD14, IL-1β and SOCS-3 in mononuclear cells after an HFHC meal. It also stimulates specific Nrf-2 activity and induces the expression of the related antioxidant genes, NQO-1 and GST-P1. These results demonstrate the acute antioxidant and antiinflammatory effects of resveratrol and polyphenolic compounds in humans in the postprandial state"
  • RESVERATROL-MEDIATED SIRT-1 INTERACTIONS WITH P300 MODULATE RANKL-ACTIVATION OF NF-kappaB SIGNALING AND INHIBIT OSTEOCLASTOGENESIS IN BONE-DERIVED CELLS - J Biol Chem. 2011 Jan 14 - "Resveratrol is a polyphenolic phyto-estrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activity result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis (RA) and osteoporosis. Receptor activator of NF-kappaB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study we investigated the effects of resveratrol on RANKL during bone morphogenesis in high-density bone cultures in vitro ... Treatment with RANKL induced formation of TRAP positive multinucleated cells that exhibited morphological features of osteoclasts. RANKL induced NF-kappaB activation, whereas pre-treatment with resveratrol completely inhibited this activation, suppressed the activation of IkappaBα kinase, IkappaBα phosphorylation and degradation ... Resveratrol inhibited RANKL-induced acetylation and nuclear translocation of NF-kappaB in a time and concentration dependent manner. In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and pre-osteoblastic cells, leading to deacetylation of RANKL-induced NF-kappaB, inhibition of NF-kappaB transcriptional activation and osteoclastogenesis. Co-treatment with resveratrol activated the bone transcription factor Cbfa-1, Sirt-1 and induced the formation of Sirt-1/Cbfa-1-complexes. Overall, these results demonstrate that resveratrol-activated Sirt-1 plays pivotal roles in regulating the balance between osteoclastic versus osteoblastic activity result in bone formation in vitro thereby highlighting its therapeutic potential for treating osteoporosis and RA-related bone loss"
  • Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L - J Biol Chem. 2011 Jan 7 - "RSV promotes adiponectin multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. In addition, we show that the stimulatory effect of RSV is regulated by both the Akt/FOXO1 and the AMPK signaling pathways. Last, we show that DsbA-L plays a critical role in the promoting effect of RSV on adiponectin multimerization and cellular levels"
  • Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling - Cancer Lett. 2010 Dec 16 - "The anti-tumor activity of rapamycin is compromised by the feedback-loop-relevant hyperactive PI3K and ERK-MAPK pathway signaling. In breast cancer cells treated with rapamycin, we observed a moderate increase of AKT phosphorylation (P-AKT) in a rapamycin resistant cell line, MDA-MB-231, as well as a slight increase of P-AKT in a rapamycin sensitive cell line, MCF-7. We found that resveratrol, a natural phytoalexin, suppressed the phosphorylation and activation of the PI3K/AKT pathway in all the three breast cancer cell lines that we tested. It also had a weak inhibitory effect on the activation of the mTOR/p70S6K pathway in two cell lines expressing wildtype PTEN, MCF-7 and MDA-MB-231. The combined use of resveratrol and rapamycin resulted in modest additive inhibitory effects on the growth of breast cancer cells, mainly through suppressing rapamycin-induced AKT activation"
  • Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through Sirt1 dependent mechanism - J Biol Chem. 2010 Dec 16 - "Resveratrol, a polyphenol compound, is known for its effects on energy homeostasis. With properties of energy sensors mediating effects of calorie restriction, sirtuins are targets of resveratrol ... Resveratrol markedly enhanced the glucose response of INS-1E cells and human islets, even after removal of the compound from the medium. These effects were mediated by and fully dependent on active Sirt1, defining a new role for Sirt1 in the regulation of insulin secretion"
  • Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver - Biochem Biophys Res Commun. 2010 Nov 12 - "Our results indicate that resveratrol upregulates the expression of gluconeogenic genes by attenuating insulin signaling and by deacetylating FOXO1, which are SIRT1-independent in the cytosol and SIRT1-dependent in the nucleus, respectively"
  • Resveratrol Protects against Oxidized LDL-Induced Breakage of the Blood-Brain Barrier by Lessening Disruption of Tight Junctions and Apoptotic Insults to Mouse Cerebrovascular Endothelial Cells - J Nutr. 2010 Oct 27 - "Cerebrovascular endothelial cells (CEC) ... Exposure of mouse CEC to 200 μmol/L oxLDL for 1 h did not cause cell death but significantly altered the permeability and transendothelial electrical resistance of the cell monolayer. However, resveratrol completely normalized such injury. As for the mechanisms, resveratrol completely protected oxLDL-induced disruption of F-actin and microtubule cytoskeletons as well as occludin and zona occludens-1 (ZO-1) tight junctions. The oxLDL-induced decreases in the mitochondrial membrane potential and intracellular ATP levels were normalized by resveratrol. Exposure of mouse CEC to 200 μmol/L oxLDL for 24 h elevated oxidative stress and simultaneously induced cell apoptosis. However, resveratrol partially protected against oxLDL-induced CEC apoptosis. The oxLDL-induced alterations in levels of Bcl-2, Bax, and cytochrome c were completely normalized by resveratrol. Consequently, resveratrol partially decreased oxLDL-induced activation of caspases-9 and -3. Therefore, in this study, we show that resveratrol can protect against oxLDL-induced damage of the BBB through protecting disruption of the tight junction structure and apoptotic insults to CEC"
  • Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes - Am J Clin Nutr. 2010 Oct 13 - "These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-α-mediated inflammation and insulin resistance in primary human adipocytes" - See quercetin at Amazon.com.
  • Dietary polyphenols: Focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis - Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):618-25 - "Plants continuously produce an extraordinary variety of biologically active low-molecular-mass compounds. Among them, resveratrol (3,5,4'-trihydroxystilbene) is endowed with significant positive activities by protecting against cardiovascular diseases and preventing the development and progression of atherosclerosis. Furthermore, the molecule significantly ameliorates glucose homeostasis in obese mice. These beneficial effects have driven considerable interest towards resveratrol molecular activities, and intensive efforts for the identification of the stilbene targets have been made. The molecule shows a pleiotropic mode of action. Particularly, its cellular targets are crucial for cell proliferation and differentiation, apoptosis, antioxidant defence and mitochondrial energy production. The complexity of resveratrol activities might account for its effectiveness in ameliorating multifactorial processes, including the onset and/or progression of several degenerative diseases such as myocardial infarction, atherosclerosis and type 2 diabetes"
  • Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR - J Biol Chem. 2010 Sep 17 - "Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert anti-oxidant, anti-inflammatory, and neuroprotective properties. However, how RSV exerts its beneficial health effects remains largely unknown. Here we show that RSV inhibits insulin- and leucine-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1-independent mechanism ... Taken together, our studies reveal that RSV inhibits leucine-stimulated mTORC1 activation by promoting mTOR/DEPTOR interaction and thus uncover a novel mechanism by which RSV negatively regulates mTOR activity"
  • Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia - Circulation. 2010 Sep 14;122(11 Suppl):S142-9 - "hypercholesterolemic diet with supplemental resveratrol (100 mg/kg/d orally, HCRV ... Total cholesterol was lowered about 30% in HCRV animals (P<0.001). Regional wall motion analysis demonstrated a significant decrease in inferolateral function from baseline to 7 weeks in HCC swine (P=0.04). There was no significant change in regional function in HCRV swine from baseline to 7 weeks (P=0.32). Tissue blood flow during stress was 2.8-fold greater in HCRV swine when compared with HCC swine (P=0.04). Endothelium-dependent microvascular relaxation response to Substance P was diminished in HCC swine, which was rescued by resveratrol treatment (P=0.004). Capillary density (PECAM-1 staining) demonstrated fewer capillaries in both HCC and HCRV swine versus control swine (P=0.02). Immunoblot analysis demonstrated significantly greater expression in HCRV versus HCC swine of the following markers of angiogenesis: VEGF (P=0.002), peNOS (ser1177) (P=0.04), NFkB (P=0.004), and pAkt (thr308) (P=0.001) ... Supplemental resveratrol attenuates regional wall motion abnormalities, improves myocardial perfusion in the collateral dependent region, preserves endothelium-dependent coronary vessel function, and upregulates markers of angiogenesis associated with the VEGF signaling pathway"
  • Resveratrol prevents RANKL induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production - Biochem Biophys Res Commun. 2010 Sep 16 - "The bone protective effects of resveratrol have been demonstrated in several osteoporosis models while the underlying mechanism is largely unclear ... We postulate that the direct inhibitory effects of resveratrol on osteoclastogenesis are mediated via inhibition of ROS generation"
  • Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients - Cancer Res. 2010 Sep 14 - "Consumption of resveratrol reduced tumor cell proliferation by 5% (P = 0.05). The results suggest that daily p.o. doses of resveratrol at 0.5 or 1.0 g produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects. Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent"
  • Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome? - Curr Opin Clin Nutr Metab Care. 2010 Sep 4 - "Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome"
  • Resveratrol differentially modulates inflammatory responses of microglia and astrocytes - J Neuroinflammation. 2010 Aug 17;7(1):46 - "These results suggest that murine microglia and astrocytes produce proinflammatory cytokines and NO in response to LPS in a similar pattern with some differences in signaling molecules involved, and further suggest that resveratrol exerts anti-inflammatory effects in microglia and astrocytes by inhibiting different proinflammatory cytokines and key signaling molecules"
  • An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol - J Clin Endocrinol Metab. 2010 Jun 9 - "The extract induced a significant reduction in reactive oxygen species generation, the expression of p47(phox), intranuclear nuclear factor-kappaB binding, and the expression of jun-N-terminal kinase-1, inhibitor of kappaB-kinase-beta, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo. Conclusions: The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress"
  • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure - Nutr Metab Cardiovasc Dis. 2010 Jul 29 - "Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD ... One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration"
  • Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat - Am J Hypertens. 2010 Jul 29 - "The ability of resveratrol to limit the increase in compliance of SHR arteries is likely related to inhibitory effects on remodeling and pro-growth ERK signaling rather than blood pressure or arterial wall component stiffness"
  • Anti-atherogenic effects of resveratrol - Eur J Clin Nutr. 2010 May 19 - "RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates alpha-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD"
  • Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner - Am J Clin Nutr. 2010 May 12 - "Taken together, our data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. Thus, our findings open up the new perspective that resveratrol-induced intracellular pathways could be a target for prevention or treatment of obesity-associated endocrine and metabolic adverse effects"
  • Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice - Eur J Pharmacol. 2010 May 10;633(1-3):78-84 - "Our results demonstrated that resveratrol group significantly attenuated the clinical signs such as loss of body weight, diarrhea and rectal bleeding improving results from disease activity index and inflammatory score. Moreover, the totality of resveratrol-fed animals survived and finished the treatment while animals fed with standard diet showed a mortality of 40%. Three weeks after DSS removal, the polyphenol caused substantial reductions of the rise of pro-inflammatory cytokines, TNF-alpha and IL-1beta and an increase of the anti-inflammatory cytokine IL-10. Also resveratrol reduced prostaglandin E synthase-1 (PGES-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins expression, via downregulation of p38, a mitogen-activated protein kinases (MAPK) signal pathway. We conclude that resveratrol diet represents a novel approach to the treatment of chronic intestinal inflammation"
  • Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants - Int J Obes (Lond). 2010 Jun 8 - "This study is the first to show anti-inflammatory effects of RSV on adipokine expression and secretion in human adipose tissue in vitro through the SIRT1 pathway. Thus, RSV is hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity"
  • Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by l-arginine - Br J Pharmacol. 2010 Jan 8 - "Although resveratrol is currently being evaluated in pre-clinical studies as a potential cancer chemopreventive agent and cardiovascular stress-releasing compound, treatment with resveratrol severely delays healing of pre-existing gastric ulcers. Resveratrol treatment can also induce endothelial NOS (eNOS) expression ... Resveratrol significantly aggravated damage from indomethacin-induced gastric ulcers, and delayed healing, as shown by increased DS and MPO activity. The mRNA for cyclooxygenase (COX)-1, but not that for COX-2, was inhibited by resveratrol treatment, with reduced synthesis of PGE(2) by gastric tissue. However, resveratrol treatment induced eNOS gene expression and shifted the eNOS/iNOS balance. l-Arginine given before resveratrol in mice with indomethacin-induced ulcers significantly increased tissue NO synthesis and improved ulcer healing" - See L-arginine products at Amazon.com.
  • Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure - Am J Hypertens. 2009 Nov 26 - "Resveratrol treatment significantly prevented the development of concentric hypertrophy, and systolic and diastolic dysfunction in SHR without lowering blood pressure. Resveratrol also significantly reduced the oxidative stress levels of cardiac tissue in SHR.ConclusionsResveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR. The cardioprotective effect of resveratrol in SHR may be partially mediated by a reduction in oxidative stress. Thus, resveratrol may have potential in preventing cardiac impairment in patients with essential hypertension"
  • Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases"
  • Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells - J Nutr Biochem. 2009 Oct 2 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein. Moreover, resveratrol significantly enhanced p53-dependent transcriptional activity, but slightly reduced NF-kappaB-dependent transcriptional activity. On knockdown analysis, genistein, resveratrol and glycitein all reduced the Bcl-2/Bax ratio in the presence of apoptosis-inducing stimuli, and estrogen receptor (ER) alpha silencing had no effect on these reductions. In contrast, in the absence of apoptosis-inducing stimuli, only resveratrol reduced the ratio, and ERalpha silencing abolished this reduction. Thus, resveratrol might be the most promising candidate for HRT and chemoprevention of breast cancer due to its estrogenic activity and high antitumor activity" - See resveratrol products at Amazon.com.
  • Effect of resveratrol on helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells - Biol Pharm Bull. 2009 Nov;32(11):1931-5 - "preincubation of the cells with 75 and 100 muM of resveratrol significantly (p<0.05 and p<0.01 respectively) inhibited the secretion of IL-8 from H. pylori-infected cells. In addition, resveratrol pretreatment at 1-100 muM suppressed H. pylori-induced ROS generation in a concentration dependent manner. Moreover, H. pylori-initiated morphological changes were markedly blocked by resveratrol. Hence, resveratrol can be considered as a potential candidate against various H. pylori related gastric pathogenic processes" - See resveratrol products at Amazon.com.
  • Curcumin synergizes with resveratrol to inhibit colon cancer - Nutr Cancer. 2009;61(4):544-53 - "the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer"
  • The red wine polyphenol resveratrol reduces polycyclic aromatic hydrocarbon-induced DNA damage in MCF-10A cells - Br J Nutr. 2009 Oct 8:1-7 - "In summary, resveratrol might protect breast cells against PAH-induced DNA damage. The underlying mechanism was mediated by phase I enzyme suppression rather than phase II enzyme induction or oxidative DNA repair"
  • Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex - Int J Cancer. 2009 Oct 6 - "Our study identifies MTA1 as a new molecular target of Res that may have important clinical applications for PCa chemoprevention and therapy, and points to the combination of Res with HDAC inhibitors as an innovative therapeutic strategy for the treatment of PCa"
  • Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase - Biochem Biophys Res Commun. 2009 Aug 7 - "Endothelial dysfunction secondary to persistent hyperglycemia plays a key role in the development of type 2 diabetic vascular disease ... These results provide new insight into the protective properties of resveratrol against endothelial dysfunction caused by high glucose, which is attributed to the AMPK mediated reduction of superoxide level" - Click here for a definition of endothelial dysfunction.
  • Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats - Hypertension. 2009 Jul 13 - "Pulmonary hypertension was associated with an upregulation of NAD(P)H oxidase in small pulmonary arteries, which was significantly attenuated by resveratrol treatment. Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension"
  • A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux - Atherosclerosis. 2009 May 22 - "Resveratrol thus appears to be a natural antioxidant that enhances cholesterol efflux. These properties make it a potential natural antioxidant that could be used to prevent and treat CVD"
  • Resveratrol Alters Proliferative Responses and Apoptosis in Human Activated B Lymphocytes in Vitro - J Nutr. 2009 Jun 23 - "These data show that human B lymphocyte proliferation and apoptosis are modified by physiological concentrations of resveratrol and suggest that exposure of human B cells to resveratrol may increase survival by upregulating Bcl-2" - See resveratrol products at Amazon.com.
  • Resveratrol Enhances Ultraviolet B-Induced Cell Death through Nuclear Factor-kappa B Pathway in Human Epidermoid Carcinoma A431 Cells - Biochem Biophys Res Commun. 2009 Apr 24 - "In conclusion, our study demonstrates that the combination of resveratrol and UVB act synergistically against skin cancer cells. Thus, resveratrol is a potential chemotherapeutic agent against skin carcinogenesis"
  • Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis - Hypertens Res. 2009 Apr 17 - "Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol"
  • Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1 - Circulation. 2009 Mar 16 - "Our data identify a molecular mechanism in the cardiomyocyte involving the oxidative stress-derived lipid peroxidation byproduct HNE and the LKB1/AMPK signaling pathway that contributes to the development of left ventricular hypertrophy. We also suggest that resveratrol may be a potential therapy for patients at risk for developing pathological cardiac hypertrophy by preventing this prohypertrophic process" - See resveratrol products at Amazon.com.
  • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway - Biochem Biophys Res Commun. 2009 Mar 13;380(3):644-9 - "Our results suggest that resveratrol may attenuate fat deposition by inhibiting SREBP1 expression via Sirt1-FOXO1 pathway and thus may have application for the treatment of NAFLD"
  • Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes - Eur J Clin Invest. 2009 Mar;39(3):211-8 - "Results here reported show that in isolated hepatocytes from normal rats a resveratrol-induced short-term inhibition of fatty acid and triacylglycerol synthesis occurs. This finding may represent a potential mechanism contributing to the reported hypolipidemic effect of resveratrol"
  • Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model - J Agric Food Chem. 2009 Feb 19 - "Resveratrol increased lactobacilli and bifidobacteria as well as diminished the increase of enterobacteria upon DSS treatment. Resveratrol significantly protected the colonic mucosa architecture, reduced body weight loss, diminished the induced anemia and reduced systemic inflammation markers, colonic mucosa prostaglandin E(2), cycloxygenase-2, prostaglandin E synthase and nitric oxide levels. In addition, the expression of 2,655 genes in distal colon mucosa related to important pathways was varied. These results reinforce the concept of resveratrol as a dietary beneficial compound in intestinal inflammation at doses possibly attainable with resveratrol-enriched nutraceuticals"
  • Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells - Atherosclerosis. 2008 Nov 24 - "Smooth muscle cell (SMC) proliferation is a major feature in atherosclerosis, since it contributes to the formation of the fibrous cap, thus to plaque stability, but also to arterial stenosis and post-angioplasty restenosis ... These data indicate that the mTOR pathway is activated by oxLDL via PI3K/PDK1/Akt, and is required for SMC proliferation. Resveratrol blocks specifically this pathway, thereby inhibiting oxLDL-induced SMC proliferation. These data highlight a new property for resveratrol that could contribute to the general anti-atherogenic properties of this polyphenol"
  • Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway - Biochem Biophys Res Commun. 2008 Dec 3 - "Loss of cardiomyocytes through apoptosis has been proposed as a cause of ventricular remodeling and heart failure. Ischemia- and hypoxia-induced apoptosis of cardiomyocytes reportedly plays an important role in many cardiac pathologies. We investigated whether resveratrol (Res) has direct cytoprotective effects against ischemia/hypoxia for cardiomyocytes. Exposure of H9c2 embryonic rat heart-derived cells to hypoxia for 24h caused a significant increase in apoptosis, as evaluated by TUNEL and flow cytometry, while treatment with 20muM Res greatly decreased hypoxia-induced apoptosis in these cells. Exposure of the cells to Res (20muM) caused rapid activation of SIRT1, which had a dual effect on FoxO1 function: SIRT1 increased FoxO1's ability to induce cell cycle arrest, but inhibited FoxO1's ability to induce cell death. This effect could be reversed by SIRT1 inhibition. Results of our study indicate that Res inhibits hypoxia-induced apoptosis via the SIRT1-FoxO1 pathway in H9c2 cells. This polyphenol may have potential in preventing cardiovascular disease, especially in coronary artery disease (CAD) patients"
  • Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production - J Nutr. 2008 Sep;138(9):1602-8 - "resveratrol, at concentrations attainable after moderate wine intake, activates platelet eNOS and in this way blunts the proinflammatory pathway linked to p38MAPK, thus inhibiting ROS production and ultimately platelet function. This activity may contribute to the beneficial effects of moderate wine intake on ischemic cardiovascular disease"
  • Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice - Biochem Biophys Res Commun. 2008 Jul 5 - "The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo E(-/-) mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo E(-/-) mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo E(-/-) mice that were fed a normal diet"
  • Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms - Br J Pharmacol. 2008 Jun 30 - "Resveratrol significantly increased telomerase activity and Akt phosphorylation ... Resveratrol delayed the onset of EPC senescence and this effect was accompanied by activation of telomerase through the PI3K-Akt signalling pathway. The inhibition of EPCs senescence by resveratrol might protect EPCs against dysfunction induced by pathological factors in vivo and improve EPC functional activities in a way that may be important for cell therapy"
  • Resveratrol Induces Apoptosis through ROS-Dependent Mitochondria Pathway in HT-29 Human Colorectal Carcinoma Cells - J Agric Food Chem. 2008 Jun 4 - "Results of the present study provide evidence demonstrating the antitumor effect of trans-resveratrol via a ROS-dependent apoptosis pathway in colorectal carcinoma"
  • Antioxidant Protection of Resveratrol and Catechin in Saccharomyces cerevisiae - J Agric Food Chem. 2008 May 20 - "In this work, the capacity of resveratrol and catechin to protect the eukaryotic microorganism Saccharomyces cerevisiae against oxidative stress caused by different agents, hydrogen peroxide, carbon tetrachloride, and cadmium, was evaluated. Under all stress conditions, both polyphenols increased tolerance, although their protection was more evident under peroxide exposure. By using mutant strains deficient in specific antioxidant defense systems (superoxide dismutases, catalase, or glutathione), it was observed that increased H 2O 2 tolerance produced by both polyphenols was associated with catalase, as well as the rise in survival rates caused by resveratrol under CCl 4. The acquisition of tolerance was correlated with a reduction in lipid peroxidation, indicating that the antioxidant property of resveratrol and catechin involves protection against membrane oxidation"
  • Dietary resveratrol administration increases MnSOD expression and activity in mouse brain - Biochem Biophys Res Commun. 2008 May 15 - "trans-Resveratrol (3,4',5-trihydroxystilbene; RES) ... The increase in MnSOD was not due to a substantial proliferation of mitochondria, as RES treatment induced a 10% increase in mitochondrial abundance (Citrate Synthase activity). The potential neuroprotective properties of MnSOD have been well established, and we demonstrate that a dietary delivery of RES is able to increase the expression and activity of this enzyme in vivo"
  • Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo - Br J Pharmacol. 2008 Mar 10 - "The clinical use of arsenic trioxide (As(2)O(3)), a potent antineoplastic agent, is limited by its severe cardiotoxic effects ... resveratrol significantly attenuated As(2)O(3)-induced QT prolongation, structural abnormalities and oxidative damage in the heart. In H9c2 cardiomyocytes, resveratrol also decreased apoptosis, production of ROS and intracellular calcium mobilization induced by treatment with As(2)O(3). These observations suggested that resveratrol has the potential to protect against cardiotoxicity in As(2)O(3)-exposed patients"
  • Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters - Biochem Biophys Res Commun. 2007 Dec 28 - "The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group"
  • Differential expression of genes induced by resveratrol in human breast cancer cell lines - Nutr Cancer. 2006;56(2):193-203 - "The phytoalexin, trans-resveratrol (RES), is a polyphenolic compound found in plants and fruits that seems to have a wide spectrum of biological activities. It has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumor initiation, promotion, and progression. RES is also a phytoestrogen, which binds to and activates estrogen receptors (ERs) that regulate the transcription of estrogen-responsive target genes"
  • Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes  - Biochem Biophys Res Commun. 2007 Oct 26 - "resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines"
  • Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: Their inhibition by resveratrol - Cancer Lett. 2007 Oct 3 - "Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in various cellular events, including tumor invasion and metastasis ... Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol"
  • Resveratrol Inhibits the Activity of Equine Neutrophil Myeloperoxidase by a Direct Interaction with the Enzyme - J Agric Food Chem. 2007 Sep 11 - "Resveratrol is a polyphenolic antioxidant present in beverage and food known for its multiple protective effects. We report the inhibitory effects of resveratrol on equine myeloperoxidase (MPO), a hemic peroxidase present in the granules of the neutrophils involved in the inflammatory response. Resveratrol inhibited the production of reactive oxygen species (ROS) by stimulated equine neutrophils by acting as a direct scavenger of the ROS released by the cells but did not modify the degranulation of the stimulated neutrophils as the amounts of released MPO were unchanged. Resveratrol strongly inhibited the chlorination, oxidation, and nitration activities of MPO in a dose-dependent manner"
  • Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes - Atherosclerosis. 2007 May 11 - "Monocyte chemotactic protein-1 and its receptor, CCR2, play a key role in atherosclerosis ... These inhibitory effects of resveratrol on chemokine receptor binding and expression may contribute, in part, to its cardiovascular protective activity in vivo"
  • The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 - Br J Cancer 2002 Mar 4;86(5):774-8 - "This observation provides a novel explanation for the cancer preventative properties of resveratrol. It demonstrates that a natural dietary cancer preventative agent can be converted to a compound with known anticancer activity by an enzyme that is found in human tumours"

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