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Recent Longevity News for the seven days ending 10/5/11.  You should consult your doctor if you are taking any medications.

Sometimes I wonder whether someone at the National Institute of Health goes on vacation and then comes back and publishes all the backlogged abstracts at once.

Green tea helps mice keep off extra pounds - Science Daily, 10/4/11 - "in the current online version of Obesity, fed two groups of mice a high-fat diet. Mice that were fed Epigallocatechin-3-gallate -- EGCG -- a compound found in most green teas, along with a high-fat diet, gained weight 45 percent more slowly than the control group of mice eating the same diet without EGCG ... In addition to lower weight gain, the mice fed the green tea supplement showed a nearly 30 percent increase in fecal lipids, suggesting that the EGCG was limiting fat absorption ... A person would need to drink ten cups of green tea each day to match the amount of EGCG used in the study" - See green tea extract at Amazon.com.

Vitamin D could lower risk of developing Type 2 diabetes, study suggests - Science Daily, 10/4/11 - "New tests performed on participants of the KORA study have shown that people with a good supply of vitamin D have a lower risk of developing Type 2 diabetes mellitus, while individuals with lower concentrations of vitamin D in their blood have a higher risk. This effect could be attributable, amongst other things, to the anti-inflammatory effect of vitamin D"

Residential washers may not kill hospital-acquired bacteria - Science Daily, 10/3/11 - "washing uniforms in residential washing machines with detergent and water temperature of 60 degrees Celsius (140 degrees Fahrenheit) was enough to eliminate both MRSA and Acinetobacter. At 40 degrees Celsius (104 degrees Fahrenheit), MRSA was eliminated, but substantial amounts of Acinetobacter were detected"

Vitamin D deficiency common in cancer patients - Science Daily, 10/3/11 - "More than three-quarters of cancer patients have insufficient levels of vitamin D (25-hydroxy-vitamin D) and the lowest levels are associated with more advanced cancer ... Researchers are just starting to examine how vitamin D may impact specific features of cancer, such as the stage or extent of tumor spread, prognosis, recurrence or relapse of disease, and even sub-types of cancer" - See vitamin D at Amazon.com.

Cancer spike in men tied to HPV from oral sex - MSNBC, 10/3/11 - "Within the next decade, the study authors argue, the incidence of such cancers — which are almost always contracted as a result of oral sex — will surpass that of cervical cancer, and the majority of those cases are going to be in men ... in many cases, health experts believe that economics and health are aligned on this issue and that boys and young men ought to be receiving the HPV vaccine right now"

Highest Testosterone Levels Equal Lowest Risk for CV Events - Medscape, 10/3/11 - "elderly men in the highest quartile of serum testosterone levels have around a 30% lower risk of cardiovascular events over five years compared with men in the lower three quartiles" - Note:  My testosterone has always been slightly above normal.  I think part of it might be taking a quarter table of letrozole every other day.  See Femara (letrozole) at OffshoreRX.

Stress hormones may increase cardiovascular risks for shift workers - Science Daily, 10/3/11 - "working in shifts leads to changes in long-term cortisol levels, suggesting that the stress hormone cortisol might be one of the factors contributing to the increased cardiovascular risks of shift workers ... In this study, researchers collected hair samples from 33 shift workers and 89 day workers"

BPA exposure in utero may increase predisposition to breast cancer - Science Daily, 10/3/11 - "Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk ... adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what is seen upon similar exposure to another estrogenic compound, diethyllbestrol (DES). Uterine exposure to DES in the human population has been shown to increase the relative risk of getting breast cancer two-fold as women reach their fifties"

Meta-analysis supports lutein’s eye health benefits - Nutra USA, 10/3/11 - "The new meta-analysis pooled data from only six longitudinal cohort studies. Crunching the numbers showed that the highest intakes of lutein and zeaxanthin were not associated with a reduced risk of early AMD ... On the other hand, the highest intake of these carotenoids was associated with 26% reduction in the risk of late AMD, and a significant reduction in the risk of neovascular AMD" - [Abstract] - See Jarrow Formulas, CarotenALL at Amazon.com.

The Body Odd - Why some of us are terrible singers - MSNBC, 9/29/11 - "Singing is complicated because you need to match a note with your voice and perceive it accurately, you need to figure out the right way to configure your vocal muscles, and you need to control those muscles well enough to belt out a tune ... anywhere from 40 to 62 percent of non-musicians were poor singers ... roughly 20 percent of people can't sing accurately because they don't have good control of their vocal muscles. Another 35 percent of poor singers have trouble matching the pitch of their own voice to the same sound heard in other timbres, such as when it's coming from a trumpet, piano, or a person of the opposite sex. And 5 percent of lousy singers lack the ability to hear differences in pitch or discriminate between two different sounds" - Note:  Many studies show that exercising the brain helps keep it sharp.  If this article is valid, karaoke might be another way to do that.  Click here from my recommended karaoke system.

Oral steroids linked to severe vitamin D deficiency in nationwide US study - Science Daily, 9/29/11 - "People taking oral steroids are twice as likely as the general population to have severe vitamin D deficiency ... When doctors write that prescription for steroids and they're sending the patients for lab tests, they should also get the vitamin D level measured" - See vitamin D at Amazon.com.

Antioxidant-rich cocoa shows short-term heart benefits: Harvard review - Nutra USA, 9/29/11 - "Consumption of flavonoid-rich cocoa was associated with an average decrease in systolic blood pressure of about 1.6 mmHg ... It has been reported that a mere 2 mmHg decrease in systolic blood pressure could lead to 6% fewer stroke-related deaths, a 4% lower rate of heart disease deaths and a 3% reduction in overall deaths among Americans ... the Boston-based scientists also report a significant increase in levels of HDL cholesterol following consumption of antioxidant-rich cocoa ... The maximum effects were observed for a flavonoid dose of 500 mg/d"

Red wine ingredient resveratrol stops breast cancer growth, study suggests - Science Daily, 9/29/11 - "resveratrol, the "healthy" ingredient in red wine, stops breast cancer cells from growing by blocking the growth effects of estrogen ... resveratrol is able to counteract the malignant progression since it inhibits the proliferation of hormone resistant breast cancer cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy ... Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy" - See resveratrol products at Amazon.com.

Commonly used supplement may improve recovery from spinal cord injuries - Science Daily, 9/28/11 - "in experimental models, severe spinal cord injury can be treated effectively by administering the supplement acetyl-L-carnitine or ALC, a derivative of essential amino acids that can generate metabolic energy, soon after injury ... following spinal cord injury, the mitochondria, or energy-generation components of cells, are overwhelmed by chemical stresses and lose the ability to produce energy in the form of the compound adenosine triphosphate (ATP). [1,2] This leads to cell death at the injury site and, ultimately, paralysis of the body below the injury level ... ALC can preserve the vitality of mitochondria by acting as an alternative biofuel providing energy to cells, thus bypassing damaged mitochondrial enzymes and promoting neuroprotection" - See aetyl-l-carnitine products at iHerb.

Dietary Fructose and Risk of Metabolic Syndrome in Adults - Medscape, 9/28/11 - "in our study the association between dietary fructose and metabolic syndrome and its components was observed only in the third and fourth quartiles of fructose intakes, approximately over 8 and 12% of energy intake (> 50 g/d); while dietary intake of fructose from natural sources including fruits and vegetables, even in the fourth quartile of fructose intakes was only 5% of energy, approximately 30 g/d. Thus, the increased risk of metabolic syndrome and its components may be attributed to increase fructose intake from industrialized foods"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Flavonoid-Rich Cocoa Consumption Affects Multiple Cardiovascular Risk Factors in a Meta-Analysis of Short-Term Studies - J Nutr. 2011 Sep 28 - "A growing body of evidence suggests that the consumption of foods rich in polyphenolic compounds, particularly cocoa, may have cardioprotective effects ... flavonoid-rich cocoa (FRC) .. In response to FRC consumption, systolic blood pressure decreased by 1.63 mm Hg (P = 0.033), LDL cholesterol decreased by 0.077 mmol/L (P = 0.038), and HDL cholesterol increased by 0.046 mmol/L (P = 0.037), whereas total cholesterol, TG, and C-reactive protein remained the same. Moreover, insulin resistance decreased (HOMA-IR: -0.94 points; P < 0.001), whereas FMD increased (1.53%; P < 0.001). A nonlinear dose-response relationship was found between FRC and FMD (P = 0.004), with maximum effect observed at a flavonoid dose of 500 mg/d; a similar relationship may exist with HDL cholesterol levels (P = 0.06). FRC consumption significantly improves blood pressure, insulin resistance, lipid profiles, and FMD. These short-term benefits warrant larger long-term investigations into the cardioprotective role of FRC"

Curcumin is a potent modulator of microglial gene expression and migration - J Neuroinflammation. 2011 Sep 29;8(1):125 - "our results suggest that curcumin is a potent modulator of the microglial transcriptome. Curcumin attenuates microglial migration and triggers a phenotype with anti-inflammatory and neuroprotective properties. Thus, curcumin could be a nutraceutical compound to develop immuno-modulatory and neuroprotective therapies for the treatment of various neurodegenerative disorders" - See curcumin products at Amazon.com.

Physical activity, energy restriction, and the risk of pancreatic cancer: a prospective study in the Netherlands - Am J Clin Nutr. 2011 Sep 28 - "For past sports activities, we observed a significantly decreased risk of pancreatic cancer (HR: 0.80; 95% CI: 0.64, 0.99). Proxies for energy restriction were not related to pancreatic cancer risk. When the results for energy restriction were stratified by height, a significant multiplicative interaction was observed for the Economic Depression period (P = 0.002). Shorter individuals (height less than the sex-specific median adult height) with an unemployed father during the Economic Depression period had a significantly lower cancer risk (HR: 0.31; 95% CI: 0.14, 0.66) than did taller individuals with an employed father. No significant interactions were observed for exposure to energy restriction during the World War II years and the Hunger winter"

Inhibitory Effects of Combination of Lycopene and Genistein on 7,12- Dimethyl Benz(a)anthracene-Induced Breast Cancer in Rats - Nutr Cancer. 2011 Sep 29 - "Breast cancer is one of the most common cancers in women. Carotenoids and soy isoflavones have been postulated to have breast cancer preventive effects ... 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogen known to induce breast tumors ... Tumor weight decreased by 48%, 61%, and 67%, and mean tumor volume decreased by 18%, 35%, and 65% with lycopene, genistein, and lycopene + genistein, respectively (P < 0.01 for the combination). The proportions of adenocarcinoma masses decreased with lycopene and genistein combination (P < 0.05). Administration of lycopene and genistein combination suppressed breast cancer development and was associated with a decrease in MDA, 8-isoprostane, and 8-OhdG levels and with an increase in serum lycopene and genistein levels. Animals administered DMBA developed breast cancer, which was associated with increased expression of Bcl-2 and decreased expression of Bax, caspase 3, and caspase 9 in mammary tissues. Administration of genistein and lycopene in combination was more effective in inhibiting DMBA-induced breast tumors and modulating the expression of apoptosis associated proteins than the administration of each agent alone" - See lycopene at Amazon.com and genistein at Amazon.com.

Zyflamend Reduces the Expression of Androgen Receptor in a Model of Castrate-Resistant Prostate Cancer - Nutr Cancer. 2011 Sep 29 - "These results demonstrated that Zyflamend inhibited IGF-1-stimulated cell growth, IGF-1R expression, and androgen receptor expression and its nuclear localization, but these effects were not dependent upon phosphatidylinositol 3-kinase/pAKT signaling. In conclusion, Zyflamend decreased cell proliferation and inhibited IGF-1R and androgen receptor expression in a phosphatidylinositol 3-kinase/pAKT independent manner" - See Zyflamend at Amazon.com.

Low-Dose Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in Adiponectin Knockout and Wild-Type Mice - Nutr Cancer. 2011 Sep 29 - "Obesity is associated with a decrease in the antiinflammatory hormone, adiponectin, and increases in the circulating concentrations of multiple proinflammatory cytokines. These changes contribute to colon tumorigenesis. Resveratrol increases adiponectin production in adipocytes and attenuates the development of colon cancer. Thus, we hypothesized that adiponectin is an integral component of the mechanism by which resveratrol antagonizes colorectal tumorigenesis. To investigate this, we induced tumorigenesis in adiponectin knockout (KO) and wild-type (Wt) C57BL/6 mice through combined azoxymethane and dextran sodium sulfate treatment during which mice were fed a high-fat, lard-based diet, or the same diet containing 20 mg/kg resveratrol. After 14 wk on diet, Wt mice gained more weight and, on a percentage basis, had higher fat mass and lower lean mass than KO mice. Resveratrol tended to attenuate this response in male Wt mice. Resveratrol also tended to reduce aberrant crypt foci development and decrease circulating interleukin 6 and insulin concentrations in male but not female Wt mice. Taken together, resveratrol improved overall health of obese Wt but not KO mice as hypothesized with a differential sex response" - See resveratrol products at Amazon.com.

Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia - Stroke. 2011 Sep 29 - "In the present study, adult male mice were socially isolated (housed individually) or socially paired (housed with an ovariectomized female); social pairing increased hypothalamic OT gene expression. To determine whether a causal relationship exists between increased OT and improved stroke outcome, mice were treated with exogenous OT or OT receptor antagonist beginning 1 week before induction of experimental stroke via middle cerebral artery occlusion ... Relative to social isolation, social housing attenuated infarct size, neuroinflammation, and oxidative stress following experimental stroke; the neuroprotective effect of social housing was eliminated by receptor antagonist treatment. In contrast, administration of OT to socially isolated mice reproduced the neuroprotection conferred by social housing. We further report evidence for a direct suppressive action of OT on cultured microglia, which is a key instigator in the development of neuroinflammation after cerebral ischemia" - See Oxytocin 6x5iu tablets at International Antiaging Systems.

Relationship between Urinary Bisphenol A Levels and Diabetes Mellitus - J Clin Endocrinol Metab. 2011 Sep 28 - "Bisphenol A (BPA) is a widely used chemical in the manufacture of polycarbonate plastics and epoxy resins. Recent animal studies have suggested that BPA exposure may have a role in the development of weight gain, insulin resistance, pancreatic endocrine dysfunction, thyroid hormone disruption, and several other mechanisms involved in the development of diabetes ... We examined the association between urinary BPA levels and diabetes mellitus in the National Health and Nutritional Examination Survey (NHANES) 2003-2008. Urinary BPA levels were examined in quartiles. The main outcome of interest was diabetes mellitus defined according the latest American Diabetes Association guidelines.  Results:  Overall, we observed a positive association between increasing levels of urinary BPA and diabetes mellitus, independent of confounding factors such as age, gender, race/ethnicity, body mass index, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) of diabetes associated with quartile 4 was 1.50 (1.05-2.14) (p-trend = 0.03). The association was present among normal-weight as well as overweight and obese subjects"

Impact of cell phone use on men's semen parameters - Andrologia. 2011 Oct;43(5):312-6 - "Serum free testosterone (T), follicle stimulating hormone (FSH), luteinising hormone (LH) and prolactin (PRL) were collected from all patients ... Patients with cell phone usage showed significantly higher T and lower LH levels than those who did not use cell phone. No significant difference between the two groups was observed regarding FSH and PRL values. Our results showed that cell phone use negatively affects sperm quality in men"

A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat - Obes Rev. 2011 Sep 26 - "systematic review and meta-analysis was performed to assess the efficacy of exercise interventions on VAT content/volume in overweight and obese adults ... These data suggest that aerobic exercise is central for exercise programmes aimed at reducing VAT, and that aerobic exercise below current recommendations for overweight/obesity management may be sufficient for beneficial VAT modification"

Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination - Neurology. 2011 Sep 27;77(13):1276-82 - "Concentrations of all vitamin B12-related markers, but not serum vitamin B12 itself, were associated with global cognitive function and with total brain volume. Methylmalonate levels were associated with poorer episodic memory and perceptual speed, and cystathionine and 2-methylcitrate with poorer episodic and semantic memory. Homocysteine concentrations were associated with decreased total brain volume. The homocysteine-global cognition effect was modified and no longer statistically significant with adjustment for white matter volume or cerebral infarcts. The methylmalonate-global cognition effect was modified and no longer significant with adjustment for total brain volume ... Methylmalonate, a specific marker of B12 deficiency, may affect cognition by reducing total brain volume whereas the effect of homocysteine (nonspecific to vitamin B12 deficiency) on cognitive performance may be mediated through increased white matter hyperintensity and cerebral infarcts. Vitamin B12 status may affect the brain through multiple mechanisms" - See vitamin B12 at Amazon.com.

Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk - Int J Cancer. 2011 Sep 22 - "Folate, methionine, vitamin B(6) , and vitamin B(12) may influence carcinogenesis due to their roles in the one-carbon metabolism pathway which is critical for DNA synthesis, methylation, and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon, and endometrial cancers ... We observed an inverse association between dietary vitamin B(6) (covariate-adjusted OR=0.76, 95% CI 0.64-0.92; p(trend) =0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60-0.87; p(trend) <0.001) and ovarian cancer risk comparing the highest to lowest quartile. The association with dietary vitamin B(6) was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32-0.77; p(trend) =0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58-0.94; p(trend) =0.012) subtypes. Overall, we observed no significant association between folate and ovarian cancer risk. One-carbon metabolism related nutrients, especially vitamin B(6) and methionine, may lower ovarian cancer risk"

Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial - Eur J Clin Nutr. 2011 Sep 28 - "Previous clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein ... Compared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of -3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to -0.05, P=0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of -1.13 mg/dl (-2.05 to -0.22, P=0.02). Conclusions: This randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals"

Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A meta-analysis - Diabetes Care. 2011 Oct;34(10):2323-8 - "Both in vitro and in vivo studies indicate that metformin inhibits cancer cell growth and reduces cancer risk ... The analysis included five studies comprising 108,161 patients with type 2 diabetes. Metformin treatment was associated with a significantly lower risk of colorectal neoplasm (relative risk [RR] 0.63 [95% CI 0.50-0.79]; P < 0.001). After exclusion of one study that investigated colorectal adenoma, the remaining four studies comprised 107,961 diabetic patients and 589 incident colorectal cancer cases during follow-up. Metformin treatment was associated with a significantly lower risk of colorectal cancer (0.63 [0.47-0.84]; P = 0.002)" - See metformin at IAS.

Low Glycated Hemoglobin and Liver Disease in the U.S. Population - Diabetes Care. 2011 Sep 27 - "We observed J-shaped associations between HbA(1c) and liver enzymes and hepatic steatosis. In adjusted models, HbA(1c) <4.0% was strongly associated with elevated alanine aminotransferase (OR 3.62 [95% CI 1.09-12.02]) and aspartate aminotransferase (6.80 [2.99-15.43]).CONCLUSIONSLow HbA(1c) values were associated with liver enzymes and steatosis in the U.S. population. Liver disease may partially explain the association of HbA(1c) with mortality and other long-term outcomes"

Pioglitazone induces regression and stabilization of coronary atherosclerotic plaques in patients with impaired glucose tolerance - Diabet Med. 2011 Sep 26 - "Compared with the control group, 6 months' treatment with pioglitazone significantly decreased coronary plaque burden (50.7 +/- 11.1 vs. 64.1 +/- 10.3%, P < 0.05), plaque area (6.22 +/- 2.03 vs. 8.31 +/- 4.29, P < 0.05), thin-cap fibroatheroma prevalence (11 vs. 22%, P < 0.05) and percentage of necrotic core area (16 +/- 8 vs. 31 +/- 7%, P < 0.05). Compared with the control group, serum high-sensitivity C-reactive protein and plasma endothelin-1 levels were significantly lower and adiponectin level significantly higher in patients in the pioglitazone group. Serum adiponectin level was negatively correlated with plasma endothelin-1 level and coronary plaque area (r = 0.739 and -0.431, respectively, both P < 0.05). Conclusions:  Pioglitazone may induce regression and stabilization of coronary atherosclerotic plaques. The mechanisms might involve inhibition of inflammation, increase in adiponectin level and improvement in endothelial function" - See pioglitazone at OffshoreRx1.com.

Effects of Green Tea Polyphenol (-)-Epigallocatechin-3-gallate on a Newly Developed High-fat/Western-style Diet-induced Obesity and Metabolic Syndrome in Mice - J Agric Food Chem. 2011 Sep 20 - "EGCG treatment significantly reduced body weight gain associated with increased fecal lipids, and decreased blood glucose and alanine aminotransferase (ALT) levels compared to the HFW group. Fatty liver incidence, liver damage and liver triglyceride levels were also decreased by EGCG treatment. Moreover, EGCG treatment attenuated insulin resistance and levels of plasma cholesterol, monocyte chemoattractant protein-1 (MCP-1), C-reactive protein (CRP), interlukin-6 (IL-6), and granulocyte colony-stimulating factor (G-CSF). Our results demonstrate that the HFW diet produces more severe symptoms of metabolic syndrome than the HF diet and EGCG treatment can alleviate these symptoms and body fat accumulation. The beneficial effects of EGCG are associated with decreased lipid absorption and reduced levels of inflammatory cytokines" - See green tea extract at Amazon.com.

Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side by side comparison - J Agric Food Chem. 2011 Sep 20 - "Cell viability tests indicated that IC50s of pterostilbene were 2~5-fold lower than those of resveratrol in all three cancer cells. Pterostilbene was also more potent in inhibiting colony formation of all three cancer cells. Annexin V/Propidium Iodide (PI) co-staining assay and western blotting analysis showed pterostilbene had stronger apoptosis-inducing effects, which was evidenced by the higher percentage of annexin V positive cells and higher levels of cleaved caspae-3 and Poly (ADP-ribose) polymerase (PARP) proteins in cancer cells treated with pterostilbene than resveratrol. High performance liquid chromatography (HPLC) analysis demonstrated that intracellular levels of pterostilbene were 2~4-fold higher than those of resveratrol after treatments with individual compounds at the same concentration. Overall, our results demonstrated that pterostilbene had more potent inhibitory effects on colon cancer cells than resveratrol, which may be associated with the superior bioavailability of pterostilbene to resveratrol" - See pterostilbene at Amazon.com.

Health Focus (Hypertension):

Click here for why I feel that Micardis® (telmisartan) should be the first line treatment for hypertension.

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  • Isomer-specific effects of conjugated linoleic acid on blood pressure, adipocyte size and function - Br J Nutr. 2011 Sep 23:1-9 - "Consumption of conjugated linoleic acid (CLA) has been shown to modulate cytokine release from adipocytes and positively influence blood pressure in younger rats, but its physiological actions in older models with established hypertension and isomer-specific effects on adipocyte size remain to be determined. Therefore, we investigated the effects of CLA isomers on adipocyte size in relation to blood pressure and adipokine production by hypertrophic adipocytes in older fa/fa Zucker rats with established hypertension. fa/fa Zucker rats were fed with cis(c)9, trans(t)11-CLA or t10, c12-CLA isomers for 8 weeks and compared with lean and obese rats fed with the control diet. Blood pressure and adipocyte size were subsequently measured. Collagenase-isolated adipocytes were size-separated and angiotensinogen and adiponectin protein levels quantified by Western blotting. The t10, c12-CLA group had reduced blood pressure, fewer large adipocytes and increased serum adiponectin. Angiotensinogen was present at higher levels in the large adipocytes, whereas the converse was observed for adiponectin. The beneficial effects of the t10, c12-CLA isomer on blood pressure and adipocyte size in vivo may be due to its ability to reduce the number of large adipocytes, which alters the levels of vasoactive molecules secreted from adipose tissue" - See conjugated linoleic acid at Amazon.com.
  • Feasibility and antihypertensive effect of replacing regular salt with mineral salt- rich in magnesium and potassium- in subjects with mildly elevated blood pressure - Nutr J. 2011 Sep 2;10(1):88 - "subjects consumed processed foods salted with either NaCl or Smart Salt ... 24-h dU-Na decreased significantly in the Smart Salt group (-29.8 mmol; p=0.012) and remained unchanged in the control group: resulting in a 3.3 g difference in NaCl intake between the groups. Replacement of NaCl with Smart Salt resulted in a significant reduction in SBP over 8 weeks (-7.5 mmHg; p=0.016). SBP increased (+3.8 mmHg, p=0.072) slightly in the Regular salt group" - See smartsalt.com.
  • Natural therapies: Cardiologists examine alternatives to halt high blood pressure - Science Daily, 8/30/11 - "The shining star among supplements is coenzyme Q10, an enzyme involved in energy production that also acts as an antioxidant. Patients with hypertension tend to have lower levels of the enzyme, and a meta-analysis -- an overarching analysis of past studies -- found that treatment with coenzyme Q10 supplements significantly reduced blood pressure ... Coenzyme Q10 has a pretty profound effect on blood pressure, but whenever research is based on a collection of other data you have to have some skepticism ... potassium helps lower blood pressure, and there is evidence that increasing the amount of potassium we get through the foods we eat could carry some of the same mild benefits as taking supplements" - See ubiquinol products at Amazon.com and potassium citrate at Amazon.com.
  • Breakfast cereals and risk of hypertension in the Physicians' Health Study I - Clin Nutr. 2011 Aug 23 - "The average age of study participants was 52.4 +/- 8.9 years (range 39.7-85.9) during the initial assessment of cereal intake (1981-1983). During a mean follow up of 16.3 years, 7267 cases of hypertension occurred. The crude incidence rates of hypertension were 36.7, 34.0, 31.7, and 29.6 cases/1000 person-years for people reporting breakfast cereal intake of 0, ≤1, 2-6, and ≥7 servings/week, respectively. In a Cox regression model adjusting for age, smoking, body mass index, alcohol consumption, fruit and vegetable consumption, physical activity, and history of diabetes mellitus, hazard ratios (95% CI) for hypertension were 1.0 (reference), 0.93 (0.88-0.99), 0.88 (0.83-0.94), and 0.81 (0.75-0.86) from the lowest to the highest category of cereal consumption, respectively (p for trend <0.0001). This association was strongest for whole grain cereals and was observed in lean as well as overweight or obese participants"
  • Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans - Nutr J. 2011 Aug 9;10(1):82 - "Twenty-two women and eight men (aged 49.8 +/- 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks ... malondialdehyde (MDA) ... The results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 +/- 6.8 vs. 121.0 +/- 9.0 mmHg, P < 0.05) and MDA level (1.8 +/- 0.6 vs. 1.2 +/- 0.6 micromol/L, P < 0.05), and increased vitamin E level (29.4 +/- 6.0 vs. 38.2 +/- 7.8 micromol/L, P < 0.01). In the black sesame meal group, the change in systolic BP tended to be positively related to the change in MDA (R = 0.50, P = 0.05), while the change in diastolic BP was negatively related to the change in vitamin E (R = -0.55, P <0.05)" - See sesame seed oil at Amazon.com.  Note:  An 8.3 point drop in systolic seems impressive.  That's about what you get from medication plus it's systolic that most have a problem with.
  • The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials - J Am Diet Assoc. 2011 Aug;111(8):1173-81 - "Upon meta-analysis, grape seed extract significantly lowered systolic blood pressure (weighted mean difference -1.54 mm Hg (95% confidence interval -2.85 to -0.22, P=0.02]), and heart rate (weighted mean difference -1.42 bpm (95% confidence interval -2.50 to -0.34, P=0.01]). No significant effect on diastolic blood pressure, lipid levels, or CRP was found. No statistical heterogeneity was observed for any analysis (I(2)<39% for all). Egger's weighted regression statistic suggested low likelihood of publication bias in all analysis (P>0.05 for all), except for the effect on diastolic blood pressure (P=0.046). Based on the currently available literature, grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or CRP levels" - See Jarrow Formulas, OPCs + 95 at Amazon.com.
  • Effect of Dietary Protein Supplementation on Blood Pressure: A Randomized, Controlled Trial - Circulation. 2011 Jul 18 - "The trial participants were assigned to take 40 g/d soy protein, milk protein, or carbohydrate supplementation each for 8 weeks in a random order. A 3-week washout period was implemented between the interventions. Three BPs were measured at 2 baseline and 2 termination visits during each of 3 intervention phases with a random-zero sphygmomanometer. Compared with carbohydrate controls, soy protein and milk protein supplementations were significantly associated with -2.0 mm Hg (95% confidence interval -3.2 to -0.7 mm Hg, P=0.002) and -2.3 mm Hg (-3.7 to -1.0 mm Hg, P=0.0007) net changes in systolic BP, respectively. Diastolic BP was also reduced, but this change did not reach statistical significance. There was no significant difference in the BP reductions achieved between soy or milk protein supplementation"
  • Pine bark extract plus CoQ10 shows benefits for heart failure patients - Nutra USA, 6/23/11 - "12 weeks of daily supplementation with 350 milligrams of CoQ10 (Kaneka) and 105 milligrams of the branded pine bark extract Pycnogenol ... recruited 53 heart failure patients aged between 54 and 68 were randomly assigned to receive either the PycnoQ10 supplement or placebo for 12 weeks ... systolic and diastolic blood pressure decreased following the CoQ10-pine bark combination, from 139.2 to 133.2 mmHg and 82.3 to 77.3 mmHg, respectively. Systolic and diastolic blood pressure decreased from 140.3 to 139.5 mmHg and 83.4 to 81.2 mmHg, respectively, in the placebo group ... In addition to increases in the amount of blood pumped by the heart, the researchers also reported improvements in heart rate were also observed in the PycnoQ10 supplement group from 78.4 to 74.2 beats per minute, compared with a decrease from 79.1 to 78.4 in the placebo group" - [Abstract] - See Pycnogenol at Amazon.com and ubiquinol products at Amazon.com.
  • Sodium intake in men and potassium intake in women determine the prevalence of metabolic syndrome in Japanese hypertensive patients: OMEGA Study - Hypertens Res. 2011 Jun 9 - "High sodium intake was significantly related to increased SBP (P=0.0003) and DBP (P=0.0130). Low potassium intake was significantly related to increased SBP (P=0.0057) and DBP (P=0.0005). Low soybean/fish intake was significantly related to increased SBP (P=0.0133). A significantly higher prevalence of MS was found in men in the highest quartile of sodium intake compared with the lower quartiles (P=0.0026) and in women in the lowest quartile of potassium intake compared with the higher quartiles (P=0.0038). A clear relation between dietary habits and blood pressure was found in Japanese hypertensive patients using a patient-administered questionnaire. Sodium and potassium intake affect MS prevalence. Dietary changes are warranted within hypertension treatment strategies"
  • Vitamin D levels linked with health of blood vessels - Science Daily, 4/3/11 - "Forty-two study participants with vitamin D insufficiency whose levels later went back to normal had an average drop in blood pressure of 4.6 millimeters mercury" - See vitamin D at Amazon.com.
  • Singing lowers patient's blood pressure prior to surgery, case study reports - Science Daily, 3/30/11 - "Upon admission to the hospital for surgery the patient's blood pressure was 160/90 mm Hg, controlled by her normal regimen of nifedipine and lisinopril. In the preoperative area, the woman's blood pressure increased to 240/120 mm Hg and persisted, requiring doctors to postpone surgery ... The patient asked doctors if she could sing, which the patient reported doing frequently to calm herself down and to help with sleeping. The medical team encouraged her to so, and after two songs checked her blood pressure which had lowered to 180/90 mm Hg. With continued singing for 20 minutes, the patient's blood pressure remained lower and persisted for several hours after. As instructed by doctors, the patient sang periodically through the night which kept her blood pressure at acceptable levels. The following morning, the woman was cleared for knee replacement surgery, which was successful and without complications" - See my Karaoke page and my Song Book Page.
  • Physical activity decreases salt's effect on blood pressure, study finds - Science Daily, 3/23/11 - "Investigators compared study participants' blood pressure on two one-week diets, one low in sodium (3,000 mg/day) and the other high in sodium (18,000 mg/day) ... The American Heart Association recommends consuming less than 1,500 mg/day of sodium ... Compared with the sedentary group, the odds of being salt-sensitive, adjusted for age and gender, fell: 10 percent in the next-to-lowest activity group ... 17 percent in the next-to-highest activity group ... 38 percent in the most active group"
  • Olive leaf extract may help hypertension: Frutarom study - Nutra USA, 3/9/11 - "Olive leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5–25 mg twice daily ... after eight weeks of treatment, both treatment groups experienced significant reductions in systolic and diastolic blood pressure from baseline. They added that such reductions were not significantly different between groups ... However, they reported that a significant reduction of triglyceride level was observed for the group receiving olive leaf extract, but not in Captopril group ... the anti-hypertensive activity “lies probably in its content of oleuropein acting synergistically with other active substances to exert both ACE inhibitory and calcium channel blocking activities."" - [Abstract] - See olive leaf extract at Amazon.com.
  • Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with Captopril - Phytomedicine. 2011 Feb 15;18(4):251-8 - "Mean SBP at baseline was 149.3+/-5.58mmHg in Olive group and 148.4+/-5.56mmHg in Captopril group; and mean DBPs were 93.9+/-4.51 and 93.8+/-4.88mmHg, respectively. After 8 weeks of treatment, both groups experienced a significant reduction of SBP as well as DBP from baseline; while such reductions were not significantly different between groups. Means of SBP reduction from baseline to the end of study were -11.5+/-8.5 and -13.7+/-7.6mmHg in Olive and Captopril groups, respectively; and those of DBP were -4.8+/-5.5 and -6.4+/-5.2mmHg, respectively. A significant reduction of triglyceride level was observed in Olive group, but not in Captopril group. In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25mg twice daily" - See olive leaf extract at Amazon.com.
  • 25-hydroxyvitamin d levels and hypertension rates - J Clin Hypertens (Greenwich). 2011 Mar;13(3):170-7 - "Vitamin D deficiency has been linked to cardiovascular disease and risk factors including hypertension ... Patients were categorized into quartiles according to 25-hydroxyvitamin D levels: ideal (≥40 ng/mL), adequate (30-39 ng/mL), deficient (15-29 ng/mL), and severely deficient (<15 ng/mL). Prevalence rates of hypertension and odds ratios were calculated for each 25-hydroxyvitamin D quartile, adjusting for age, sex, race, and renal insufficiency. A total of 2722 individuals met the inclusion criteria for the study. The overall prevalence of hypertension in the study population was 24%. Hypertension rates were 52%, 41%, 27%, and 20% in 25-hydroxyvitamin D quartiles <15 ng/mL, 15 to 29 ng/mL, 30 to 39 ng/mL, and ≥40 ng/mL, respectively (P<.001). Odds ratios (95% confidence intervals) for hypertension adjusting for age, sex, race, and renal insufficiency were 2.7 (1.4-5.2), 2.0 (1.5-2.6), and 1.3 (1.2-1.6) for 25-hydroxyvitamin D levels <15 ng/mL, 15 to 29 ng/mL, and 30 to 39 ng/mL, respectively, compared with the ≥40 ng/mL group. This study demonstrates increased rates of hypertension in individuals who tested for lower levels of 25-hydroxyvitamin D starting at levels <40 ng/mL. This retrospective analysis raises the question of whether supplementing to optimal vitamin D levels can prevent or improve hypertension" - See vitamin D at Amazon.com.
  • Sugar-sweetened drinks associated with higher blood pressure - Science Daily, 3/1/11 - "for every extra sugar-sweetened beverage drunk per day participants on average had significantly higher systolic blood pressure by 1.6 millimeters of mercury (mm Hg) and diastolic blood pressure higher by 0.8 mm Hg ... They found no consistent association between diet soda intake and blood pressure levels. Those who drank diet soda had higher mean BMI than those who did not and lower levels of physical activity ... One possible mechanism for sugar-sweetened beverages and fructose increasing blood pressure levels is a resultant increase in the level of uric acid in the blood that may in turn lower the nitric oxide required to keep the blood vessels dilated. Sugar consumption also has been linked to enhanced sympathetic nervous system activity and sodium retention"
  • Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials - Br J Nutr. 2011 Feb 23:1-10 - "Meta-analyses of twenty-seven RCT showed a mean decrease of 2.21 mmHg (95 % CI - 4.10, - 0.33; P = 0.021) for systolic BP (SBP) and 1.44 mmHg (95 % CI - 2.56, - 0.31; P = 0.012) for diastolic BP (DBP), comparing the participants in the soya protein group with those in the control group. Soya protein consumption significantly reduced SBP and DBP in both hypertensive and normotensive subjects, and the reductions were markedly greater in hypertensive subjects. Significant and greater BP reductions were also observed in trials using carbohydrate, but not milk products, as the control diet. Meta-regression analyses further revealed a significantly inverse association between pre-treatment BP and the level of BP reductions. In conclusion, soya protein intake, compared with a control diet, significantly reduces both SBP and DBP, but the BP reductions are related to pre-treatment BP levels of subjects and the type of control diet used as comparison"
  • Effect of soy isoflavones on blood pressure: A meta-analysis of randomized controlled trials - Nutr Metab Cardiovasc Dis. 2011 Feb 8 - "A total of eleven trials were reviewed. Meta-analysis results showed a mean decrease of 2.5 mm Hg (95% CIs, - 5.35 to 0.34 mm Hg; P = 0.08) for systolic blood pressure and 1.5 mm Hg (95% CIs, - 3.09 to 0.17 mm Hg; P = 0.08) for diastolic blood pressure in the soy isoflavones-treated group compared to placebo. Meta-regression and subgroup analyses indicated that blood pressure status was a significant predictor of heterogeneity for the effect of soy isoflavones on blood pressure. Subgroup analysis of hypertensive subjects revealed that a greater blood pressure reduction was identified in the soy isoflavone-treated group compared to placebo (5 trials; SBP: - 5.94, 95% CIs [- 10.55, - 1.34] mm Hg, P = 0.01; DBP: - 3.35, 95% CIs [- 6.52, - 0.19] mm Hg, P = 0.04). In contrast, treatment with soy isoflavones did not lead to a significant reduction in blood pressure in normotensive subjects (6 trials; SBP: 0.29, 95% CIs [- 2.39, 2.97] mm Hg, P = 0.83; DBP: - 0.43, 95% CIs [- 1.66, 0.81] mm Hg, P = 0.50)" - See soy isoflavones at Amazon.com.
  • A systematic review and meta-analysis of elevated blood pressure and consumption of dairy foods - J Hum Hypertens. 2011 Feb 10 - "elevated blood pressure (EBP) ... Meta-analysis of consumption of dairy foods and EBP in adults gave a relative risk (RR) of 0.87 (95% confidence interval (CI) 0.81-0.94). Separation of high- and low-fat dairy foods, however, indicated a significant association with low-fat dairy foods only (RR of 0.84 (95% CI 0.74-0.95)). Additional analyses showed no association between EBP and cheese, although fluid dairy foods were significantly associated with a reduced development in EBP (RR of 0.92 (95% CI 0.87-0.98)). Little heterogeneity was observed among the data presented. This meta-analysis supports the inverse association between low-fat dairy foods and fluid dairy foods and risk of EBP"
  • Polyunsaturated fatty acid intake and blood pressure in adolescents - J Hum Hypertens. 2011 Feb 10 - "systolic BP was inversely associated with intakes of polyunsaturated (b=-0.436, P<0.01), omega-3 (b=-2.47, P=0.02), omega-6 (b=-0.362, P=0.04) and long chain omega-3 fatty acids (b=-4.37, P=0.04) in boys. Diastolic BP and mean arterial pressure were inversely associated with intakes of long chain omega-3 fatty acids in boys (b=-3.93, P=0.01, b=-4.05, P=0.01, respectively). For specific long-chain omega-3s, significant inverse associations were observed between eicosapentaenoic acid (EPA) and docosahexaenoic acid, such as systolic BP decreasing by 4.7 mm Hg (95% CI -9.3 to -0.1) for a quarter gram increase in EPA, but no significant associations were observed with docosapentaenoic acid. No significant associations were observed in girls, or with the omega-6 to omega-3 ratio. Our results suggest that gender may moderate relationships between fatty acid intake and BP in adolescence" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Taurine Prevents Hypertension and Increases Exercise Capacity in Rats With Fructose-Induced Hypertension - Am J Hypertens. 2011 Feb 3 - "Five groups of 15 Sprague-Dawley rats were allocated and designated as control, high fructose-fed (fructose), high fructose-fed plus exercise (FE), high fructose-fed plus 2% taurine supplement (FT) and high fructose-fed plus 2% taurine supplement and exercise (FET) groups ... Noninvasive SBP differed significantly (P < 0.001) from week 3, both noninvasive and invasive ABP increased significantly (P < 0.001), and exercise capacity significantly decreased (P < 0.001) in the fructose group compared with the control group. The individual effects of swimming and taurine supplementation were incapable of preventing the development of hypertension and SBP significantly (P < 0.001) increased in the FE and FT groups; exercise capacity in those groups remained similar to control. The combined effects of exercise and taurine alleviated hypertension and significantly increased exercise capacity in the FET group. Insulin resistance increased significantly and plasma nitric oxide (NO) decreased significantly in the F, FE, and FT groups. Both parameters remained similar to control values in the FET group with an increasing antioxidant activity. Conclusion Taurine supplementation in combination with exercise prevents hypertension and increases exercise capacity by possibly antioxidation and maintaining NO concentrations" - See taurine at Amazon.com.
  • Prediabetes and Prehypertension in Healthy Adults Are Associated With Low Vitamin D Levels - Diabetes Care. 2011 Jan 31 - "The odds ratio for comorbid PreDM and PreHTN in Caucasian men (n = 898) and women (n = 813) was 2.41 (P < 0.0001) with vitamin D levels ≤76.3 versus >76.3 nmol/L after adjusting for age, sex, and BMI. CONCLUSIONS This study strengthens the plausibility that low serum vitamin D levels elevate the risk for early-stage diabetes (PreDM) and hypertension (PreHTN)" - See vitamin D at Amazon.com.
  • The association of serum potassium level with left ventricular mass in patients with primary aldosteronism - Eur J Clin Invest. 2011 Jan 21 - "Primary aldosteronism (PA) is associated a worse cardiovascular outcome than essential hypertension. Hypokalemia, which is one major characteristic of PA, can affect both cardiac structure and function ... the control group (group 1). Thirty-two patients with serum potassium < 3.5 mmol L(-1) were defined as hypokalemia (group 2), and 53 patients with serum potassium ≥ 3.5 mmol L(-1) were defined as normokalemia (group 3) ... Group 2 patients had significant higher systolic and diastolic blood pressure (DBP), log-transformed plasma aldosterone concentration, log-transformed aldosterone-to-renin ratio and lower serum potassium level than groups 1 and 3. In echocardiographic measurement, group 2 patients had higher LV mass index (LVMI) than groups 1 and 3. In multivariate analysis for factors affecting LVMI in PA patients, only serum potassium level (P = 0.001), use of spironolactone (P = 0.004) and DBP (P = 0.005) were independent factors. In the TDI study, both groups 2 and 3 had lower e' and E/e' values than group 1. Conclusions  Serum potassium level is significantly associated with LVMI in PA patients. Compared with essential hypertensive patients, PA patients had a greater impairment of cardiac diastolic function" - See potassium citrate at Amazon.com.
  • Bioactive compounds in berries can reduce high blood pressure - Science Daily, 1/14/11 - "bioactive compounds in blueberries called anthocyanins offer protection against hypertension. Compared with those who do not eat blueberries, those eating at least one serving a week reduce their risk of developing the condition by 10 per cent" - See blueberry extract at Amazon.com.
  • Three Whole-Grain Portions Daily May Lower Cardiovascular Risk - Medscape, 1/4/11 - "Daily consumption of 3 portions of whole-grain foods (WGF) is linked to lower cardiovascular disease (CVD) risk in healthy, middle-aged people mainly by lowering blood pressure (BP) ... assigned to continue the refined diet (control) or to switch to a whole-wheat diet or to a whole-wheat plus oat diet, for 12 weeks ... Compared with the control group, the WGF groups had a significant reduction in systolic BP (6 mm Hg) and a significant reduction (3 mm Hg) in pulse pressure ... The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥ 15% and 25%, respectively"
  • Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis - J Hypertens. 2010 Dec 28 - "Of the 18 studies included in the meta-analysis, 4 were prospective studies and 14 were cross-sectional studies. The pooled odds ratio of hypertension was 0.73 [95% confidence interval (CI) 0.63-0.84] for the highest versus the lowest category of blood 25-hydroxyvitamin D concentration. In a dose-response meta-analysis, the odds ratio for a 40 nmol/l (16 ng/ml) (approximately 2 SDs) increment in blood 25-hydroxyvitamin D concentration was 0.84 (95% CI 0.78-0.90)" - See vitamin D at Amazon.com.
  • Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials - Maturitas. 2010 Dec 14 - "Lycopene, a carotenoid found in tomatoes ... Meta-analysis of the effect of lycopene on systolic blood pressure of all trials suggested a significant blood pressure reducing effect (mean systolic blood pressure change+/-SE: -5.60+/-5.26mm Hg, p=0.04) ... Our meta-analysis suggests that lycopene taken in doses ≥25mg daily is effective in reducing LDL cholesterol by about 10% which is comparable to the effect of low doses of statins in patient with slightly elevated cholesterol levels" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Orange juice flavanone may benefit heart health: Study - Nutra USA, 12/17/10 - "The researchers reported that blood pressure was significantly lowered after 4 weeks consumption of orange juice or a hesperidin rich drink when compared to a placebo drink" - [Abstract] - See hesperidin at Amazon.com.
  • Lifetime Fruit and Vegetable Consumption and Arterial Pulse Wave Velocity in Adulthood: The Cardiovascular Risk in Young Finns Study - Circulation. 2010 Nov 29 - "Vegetable consumption in childhood was inversely associated with adulthood PWV (β=-0.06, P=0.02), and this association remained significant (β=-0.07, P=0.004) when adjusted for traditional risk factors (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body mass index, and smoking). Vegetable consumption was also an independent predictor of PWV in adulthood when adjusted for lifestyle or traditional risk factors (β=-0.08, P=0.002 and β=-0.07, P=0.0007, respectively). Persistently high consumption of both fruits and vegetables from childhood to adulthood was associated with lower PWV compared with persistently low consumption (P=0.03 for both). The number of lifestyle risk factors (the lowest quintile for vegetable consumption, fruit consumption, physical activity, and smoking) in childhood was directly associated with PWV in adulthood (P=0.001). This association remained significant when adjusted for the number of lifestyle risk factors in adulthood ... lifetime lifestyle risk factors, with low consumption of fruits and vegetables in particular, are related to arterial stiffness in young adulthood"
  • The effects of tomato consumption on serum glucose, apolipoprotein B, apolipoprotein A-I, homocysteine and blood pressure in type 2 diabetic patients - Int J Food Sci Nutr. 2010 Dec 8 - "32 type 2 diabetes patients received 200 g raw tomato daily for 8 weeks ... There were significant decreases in systolic and diastolic blood pressure and also a significant increase in apoA-I at the end of study compared with initial values"
  • Whey supplements lower blood pressure: Low-cost protein gets big results in people with elevated blood pressure - Science Daily, 12/8/10 - "Beverages supplemented by whey-based protein can significantly reduce elevated blood pressure, reducing the risk of stroke and heart disease ... daily doses of commonly available whey brought a more than six-point reduction in the average blood pressure of men and women with elevated systolic and diastolic blood pressures ... blood-pressure reductions like those seen by Fluegel can reduce cardiovascular disease and bring a 35 to 40 percent reduction in fatal strokes" - See whey protein at Amazon.com.
  • Role of vitamin D in arterial hypertension - Expert Rev Cardiovasc Ther. 2010 Nov;8(11):1599-608 - "Vitamin D deficiency is highly prevalent and may contribute to arterial hypertension. The antihypertensive effects of vitamin D include suppression of renin and parathyroid hormone levels and renoprotective, anti-inflammatory and vasculoprotective properties. Low 25-hydroxyvitamin D levels, which are used to classify the vitamin D status, are an independent risk factor for incident arterial hypertension. Meta-analyses of randomized controlled trials showed that vitamin D supplementation reduces systolic blood pressure by 2-6 mmHg ... vitamin D might be useful for the treatment of arterial hypertension as well as other chronic diseases. Therefore, we recommend that testing for and treating vitamin D deficiency in patients with arterial hypertension should be seriously considered" - See vitamin D at Amazon.com.
  • Greater Coffee Intake in Men Is Associated With Steeper Age-Related Increases in Blood Pressure - Am J Hypertens. 2010 Nov 18 - "Greater coffee intake in men was associated with steeper age-related increases in SBP and pulse pressure, particularly beyond 70 years of age and in overweight to obese men"
  • Blueberries linked to improved blood vessel health: Rat study - Nutra USA, 11/18/10 - "Our data provide clear evidence that the 8 week dietary treatment with 8 percent wild blueberry in the adult SHR with established endothelial dysfunction results in a significant moderation of the increased aortic vascular tone ... The berries were proposed to act via the NO pathway – nitric oxide is a potent vasodilator, or compound that promotes the dilation or relaxation of blood vessels, thereby easing blood pressure" - [Abstract] - See blueberry extract at Amazon.com.
  • A Wild Blueberry-Enriched Diet ( Vaccinium angustifolium ) Improves Vascular Tone in the Adult Spontaneously Hypertensive Rat - J Agric Food Chem. 2010 Nov 24 - "The vasoconstriction elicited by Phe was reduced in the WB group, attributed to the NO pathway, favoring a lower vascular tone under basal conditions. Acetylcholine-induced vasorelaxation in the WB group was possibly mediated through the COX, but not the NO pathway. These findings document the potential of wild blueberries to modify major pathways of vasomotor control and improve the vascular tone in the adult SHR with endothelial dysfunction" - See blueberry extract at Amazon.com.
  • Aged garlic shows blood pressure improvement benefits: Study - Nutra USA, 11/17/10 - "an aged garlic extract may reduce systolic blood pressure by 10.2 mmHg ... the benefits were only observed in people with initial systolic pressure (SBP) of 140 mmHg or over, and that no effects were observed in people with lower SBP ... aged garlic extract of 3.84 grams (Kyolic, Garlic High Potency Everyday Formula 112, Wakunga/Wagner) or placebo for 12 weeks ... Results showed a “marked difference” between the garlic and control groups in subjects with ‘uncontrolled hypertension’" - [Abstract] - See garlic supplements at Amazon.com.
  • Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial - Maturitas. 2010 Oct;67(2):144-50 - "In patients with uncontrolled hypertension (SBP ≥ 140 mmHg at baseline), systolic blood pressure was on average 10.2 +/- 4.3 mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP<140 mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%)" - See garlic supplements at Amazon.com.
  • Why chocolate protects against heart disease - Science Daily, 11/10/10 - "ate 75 grams of unsweetened chocolate with a cocoa content of 72 percent. To analyze what happened with the ACE enzyme, blood samples were taken in advance and then a half hour, one hour, and three hours afterward ... In the sample taken three hours afterward, there was a significant inhibition of ACE activity. The average was 18 percent lower activity than before the dose of cocoa, fully comparable to the effect of drugs that inhibit ACE and are used as a first-choice treatment for high blood pressure"
  • Low serum magnesium concentrations predict increase in left ventricular mass over 5 years independently of common cardiovascular risk factors - Atherosclerosis. 2010 Sep 21 - "Mg(2+) at baseline (0.790+/-0.003mmol/l, mean+/-SEM) inversely correlated with the difference in LVM over 5 years (p<0.0001, females: p<0.002, males: p<0.024). In the lowest Mg(2+)-quintile (Mg(2+)<=0.73mmol/l), LVM (187.4+/-3.1g at baseline) increased by 14.9+/-1.2g, while in the highest Mg(2+)-quintile (Mg(2+)>=0.85mmol/l) LVM (186.7+/-3.4g at baseline) decreased by -0.5+/-2.8g (p<0.0001 between quintiles). By multivariable analysis including several cardiovascular risk factors and antihypertensive treatment, serum Mg(2+) was associated with the increase in LVM at a statistically high significant level (p<0.0001). LVM after 5 years was significantly higher in subjects within the lower Mg(2+)-quintiles. This association remained highly significant after adjustment for several cardiovascular risk factors including arterial hypertension and diabetes mellitus" - See magnesium supplements at Amazon.com.
  • Consumption of 'good salt' can reduce population blood pressure levels, research finds - Science Daily, 9/13/10 - "the average potassium intake in 21 countries including the US, China, New Zealand, Germany and the Netherlands varies between 1.7 and 3.7 g a day. This is considerably lower than the 4.7 g a day, which has been recommended based on the positive health effects observed at this level of intake ... A hypothetical increase in the potassium intake to the recommended level would reduce the systolic blood pressure in the populations of these countries by between 1.7 and 3.2 mm Hg ... Earlier studies have shown that salt reduction of 3 g per day in food could reduce blood pressure and prevent 2500 deaths per year due to cardiovascular diseases in the Netherlands. In Western countries, salt consumption can be as high as 9-12 g a day whereas 5 g is the recommended amount according to WHO standards"
  • Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study - Menopause. 2010 Aug 31 - "Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown ... CONCLUSIONS: Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women" - Note:  See raysahelian.com/inositol.html  and http://en.wikipedia.org/wiki/Inositol which claim myo-inositol and inositol are the same.  See myo inositol at Amazon.com.
  • Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial - Am J Clin Nutr. 2010 Aug 4 - "randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 w ... Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group ... Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure-lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ge 15% and 25%, respectively"
  • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure - Nutr Metab Cardiovasc Dis. 2010 Jul 29 - "Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD ... One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration" - See resveratrol products at Amazon.com.
  • Chili peppers may come with blood pressure benefits - Science Daily, 8/3/10 - "We found that long-term dietary consumption of capsaicin, one of the most abundant components in chili peppers, could reduce blood pressure in genetically hypertensive rats" - See capsaicin supplements at Amazon.com.
  • Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome - J Nutr. 2010 Jul 21 - "The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (-6 and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05)" - See blueberry extract at Amazon.com.
  • Fitness, Fatness, and Blood Pressure - Medscape, 7/19/10 - "In this cohort, consisting mainly of white men (average age, 46 years), normal-weight individuals had a mean systolic blood pressure 12 mm Hg lower than obese individuals (115 vs 127 mm Hg, p<0.001). In contrast, individuals with high levels of fitness, those in the highest quartile, had a 6 mm Hg lower systolic blood pressure than those least fit (119 vs 125 mm Hg, p<0.001)"
  • Effects of Vitamin D Supplementation on Blood Pressure - South Med J. 2010 Jul 8 - "From 244 retrieved papers, four RCTs involving 429 participants met our inclusion criteria for this meta-analysis. Vitamin D supplementation reduced systolic blood pressure (SBP) by 2.44 mm Hg (weighted mean difference [WMD]: -2.44, 95% confidence interval [CI]: -4.86, -0.02), but not diastolic blood pressure (DBP) (WMD: -0.02, 95% CI: -4.04, 4.01) compared with calcium or placebo. Subgroup analysis suggested that the change of blood pressure did not vary markedly across the dose of vitamin D supplementation, study length, or intervention. CONCLUSIONS:: Oral vitamin D supplementation may lead to a reduction in systolic blood pressure but not diastolic blood pressure" - See vitamin D at Amazon.com.
  • Cocoa flavanols improve vascular and blood pressure measures for coronary artery disease patients - Science Daily, 7/6/10 - "The findings indicate that foods rich in flavanols -- such as cocoa products, tea, wine, and various fruits and vegetables -- have a cardio-protective benefit for heart disease patients ... The study found a protective effect from a cocoa drink with 375 mg of flavanols, but according to researchers, a standard or recommended dosage has not yet been defined to achieve optimal health benefit ... In the current study, the benefit seen from the two-fold increase in circulating angiogenic cells was similar to that achieved by therapy with statins and with lifestyle changes such as exercise and smoking cessation"
  • Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomised controlled trial - Maturitas. 2010 Jun 29 - "In patients with uncontrolled hypertension (SBP>/=140mmHg at baseline), systolic blood pressure was on average 10.2+/-4.3mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP<140mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%). CONCLUSION: Our trial suggests that aged garlic extract is superior to placebo in lowering systolic blood pressure similarly to current first line medications in patients with treated but uncontrolled hypertension" - See garlic supplements at Amazon.com.
  • Dark chocolate lowers blood pressure, research finds - Science Daily, 6/28/10 - "Flavanols have been shown to increase the formation of endothelial nitric oxide, which promotes vasodilation and consequently may lower blood pressure. There have, however, been conflicting results as to the real-life effects of eating chocolate. We've found that consumption can significantly, albeit modestly, reduce blood pressure for people with high blood pressure but not for people with normal blood pressure ... The pressure reduction seen in the combined results for people with hypertension, 5mm Hg systolic, may be clinically relevant -- it is comparable to the known effects of 30 daily minutes of physical activity (4-9mm Hg) and could theoretically reduce the risk of a cardiovascular event by about 20% over five years" - See flavonoids at Amazon.com.
  • Low calcium intake linked with increased risk of osteoporosis and hypertension in postmenopausal women - Science Daily, 6/18/10 - "a significantly increased proportion of women (35.4%) who consumed a lower amount of calcium through intake from dairy sources, had a concurrent diagnosis of both hypertension and osteoporosis, compared with women who consumed a higher amount of calcium (19.3% p<0.001) ... Further statistical analyses revealed that a lower calcium intake was associated with an increased risk of developing hypertension or osteoporosis over time when compared with controls (Odds Ratio (OR) hypertension: 1.43; 95%CI: 1.12-1.82, osteoporosis: OR 1.46; CI: 1.15-1.85). Women who consumed a lower amount of calcium were shown to be most likely to develop both conditions over time compared with women consuming a higher amount of calcium (OR 1.60; CI: 1.09-2.34)"
  • Drinking fewer sugar-sweetened beverages may lower blood pressure - Science Daily, 5/24/10 - ""Our findings suggest that reducing sugar-sweetened beverages and sugar consumption may be an important dietary strategy to lower blood pressure and further reduce other blood pressure-related diseases," Chen said. "It has been estimated that a 3-millimeters of mercury (mm Hg) reduction in systolic blood pressure should reduce stroke mortality by 8 percent and coronary heart disease mortality by 5 percent. Such reductions in systolic blood pressure would be anticipated by reducing sugar-sweetened beverages consumption by an average of 2 servings per day ... a reduction of one serving/day of SSB was associated with a 1.8 millimeters of mercury (mm Hg) drop in systolic pressure and a 1.1 mm Hg decline in diastolic pressure over 18 months"
  • Arterial Stiffness and Wave Reflections in Marathon Runners - Am J Hypertens. 2010 May 20 - "Marathon runners had significantly higher systolic, diastolic, pulse (both aortic and brachial), and mean pressures compared to controls (P < 0.05 for all). Marathon runners had significantly higher PWV (6.89 m/s vs. 6.33 m/s, P < 0.01), whereas there was no difference in AIx and AIx corrected for heart rate (AIx@75) compared to controls (13.8% vs. 13.9%, P = 0.985 and 8.2% vs. 10.3%, P = 0.340, respectively). Marathon race caused a significant fall in both AIx (12.2% vs. -5.8%, P < 0.001) and AIx@75 (7.0% vs. 0.0%, P = 0.01), whereas PWV did not change significantly (6.66 m/s vs. 6.74 m/s, P = 0.690). Aortic and brachial systolic, diastolic, and mean pressures were also decreased (P < 0.05).Conclusions A significant fall in wave reflections was observed after marathon race, whereas aortic stiffness was not altered. Moreover, marathon runners have increased aortic stiffness and pressures, whereas wave reflections indexes do not differ compared to controls"
  • Grapes reduce risk factors for heart disease and diabetes, animal study shows - Science Daily, 5/10/10 - "After three months, the rats that received the grape-enriched diet had lower blood pressure, better heart function, and reduced indicators of inflammation in the heart and the blood than rats who received no grape powder. Rats also had lower triglycerides and improved glucose tolerance" - See Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules.
  • Effects of continuous vs. interval exercise training on blood pressure and arterial stiffness in treated hypertension - Hypertens Res. 2010 Apr 9 - "Continuous and interval exercise training were beneficial for blood pressure control, but only interval training reduced arterial stiffness in treated hypertensive subjects"
  • Brown rice and cardiovascular protection -Science Daily, 4/26/10 - "brown rice might have an advantage over white rice by offering protection from high blood pressure and atherosclerosis ("hardening of the arteries") ... a component in a layer of tissue surrounding grains of brown rice may work against angiotensin II. Angiotensin II is an endocrine protein and a known culprit in the development of high blood pressure and atherosclerosis"
  • Pine bark extract may benefit blood pressure-related kidney health - Nutra USA, 3/5/10 - "55 hypertensive patients to participate in the randomized, controlled study. Subjects were assigned to receive Ramipril [an ACE inhibitor] (10 mg per day), and 29 of these people were randomly selected to also receive Pycnogenol (150 mg per day) ... After six months in the Ramipril-only group the albumin levels decreased by 26 per cent to 64 mg per 24-hour period, while additional Pycnogenol produced levels that averaged 39 mg per 24-hour period, equivalent to a 57 per cent decrease ... Statistically significant decreases in patients’ blood pressure were also observed, with systolic and diastolic blood pressures dropping by more than 30 and 8 per cent, respectively in the Ramipril-only group, and by a further 3 to 6 per cent in the combination group ... Diastolic and systolic blood flow improved by 8 and 12 per cent, in the combination group" - [Abstract] - See Pycnogenol at Amazon.com.
  • Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study - J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6 - "evaluated the effects of Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive patients presenting with early signs of renal function problems. One group of 26 patients was medicated with 10 mg ramipril per day only; a second group of 29 patients took Pycnogenol in addition to the ACE inhibitor over a period of 6 months ... Urinary albumin decreased from 87 +/- 23 to 64 +/- 16 mg/d with ramipril only. Additional Pycnogenol lowered albumin significantly better from 91 +/- 25 to 39 +/- 13 mg/day (P < .05). In both groups, serum creatinine was lowered; however, only in the combination treatment group did the effect reached statistical significance. In both groups, CRP levels decreased from 2.1 to 1.8 with ramipril and from 2.2 to 1.1 with the ramipril-Pycnogenol combination; the latter reached statistical significance. Kidney cortical flow velocity was investigated by Doppler color duplex ultrasonography. Both systolic and diastolic flow velocities increased significantly after 6 months medication with ramipril. The addition of Pycnogenol to the regimen statistically significantly further enhanced kidney cortical flow velocities, by 8% for diastolic flow and 12% for systolic flow, relative to values found for the group taking ramipril only" - See Pycnogenol at Amazon.com.
  • Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk - Nutr Metab Cardiovasc Dis. 2010 Feb 16 - "Participants in the highest quartile of urinary TPE had a reduced prevalence of hypertension compared to those in the lowest quartile (Odds Ratio=0.64; 95% confidence interval 0.45 to 0.92; P=0.015). Systolic and diastolic BP were inversely associated with urinary TPE after adjustment for potential confounders ... Polyphenol intake, assessed via TPE in urine, was negatively associated with BP levels and prevalence of hypertension in an elderly Mediterranean population at high cardiovascular risk. Participants with the highest intake of polyphenol-rich foods showed the lowest BP measurements"
  • Low-Carb Diet Lowers Blood Pressure - WebMD, 1/25/10
  • Urinary melatonin and risk of incident hypertension among young women J Hypertens. 2010 Jan 19 - "During 8 years of follow-up, a total of 125 women developed hypertension. The relative risk for incident hypertension among women in the highest quartile of urinary melatonin (>27.0 ng/mg creatinine) as compared with the lowest quartile (<10.1 ng/mg creatinine) was 0.49 (95% confidence interval 0.28-0.85, P < 0.001). CONCLUSION: First morning melatonin levels are independently and inversely associated with incident hypertension; low melatonin production may be a pathophysiologic factor in the development of hypertension" - See melatonin at Amazon.com.
  • High Fructose Intake Linked to Metabolic Syndrome, Kidney Disease - Science Daily, 1/14/10 - "men who were randomized to receive 200 g fructose daily for 2 weeks without or without allopurinol ... Fructose intake was associated with an average increase in systolic and diastolic blood pressure of 7 and 5 mm Hg, respectively ... Mean fasting triglyceride levels rose by 0.62 mmol/L (p < 0.002), while high-density lipoprotein cholesterol levels fell by 0.06 mmol/L ... the prevalence of metabolic syndrome increased by 25% to 33%"
  • Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure - Am J Hypertens. 2009 Nov 26 - "Resveratrol treatment significantly prevented the development of concentric hypertrophy, and systolic and diastolic dysfunction in SHR without lowering blood pressure. Resveratrol also significantly reduced the oxidative stress levels of cardiac tissue in SHR.ConclusionsResveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR. The cardioprotective effect of resveratrol in SHR may be partially mediated by a reduction in oxidative stress. Thus, resveratrol may have potential in preventing cardiac impairment in patients with essential hypertension" - See resveratrol products at Amazon.com.
  • Artificial Sweetener May Lower Blood Pressure - WebMD, 11/20/09 - "Systolic blood pressure dropped an average of 6.9 points in the OFS group, compared with 3.5 in the placebo group ... Diastolic blood pressure decreased an average of 7.3 points in the OFS group vs. 2.3 in the placebo group ... Levels of total cholesterol, low-density lipoprotein ( LDL or “bad” cholesterol), and triglycerides also dropped more in participants given OFS than in those who took placebo tablets" - See:

    • Fructooligosaccharide - Wikipedia, the free encyclopedia - "Fructooligosaccharides (FOS) also sometimes called oligofructose or oligofructan, is a class of oligosaccharides used as an artificial or alternative sweetener. FOS exhibits sweetness levels between 30 and 50 percent of sugar in commercially-prepared syrups. [1] Its use emerged in the 1980s in response to consumer demand for healthier and calorie-reduced foods. The term oligosaccharide refers to a short chain of sugar molecules (in the case of FOS, fructose molecules). Oligo means few, and saccharide means sugar"
    • See inulin at Amazon.com.
  • Low Total and Nonheme Iron Intakes Are Associated with a Greater Risk of Hypertension - J Nutr. 2009 Nov 18 - "Low nonheme iron intake at baseline was associated with a greater increase in systolic BP (SBP) and pulse pressure over time after adjustment for multiple possible confounding factors (P-trend = 0.002 and 0.0005, respectively). Conversely, participants in the 3rd tertile of nonheme iron intake at baseline had a 37% lower risk of hypertension after 5.4 y of follow-up compared with those in the first tertile (P-trend = 0.04). Heme iron intake was not associated with BP changes or risk of hypertension. Meat intake was positively associated with an increase in SBP (P-trend = 0.04). However, that relation became nonsignificant after adjusting for dietary pattern scores. Baseline hemoglobin and ferritin concentrations were not associated with changes in BP or incidental hypertension. Our data support a possible role of low nonheme iron intake, independent of heme iron intake, in the development of hypertension"
  • High Fructose Corn Syrup: A Recipe For Hypertension, Study Finds - Science Daily, 11/10/09 - "people who ate or drank more than 74 grams per day of fructose (2.5 sugary soft drinks per day) increased their risk of developing hypertension. Specifically, a diet of more than 74 grams per day of fructose led to a 28%, 36%, and 87% higher risk for blood pressure levels of 135/85, 140/90, and 160/100 mmHg, respectively. (A normal blood pressure reading is below 120/80 mmHg.)"
  • High Fructose Intake May Raise Blood Pressure - WebMD, 11/2/09 - "About 2.5 sugary soft drinks a day is enough to elevate the pressure ... Overall, intakes of 74 grams or more daily was associated with a 36% higher risk of having blood pressure of 140/90 or higher, she found. Ideally, blood pressure should be below 120/80 ... ''We know that fructose has the potential to reduce nitric oxide production within the blood vessels,'' she says. "Nitric oxide relaxes the vessel and is supposed to lower blood pressure. Fructose reduces the production of nitric oxide and makes it difficult for the vessels to relax and dilate." ... Fructose also raises uric acid in the blood, she says, and that could raise blood pressure. "Fructose can tell the kidneys to 'hold onto' more salt, and that can contribute to high blood pressure,""
  • Oral L-Citrulline Supplementation Attenuates Blood Pressure Response to Cold Pressor Test in Young Men - Am J Hypertens. 2009 Oct 22 - "Compared to placebo, oral L-citrulline treatment decreased (P < 0.05) brachial SBP (-6 +/- 11 mm Hg), aortic SBP (-4 +/- 10 mm Hg), and aortic PP (-3 +/- 6 mm Hg) during CPT but not at rest. There was an inverse correlation (r = -0.40, P < 0.05) between changes in aortic SBP and Tr during CPT after L-citrulline supplementation" - See citrulline malate at Amazon.com.
  • Antioxidant Treatment With Tempol and Apocynin Prevents Endothelial Dysfunction and Development of Renovascular Hypertension - Am J Hypertens. 2009 Sep 24 - "The data suggest that a compromised mechanism of antioxidant defense and an increase in oxidative damage contribute to the development of hypertension and associated vascular dysfunction in 2K-1C rats, and that tempol and apocynin prevent these effects"
  • Does Vitamin D Protect Against High BP? - WebMD, 9/24/09 - "Vitamin D deficiency earlier in life appeared to be a predictor of hypertension more than a decade later" - See vitamin D at Amazon.com.
  • Insomnia Is Bad For The Heart; Increases Blood Pressure - Science Daily, 9/4/09 - "A new study published in the journal Sleep has found that people who suffer from insomnia have heightened nighttime blood pressure, which can lead to cardiac problems"
  • Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats - J Hypertens. 2009 Aug;27 Suppl 6:S5-10 - "It is concluded that although melatonin, in comparison with captopril, did not reverse left ventricle hypertrophy, it reversed left ventricular fibrosis. This protection by melatonin may be caused by its prominent antioxidative effect" - See melatonin at Amazon.com.
  • The circadian melatonin rhythm and its modulation: possible impact on hypertension - J Hypertens. 2009 Aug;27 Suppl 6:S17-20 - "The chronic administration of melatonin to individuals with hypertension induces a measurable drop in night time systolic and diastolic blood pressure. Moreover, the higher the night time level of endogenous melatonin (estimated from urinary metabolite of melatonin, 6-hydroxymelatonin sulphate), the greater the reduction in arterial blood pressure at night. The implication of these findings is that melatonin may have utility as an antihypertensive agent" - See melatonin at Amazon.com.
  • Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk. Effects of Acetyl-L-Carnitine Therapy - Hypertension. 2009 Jul 20 - "glucose disposal rate (GDR) ... Systolic blood pressure decreased from 144.0+/-13.6 to 135.1+/-8.4 mm Hg and from 130.8+/-12.4 to 123.8+/-10.8 mm Hg in the lower and higher GDR groups, respectively (P<0.05 for both; P<0.001 overall) and progressively recovered toward baseline over 8 weeks posttreatment. Total and high molecular weight adiponectin levels followed specular trends. Diastolic blood pressure significantly decreased only in those with higher GDRs. Treatment was well tolerated in all of the patients. Acetyl-L-carnitine safely ameliorated arterial hypertension, insulin resistance, impaired glucose tolerance, and hypoadiponectinemia in subjects at increased cardiovascular risk" - See acetyl l-carnitine products at Amazon.com.
  • Oral Magnesium Supplementation Reduces Ambulatory Blood Pressure in Patients With Mild Hypertension - Am J Hypertens. 2009 Jul 16 - "In the Mg(2+) supplementation group, small but significant reductions in mean 24-h systolic and diastolic BP levels were observed, in contrast to control group (-5.6 +/- 2.7 vs. -1.3 +/- 2.4 mm Hg, P < 0.001 and -2.8 +/- 1.8 vs. -1 +/- 1.2 mm Hg, P = 0.002, respectively)" - See magnesium supplements at Amazon.com.
  • Cut Hypertension Drugs With Low-Salt Diet - WebMD, 7/21/09
  • Glutamic Acid, the Main Dietary Amino Acid, and Blood Pressure. The INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure) - Circulation. 2009 Jul 6 - "Dietary glutamic acid (percentage of total protein intake) was inversely related to BP. Across multivariate regression models (model 1, which controlled for age, gender, and sample, through model 5, which controlled for 16 possible nonnutrient and nutrient confounders), estimated average BP differences associated with a glutamic acid intake that was higher by 4.72% of total dietary protein (2 SD) were -1.5 to -3.0 mm Hg systolic and -1.0 to -1.6 mm Hg diastolic (z scores -2.15 to -5.11)" - See l-glutamic acid at Amazon.com.
  • Component Of Vegetable Protein May Be Linked To Lower Blood Pressure - Science Daily, 7/6/09 - "Researchers found that a 4.72 percent higher dietary intake of the amino acid glutamic acid as a percent of total dietary protein correlated with lower group average systolic blood pressure, lower by 1.5 to 3.0 millimeters of mercury (mm Hg). Group average diastolic blood pressure was lower by 1.0 to 1.6 mm Hg" - See l-glutamic acid at Amazon.com.
  • Whole grains and incident hypertension in men - Am J Clin Nutr. 2009 Jul 1 - "whole-grain intake was inversely associated with risk of hypertension, with a relative risk (RR) of 0.81 (95% CI: 0.75-0.87) in the highest compared with the lowest quintile (P for trend < 0.0001). In the multivariate model, total bran was inversely associated with hypertension, with a relative risk (RR) of 0.85 (95% CI: 0.78, 0.92) in the highest compared with the lowest quintile"
  • Too little sleep may raise blood pressure - MSNBC, 6/9/09 - "The study ... found missing an average one hour of sleep over five years raised the risk of developing high blood pressure by 37 percent"
  • Omega-3 may improve blood pressure during weight loss - Nutra USA, 6/2/09 - "Consumption of fatty fish like salmon, or fish oil supplements, may reduce blood pressure during an energy-restricted diet" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Magnesium may benefit blood pressure in hypertensives - Nutra USA, 5/19/09 - "receive either daily supplements of 300 mg of elemental magnesium in the magnesium oxide form or placebo for 12 weeks ... At the end of the study, no significant differences were observed between the magnesium or placebo groups. However, when the researchers looked specifically at hypertensives, significant decreases in both systolic and diastolic blood pressure were observed in the magnesium group (17.1 and 3.4 mmHg, respectively), compared to placebo (6.7 and 0.8 mmHg, respectively)" - [Abstract] - See magnesium supplements at Amazon.com.
  • Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults - Nutr Metab Cardiovasc Dis. 2009 Apr 7 - "These results suggested that magnesium supplementation does not reduce BP and enhance insulin sensitivity in normo-magnesemic nondiabetic overweight people. However, it appears that magnesium supplementation may lower BP in healthy adults with higher BP" - See magnesium supplements at Amazon.com.
  • Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study - Br J Nutr. 2009 Apr 30:1-10 - "Subjects were randomised to receive 150 mg quercetin/d in a double-blinded, placebo-controlled cross-over trial with 6-week treatment periods separated by a 5-week washout period. Mean fasting plasma quercetin concentrations increased from 71 to 269 nmol/l (P < 0.001) during quercetin treatment. In contrast to placebo, quercetin decreased systolic blood pressure (SBP) by 2.6 mmHg (P < 0.01) in the entire study group, by 2.9 mmHg (P < 0.01) in the subgroup of hypertensive subjects and by 3.7 mmHg (P < 0.001) in the subgroup of younger adults aged 25-50 years. Quercetin decreased serum HDL-cholesterol concentrations (P < 0.001), while total cholesterol, TAG and the LDL:HDL-cholesterol and TAG:HDL-cholesterol ratios were unaltered. Quercetin significantly decreased plasma concentrations of atherogenic oxidised LDL, but did not affect TNF-alpha and C-reactive protein when compared with placebo ... Blood parameters of liver and kidney function, haematology and serum electrolytes did not reveal any adverse effects of quercetin. In conclusion, quercetin reduced SBP and plasma oxidised LDL concentrations in overweight subjects with a high-CVD risk phenotype. Our findings provide further evidence that quercetin may provide protection against CVD" - See quercetin at Amazon.com.
  • Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension - Hypertens Res. 2009 Apr 24 - "hypotensive action of time-released garlic powder tablets (Allicor) was compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension ... Allicor treatment (600 mg daily) resulted in a reduction of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively. Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit. Treatment with Kwai resulted in the same decrease in systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as that seen with Allicor, but no decrease in diastolic blood pressure was observed with Kwai ... The results of this study show that time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements" - See garlic supplements at Amazon.com.
  • Benefit Of Grapes May Be More Than Skin Deep: Lower Blood Pressure, Reduced Heart Damage - Science Daily, 4/22/09 - "After 18 weeks, the rats that received the grape-enriched diet powder had lower blood pressure, better heart function, and fewer signs of heart muscle damage than the rats that ate the same salty diet but didn't receive grapes ... Rats that received the blood pressure medicine, hydrazine, along with a salty diet also had lower blood pressure, but their hearts were not protected from damage as they were in the grape-fed group" - See grape seed extract at Amazon.com.
  • Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis - Hypertens Res. 2009 Apr 17 - "Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol" - See resveratrol products at Amazon.com.
  • Late Bedtimes Linked to Heart Disease - WebMD, 3/30/09 - "The fewer hours a man slept each night, the higher his BMI, blood pressure, and triglyceride levels"
  • Chronic Insomnia With Short Sleep Duration Is Significant Risk Factor For Hypertension - Science Daily, 4/1/09 - "A study in the April 1 issue of the journal SLEEP is the first to demonstrate that chronic insomnia with objectively measured short sleep time is an independent and clinically significant risk factor for hypertension"
  • Conjugated Linoleic Acid Supplementation Enhances Antihypertensive Effect of Ramipril in Chinese Patients With Obesity-Related Hypertension - Am J Hypertens. 2009 Mar 19 - "Participants were randomized to a daily dose of 4.5 g/day CLA (nine 0.5-g capsules; a 50:50 isomer blend of c 9,t 11 and t 10,c 12 CLA) with 37.5 mg/day ramipril (group 1) or placebo with 37.5 mg/day ramipril (group 2) for 8 weeks ... Treatment with CLA significantly enhanced the reduction effect of ramipril on systolic BP and diastolic BP (P < 0.05). It also increased plasma adiponectin concentration (P < 0.05) and decreased plasma concentrations of leptin and angiotensinogen (P < 0.05); however, significant change was not observed in ACE activity" - See conjugated linoleic acid at Amazon.com.
  • Low Vitamin D Hurts Teenagers’ Hearts - WebMD, 3/11/09 - "Compared to the 25% of teens with the highest levels of vitamin D in their blood (more than 26 nanograms per milliliter), the 25% of teens with the lowest vitamin D levels (less than 15 ng/mL) had: ... Fourfold greater risk of metabolic syndrome, a combination of risk factors for diabetes ... 2.54 times greater risk of high blood sugar ... 2.36 times greater risk of high blood pressure" - See vitamin D at Amazon.com.
  • Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression - Atherosclerosis. 2009 Feb 3 - "studies have indicated that regular intake of green tea reduces the risk of cardiovascular diseases. This study examined whether catechin prevents endothelial dysfunction and hyperglycemia in the prediabetic stage of a type 2 diabetic (T2D) rat ... Catechin significantly reduced blood pressure (OLETF vs. Catechin-OLETF; 138+/-16mmHg vs. 126+/-16mmHg, p=0.013), fasting sugar (129+/-11mg/dL vs. 118+/-9mg/dL, p=0.02) and the insulin level (2.13+/-1.29ng/mL vs. 0.53+/-0.27ng/mL, p=0.004). In the aorta of Catechin-OLETF at 25 weeks, endothelium-dependent relaxations were significantly improved and NADPH oxidase activity in aortic rings was markedly decreased compared with those of OLETF. Catechin reduced vascular reactive oxygen species formation in the aorta and suppressed the expression of p22phox and p47phox NADPH oxidase subunits" - See green tea extract at Amazon.com.
  • Vitamin C-rich foods may boost artery health - Nutra USA, 2/17/09 - "increased intakes of vitamin C and fruit and berries were associated with less thickening of the carotid artery ... one mg per decilitre increase in blood vitamin C levels was linked to a 4.1 and 4.0 mmHg in systolic and diastolic blood pressures" - [Abstract] - See vitamin C products at Amazon.com.
  • Low-fat dairy linked to blood pressure improvements: Study - Nutra USA, 1/29/09 - "The systolic and diastolic blood pressures of those with the highest average level of low-fat dairy intake (631 grams per day) were 4.2 and 1.8 mmHg lower than for participants with the lowest average intakes (3.1 grams per day)"
  • Low-Sodium, High Potassium is Effective in Lowering Blood Pressure - Science Daily, 1/26/09 - "Those with the highest sodium levels in their urine were 20% more likely to suffer strokes, heart attacks, or other forms of cardiovascular disease compared with their counterparts with the lowest sodium levels. However this link was not strong enough to be considered statistically significant ... By contrast, participants with the highest sodium-to-potassium ratio in urine were 50% more likely to experience cardiovascular disease than those with the lowest sodium-to-potassium ratios. This link was statistically significant ... To lower blood pressure and blunt the effects of salt, adults should consume 4.7 grams of potassium per day unless they have a clinical condition or medication need that is a contraindication to increased potassium intake" - See potassium citrate at Amazon.com.
  • Reducing Salt Intake Isn't The Only Way To Reduce Blood Pressure - Science Daily, 1/26/09 - "A new study suggests that people trying to lower their blood pressure should also boost their intake of potassium, which has the opposite effect to sodium ... To lower blood pressure and blunt the effects of salt, adults should consume 4.7 grams of potassium per day unless they have a clinical condition or medication need that is a contraindication to increased potassium intake" - See potassium citrate at Amazon.com.
  • Vitamin C and BP - Medscape, 1/6/09 - "plasma vitamin-C concentrations were inversely associated with blood pressure in young women [1]. The results suggest that this nutrient may favorably influence blood pressure in healthy young adults ... plasma ascorbic acid at year 10 was inversely associated with systolic and diastolic BP. Those in the highest quartile of plasma vitamin C had 4.66-mm-Hg lower systolic BP and 6.04-mm-Hg lower diastolic BP (p=0.0002) than those in the lowest quartile ... Block says she has recently authored two papers detailing possible mechanisms by which vitamin C could lower BP. These show that vitamin C significantly lowers F2-isprostane, a marker of oxidative stress, and CRP, a marker of inflammation [2,3]. "Both inflammation and oxidative stress are pretty well established as having a role in hypertension ... Vitamin C is a powerful antioxidant in vitro, and in some animal studies it has been shown to act as a vasodilator, possibly by enhancing the bioavailability of nitric oxide" - See vitamin C products at Amazon.com.
  • Treatment of white coat hypertension with metformin - Int Heart J. 2008 Nov;49(6):671-9 - "White coat hypertension (WCH) is most likely a disorder associated with metabolic syndrome ... Twenty-five cases (14.7%) stopped metformin therapy due to excessive anorexia. At the end of a 6-month period, there were highly significant differences between the two groups with respect to the prevalences of resolved WCH, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, overweight and obesity, and decreased fasting plasma glucose below 110 mg/dL ... Thus, the management of WCH should not focus solely on the regulation of blood pressure with antihypertensive medications, but rather on the prevention of future excess weight and various associated disorders, and metformin alone is an effective therapeutic option, most likely due to its powerful inhibitory effect on appetite"
  • The Effects of Natural Antioxidants from Tomato Extract in Treated but Uncontrolled Hypertensive Patients - Cardiovasc Drugs Ther. 2008 Dec 4 - "two double blind cross-over treatment periods of 6 weeks each, with standardized tomato extract or identical placebo ... There was a significant reduction of systolic BP after 6 weeks of tomato extract supplementation, from 145.8 +/- 8.7 to 132.2 +/- 8.6 mmHg (p < 0.001) and 140.4 +/- 13.3 to 128.7 +/- 10.4 mmHg (p < 0.001) in the two groups accordingly. Similarly, there was a decline in diastolic BP from 82.1 +/- 7.2 to 77.9 +/- 6.8 mmHg (p = 0.001) and from 80.1 +/- 7.9 to 74.2 +/- 8.5 mmHg (p = 0.001). There was no significant change in systolic and diastolic BP during the placebo period" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Potassium Loss From Blood Pressure Drugs May Explain Higher Risk Of Adult Diabetes - Science Daily, 11/24/08 - "a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes" - See potassium citrate at Amazon.com.
  • Effects of Garlic on Blood Pressure in Patients With and Without Systolic Hypertension: A Meta-Analysis (December) - Ann Pharmacother. 2008 Nov 18 - "Garlic reduced SBP by 16.3 mm Hg (95% CI 6.2 to 26.5) and DBP by 9.3 mmHg (95% CI 5.3 to 13.3) compared with placebo in patients with elevated SBP" - See garlic supplements at Amazon.com.
  • The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial - J Hum Hypertens. 2008 Nov 20 - "Over 4 months, subjects in the intervention group received 2.5 g of MgCl(2) (50 ml of a solution containing 50 g of MgCl(2) per 1000 ml of solution) equivalent to 450 mg of elemental magnesium, and control subjects inert placebo ... SBP (-20.4+/-15.9 versus -4.7 +/- 12.7 mm Hg, P=0.03) and DBP (-8.7+/-16.3 versus -1.2+/-12.6 mm Hg, P=0.02) showed significant decreases, and high-density lipoprotein-cholesterol (0.1+/-0.6 versus -0.1+/-0.7 mmol l(-1), P=0.04) a significant increase in the magnesium group compared to the placebo group. The adjusted odds ratio between serum magnesium and BP was 2.8 (95%CI: 1.4-6.9). Oral magnesium supplementation with MgCl(2) significantly reduces SBP and DBP in diabetic hypertensive adults with hypomagnesaemia" - See magnesium supplements at Amazon.com.
  • Hibiscus Tea May Cut Blood Pressure - WebMD, 11/10/08 - "Overall, drinking hibiscus tea blends lowered systolic blood pressure -- the top number in the blood pressure reading -- by an average of 7 points. That was significantly more than the 1-point drop observed in people who were given a placebo in the form of hibiscus-flavored water"
  • Low Potassium Linked To High Blood Pressure - Science Daily, 11/8/08 - "As a risk factor for high blood pressure, low levels of potassium in the diet may be as important as high levels of sodium" - See potassium citrate at Amazon.com.
  • Grapes May Aid A Bunch Of Heart Risk Factors, Animal Study Finds - Science Daily, 10/29/08 - "Could eating grapes help fight high blood pressure related to a salty diet? And could grapes calm other factors that are also related to heart diseases such as heart failure? A new University of Michigan Cardiovascular Center study suggests so" - See grape seed extract at Amazon.com.
  • Chicken Soup May Help Fight High Blood Pressure - Science Daily, 10/13/08 - "Saiga and colleagues extracted collagen from chicken legs and tested its ability to act as an ACE inhibitor in the laboratory studies. They identified four different proteins in the collagen mixture with high ACE-inhibitory activity. Given to rats used to model human high blood pressure, the proteins produced a significant and prolonged decrease in blood pressure"
  • Olive Leaf Extract Can Help Tackle High Blood Pressure And Cholesterol - Science Daily, 8/27/08 - "This works showed that taking a 1000mg dose has substantial effects in people with borderline hypertension" - See olive leaf extract at Amazon.com.
  • High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets - J Hypertens. 2008 Jul;26(7):1402-1410 - "Diets high in sugar accelerated cardiac systolic dysfunction and mortality in hypertension compared to either a low-carbohydrate/high-fat or high-starch diet"
  • Chromium ingredient may lower blood pressure: study - Nutra USA, 5/15/08 - "niacin-bound chromium III (NBC) may act as an ACE inhibitor, which work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure" - I've been told that niacin-bound chromium is sold as ChromeMate®.  See chromium supplements at Amazon.com.
  • Pine bark extract may boost diabetics' heart health - Nutra USA, 5/12/08 - "recruited diabetic subjects with an average age of 60 and randomly assigned them to receive daily supplements of Pycnogenol (125 mg) or placebo for 12 weeks ... All subjects were receiving pharmaceutical anti-hypertension treatment (angiotensin- converting enzyme [ACE] inhibitors) ... 58.3 per cent of subjects in the Pycnogenol group experienced blood pressure control, defined as attaining a stable systolic blood pressure, compared to 20.8 per cent in the placebo group ... use of ACE inhibitors was reduced by 50 per cent in the group receiving the pine bark extract ... a 23.7 mg/dL reduction in fasting blood glucose levels in the Pycnogenol group, compared to only 5.7 mg/dL in the placebo group" - See Pycnogenol at Amazon.com.
  • Happy Marriage, Better Blood Pressure - WebMD, 3/20/08
  • Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels - Diabet Med. 2008 Feb 13 - "Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo" - See vitamin D at Amazon.com.
  • Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report - Lipids Health Dis. 2007 Nov 26;6:33 - "the calculated values for cholesterol associated to low density lipoprotein (LDL-C) were significantly reduced by the Spirulina maxima ... significant differences were found comparing initial and final SYST-P and DIAST-P blood pressure in both male and female: SYST-P male 121 +/- 9 vs. 111 +/- 8 mm Hg (p < 0.01), DIAST-P male 85 +/- 6.5 vs. 77 +/- 9 mm Hg (p < 0.01); SYST-P female 120 +/- 9.5 vs. 109 +/- 11 mm Hg (p < 0.002), DIAST-P female 85 +/- 11 vs. 79 +/- 7.5 mm Hg" - See spirulina at Amazon.com.
  • Dietary pattern and blood pressure control in a hypertension outpatient clinic - Hypertens Res. 2007 Nov;30(11):1043-50 - "those who return to a diet richer in vegetables, legumes and fish and poorer in saturated fat and salt achieve better control of their BP, without increasing the number of antihypertensive pills"
  • n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study - Public Health Nutr. 2008 Jan;11(1):17-29 - "Word Fluency Test (WFT) ... an increase of one standard deviation in dietary long-chain n-3 fatty acids (% of energy intake) and balancing long-chain n-3/n-6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66-0.95) and 0.81 (0.68-0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n-3 fatty acids (g day-1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51" - See Mega Twin EPA at Amazon.com.
  • Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey - Am J Clin Nutr. 2008 Jan;87(1):136-41 - "systolic blood pressure (SBP) ... SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States" - Note:  SBP is the upper number.  See vitamin D at Amazon.com.
  • Ascorbic Acid Decreases the Binding Affinity of the AT(1) Receptor for Angiotensin II - Am J Hypertens. 2008 Jan;21(1):67-71 - "Ascorbic acid decreases the binding affinity of the AT(1) receptor. These results offer a mechanistic explanation for the reported blood pressure lowering effect of ascorbic acid"
  • Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts - Am J Hypertens. 2007 Dec;20(12):1321-8 - "green tea extract (GTE) ... The GTE prevented hypertension and target organ damage induced by a high Ang II dose, likely by prevention or scavenging of superoxide anion generation" - See green tea extract at Amazon.com.
  • Pycnogenol((R)), French maritime pine bark extract, augments endothelium-dependent vasodilation in humans - Hypertens Res. 2007 Sep;30(9):775-80 - "These findings suggest that Pycnogenol((R)) augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol((R)) would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction" - Some say that grape seed extract is the same as Pycnogenol((R)) without the patent markup.  See Pycnogenol at Amazon.com and grape seed extract at Amazon.com.
  • n-3 Fatty acids, hypertension and risk of cognitive decline among older adults in the Atherosclerosis Risk in Communities (ARIC) study - Public Health Nutr. 2007 Jul 12;:1-13 - "Word Fluency Test (WFT) ... Findings indicated that an increase of one standard deviation in dietary long-chain n-3 fatty acids (% of energy intake) and balancing long-chain n-3/n-6 decreased the risk of 6-year cognitive decline in verbal fluency with an odds ratio (95% confidence interval) of 0.79 (0.66-0.95) and 0.81 (0.68-0.96), respectively, among hypertensives. An interaction with hypertensive status was found for dietary long-chain n-3 fatty acids (g day-1) and WFT decline (likelihood ratio test, P = 0.06). This exposure in plasma cholesteryl esters was also protective against WFT decline, particularly among hypertensives (OR = 0.51"
  • Onion compound linked to lower blood pressure - Nutra USA, 10/23/07 - "receive a daily supplement of quercetin (730 mg, USANA Health Sciences) or placebo for 28 days ... the hypertensives receiving the quercitin supplement experienced reductions in systolic and diastolic BP of seven and five mmHg, respectively, compared to placebo" - See quercetin at Amazon.com.
  • Quercetin reduces blood pressure in hypertensive subjects - J Nutr. 2007 Nov;137(11):2405-11 - "730 mg quercetin/d for 28 d vs. placebo ... reductions in (P < 0.01) systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg), and mean arterial pressures (-5 +/- 2 mm Hg) were observed in stage 1 hypertensive patients after quercetin treatment" - See quercetin at Amazon.com.
  • Modest Weight Loss Cuts Hypertension - WebMD, 10/1/07 - "A little more than half (52%) of those who met the weight loss goal also got their blood pressure down into the normal range ... The bottom line: It didn't take a whole lot of weight loss to curb high blood pressure"
  • Whole Grains vs. High Blood Pressure - WebMD, 8/10/07 - "Compared to women who reported eating less than half a daily serving of whole grains, women who claimed to eat at least four daily servings of whole grains were about 23% less likely to be diagnosed with high blood pressure during the study"
  • Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohort - Am J Clin Nutr. 2007 Jun;85(6):1650-6 - "high fruit and vegetable intakes may be associated with a lower increase in BP with aging"
  • Omega-3s May Lower Blood Pressure - WebMD, 6/4/07 - "Participants with the highest intake of omega-3 fatty acids tended to have the lowest blood pressure" - See Mega Twin EPA at Amazon.com or Jarrow Max DHA at Amazon.com.
  • Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease - J Clin Hypertens (Greenwich). 2007 Apr;9(4):249-55 - "Mitochondria produce reactive oxygen species that may contribute to vascular dysfunction. alpha-Lipoic acid and acetyl-L-carnitine reduce oxidative stress and improve mitochondrial function ... Active treatment increased brachial artery diameter by 2.3% (P=.008), consistent with reduced arterial tone. Active treatment tended to decrease systolic blood pressure for the whole group (P=.07) and had a significant effect in the subgroup with blood pressure above the median (151+/-20 to 142+/-18 mm Hg; P=.03) and in the subgroup with the metabolic syndrome (139+/-21 to 130+/-18 mm Hg; P=.03)" - See acetyl l-carnitine at Amazon.com and the alpha lipoic acid at Amazon.com.
  • Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Apr;21(4):297-306 - "coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects" - See ubiquinol at Amazon.com.
  • Supplementation with vitamins C and e improves arterial stiffness and endothelial function in essential hypertensive patients - Am J Hypertens. 2007 Apr;20(4):392-7 - "Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients"
  • Chiropractic Cuts Blood Pressure - WebMD, 3/16/07
  • Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Feb 8 - "We conclude that coenzyme Q(10) has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects" - See coenzyme Q10 at Amazon.com.
  • Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients - Eur J Clin Nutr. 2007 Jan 31 - "Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA" - See flax seed at Amazon.com.
  • Moderate Consumption of Olive Oil by Healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants J Nutr. 2007 Jan;137(1):84-87 - "General linear models showed that the administration of the sequence of the 3 olive oils was responsible for a 3% decrease in systolic BP (SBP) (P < 0.05), but not in diastolic BP, in the non-Mediterranean subjects"
  • Whole-grain diets reduce blood pressure in mildly hypercholesterolemic men and women - J Am Diet Assoc. 2006 Sep;106(9):1445-9 - "Systolic pressure was lower after the wheat/rice and half-and-half diets. Diastolic and mean arterial pressures were reduced by all whole-grain diets"
  • Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension - Clin Exp Hypertens. 2006 Jul;28(5):489-97 - "magnesium, 70.8 mg/d; potassium, 217.2 mg/d ... On K+ and Mg2+ supplementation, systolic and diastolic BP decreased 7.83 +/- 1.87 mm Hg and 3.67 +/- 1.03 mm Hg"
  • Low-Fat Dairy Lowers Blood Pressure - WebMD, 6/26/06 - "the systolic blood pressure of people who ate the most low-fat dairy -- more than three servings a day -- was 2.6 points lower than those who ate the least -- less than half a serving a day"
  • Grape Seed Extract for Blood Pressure? - WebMD, 3/27/06
  • Study Shows Grape Seed Extract May Be Effective In Reducing Blood Pressure - Science Daily, 3/27/06 - "The first group received a placebo, while the second and third groups received 150 milligrams and 300 milligrams, respectively, of a new grape seed extract ... Participants in the two groups receiving grape seed extract experienced an equal degree of reduced blood pressure. The average drop in systolic pressure was 12 millimeters. The average drop in diastolic pressure was 8 millimeters" - See iHerb or Vitacosticon grape seed extracts.
  • Salt Substitute Significantly Reduces Hypertension Amongst Rural Chinese - Science Daily, 3/14/06 - "Among the 600 individuals studied in rural Northern China, the low-sodium high-potassium salt substitute demonstrated that it could reduce blood pressure to about the same extent as single drug therapy"
  • How Nice, Brown Rice: Study Shows Rice Bran Lowers Blood Pressure In Rats - Science Daily, 3/3/06 - "adding rice bran to the diets of hypertensive, stroke-prone rats lowered the animals’ systolic blood pressure by about 20 percent and, via the same mechanism, inhibited angiotensin-1 converting enzyme, or ACE"
  • Melatonin may cut hypertension - Nutra USA, 2/2/06 - "A 10 per cent decline of BP over daytime values is considered appropriate to reduce the cardiovascular risk ... During placebo use only 39 per cent of the subjects reached this value, but this rate surged to 84 per cent during melatonin administration" - See iHerb or Vitacosticon melatonin products.
  • Tomato extract helps reduce blood pressure - Nutra USA, 1/12/06 - "a daily intake of the commercial encapsulated tomato extract Lyc-O-Mato, made by Israel-based LycoRed, was linked to a drop in systolic (SBP) and diastolic blood pressure (DBP) of ten and four points after eight weeks of supplementation of a normal diet" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study - Am Heart J. 2006 Jan;151(1):100 - "Systolic blood pressure decreased from 144 (SE +/- 1.1) to 134 mm Hg (SE +/- 2, P < .001), and diastolic blood pressure decreased from 87.4 (SE +/- 1.2) to 83.4 mm Hg" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Skimmed Milk Reduces The Risk Of Hypertension By 50 Percent - Science Daily, 12/1/05 - "Those persons with an elevated consumption of skimmed milk and milk products showed a reduction of 50% in their risk of developing hypertension, compared with those with a low consumption or who did not consume these products"
  • Unsaturated Fats Can Lower Blood Pressure, Study Shows - WashingtonPost.com, 11/15/05 - "Trading about 10 percent of carbohydrates in one's diet for beans and healthy fats, such as olive oil, can help control high blood pressure and improve blood cholesterol levels"
  • High Blood Pressure: Nightly Aspirin May Help - WebMD, 9/15/05 - "After three months, these were the results: ... Aspirin at night: Significant drop in blood pressure ... Aspirin in the morning: Slightly higher blood pressure"
  • Dark Chocolate May Cut High Blood Pressure - WebMD, 7/18/05 - "With dark chocolate, 24-hour systolic blood pressure dropped 12 points; diastolic blood pressure dipped 8.5 points ... Insulin sensitivity and LDL cholesterol also improved with dark chocolate ... the dark chocolate we used had a high level of flavonoids"
  • Reduce Your Blood Pressure - ABC News, 7/5/05 - "blood pressure is the key to healthy arteries, and arteries are the key to aging ... the ideal blood pressure is 115/75"
  • Soybean Protein Supplementation May Reduce Systolic, Diastolic BP - Medscape, 7/5/05 - "randomized to receive 40 g of isolated soybean protein supplements daily ... the net blood pressure changes in the soy group after the intervention were -4.31 mm Hg systolic ... and -2.76 mm Hg diastolic"
  • WARNING! Normal Blood Pressure May Be High Blood Pressure! - Life Extension Magazine, 5/05 - "To Solve Hypertension, Address Metabolic Syndrome"
  • Exercise Alone No High Blood Pressure Cure - WebMD, 4/12/05 - "A vigorous-intensity exercise program has many benefits for older people. But curing high blood pressure doesn't seem to be one of them"
  • Folic acid: It's not just for your baby’s health - MSNBC, 4/4/05 - "The younger group of women (ages 25 to 42) who consumed 1000 micrograms of folic acid through foods and supplements had a 46 percent decrease in their risk of developing hypertension as compared to those women who consumed less than 200 micrograms ... older group of women (ages 30 to 55) 1000 micrograms of folic acid was found to decrease risk of developing hypertension to a lesser extent — 18 percent" - See iHerb or Vitacosticon folic acid products.
  • Dark Chocolate May Lower Blood Pressure - WebMD, 3/11/05 - "the participants' systolic blood pressure (the top number in a blood pressure reading) was significantly lower after 15 days of eating dark chocolate -- an average of 108 mm Hg compared with 114 mm Hg"
  • High-Fiber Diet May Fight High Blood Pressure - WebMD, 3/4/05 - "the average reduction in blood pressure was 3.12 mmHg systolic and 2.57 mmHg diastolic"
  • Folic Acid May Prevent Hypertension in Addition to Reducing the Risk of Birth Defects - Doctor's Guide, 2/24/05 - "younger women who consumed at least 1,000 micrograms per day of total folic acid (dietary plus supplemental) had a 46 percent decreased risk of hypertension, compared with those who consumed less than 200 micrograms a day of total folic acid. Older women with high total folic acid intake also had an 18 percent reduced risk of hypertension"
  • The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial - J Hypertens. 2005 Feb;23(2):427-434 - "Vitamin C alone reduced systolic BP versus placebo ... However, treatment with the combination of vitamin C and polyphenols increased systolic BP (4.8 +/- 0.9 mmHg versus placebo ... and diastolic BP (2.7 +/- 0.6 mmHg, P < 0.0001 versus placebo"
  • New Study Reveals Treatment For 'Silent Killer' Using Diet, Not Drugs - Science Daily, 1/19/04
  • Folic Acid May Fight High Blood Pressure - WebMD, 1/18/05
  • Folate intake and the risk of incident hypertension among US women - JAMA. 2005 Jan 19;293(3):320-9 - "Higher total folate intake was associated with a decreased risk of incident hypertension, particularly in younger women" - See iHerb or Vitacosticon folic acid products.
  • High Folate Intake May Reduce Risk of Hypertension in Women - Medscape, 1/18/05 - [Abstract] "younger women consuming at least 1,000 µg per day of total folate (dietary plus supplemental) had a 46% reduction in the risk of incident hypertension ... compared with those ingesting less than 200 µg per day"
  • The high five for hypertension - Functional Foods & Nutraceuticals, 12/04 - "Co-enzyme Q10 ... Omega-3 fatty acids ... Garlic ... L-arginine ... Calcium"
  • Cardiovascular effects of oral Supplementation of vitamin C, E and folic acid in young healthy males - Int J Vitam Nutr Res. 2004 Jul;74(4):285-93 - "The objective of this study was to investigate the effects of a daily dosage of 1000 mg vitamin C, 800 mg vitamin E, and 10 mg folate on markers of vascular function in 31 young healthy male adults ... Our main finding was a significant decrease (p = 0.03) in systolic blood pressure in the experimental group"
  • More Muscle Means Better Regulation Of Blood Pressure, Study Finds - Science Daily, 11/26/04 - "Fat, especially abdominal fat, secretes angiotensin which makes angiotensin II, a powerful vasoconstrictor that also directs the kidneys to absorb more sodium so blood vessels retain more fluid volume"
  • Stressed? Build Muscle to Help Blood Pressure - WebMD, 11/24/04
  • Folate Lowers Risk of High Blood Pressure - WebMD, 10/11/04 - "Young women with very low dietary folate who got their folate from vitamin supplements had a 39% lower risk of high blood pressure compared with young women who did not take folate supplements" - See iHerb or Vitacosticon folic acid products.
  • Handgrip Exercises May Lower Blood Pressure - WebMD, 10/8/04
  • Magnesium in Hypertension Prevention and Control - Life Extension Magazine, 9/04 - "Magnesium is one of the body’s most important minerals. ... Magnesium is a major factor in relaxing the smooth muscles within the blood vessels, thereby reducing peripheral vascular resistance and blood pressure.11-13 In addition, magnesium reduces nerve and muscle excitability, stabilizes cardiac conductivity, and influences neurochemical transmission.11,13,14 Magnesium also affects circulating levels of norepinephrine and the synthesis of serotonin and nitric oxide ... taking 600 mg of magnesium daily reduced systolic blood pressure by an average of 7.6 mm Hg and diastolic pressure by an average of 3.8 mm Hg"
  • Tea Drinkers Reap Blood Pressure Benefits - WebMD, 7/26/04 - "Those who drank at least a half-cup of moderate strength green or oolong tea per day for a year had a 46% lower risk of developing hypertension than those who didn't drink tea" - See iHerb or Vitacosticon green tea products.  My favorite is Jarrow Green Tea at Amazon.com.
  • The Natural Treatment of Hypertension - Medscape, 6/4/04
  • The Impact of Vitamins and/or Mineral Supplementation on Blood Pressure in Type 2 Diabetes - J Am Coll Nutr. 2004 Jun;23(3):272-9 - "group M: 200 mg Mg and 30 mg Zn (n = 16), group V: 200 mg vitamin C and 150 mg vitamin E (n = 18), group MV: minerals plus vitamins ... after three months of supplementation levels of systolic, diastolic and mean blood pressure decreased significantly in the MV group"
  • Melatonin to Lower Blood Pressure? - Dr. Weil, 2/24/04
  • Antioxidant May Help Lower Blood Pressure - WebMD, 2/20/04 - "people with high blood pressure who took the supplement, called Pycnogenol, were able to lower their daily dose of blood pressure-lowering medications by more than 30% ... researchers looked at the effects of daily supplementation with 100 milligrams of Pycnogenol" - Some claim that grape seed extract is identical to Pycnogenol without the patent mark-up.  - See iHerb or Vitacosticon grape seed extracts.
  • Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension - Hypertension. 2004 Feb;43(2):192-7 - "In patients with essential hypertension, repeated bedtime melatonin intake significantly reduced nocturnal blood pressure"- See iHerb or Vitacosticon melatonin products.
  • Pycnogenol reduces need for hypertension drugs - Nutra USA, 2/19/04 - "supplementation with 100mg Pycnogenol over a period of 12 weeks helped to reduce patients’ dose of the calcium antagonist nifedipine in a statistically significant manner" - Some claim that grape seed extract is identical to Pycnogenol without the patent mark-up.  - See iHerb or Vitacosticon grape seed extracts.
  • Nightime Melatonin Supplementation May Be Useful in the Treatment of Essential Hypertension - Doctor's Guide, 2/4/04 - "2.5 mg/day ... mean sleep systolic blood pressure decreased by 6 mm Hg and mean sleep diastolic blood pressure decreased by 4 mm Hg ... Repeated melatonin significantly increased sleep efficiency from 80% to 85% and increased actual sleep time from 5.6 to 6.1 hours. Melatonin therapy also reduced sleep latency from 33 to 22 minutes" - See iHerb or Vitacosticon melatonin products.
  • Jet Lag Hormone Lowers Blood Pressure - WebMD, 1/20/04
  • Potassium Supplementation Reduces Blood Pressure - Healthwell Exchange Daily News, 10/30/03 - "59 healthy adults between the ages of 25 and 65 years were randomly assigned to receive 600 mg of potassium chloride three times per day or a placebo for six weeks ... Systolic blood pressure, diastolic blood pressure, and MAP all decreased significantly in those taking potassium (by 7.6 mmHg, 6.5 mmHg, and 7.0 mmHg, respectively), compared with initial measurements. A significant increase in blood pressure was observed in those taking placebo" - See iHerb or Vitacosticon potassium products.
  • Increasing Calcium More Likely to Lower Blood Pressure Than Decreasing Sodium - Doctor's Guide, 10/12/03 - "When the diet is "balanced with no deficit in minerals, salt is not a problem," he said. "Salt becomes a problem when the diet is calcium deficient. Specifically, as calcium intake increases, blood pressure decreases."" - See Tums at Amazon.com.
  • Healthy BMI Prevents High Blood Pressure - WebMD, 10/9/03
  • Vitamin E Supplements Effective Treatment for Mild Hypertension - Doctor's Guide, 10/1/03 - "Vitamin E supplements of 200 IU/day improved the blood pressure status of 70 mild hypertensive ... Subjects who received vitamin E supplements had a 24% decrease in systolic blood pressure compared to a 1.6% decrease among placebo controls" - the systolic is the high number and is usually the problem.  See iHerb or Vitacosticon vitamin E products.
  • Tea Intake Is Inversely Related to Blood Pressure in Older Women - J Nutr. 2003 Sep;133(9):2883-2886 - "Tea is rich in polyphenols, which have activities consistent with blood pressure-lowering potential ... Higher tea intake and higher 4-O-methylgallic acid excretion were associated with significantly lower systolic (P = 0.002 and P = 0.040, respectively) and diastolic (P = 0.027 and P < 0.001, respectively) blood pressures. A 250 mL/d (1 cup) increase in tea intake was associated with a 2.2 (0.8, 3.6) mm Hg lower systolic blood pressure and a 0.9 (0.1, 1.7) mm Hg lower diastolic blood pressure" - See iHerb or Vitacosticon tea products and extracts.
  • A Little Exercise Lowers Blood Pressure - WebMD, 8/29/03 - "The ability to lower blood pressure was greatest among those who exercised 61-90 minutes per week -- an average of 12 point drop in systolic and eight points in diastolic. But there were no further reductions in systolic blood pressure among those who exercised more than 90 minutes a week ... The researchers also found that how many times the participants exercised per week had no obvious effect on blood pressure -- just the total amount of time"
  • Dark Chocolate Is Healthy Chocolate - WebMD, 8/27/03
  • Addition of Low-Dose Potassium to Diet Lowers Blood Pressure - Medscape, 8/19/03 - "KCl was administered as 1 slow-release tablet containing 8 mmol KCL taken 3 times daily with meals. This daily dose of potassium is equivalent to the content of 5 portions of fresh fruits and vegetables. At the end of the 6-week intervention, the 30 subjects who took potassium showed significant decreases in SBP and DBP (7.60 and 6.46 mm Hg, respectively)" - See iHerb or Vitacosticon potassium products.
  • The effect of low-dose potassium supplementation on blood pressure in apparently healthy volunteers - Br J Nutr. 2003 Jul;90(1):53-60 - "After 6 weeks of supplementation MAP [mean arterial pressure] was reduced by 7.01 ... mmHg, SBP was reduced by 7.60 ... mmHg and DBP was reduced by 6.46 ... mmHg ... A low daily dietary supplement of K, equivalent to the content of five portions of fresh fruits and vegetables, induced a substantial reduction in MAP, similar in effect to single-drug therapy for hypertension" - See iHerb or Vitacosticon potassium products.
  • What Should We Advise Our Patients About Taking Antioxidants? - J Clin Hypertens 5(3):231-233, 2003 via Medscape - "At least two randomized trials of the effects of coenzyme Q10 (another antioxidant) on blood pressure have been reported. In the first,[20] 59 treated hypertensives were randomized to either coenzyme Q10 (60 mg twice daily) or vitamin B (placebo); after 8 weeks, clinic blood pressure was 14/7 mm Hg lower in the treated group. In the second,[21] 83 patients with isolated systolic hypertension were treated with coenzyme Q10 (using the same dose as the earlier study) for 12 weeks. The mean reduction of blood pressure was 17.8/7.3 mm Hg" - See iHerb or Vitacosticon coenzyme Q10 products.
  • Night Time Aspirin Regimen Found to Reduce Blood Pressure - Doctor's Guide, 6/4/03 - "Researchers randomly assigned participants to 3 subgroups, which received a regimen of no aspirin, 100 mg aspirin after waking, or 100 mg aspirin before sleeping ... The subgroup following a regimen of evening aspirin administration showed a reduction in the 24 hour mean of 6.2 mm Hg in systolic blood pressure and 4.1 mm Hg in diastolic blood pressure ... the effect was not evident for the subgroups receiving no aspirin or morning administration" - See aspirin at Amazon.com.
  • DASH Diet Works Like Hypertension Drug - WebMD, 5/19/03 - "the DASH diet -- created to fight high blood pressure -- works just like water pills ... If people eat the DASH diet with low salt intake -- especially older people -- their blood pressure goes down 15 points"
  • Lifestyle Changes Improve Blood Pressure - WebMD, 5/14/03 - "Weight loss ... 5 - 20 points per 22 lbs. lost ... DASH eating plan ... 8 -14 points ... Exercise ... 4 - 9 points ... Moderate drinking ... 2 - 4 points"
  • Fatty Acids Added To Infant Formula May Cut Later Heart Disease Risks - Doctor's Guide, 5/1/03 - "Several studies have reported lower blood pressure in adults whose diet was supplemented with omega 3 fatty acids, but no published studies have looked at the effect of LCPUFA supplementation on blood pressure in children ... The LCPUFA group had significantly lower mean blood pressure: mean difference -3.0 mm Hg, and mean difference of -3.5 mm Hg diastolic"
  • Fortified Formulas Promote Healthy Heart - WebMD, 5/1/03
  • Sesame Oil Benefits Blood Pressure - WebMD, 4/28/03 - "studied 195 men and 133 women with high blood pressure. All were taking nifedipine (brand names include Adalta, Nifedical, and Procardia), a common blood pressure-lowering drug. Despite this treatment, all patients still had moderate high blood pressure. Sankar's team asked the patients to switch to sesame oil as the only cooking oil they used ... Sixty days later, the patients' average blood pressure dropped into the normal range ... he doesn't think that the PUFAs are involved in the blood-pressure-lowering effect of sesame oil. But he speculates that lower blood pressure may be an indirect effect of sesamin, sesamol, or both"
  • Grape Seed Extract May Be A Useful Supplement To Blunt Hypertension In Postmenopausal Women - Intelihealth, 4/10/03 - "a diet moderately high in grape seed extract can blunt salt (sodium chloride)-sensitive hypertension to about the same extent as treatment with either plant estrogens or 17ß-estradiol. This suggests that mechanisms other than the estrogen receptor activation actually provides the beneficial effects of estrogen therapy and that grape seed extract may be a useful supplement to blunt hypertension and other cardiovascular symptoms in postmenopausal women" - See iHerb or Vitacosticon grape seed extract products.
  • Remember Sodium? We're Still Getting Too Much - Intelihealth, 3/14/03 - "The average American consumes 4,000 milligrams of sodium per day, far exceeding the maximum of 2,400 milligrams recommended ... only an estimated 25 percent of daily sodium intake is added at the table. The remainder is unseen, consumed in restaurant and processed foods ... A Weight Watchers Smart Ones frozen entree may be low in fat and calories, but it's not so light in sodium ... a Burger King Broiler Chicken Sandwich has 1,110 milligrams of sodium ... about 90 percent of the population is diagnosed with hypertension by the age of 80. People with high blood pressure have an increased risk for heart disease and stroke. High sodium levels also raise the risk of osteoporosis and kidney problems ... In the case of osteoporosis, potassium appears to offset calcium losses from excessive sodium ... postmenopausal women with diets high in salt lost higher amounts of bone mineral. Eating potassium-rich foods such as bananas, tomatoes and orange juice helped stem the calcium loss"
  • A fermented milk high in bioactive peptides has a blood pressure–lowering effect in hypertensive subjects - Am. J. of Clin. Nutr., 2/03 - "received 150 mL/d [5 ounces] of either L. helveticus LBK-16H fermented milk or a control product for 21 wk after a 2-wk run-in period ... There was a mean difference of 6.7 +/- 3.0 mm Hg in systolic blood pressure (P = 0.030) and of 3.6 +/- 1.9 mm Hg (P = 0.059) in diastolic blood pressure between the test product and control groups" - Related articles:
  • Vitamin C May Aid People with Diabetes - New Hope Natural Media, 2/13/03 - "randomly assigned to receive 500 mg of vitamin C per day or a placebo. After four weeks of treatment, the average blood pressure decreased significantly in the group taking vitamin C, whereas no change was seen in the placebo group. The systolic blood pressure (the higher number) decreased by an average of 9.8 mm Hg, while the diastolic blood pressure (the lower number) decreased by 4.4 mm Hg. These changes in blood pressure are nearly as great as one might expect from taking a prescription blood pressure-lowering medication. In addition, the stiffness of the arteries decreased significantly in the vitamin C group" - [J. Hypertension/Medline]- See iHerb or Vitacosticon vitamin C products.
  • Coenzyme Q10 Improves High Blood Pressure - New Hope Natural Media, 1/9/03 - "recruited 83 people with a condition called isolated systolic hypertension (ISH), in which the higher blood pressure ... These people were assigned to take either 60 mg of CoQ10 twice daily or a placebo for 12 weeks ... The people taking CoQ10 had an 18-point (18 mm Hg) reduction in systolic blood pressure (from 165 to 147 mm Hg), compared with only a 2-point decline in the placebo group ... ISH is the most common type of high blood pressure in the United States" - See iHerb or Vitacosticon coenzyme Q10 products.
  • Evidence-based Products - Functional Foods & Nutraceuticals, 12/02 - "3g EPA/d and 3g DHA/d (ROPUFA) increased systemic arterial compliance in 38 dyslipidemic men and women, resulting in reduced pulse pressure and total vascular resistance ... Results showed that ROPUFA increased SAC—36 per cent with EPA and 27 per cent with DHA—compared with placebo" - See Mega Twin EPA at Amazon.com or Vitacosticon and Jarrow Max DHA at Amazon.com.
  • Folic Acid Improves Endothelial Function And Blood Pressure In Smokers - Doctor's Guide, 12/18/02 - "Smokers were randomly assigned to receive either 5 milligrams of folic acid or placebo every day ... Mean blood pressure was significantly reduced from 88 +/- 2 to 83 +/- 1 mmHg in those patients who received supplementation" - Seems like they could have tested non-smokers for the same effect while they were at it.  5 points is probably half of what you'd get from the standard dose of most anti-hypertensive medications. - Ben
  • Slowing Down May Protect Heart - WebMD, 11/20/02
  • Health Group Urges Less Salt In Food - Intelihealth, 11/13/02 - "The nation's largest public health group is recommending a 50 percent decrease in salt in processed food and restaurant meals over the next 10 years ... Government guidelines already recommend limiting intake of sodium - which increases blood pressure - to no more than 2.4 grams daily, or the equivalent of about a teaspoon of table salt. But the average American adult consumes nearly 4 grams a day"
  • Banana growers given the nod on low BP claims - CNN, 11/2/00
  • Moderate Intensity Aerobic Exercise Recommended for Hypertensive Patients - Doctor's Guide, 10/1/02
  • Folic Acid May Have Benefits for Smokers - Doctor's Guide, 9/13/02 - "randomised to four weeks of folic acid 5 mg/day or placebo ... Results showed that folic acid reduced homocysteine concentrations (10.8+/-0.6 versus 7.9+/-0.5 µmol/L, p<0.001) and there was a significant reduction in blood pressure (mean BP 88+/-2 versus 83+/-1 mmHg, p<0.01) ... Benefits also seem to be largely independent of the lowering of homocysteine concentrations"
  • Soy Milk Lowers Blood Pressure - New Hope Natural Media, 8/30/02 - "After three months, the average systolic blood pressure (the higher number) had decreased by 18.4 mm Hg and the diastolic blood pressure (the lower number) had fallen by 15.9 mm Hg in the soy group. This reduction is comparable to that seen with many prescription blood pressure-lowering drugs"
  • Sunflower Seed May Hold Key To Reducing Hypertension And Preventing Debilitating Strokes - Intelihealth, 8/27/02 - "One of the leading contributors to a stroke is hypertension. Before a stroke occurs, prolonged hypertension has been associated with a range of impairments and cognitive ability ... Now a researcher suggests that linoleic acid, a doubly unsaturated fatty acid, which is essential in nutrition in mammals. It cannot be produced in animals, the sources of this needed nutrient are vegetable seed oils, such as: safflower, sunflower, and hemp seed ... Linoleic acid administration seems to significantly decrease the systolic blood pressures of SHRs [spontaneously hypertensive rats] at three and six months"
  • Reduction of Left Ventricular Hypertrophy After Exercise and Weight Loss in Overweight Patients With Mild Hypertension - Doctor's Guide, 7/15/02 - "Blood pressure fell by 7.0 / 6.0 mmHg in the weight management group and by 3.0 / 4.0 mmHg in the aerobic exercise group"
  • New Evidence Fruit and Vegetable Intake Reduces Hypertension - Doctor's Guide, 5/28/02 - "systolic and diastolic blood pressure decreased more in the intervention group than in the control group ... A reduction of two mm Hg in diastolic blood pressure results in a decrease of about 17 percent in the incidence of high blood pressure, six percent in the risk of coronary heart disease, and 15 percent in the risk of stroke and transient ischaemic attack, they say"
  • Putting Antioxidants To Use In Functional Formulas - Functional Foods & Nutraceuticals, 5/02 - "In one study of 38 people, Joseph A. Vita, MD, of the Boston University School of Medicine, found that 500mg/day vitamin C lowered systolic blood pressure by an average of 10 percent after only one month"
  • Aerobics Best for Cutting Blood Pressure - WebMD, 5/17/02 - "They found that those who participated in only aerobic exercise, such as walking, jogging, or cycling, had lower blood pressure levels than those who participated in both aerobic exercise and weight lifting or calisthenics ... This suggests that there is a detrimental effect of [weight lifting] that blunts the benefit of walking, running, and jogging ... possible explanation for their finding may be that by creating bigger muscle mass, weight lifting creates an oxygen debt in the body, which means the body must work harder to supply oxygen. Another may be that weight lifting stimulates more damaging free radicals and oxidants than aerobic exercise"
  • Fiber Stalls High Blood Pressure - WebMD, 5/15/02 - "Whole grains are included as part of the DASH (Dietary Approaches to Stop Hypertension) diet, which has been found to help reduce blood pressure. The diet emphasizes fruits, vegetables, and low-fat dairy products and recommends a daily intake of more than 25 grams of fiber a day. But Samuel says that based on the results of this study, whole grains aren't emphasized enough"
  • Take Aspirin at Night for Heart Benefits - WebMD, 5/15/02 - "Aspirin didn't affect blood pressure if given in the morning. But when given at night, it had a significant effect: a 7.0 mmHg decrease in systolic blood pressure (the top number in a blood-pressure reading) and a 4.8 mmHg decrease in diastolic blood pressure (the bottom number)."
  • What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 - "Tocotrienols and hypertension ..." - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Exercise Said Best For Blood Pressure - Intelihealth, 4/22/02 - "The average reduction was 3.8 milligrams of mercury in systolic pressure ... average diastolic ... 2.58 milligrams of mercury lower"
  • Exercise Helps Everyone's Heart - WebMD, 4/1/02 - "The overwhelming evidence shows exercise can reduce blood pressure in virtually anyone -- regardless of weight, race, or current blood pressure level ... regular aerobic exercise decreased systolic blood pressure (the top number) by an average of 3.8 mmHg and diastolic (the bottom number) by 2.58 mmHg, in people who were previously inactive"
  • Orange Juice for the Heart - WebMD, 3/22/02
  • Pycnogenol - Functional Foods & Nutraceuticals, 3/02 - "Subjects taking pycnogenol experienced a significant decrease in systolic blood pressure, although there was no statistical significance in diastolic blood pressure when compared to placebo"
  • Acupuncture Can Lower High Blood Pressure - WebMD, 6/11/01
  • Is My Doctor Making My Blood Pressure Rise? - Dr. Weil, 1/25/02
  • Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's Guide, 11/14/01 - "increasing levels of serum beta- carotene were associated with significant reductions in systolic blood pressure, while increasing levels of serum vitamin C were associated with significant reductions in diastolic pressure ... In contrast, serum levels of vitamin E were associated with significant increases in diastolic blood pressure"
  • Suggestions For Blood Pressure - Intelihealth, 11/5/01 - "Diet and exercise are common prescriptions for treatment of hypertension. But the study showed weight loss had a greater effect than exercise did"
  • Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension - South Med J 2001 Nov;94(11):1112-7 - "conducted a 12-week randomized, double-blind, placebo-controlled trial with twice daily administration of 60 mg of oral CoQ ... The mean reduction in systolic blood pressure of the CoQ-treated group was 17.8"
  • Pets Diminish Blood Pressure Responses To Stress - Intelihealth, 10/25/01 - "pets may help people with high blood pressure deal with stress more effectively than the leading medication"
  • Tomatoes May Help Fight High Blood Pressure - Doctor's Guide, 5/20/01 - "patients were treated with a placebo for four weeks and then tomato extract (Lyc-O-Mato, LycoRed Natural Products Industries, Ltd.), for eight weeks ... Results showed a significant reduction in systolic blood pressure, from 144 mm Hg to 135 mm Hg, representing a mean 9 mm Hg reduction. Additionally, some favorable effects on diastolic blood pressure, blood lipids, lipoproteins, and oxidative stress markers were noted" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Has Hypertension Met Its Match? - Nutrition Science News, 4/01 - "These study results indicate that reducing sodium lowers blood pressure in people with or without hypertension. The researchers concluded that the recommended sodium intake, already substantially lower than the average intake, should be lowered further, and that more low-sodium products should be made available"
  • Less Salt Is Often Still Too Much, Watch Out for High Salt Levels in Fast Foods, Processed Foods - WebMD, 1/3/01
  • Vitamin E Supplements May Help Prevent Stroke In Men With Hypertension - Doctor's Guide, 11/6/00
  • HMB Pumps You Up While Lowering Cholesterol and Blood Pressure - WebMD, 8/18/00 - "These figures (for HMB) are just about what you would see by taking medications for hypertension or lowering cholesterol."
  • Meditation may lower blood pressure - CNN, 7/24/00
  • Vitamin C: A possible treatment for high blood pressure - CNN, 12/20/99 - "After one month, the average blood pressure of patients who took vitamin C [500 mg/day] dropped significantly more than that of patients in the placebo group, or 9.1 percent compared to 2.7 percent"
  • Sidestep Heart Disease - Nutrition Science News, 3/99
  • Potassium-Magnesium Citrate Effective In Correcting Thiazide-Induced Side Effects - Doctor's Guide, 11/13/98 - "Thiazide diuretics are commonly prescribed for hypertension and other medical conditions and are known to deplete stores of both potassium and magnesium. Depletion of either potassium or magnesium can cause frequent and sometimes serious complications, including muscle weakness, paralysis and cardiac arrhythmia. Further, magnesium depletion is probably under-diagnosed, with more importance placed on potassium depletion, but magnesium depletion, if left uncorrected, can result in potassium depletion"

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