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Recent Longevity News for the seven days ending 5/4/11.  You should consult your doctor if you are taking any medications.

Study evaluates relationship of urinary sodium with health outcomes - Science Daily, 5/3/11 - "The assumption that lower salt intake would in the long run lower blood pressure, to our knowledge, has not yet been confirmed in longitudinal population-based studies ... among 3,681 participants followed up for a median (midpoint) 7.9 years, cardiovascular deaths decreased across increasing tertiles (one of three groups) of 24-hour urinary sodium: from 50 deaths in the low (death rate, 4.1 percent), 24 deaths in the medium, (death rate, 1.9 percent) and 10 deaths in the high tertile (death rate, 0.8 percent). Analysis indicated that the risk of cardiovascular mortality was significantly elevated in the low tertile with a significant inverse association between cardiovascular mortality and tertile of sodium excretion. Baseline sodium excretion predicted neither total mortality nor fatal combined with nonfatal CVD events. ... The associations between systolic pressure and sodium excretion did not translate into less morbidity or improved survival. On the contrary, low sodium excretion predicted higher cardiovascular mortality. Taken together, our current findings refute the estimates of computer models of lives saved and health care costs reduced with lower salt intake. They do also not support the current recommendations of a generalized and indiscriminate reduction of salt intake at the population level. However, they do not negate the blood pressure-lowering effects of a dietary salt reduction in hypertensive patients"

Mouse study turns fat-loss/longevity link on its head - Science Daily, 5/3/11 - "studied the effect of food restriction on fat and weight loss in 41 genetically different strains of mice. The scientists then correlated the amount of fat reduction to life span ... The answer: Mice that maintained their fat actually lived longer. Those that lost fat died earlier ... People are best advised to adopt a moderate approach, not losing all fat but definitely not keeping unhealthy amounts of fat, either ... None of the mice in this study were what we would consider to be obese"

Study Finds Low-Salt Diet Ineffective but Draws Criticism From C.D.C. - NYTimes.com - NY Times, 5/3/11 - "At the moment, this study might need to be taken with a grain of salt ... The investigators found that the less salt people ate, the more likely they were to die of heart disease – 50 people in the lowest third of salt consumption (2.5 grams of sodium per day) died during the study as compared with 24 in the medium group (3.9 grams of sodium per day) and 10 in the highest salt consumption group (6.0 grams of sodium per day). And while those eating the most salt had, on average, a slight increase in systolic blood pressure — a 1.71-millimeter increase in pressure for each 2.5-gram increase in sodium per day — they were no more likely to develop hypertension ... One of the problems with the salt debates, Dr. Alderman said, is that all the studies are inadequate" - Note:  Some studies do support this study but see my sodium page.  Most studies are the other way:

A Study Shows Connections Between Maternal Exposure to BPA and Childhood Asthma - Time Magazine, 5/2/11 - "At 6 months old, infants whose mothers had high levels of BPA were twice as likely to show wheezing as babies whose mothers who had low levels"

Aspirin reduces the risk of cancer recurrence in prostate cancer patients, study suggests - Science Daily, 5/2/11 - "After 10-years from completion of treatment, 31% of the men who took aspirin developed recurrence compared with 39% of non-aspirin users (p=0.0005). There was also a 2% improvement in 10-year prostate cancer related survival associated with aspirin use with a trend toward statistical significance"

Dual medications for depression increases costs, side effects with no benefit to patients, study suggests - Science Daily, 5/2/11 - "One group received escitalopram (a selective serotonin reuptake inhibitor, or SSRI) and a placebo; the second group received the same SSRI paired with bupropion (a non-tricyclic antidepressant); and a third group took different antidepressants: venlafaxine (a tetracyclic antidepressant) and mirtazapine (a serotonin norepinephrine reuptake inhibitor) ... After 12 weeks of treatment, remission and response rates were similar across the three groups: 39 percent, 39 percent and 38 percent, respectively, for remission, and about 52 percent in all three groups for response. After seven months of treatment, remission and response rates across the three groups remained similar, but side effects were more frequent in the third group ... Only about 33 percent of depressed patients go into remission in the first 12 weeks of treatment with antidepressant medication" - Note:  Considering that most know that they are getting the real drug because of the side effects, it makes you wonder how much of the 33% are from the placebo effect.

Before you start bone-building meds, try dietary calcium and supplements, experts urge - Science Daily, 5/2/11 - "For many people, prescription bone-building medicines should be a last resort ... adults who increase their intake of calcium and vitamin D usually increase bone mineral density and reduce the risk for hip fracture significantly ... I suspect that many doctors reach for their prescription pads because they believe it's unlikely that people will change their diets ... prescription bone-building medications are expensive, and many have side effects, including ironically an increase in hip fractures and jaw necrosis. They should be used only if diet and supplements don't do the trick ... For bone health, the researchers also encourage consuming adequate protein, less sodium, and more magnesium and potassium"

Insomnia linked to high insulin resistance in diabetics - Science Daily, 5/2/11 - "Among the diabetics, poor sleepers had 23% higher blood glucose levels in the morning, and 48% higher blood insulin levels. Using these numbers to estimate a person's insulin resistance, the researchers found that poor sleepers with diabetes had 82% higher insulin resistance than normal sleepers with diabetes"

Packing on the pounds in middle age linked to dementia - Science Daily, 5/2/11 - "people who were overweight or obese at midlife had an 80 percent higher risk of developing dementia, Alzheimer's disease or vascular dementia in late life compared to people with normal BMI"

Washing with contaminated soap increases bacteria on hands, research finds - Science Daily, 5/2/11 - "Bulk-soap-refillable dispensers, in which new soap is poured into a dispenser, are the predominant soap dispenser type in community settings, such as public restrooms. In contrast to sealed-soap dispensers, which are refilled by inserting a new bag or cartridge of soap, they are prone to bacterial contamination and several outbreaks linked to the use of contaminated soap have already been reported in healthcare settings ... Gram-negative bacteria on the hands of students and staff increased 26-fold after washing with the contaminated soap"

New method to measure cortisol could lead to better understanding of development of common diseases - Science Daily, 5/2/11 - "Currently the standard method to measure cortisol levels is to take a blood or saliva sample. However, since cortisol is released in a circadian rhythm and with pulses throughout the day, levels can fluctuate considerably, meaning it is difficult to estimate an individual's long-term exposure to cortisol through blood and saliva tests alone ... hair cortisol levels correlated positively with waist to hip ratio (r=0.425, p=0.003) and waist circumference (r=0.392, p=0.007), meaning people with higher exposure to cortisol showed higher abdominal obesity ... measuring the amount of cortisol in hair can potentially be used to monitor a person's long-term exposure to cortisol"

Low vitamin D in kids may play a role in anemia - Science Daily, 5/1/11 - "vitamin D deficiency may play an important role in anemia ... looked at data from the blood samples of more than 9,400 children, 2 to 18 years of age. The lower the vitamin D levels, the lower the hemoglobin and the higher the risk for anemia, the researchers found. Children with levels below 20 nanograms per milliliter (ng/ml) of blood had a 50 percent higher risk for anemia than children with levels 20 ng/ml and above. For each 1 ng/ml increase in vitamin D, anemia risk dropped by 3 percent" - See vitamin D products at iHerb.

Too much or too little sleep may accelerate cognitive aging, study shows - Science Daily, 5/1/11 - "women and men who begin sleeping more or less than 6 to 8 hours per night are subject to an accelerated cognitive decline that is equivalent to four to seven years of aging ... The researchers also found that, in women, sleep duration of 7 hours of sleep per night was associated with the highest score for every cognitive measure, followed closely by 6 hours of nightly sleep. Among men, cognitive function was similar for those who reported sleeping 6, 7 or 8 hours; only short and long sleep durations of less than 6 hours or more than 8 hours appeared to be associated with lower scores"

System in brain -- target of class of diabetes drugs -- linked to weight gain - Science Daily. 5/1/11 - "PPAR-γ is the target of a class of diabetes drugs called TZDs (thiazolidinediones). This class of drugs reduces blood glucose levels but also causes considerable weight gain ... Seeley and his team set out to determine whether or not the brain's PPAR-γ system was responsible for the weight gain associated with TZDs ... by giving TZD drugs in the same manner that people take them, rats gained weight. This was because the drugs activated PPAR-γ in the brain. Thus, weight gain associated with this class of drugs may not be a result of action of PPAR-γ in fat as had been previously thought, but rather a result of a change in activity in parts of the brain known to regulate appetite ... If you artificially turn on PPAR-γ, you can increase food intake in rats ... If you block these receptors in animals on high-fat diets that make animals obese, animals gain less weight ... In the past, says Seeley, people thought that the production of more fat cells in response to TZD drugs was the cause of the resulting weight gain, but he adds, "Just having more fat cells is not enough to make animals or people fatter. Rather you have to eat more calories than you burn and that is exactly what happens when you turn on the brain PPAR-γ system"

Low Vitamin D Linked to Aggressive Breast Cancer - WebMD, 4/29/11 - "Women in the study with triple-negative tumors, which do not respond to hormone treatments, were almost three times more likely to have suboptimal vitamin D levels as women with other breast cancers"

Melatonin might help in controlling weight gain and preventing heart diseases associated to obesity - Science Daily, 4/28/11 - "melatonin -a natural hormone produced by the body- helps in controlling weight gain -even without reducing the intake of food-, improves blood lipid profile -as it reduces triglicerids-, increases HDL cholesterol and reduces LDL cholesterol ... analyzed in young Zucker diabetic obese rats the effects of melatonin on obesity, dyslipidemia and high blood pressure associated to obesity. Melatonin was found to be beneficial for young rats that had not still developed any methabolic or heart disease" - See Source Naturals, Melatonin, Peppermint Flavored Sublingual, 1 mg, 300 Tablets at iHerb.

Obese adolescents lacking vitamin D, study suggests - Science Daily, 4/28/11 - "For this retrospective study, Harel and his co-authors explored the prevalence of low vitamin D status among 68 obese adolescents, and examined the impact of treatment of low vitamin D status in these patient ... low vitamin D status was present in all of the girls (72 percent deficient and 28 percent insufficient) and in 91 percent of the boys (69 percent deficient and 22 percent insufficient). Of those with vitamin D deficiency or insufficiency, 43 patients had a repeat measurement of vitamin D level after treatment. While there was a significant increase in vitamin D levels following treatment, serum vitamin D levels normalized in only 28percent of these patients. Repeat multiple courses of vitamin D treatment in the patients who did not normalize their vitamin D levels after initial course, failed to normalize their low vitamin D status ... The researchers question whether a higher daily vitamin D intake than the one recently recommended by the Institute of Medicine (600 international units of vitamin D/day) may be required as part of treatment in obese adolescents, in an attempt to increase their vitamin D status" - See vitamin D products at iHerb.

Vitamin E helps diminish a type of fatty liver disease in children, study suggests - Science Daily, 4/27/11 - "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease among U.S. children. NAFLD ranges in severity from steatosis (fat in the liver without injury) to nonalcoholic steatohepatitis or NASH (fat, inflammation, and liver damage). Fatty liver increases a child's risk of developing heart disease and liver cirrhosis ... after 96 weeks of treatment, 58 percent of the children on vitamin E no longer had NASH, compared to 41 percent of the children on metformin (a diabetes drug), and 28 percent on placebo. Vitamin E was better than placebo because it significantly reduced enlargement and death of liver cells ... These results suggest that vitamin E improves or resolves NASH in at least half of children, which we previously showed to be true in adults" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.

Increased metabolic rate may lead to accelerated aging - Science Daily, 4/27/11 - "higher endogenous metabolic rate, that is how much energy the body uses for normal body functions, is a risk factor for earlier mortality .... This increased metabolic rate may lead to earlier organ damage (in effect accelerated aging) possibly by accumulation of toxic substances produced with the increase in energy turnover ... these data do not apply to exercise-related energy expenditure"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Combined Effect of High-Normal Blood Pressure and Low HDL Cholesterol on Mortality in an Elderly Korean Population: The South-West Seoul (SWS) Study - Am J Hypertens. 2011 Apr 28 - "high-normal blood pressure (HNBP) ... Study, a prospective cohort study of 2,376 elderly Koreans, aged >60 years. Results During the median follow-up of 7.6 years, 353 deaths occurred from all causes, and 113 of these were attributed to CVD. Prehypertension was nonsignificantly associated with an increased risk of mortality (hazard ratio (HR): 1.06, 95% confidence interval (CI): 0.68-1.64). Subjects with HNBP exhibited a nonsignificantly higher risk of mortality compared with those with optimal blood pressure by the ESH/ESC guideline (HR: 1.35, 95% CI: 0.84-2.18). However, the combination of low high-density lipoprotein (HDL) cholesterol and HNBP showed a twofold higher risk of all-cause mortality (HR: 2.01, 95% CI: 1.11-3.64) independent of other risk factors. Conclusions Although prehypertension was not associated with increased risk of mortality, individuals in the elderly Korean population with HNBP, especially when combined with low HDL cholesterol, showed a significantly increased risk of all-cause mortality"

Prophylactic Application of Bovine Colostrum Ameliorates Murine Colitis via Induction of Immunoregulatory Cells - J Nutr. 2011 Apr 27 - "Herein, we addressed the question whether bovine colostrum, the first milk produced by mammals, is able to prevent dextran sulfate sodium (DSS)-induced colitis in mice ... Following 2 wk of observation, the colons were removed for histologic and immunohistochemical evaluation of inflammation. Flow cytometric phenotyping of leukocyte subsets was performed from peripheral blood, mesenteric lymph nodes, and spleens. Administration of bovine colostrum improved the clinical and histologic severity of colorectal inflammation. Compared with BSA-fed and water-fed controls, BV-20 pretreated mice had significantly less severe weight loss and decreased colon shortening. Beneficial effects were accompanied by redistribution of immunoregulatory, peripheral and splenic γδ TCR(+) cells, and CD11b(+)Gr1(+) cells. Higher colostrum doses did not affect disease activity. In summary, prophylactic administration of colostrum improved clinical symptoms of colorectal inflammation in a well-established mouse model of DSS-induced colitis" - See colostrum products at iHerb.

Prenatal DHA Status and Neurological Outcome in Children at Age 5.5 Years Are Positively Associated - J Nutr. 2011 Apr 27 - "Healthy pregnant women from Spain, Germany, and Hungary were randomly assigned to a dietary supplement consisting of either fish oil (FO) (500 mg/d DHA + 150 mg/d EPA), 400 μg/d 5-methyltetrahydrofolate, both, or placebo from wk 20 of gestation until delivery ... We conclude that higher DHA levels in cord blood may be related to a better neurological outcome at 5.5 y of age" - See Jarrow Max DHA at iHerb.

Green Tea Polyphenols Provide Photoprotection, Increase Microcirculation, and Modulate Skin Properties of Women - J Nutr. 2011 Apr 27 - "Dietary constituents including polyphenols and carotenoids contribute to endogenous photoprotection and modulate skin characteristics related to structure and function of the tissue. Animal and in-vitro studies indicate that green tea polyphenols affect skin properties. In a 12-wk, double-blind, placebo-controlled study, 60 female volunteers were randomized to an intervention or control group. Participants consumed either a beverage with green tea polyphenols providing 1402 mg total catechins/d or a control beverage. Skin photoprotection, structure, and function were measured at baseline (wk 0), wk 6, and wk 12. Following exposure of the skin areas to 1.25 minimal erythemal dose of radiation from a solar simulator, UV-induced erythema decreased significantly in the intervention group by 16 and 25% after 6 and 12 wk, respectively. Skin structural characteristics that were positively affected included elasticity, roughness, scaling, density, and water homeostasis. Intake of the green tea polyphenol beverage for 12 wk increased blood flow and oxygen delivery to the skin. Likewise, in a separate, randomized, double-blind, single-dose (0.5, 1.0, and 2.0 g) study of green tea polyphenols, blood flow was maximized at 30 min after ingestion. In summary, green tea polyphenols delivered in a beverage were shown to protect skin against harmful UV radiation and helped to improve overall skin quality of women" - See Jarrow Green Tea extract at iHerb.

Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster - J Nutr. 2011 Apr 27 - "The lifespan of diabetic patients is 7-8 y shorter than that of the general population because of hyperglycemia-induced vascular complications and damage to other organs such as the liver and skeletal muscle. Here, we investigated the effects of epicatechin, one of the major flavonoids in cocoa, on health-promoting effects in obese diabetic (db/db) mice (0.25% in drinking water for 15 wk) and Drosophila melanogaster (0.01-8 mmol/L in diet). Dietary intake of epicatechin promoted survival in the diabetic mice (50% mortality in diabetic control group vs. 8.4% in epicatechin group after 15 wk of treatment), whereas blood pressure, blood glucose, food intake, and body weight gain were not significantly altered. Pathological analysis showed that epicatechin administration reduced the degeneration of aortic vessels and blunted fat deposition and hydropic degeneration in the liver caused by diabetes. Epicatechin treatment caused changes in diabetic mice that are associated with a healthier and longer lifespan, including improved skeletal muscle stress output, reduced systematic inflammation markers and serum LDL cholesterol, increased hepatic antioxidant glutathione concentration and total superoxide dismutase activity, decreased circulating insulin-like growth factor-1 (from 303 ± 21 mg/L in the diabetic control group to 189 ± 21 mg/L in the epicatechin-treated group), and improved AMP-activated protein kinase-α activity in the liver and skeletal muscle. Consistently, epicatechin (0.1-8 mmol/L) also promoted survival and increased mean lifespan of Drosophila. Therefore, epicatechin may be a novel food-derived, antiaging compound"

Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats - Lipids Health Dis. 2011 Apr 28;10(1):66 - "The purpose of this study was to determinate the effect of a lower dose of fish oil supplementation on insulin sensitivity, lipid profile, and muscle metabolism in obese rats ... Low dose of fish oil supplementation (1g/kg/day) was able to reduce TC and TG levels, in addition to improved systemic and muscle insulin sensitivity. These results lend credence to the benefits of n-3 fatty acids upon the deleterious effects of insulin resistance mechanisms" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.

Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration - Br J Nutr. 2011 Apr 27:1-5 - "DHA consumption during pregnancy may be advantageous with respect to infant body composition at birth and insulin sensitivity" - See Jarrow Max DHA at iHerb.

Glycated Hemoglobin Predicts All-Cause, Cardiovascular, and Cancer Mortality in People Without a History of Diabetes Undergoing Coronary Angiography - Diabetes Care. 2011 Apr 22 - "The multivariable-adjusted hazard ratios (HR) (95% CI) for glycated hemoglobin values of <5.0, 5.0-5.4, 5.5-5.9, 6.0-6.4, 6.5-7.4, and ≥7.5% for all-cause mortality were 1.36 (0.85-2.18), 1.00 (0.76-1.32), 1.00 (reference), 1.11 (0.88-1.41), 1.39 (1.07-1.82), and 2.15 (1.32-3.53), respectively. Similar J-shaped relationships were found between glycated hemoglobin and cardiovascular and cancer mortality. The associations of glycated hemoglobin with all-cause and cardiovascular mortality remained significant after inclusion of fasting glucose as a covariate. However, fasting glucose was not significantly related to mortality when adjusting for glycated hemoglobin"

The effects of combination therapy with dutasteride plus tamsulosin on clinical outcomes in men with symptomatic BPH: 4-year post hoc analysis of European men in the CombAT study - Prostate Cancer Prostatic Dis. 2011 Apr 19 - "Patients were randomised to daily tamsulosin 0.4 mg, dutasteride 0.5 mg or both for 4 years ... Combination therapy significantly reduced the relative risk of AUR or BPH-related surgery compared with either monotherapy at 4 years, and also significantly reduced the risk of BPH clinical progression. Combination therapy also provided significantly greater symptom improvement than either monotherapy at 4 years. Safety and tolerability of dutasteride plus tamsulosin was consistent with previous experience of this combination and with the monotherapies. These data provide further evidence to support the use of long-term combination therapy (dutasteride plus tamsulosin) in men with moderate-to-severe lower urinary tract symptoms because of BPH and prostatic enlargement"

Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients - J Hypertens. 2011 Apr 23 - "meta-analysis of individual data from 15 randomized, controlled, double-blind, parallel group trials ... In the short-term and long-term trials, PWV decreased significantly by -0.75 and -1.3 m/s in the active treatment group compared with by +0.17 and -0.44 m/s in the placebo group, respectively. Active treatment was independently related to the changes in PWV and explained 5 and 4% of the variance in the short-term and long-term trials, respectively. In the short-term trials, ACEIs were more effective than calcium antagonists and placebo on improving arterial stiffness. In the long-term trials, ACEI, calcium antagonists, beta-blocker, and diuretic reduced significantly PWV compared to placebo ... Our study shows that antihypertensive treatments improve the arterial stiffness beyond their effect on blood pressure"

Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo - Diabetes Res Clin Pract. 2011 Apr 21 - "free fatty acids (FFAs) ... This study suggests the therapeutic value of EGCG in protecting from insulin resistance caused by elevated FFAs" - See green tea products at iHerb.

More info on homemade mayonnaise:

I mentioned a couple weeks ago about homemade olive oil mayonnaise as a way to include omega-9 into your diet.  I researched it some more and below is what I found.  safeeggs.com shows store locations that sell pasteurized eggs but it appears that they are hard to find.  I ended up pasteurizing the eggs myself.  Click here for the video and making the mayonnaise in a Cuisinart.

As for pasteurizing, I used a roasting pan with a rack and filled the pan with water and put it on top of a burner.  For the temperature, I used a Weber Thermometer.  I had the burner on "warm".  When the temperature reached 130 degrees I put the eggs in and put the timer on 40 min.  At about 12 minutes remaining the water was at 140 and I turned off the burner.  At 4 minutes remaining the temperature was down to 132 so I put the burner back to "warm".  At the end of the 40 minutes the temperature of the water was 133 and I removed the eggs.

For the mayonnaise, ensure everything is at room temperature.  If you over whip or add the oil too quickly you end up with something that looks like pea soup. This method might be tedious but it works every time.  I  put 1/2 tablespoon lemon juice, 1/2 tablespoon white vinegar and one extra large egg yoke (or two egg yokes if you're using smaller eggs) into the Cuisinart and hit the pulse button once.  Then I added one cup of extra light olive oil but only one tablespoon at a time and after each tablespoon I hit the "pulse" quickly four times.  When that's done, I add a third teaspoon of Lite Salt and hit the "pulse" one more time and it's done.

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