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Recent Longevity News for the seven days ending
2/9/11. You should consult your doctor if you are taking any medications.
Why Women Feel Colder Than Men - CBS Chicago, 2/8/11 -
"Women conserve more heat around their core organs,
which means less heat circulates throughout the rest of their body ... It can
often lead to a tug-of-war over the thermostat. That fight can get worse at
night, when our bodies produce less cortisol ...
cortisol is a very powerful hormone. It’s your fight hormone. So it keeps
you warm, gets your adrenaline roaring and helps with body warming"
sleep found to be a new risk factor for colon cancer - Science Daily, 2/8/11
- "individuals who averaged less than six hours of
sleep at night had an almost 50 percent increase
in the risk of colorectal adenomas compared with
individuals sleeping at least seven hours per night. Adenomas are a precursor to
cancer tumors, and left untreated, they can turn malignant"
Postmenopausal Women With Metabolic Syndromed - Medscape, 2/7/11 -
"In conclusion, this first report concerning
myo-inositol supplementation for 6 months in
postmenopausal women affected by metabolic
syndrome demonstrated that it may improve some of the metabolic features of the
syndrome such as carbohydrate metabolism, lipid profile, and blood pressure.
Further studies and a longer time of treatment are needed to determine if the
improvement in risk markers might provide a decrease in cardiovascular morbidity
among these women" - See
products at iHerb.
Inositol - Wikipedia, the free encyclopedia -
"Inositol or cyclohexane-1,2,3,4,5,6-hexol is a chemical compound with
formula C6H12O6 or (-CHOH-)6, a sixfold alcohol (polyol) of cyclohexane. It
exists in nine possible stereoisomers, of which the most prominent form,
widely occurring in nature, is cis-1,2,3,5-trans-4,6-cyclohexanehexol, or
myo-inositol (former name meso-inositol). Inositol is a carbohydrate,
though not a classical sugar. It is almost tasteless, with a small amount of
Processed food diet in early childhood may lower subsequent IQ - Science
Daily, 2/7/11 - "A diet, high in fats, sugars, and
processed foods in early childhood may lower IQ, while a diet packed full of
vitamins and nutrients may do the opposite ... Three dietary patterns were
identified: "processed" high in fats and sugar intake; "traditional" high in
meat and vegetable intake; and "health conscious" high in salad, fruit and
vegetables, rice and pasta ... after taking account of potentially influential
factors, a predominantly processed food diet at the age of 3 was associated with
a lower IQ at the age of 8.5, irrespective of whether the diet improved after
that age. Every 1 point increase in dietary pattern score was associated with a
1.67 fall in IQ ... On the other hand, a healthy diet was associated with a
higher IQ at the age of 8.5, with every 1 point increase in dietary pattern
linked to a 1.2 increase in IQ. Dietary patterns between the ages of 4 and 7 had
no impact on IQ"
pot may hasten onset of mental illness - MSNBC, 2/7/11 -
"in the subjects who had been
pot smokers, the psychotic symptoms began
nearly 3 years earlier than in those who had not been marijuana users ... no
one's been able to prove that smoking marijuana actually causes psychotic
disorders like schizophrenia, but the new research adds to "growing evidence"
that it does, at least in some people ... Why was there disagreement in the past
over whether this effect really exists? The reasons lie in the way the
individual studies might have been done ... One study found that compared to
people who didn't use marijuana, people over 18 who did use it had twice the
risk of mental illness, but kids under 15 had five times the risk" -
Note: Regarding the second to the last statement, people will find the
study they wish to believe.
Vitamin D linked to colon cancer protection: Meta-analysis - Nutra USA,
2/7/11 - "for every 10 nanograms per milliliter increase
25(OH)D levels the associated risk of
colorectal cancer decreased by 15 percent, while the risk of breast cancer
was associated with an 11 percent decrease. However, when the researchers
restricted their analysis to prospective studies only, the breast cancer risk
was decreased by only 3 percent, whereas data from case-control studies
indicated a risk reduction of 17 percent" -[Abstract]
vitamin D at Amazon.com.
explanation for heart-healthy benefits of chocolate - Science Daily, 2/7/11
- "studies have shown that
cocoa, the main ingredient in chocolate, appears to reduce the risk of heart
disease by boosting levels of HDL, or "good" cholesterol, and decreasing levels
of low-density lipoprotein (LDL), or "bad" cholesterol. Credit for those
heart-healthy effects goes to a cadre of antioxidant compounds in cocoa called
polyphenols, which are particularly abundant in dark chocolate"
Chocolate is a 'super fruit': Rich source of antioxidants - Science Daily,
2/6/11 - "chocolate is
a rich source of antioxidants and contains more polyphenols and flavanols than
fruit juice ... both dark chocolate and cocoa had a greater antioxidant capacity
and a greater total flavanol, and polyphenol, content than the fruit juices.
However hot chocolate, due to processing (alkalization) of the chocolate,
contained little of any"
vaccine works for boys: Study shows first clear benefits - Science Daily,
2/4/11 - "The vaccine
for human papillomavirus (HPV) can prevent 90 percent of genital warts in
men when offered before exposure to the four
HPV strains covered by the vaccine ... In addition to preventing warts, the
vaccine also effectively prevented HPV-persistent infection in 86 percent of the
participants without previous exposure ... while they find it likely that the
prevention of HPV infection and disease in men will have additional benefits,
such as preventing anal, genital and
throat cancers, these benefits need to be directly demonstrated through
further clinical trials"
Whey protein holds fat fighting potential, suggests study - Nutra USA,
2/3/11 - "The amount of fat inside liver cells (known as
intra-hepatocellular lipid concentrations – IHCL) in subjects fed a short term
high fat diet has been previously shown to be reduced again through increasing
dietary protein intake ... four weeks of supplementation with
whey protein led to a significant decrease in
IHCL of 21 percent, whilst fasting plasma triglyceride was observed to
decrease by 15 percent, and total plasma cholesterol concentration decreased by
over 7 percent" - [Abstract]
whey protein at Amazon.com.
Fish Oil May Reduce the Risk of Kidney Stones - Medscape, 2/3/11 -
"Five days of supplementation with
EPA and DHA didn't
alter urinary oxalate excretion. But after 30 days of supplements, urinary
oxalate excretion dropped from 0.277 to 0.238 mmol/24 hours ... Similarly, after
5 days there was no change in relative supersaturation of calcium oxalate (RS
CaOx), a proxy for the risk of calcium oxalate stone formation. But after 30
days, RS CaOx decreased by 23%" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
may ease early iron deficiency damage - Science Daily, 2/2/11 -
"When children are deprived of iron at any point during
the last trimester of
pregnancy or the first six months of life -- a
critical period of brain development -- they suffer brain damage at least
through early adulthood, and possibly beyond. In particular, their motor
function can be impaired as well as their ability to
focus ... Iron-deficient adults often have
restless leg syndrome. People who
become iron deficient after three years of age can recover by taking
iron supplements ... iron deficiency has a major hit on dopamine systems"
Slow Fe Slow Release Iron Tablets 90-Count Box at Amazon.com.
Tonsil Removal May Lead to Weight Gain - WebMD, 2/1/11 -
"Within a year of surgery, the average increase in BMI
was around 7% among children who had their tonsils removed" - Note:
When I was a kid they told the people that the advantage of having them removed
was that after the operation you got eat all the ice cream you wanted. I'm
sure that's not the reason a year later though but can't stop thinking about it.
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
glycosylated hemoglobin on sight-threatening diabetic retinopathy: A
population-based study - Diabetes Res Clin Pract. 2011 Feb 3 -
retinopathy (STDR) ... A statistically
significant difference (p<0.05) was noted in the duration of diabetes, gender,
body mass index, HbA1c, micro- and
macro-albuminuria between both non-STDR and STDR groups as compared to the
no-diabetic retinopathy (DR) group. On multivariate analysis, HbA1c (non-STDR:
odd's ratio OR=1.23; 95% confidence interval CI=1.15-1.32; p<0.0001; STDR:
OR=1.31 95% CI=1.14-1.52; p<0.0001) was found to be significantly associated
with non-STDR and STDR when compared with the no-DR group. The Receiver
Operating Characteristic analysis showed that the cut-off value of 8.0 had 75.6%
sensitivity and 58.2% specificity with 64.9% maximum area under the curve ...
HbA1c value >8.0% was significantly related with STDR. In a screening programme,
the cut-off value of HbA1c >8.0% provided a maximum yield of STDR"
ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows
immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence
for a new link between fish oil and inflammation - Br J Nutr. 2011 Feb
4:1-10 - "Among the compounds tested,
docosahexaenoylethanolamine (DHEA), the ethanolamide of DHA, was found to be the
most potent inhibitor, inducing a dose-dependent inhibition of NO release.
Immune-modulating properties of DHEA were further studied in the same cell line,
demonstrating that DHEA significantly suppressed the production of monocyte
chemotactic protein-1 (MCP-1), a cytokine playing a pivotal role in chronic
inflammation. In LPS-stimulated mouse peritoneal macrophages, DHEA also reduced
MCP-1 and NO production. Furthermore, inhibition was also found to take place at
a transcriptional level, as gene expression of MCP-1 and inducible NO synthase
was inhibited by DHEA. To summarise, in the present study, we showed that DHEA,
a DHA-derived NAE metabolite, modulates inflammation by reducing MCP-1 and NO
production and expression. These results provide new leads in molecular
mechanisms by which DHA can modulate
inflammatory processes" - See
Jarrow Max DHA at Amazon.com.
green tea catechins on the pro-inflammatory response after
haemorrhage/resuscitation in rats - Br J Nutr. 2011 Feb 4:1-7 -
"Plant polyphenols, i.e.
green tea extract (GTE),
possess high antioxidative and anti-inflammatory capacity, thus being protective
in various models of
... Compared with both sham groups, inflammatory markers (serum IL-6 and hepatic
PMNL infiltration) were elevated after H/R (P < 0.05). Also, H/R increased IκBα
phosphorylation. GTE administration markedly (P < 0.05) decreased serum ALT and
IL-6 levels, hepatic necrosis as well as PMNL infiltration and the expression of
ICAM-1 and phosphorylated IκBα compared with H/R. In conclusion, we observed
that NF-κB activation plays an important role in the pathogenesis of liver
injury after H/R through the up-regulation of hepatic ICAM-1 expression and
subsequent PMNL infiltration. GTE pre-treatment prevents liver damage in this
model of acute inflammation through a NF-κB-dependent mechanism" - See
green tea extract at Amazon.com.
Between High-Density Lipoprotein Cholesterol and Survival to Age 85 Years in Men
(from the VA Normative Aging Study) - Am J Cardiol. 2011 Feb 4 - "We
categorized initial HDL cholesterol into <40 mg/dl
(reference group), 40 to 49 mg/dl, or ≥50 mg/dl ... Treating HDL cholesterol as
a continuous predictor, we also determined the HR for each 10-mg/dl increment in
HDL cholesterol. Fully adjusted HR (95% confidence interval) for
survival to 85 years of age for participants
with an initial HDL cholesterol level ≥50 mg/dl compared to the reference was
0.72 (0.53 to 0.98). Each 10-mg/dl increment in HDL cholesterol was associated
with a 14% (HR 0.86, 0.78 to 0.96) decrease in risk of mortality before 85 years
of age. In conclusion, after adjusting for other factors associated with
longevity, higher HDL cholesterol levels were significantly associated with
survival to 85 years of age" - See
niacin at Amazon.com
(niacin increases HDL).
Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and
colorectal, breast and prostate cancer and colorectal adenoma - Int J
Cancer. 2011 Mar 15;128(6):1414-24 - "The summary
relative risk (SRR) and (95% confidence interval) for a 10 ng/ml increase in
25-hydroxyvitamin D was 0.85 (0.79; 0.91) for
colorectal cancer (2,630 cases in 9 studies);
0.89 (0.81;0.98) for breast cancer (6,175 cases in 10 studies); and 0.99
(0.95;1.03) for prostate cancer (3,956 cases in 11 studies). For breast cancer,
case-control studies (3,030 cases) had major limitations and obtained SRR of
0.83 (0.79; 0.87) whereas SRR of prospective studies (3,145 cases) was 0.97
(0.92; 1.03). For colorectal and breast cancer, differences between cases and
controls in the season of blood draw or in overweight/obesity or physical
inactivity could not explain the results. In conclusion, a consistent inverse
relationship between serum 25-hydroxyvitamin D levels and colorectal cancer was
found. No association was found for breast and prostate cancer" - See
vitamin D at Amazon.com.
Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch
Tumors - Nutr Cancer. 2011 Feb 2:1 -
"Epidemiological studies have consistently demonstrated the protective effects
of dietary phytochemicals against cancer risk.
Quercetin, a ubiquitous dietary flavonoid, has
attracted considerable attention owing to its potent antioxidant and
antiproliferative activities ... Simultaneous administration of quercetin to
DMBA-painted hamsters reduced tumor incidence and tumor burden, while
posttreatment of quercetin resulted in a significant tumor growth delay. In
addition, quercetin administration induced cell cycle arrest and apoptosis and
blocked invasion and angiogenesis. We found a positive correlation between the
inhibition of HDAC-1 and DNMT1 by quercetin and its anticancer properties. A
dietary phytochemical such as quercetin that modulates a plethora of molecules
offers promise as an ideal candidate for multitargeted cancer prevention and
therapy" - See
quercetin at Amazon.com.
Prevents Hypertension and Increases Exercise Capacity in Rats With
Fructose-Induced Hypertension - Am J Hypertens. 2011 Feb 3 -
"Five groups of 15 Sprague-Dawley rats were allocated
and designated as control, high fructose-fed (fructose), high fructose-fed plus
exercise (FE), high fructose-fed plus 2% taurine
supplement (FT) and high fructose-fed plus 2% taurine supplement and
exercise (FET) groups ... Noninvasive SBP differed significantly (P < 0.001)
from week 3, both noninvasive and invasive ABP increased significantly (P <
0.001), and exercise capacity significantly decreased (P < 0.001) in the
fructose group compared with the control group. The individual effects of
swimming and taurine supplementation were incapable of preventing the
development of hypertension and SBP
significantly (P < 0.001) increased in the FE and FT groups; exercise capacity
in those groups remained similar to control. The combined effects of exercise
and taurine alleviated hypertension and significantly increased exercise
capacity in the FET group. Insulin resistance increased significantly and plasma
nitric oxide (NO) decreased significantly in the F, FE, and FT groups. Both
parameters remained similar to control values in the FET group with an
increasing antioxidant activity. Conclusion Taurine supplementation in
combination with exercise prevents hypertension and increases exercise capacity
by possibly antioxidation and maintaining NO concentrations" - See
taurine at Amazon.com.
Intake and Mortality in Patients With Type 2 Diabetes - Diabetes Care. 2011
Feb 2 - "Over a median of 9.9 years, there were 175
deaths, 75 (43%) of which were secondary to cardiovascular events. All-cause
mortality was inversely associated with 24hU(Na), after adjusting for other
baseline risk factors (P < 0.001). For every 100 mmol rise in 24hU(Na),
all-cause mortality was 28% lower (95% CI 6-45%, P = 0.02). After adjusting for
the competing risk of noncardiovascular death and other predictors, 24hU(Na) was
also significantly associated with cardiovascular mortality (sub-hazard ratio
0.65 [95% CI 0.44-0.95]; P = 0.03). CONCLUSIONS In patients with type 2
diabetes, lower 24-h urinary sodium excretion was paradoxically associated with
increased all-cause and cardiovascular mortality. Interventional studies are
necessary to determine if dietary salt has a
causative role in determining adverse outcomes in patients with type 2 diabetes
and the appropriateness of guidelines advocating salt restriction in this
setting" - Note: That's not the first study showing that.
Cardiovascular Risk: Low Sodium Diets Might Be Worse Than High Salt Diets
- Science Daily, 5/15/08 - "Contrary to long-held
assumptions, high-salt diets may not increase the risk of death ... The
Einstein researchers actually observed a significantly increased risk of
death from cardiovascular disease (CVD) associated with lower sodium diets"
diet increases insulin resistance in healthy subjects - Metabolism. 2010
Oct 29 - "Low-salt (LS) diet activates the
renin-angiotensin-aldosterone and sympathetic nervous systems, both of which
can increase insulin resistance (IR) ... Low-salt diet was significantly
associated with higher homeostasis model assessment index independent of
age, sex, blood pressure, body mass index, serum sodium and potassium, serum
angiotensin II, plasma renin activity, serum and urine aldosterone, and
urine epinephrine and norepinephrine. Low-salt diet is associated with an
increase in IR. The impact of our findings on the pathogenesis of diabetes
and cardiovascular disease needs further investigation"
Dietary salt restriction increases plasma lipoprotein and inflammatory
marker concentrations in hypertensive patients - Atherosclerosis. 2008
Feb 8 - "low sodium intake (LSI) ... LSI induced
alterations in the plasma lipoproteins and in inflammatory markers that are
common features of the metabolic syndrome"
Salt Use Linked To Highest Mortality - Doctor's Guide, 3/13/98
A1c as a Predictor of Incident Diabetes - Diabetes Care. 2011 Feb 2 -
"During an average follow-up of 4.4 years, 3,329 (26.9%)
developed diabetes. HbA(1c) ≥5.0% carried a
significant risk for developing diabetes during follow-up. When compared with
the reference group (HbA(1c) <4.5%), HbA(1c) increments of 0.5% between 5.0 and
6.4% had adjusted odds ratios of 1.70 (5.0-5.4%), 4.87 (5.5-5.9%), and 16.06
(6.0-6.4%) (P < 0.0001). Estimates of hazard ratios similarly showed significant
increases for HbA(1c) ≥5.0%. A risk model for incident diabetes within 5 years
was developed and validated using HbA(1c), age, BMI, and systolic blood
Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory
Stress Response to a High-Fat, High-Carbohydrate Meal - J Clin Endocrinol
Metab. 2011 Feb 2 - "High-fat, high-carbohydrate (HFHC)
meals are known to induce oxidative and inflammatory stress, an increase in
plasma endotoxin concentrations, and an increase in the expression of suppressor
of cytokine signaling-3 (SOCS-3) ... A supplement containing resveratrol and
muscadine polyphenols suppresses the increase in oxidative stress,
lipopolysaccharide and LBP concentrations, and expression of TLR-4, CD14, IL-1β
and SOCS-3 in mononuclear cells after an HFHC meal. It also stimulates specific
Nrf-2 activity and induces the expression of the related antioxidant genes,
NQO-1 and GST-P1. These results demonstrate the acute antioxidant and
antiinflammatory effects of resveratrol and polyphenolic compounds in humans in
the postprandial state" - See
resveratrol products at Amazon.com.
Prevents Sleep Disturbances and Modulates GH, TSH, and Melatonin Secretion in
Postmenopausal Women - J Clin Endocrinol Metab. 2011 Feb 2 -
"Progesterone had no
effect on undisturbed sleep but restored normal sleep when sleep was disturbed
(while currently available hypnotics tend to inhibit deep sleep), acting as a
"physiologic" regulator rather than as a hypnotic drug. Use of progesterone
might provide novel therapeutic strategies for the treatment of
sleep disturbances, in particular in aging where
sleep is fragmented and of lower quality" - See
progesterone products at iHerb.
magnesium status and magnesium intake on the blood glucose control in patients
with type 2 diabetes - Clin Nutr. 2011 Jan 31 - "Magnesium
status was influenced by kidney depuration and was altered in patients with type
diabetes, and magnesium showed to play an
important role in blood glucose control" - See
magnesium supplements at Amazon.com.
Effects of a
whey protein supplementation on intrahepatocellular lipids in obese female
patients - Clin Nutr. 2011 Jan 31 -
"intrahepatocellular lipids (IHCL) ... 60 g/day whey
protein supplement (WPS) for 4-weeks ... total liver volume (MR) ...
IHCL were positively correlated with
visceral fat and total liver volume at inclusion. WPS decreased significantly
IHCL by 20.8 +/- 7.7%, fasting total TG by 15 +/- 6.9%, and total cholesterol by
7.3 +/- 2.7%. WPS slightly increased fat free mass from 54.8 +/- 2.2 kg to 56.7
+/- 2.5 kg, p = 0.005). Visceral fat, total liver volume, glucose tolerance,
creatinine clearance and insulin sensitivity were not changed" - See
whey protein at Amazon.com.
consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved
glycemic control in patients with type 2 diabetes: a randomized clinical trial
- Am J Clin Nutr. 2011 Feb 2 - "randomly allocated to 3
groups to consume plain yogurt drink (PY; containing no
vitamin D and 150 mg Ca/250 mL), vitamin D-fortified yogurt drink (DY;
containing 500 IU vitamin D(3) and 150 mg Ca/250 mL), or vitamin D +
calcium-fortified yogurt drink (DCY; containing 500 IU vitamin D(3) and 250 mg
Ca/250 mL) twice per day for 12 wk ... Fasting serum glucose (FSG) ...
percentage fat mass (FM) ... In both the DY and DCY groups, mean serum
25(OH)D(3) improved (+32.8 +/- 28.4 and +28.8 +/- 16.1 nmol/L, respectively; P <
0.001 for both), but FSG [-12.9 +/- 33.7 mg/dL (P = 0.015) and -9.6 +/- 46.9
mg/dL (P = 0.035), respectively], Hb A(1c) [-0.4 +/- 1.2% (P < 0.001) and -0.4
+/- 1.9% (P < 0.001), respectively], HOMA-IR [-0.6 +/- 1.4 (P = 0.001) and -0.6
+/- 3.2 (P < 0.001), respectively], waist circumference (-3.6 +/- 2.7 and -2.9
+/- 3.3, respectively; P < 0.001 for both), and body mass index [in kg/m(2);
-0.9 +/- 0.6 (P < 0.001) and -0.4 +/- 0.7 (P = 0.005), respectively] decreased
significantly more than in the PY group. An inverse correlation was observed
between changes in serum 25(OH)D(3) and FSG (r = -0.208, P = 0.049), FM (r =
-0.219, P = 0.038), and HOMA-IR (r = -0.219, P = 0.005)" - See
vitamin D at Amazon.com.
training increases size of hippocampus and improves memory - Proc Natl Acad
Sci U S A. 2011 Jan 31 - "Here we show, in a randomized
controlled trial with 120 older adults, that
aerobic exercise training increases the size of the anterior hippocampus,
leading to improvements in spatial memory. Exercise training increased
hippocampal volume by 2%, effectively reversing age-related loss in volume by 1
to 2 y. We also demonstrate that increased hippocampal volume is associated with
greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus.
Hippocampal volume declined in the control group, but higher preintervention
fitness partially attenuated the decline, suggesting that fitness protects
against volume loss. Caudate nucleus and thalamus volumes were unaffected by the
intervention. These theoretically important findings indicate that aerobic
exercise training is effective at reversing hippocampal volume loss in late
adulthood, which is accompanied by improved memory function"
and Prehypertension in Healthy Adults Are Associated With Low Vitamin D Levels
- Diabetes Care. 2011 Jan 31 - "The odds ratio for
comorbid PreDM and PreHTN in Caucasian men (n = 898) and women (n = 813) was
2.41 (P < 0.0001) with vitamin D levels ≤76.3 versus >76.3 nmol/L after
adjusting for age, sex, and BMI. CONCLUSIONS This study strengthens the
plausibility that low serum
levels elevate the risk for early-stage diabetes
vitamin D at Amazon.com.
are associated with asymptomatic atherosclerosis in healthy men of primary
prevention - Eur J Clin Invest. 2011 Jan 31 -
"carotid intima-media thickness (IACC) ... The plasma-circulating transferrin
receptor concentration to plasma ferritin concentration ratio (TfR/F) showed
significant association with IACC (r = -0.310, P = 0.008 vs. r = 0.295, P =
0.012). Multivariate analysis confirmed that the correlation of TfR/F with IACC
is independent of traditional risk factors of atherosclerosis ... Our study
showed a clear association of body iron stores
expressed by the TfR/F ratio with asymptomatic carotid atherosclerosis"
modulation of body composition and insulin sensitivity during catch-up growth in
rats: effects of oils rich in n-6 or n-3 PUFA - Br J Nutr. 2011 Jan 31:1-14
- "linoleic acid (LA), α-linolenic acid (ALA),
arachidonic acid (AA) or DHA. It has been shown that, compared with
food-restricted rats refed a high-fat (lard) diet low in PUFA, those refed
isoenergetically on diets enriched in LA or ALA, independently of the n-6:n-3
ratio, show improved insulin sensitivity, lower fat mass and higher lean mass,
the magnitude of which is related to the proportion of total PUFA precursors
(LA+ALA) consumed ... Isoenergetic refeeding on high-fat diets enriched in AA or
DHA also led to improved body composition, with increases in lean mass as
predicted by the quadratic model for PUFA precursors, but decreases in fat mass,
which are disproportionately greater than predicted values; insulin sensitivity,
however, was not improved. These findings pertaining to the impact of dietary
intake of PUFA precursors (LA and ALA) and their elongated-desaturated products
(AA and DHA), on body composition and insulin sensitivity, provide important
insights into the search for diets aimed at counteracting the pathophysiological
consequences of catch-up growth. In particular, diets enriched in essential
fatty acids (LA and/or ALA) markedly improve insulin sensitivity and composition
of weight regained, independently of the n-6:n-3 fatty acid ratio" -
Here's the fat table again:
LNA - Alpha linolenic acid
GLA - Gamma linolenic acid
Dihomo gamma-linolenic Acid
(omega 3) - Docosapentaenoic acid
(omega 6) Docosapentaenoic
Neat Tech Stuff / "How To's":
Health Focus (Magnesium):
News & Research:
- Jarrow Formulas, Magnesium Optimizer Citrate at Amazon.com
- Why you need to go with a supplement with the right calcium, magnesium,
zinc, copper ratio such as Body Wise
Magnesium--A Forgotten Mineral - Health & Nutrition Breakthroughs, 9/97
"Excess calcium and phosphate also interfere with
magnesium absorption. (Thus, taking calcium supplements without adding
magnesium could result in magnesium deficiency.)"
Inhibitory effects of zinc on magnesium balance and magnesium absorption in
magnesium absorption in man - J Am Coll Nutr. 1994 Oct;13(5):479-84 -
"the overall effect of the high Zn intake of the three groups combined,
regardless of the Ca intake, was a highly significant decrease of Mg
absorption and of the Mg balance"
Zinc -- The Immune System's Missing Link? - Health & Nutrition
Breakthroughs, 12/97 -
"Supplementing with zinc is quite safe--its only
significant side effect is lowered copper levels in the body tissues, since
the two minerals compete for absorption. Considering zinc's safety, people
should consider taking zinc supplements, especially as they age--being sure
to include copper in the proper balance. Most practitioners who supplement
their patients' diets with zinc also recommend taking copper at a ratio of
10 mg to 15 mg zinc for each milligram of copper."
Calcium, Keep What You Take - Life Extension Magazine, 3/99 -
"The final study was a two-year, placebo controlled
trial on 225 postmenopausal women. One group received calcium supplements
only, the second group zinc, manganese and copper, the third group received
calcium plus zinc, manganese and copper, while the fourth group received a
placebo. After two years, the only group who experienced an improvement in
bone mineral density was the group taking calcium plus zinc, manganese and
copper" - [Abstract]
Magnesium: The Multi-Purpose Mineral - Think Muscle Newsletter -
"If you take high amounts of calcium daily, you may
have a magnesium deficiency. Most experts suggest that your calcium:
magnesium ration should be 2:1. In other words, if you take 1500 mg of
calcium daily through diet and supplementation, you should try to consume at
least 750 mg of magnesium daily as well"
Insulin Resistance - Dr. Weil - "Supplements:
... Coenzyme Q10 ... Alpha-lipoic acid ... Magnesium ... Chromium"
Serum Magnesium and
Risk of Sudden Cardiac Death in the Atherosclerosis Risk in Communities (ARIC)
Study - Medscape, 10/19/10 - "sudden cardiac death
(SCD) ... SCD was inversely associated with serum Mg (P for linear trend <
.0001). Compared with the lowest quartile of Mg, the risk of SCD was 55% lower
(HR 0.45, 95% CI 0.31–0.67) in the highest Mg quartile and 47% lower in the
second highest quartile (HR 0.53, 95% CI 0.38–0.74)"
Magnesium may decrease colon cancer risk: Study - Nutra USA, 3/15/10 -
"Intakes of the mineral of at least 327 milligrams
per day were found to reduce the risk of colon cancer by 52 per cent, compared
to intakes less than 238 milligrams per day, while no benefits were observed in
women" - [Abstract]
Remember magnesium if you want to remember: Synthetic supplement improves
memory and staves off age-related memory loss - Science Daily, 2/22/10 -
"magnesium, a key nutrient for the functioning of
memory, may be even more critical than previously thought for the neurons of
children and healthy brain cells in adults ... In the study, two groups of
rats ate normal diets containing a healthy amount of magnesium from natural
sources. The first group was given a supplement of MgT, while the control
group had only its regular diet. Behavioral tests showed that cognitive
functioning improved in the rats in the first group and also demonstrated an
increase of synapses in the brain -- connective nerve endings that carry
memories in the form of electrical impulses from one part of the brain to
the other" - Note: The problem is that the magnesium-L-theronate form
Magnesium supplements may boost lung health for asthmatics - Nutra USA,
Magnesium May Improve Memory - WebMD, 1/27/10 -
"increasing brain magnesium using a newly developed compound,
magnesium-L-threonate (MgT), improves learning abilities, working memory,
and short- and-long-term memory in rats. The magnesium also helped older
rats perform better on a battery of learning tests ... The researchers cite
that only 32% of Americans get the recommended daily allowance of magnesium"
men deficient in key nutrients - MSNBC, 6/19/09 -
"studies show that 77 percent of men don't take in
enough magnesium, that many of us are deficient in vitamin D, and that the
vitamin B12 in our diets may be undermined by a common heartburn medication.
And we haven't even mentioned our problems with potassium and iodine"
Magnesium may benefit blood pressure in hypertensives - Nutra USA,
5/19/09 - "receive either daily supplements of 300
mg of elemental magnesium in the magnesium oxide form or placebo for 12
weeks ... At the end of the study, no significant differences were observed
between the magnesium or placebo groups. However, when the researchers
looked specifically at hypertensives, significant decreases in both systolic
and diastolic blood pressure were observed in the magnesium group (17.1 and
3.4 mmHg, respectively), compared to placebo (6.7 and 0.8 mmHg,
respectively)" - [Abstract]
Magnesium Supplement Reviews - ConsumerLab.com, 5/19/09 -
"25% did not meet quality standards according to our
Low magnesium levels may increase stroke risk - Nutra USA, 4/22/09 -
"Blood levels of magnesium were negatively
associated with the risk of stroke, they said, with levels of 1.6, 1.7, and
1.8 mEq/L linked to a 22, 30, and 25 per cent reduction in stroke,
respectively, compared to 1.5 mEq/L "
Calcium May Only Protect Against Colorectal Cancer In Presence Of Magnesium
- Science Daily, 11/16/08 - "supplementation of
calcium only reduced the risk of adenoma recurrence if the ratio of calcium
to magnesium was low and remained low during treatment. "The risk of
colorectal cancer adenoma recurrence was reduced by 32 percent among those
with baseline calcium to magnesium ratio below the median in comparison to
no reduction for those above the median"
Magnesium linked to fewer gallstones - Nutra USA, 2/26/08 -
"After adjusting the results to account for age
differences, which may affect the results, Tsai and co-workers calculated
that men with the highest levels of magnesium intake (454 mg/d) were 28 per
cent less likely to develop gallstones, compared to men with the lowest
average intake (262 mg/d)" - [Abstract]
Supplements review - ConsumerLab.com, 10/31/07
Magnesium Intake May Cut Risk of Gallstones - Medscape, 2/22/08 -
"Magnesium deficiency is known to cause elevated
triglyceride levels and decreased HDL cholesterol levels, both of which may
raise the risk of gallstones ... Compared with the lowest quintile of total
magnesium intake (median 262 mg/day), the highest quintile of intake (454
mg/day) reduced the risk of gallstone disease by 33%"
Migraine Patients May Benefit From Magnesium or CoQ10 - Clinical
Psychiatry News, 8/07 - "The most important
supplement, according to Dr. Mauskop, is magnesium. “It's known that up to
50% of people with acute migraine have a magnesium deficiency. … It is much
more effective to treat them with a product they're deficient in rather than
using drugs,” ... Research has found that, for migraine, CoQ10 at 300 mg/day
is effective, and that for Parkinson's disease 1,200 mg/day is effective"
Grain Fiber And Magnesium Intake Associated With Lower Risk For Diabetes
- Science Daily, 5/14/07 - "those who consumed the
most cereal fiber had a 33 percent lower risk of developing diabetes than
those who took in the least, while those who consumed the most magnesium had
a 23 percent lower risk than those who consumed the least. There was no
association between fruit or vegetable fiber and diabetes risk"
Dietary Magnesium May Reduce Risk for Diabetes in Black Women -
Medscape, 10/9/06 - "41,186 women enrolled in the
Black Women's Health Study ... Higher magnesium intakes in the highest vs
the lowest quintile were associated with lower incidence of diabetes
mellitus with an adjusted HR of 0.69"
Magnesium supplements could help asthmatics, says study - Nutra USA,
- Need More Magnesium?
- Dr. Weil, 6/29/06 -
"a diet rich in magnesium appears to protect against
metabolic syndrome, a combination of risk factors that can lead to diabetes
and heart disease"
Lowers Heart, Diabetes Risks - WebMD, 3/27/06 -
"people in the study who consumed the most magnesium
had a 31% lower risk of developing metabolic syndrome, compared with people
who ate the least"
Magnesium Prevents Osteoporosis - Healthwell, 2/9/06 -
"a higher magnesium intake was associated with
greater whole-body bone mineral density, after adjusting for calcium and
vitamin D intake, level of exercise, use of estrogen medication, and other
factors known to be related to bone health"
More support for magnesium against colon cancer - Nutra USA, 1/31/06 -
"The hazard ratio, a measure of the risk, was
statistically 25 per cent lower for the volunteers with the highest intake
of magnesium (more than 356 mg per day)"
Magnesium In Your Diet Could Lead To Stronger Bones - Science Daily,
Dietary Magnesium Could Lead to Stronger Bones
- Doctor's Guide, 12/21/05 -
"For every 100 milligram per day increase in magnesium
intake, data showed a 1% increase in bone density ... this link was only true
for the older white men and women"
Magnesium could reduce osteoporosis risk - Nutra USA, 12/8/05 -
"Higher Mg intake through diet and supplements was
positively associated with total-body [bone mineral density] BMD in older
white men and women. For every 100 mg per day increase in Mg, there was an
approximate 2 per cent increase in whole-body BMD"
and Bone Mineral Density - Medscape, 11/8/05 -
"The mean intakes of Mg by race-sex subgroup are
listed in Table 2 . Less than 26% of the cohort met the RDA for Mg ...
twenty-five percent of the cohort took a Mg-containing supplement; the mean
dose was 83 mg ... RDA of 420 mg/d" - See
Magnesium Deficiency in Obese Children May Be Linked to Insulin Resistance
- Medscape, 5/9/05 - "Magnesium deficiency in obese
children is associated with the development of insulin resistance"
- Focus on
Magnesium - Dr. Murray's Natural Facts, 3/3/05 -
"Double-blind studies in people with CFS have shown
magnesium supplementation significantly improved energy levels, better
emotional state, and less pain"
MIT: Magnesium May Reverse Middle-age Memory Loss
- Science Daily, 12/27/04 - "In the cover story of
the Dec. 2 issue of Neuron, MIT researchers report a possible new role for
magnesium: helping maintain memory function in middle age and beyond ...
magnesium helps regulate a key brain receptor important for learning and
What to take to keep diabetes at bay - Delicious Living, 12/04 -
"Recent research suggests that magnesium keeps blood
sugars from rising too high, thus staving off
Magnesium in Hypertension Prevention and Control - Life Extension
Magazine, 9/04 - "Magnesium is one of the body’s
most important minerals. ... Magnesium is a major factor in relaxing the
smooth muscles within the blood vessels, thereby reducing peripheral
vascular resistance and blood pressure.11-13 In addition, magnesium reduces
nerve and muscle excitability, stabilizes cardiac conductivity, and
influences neurochemical transmission.11,13,14 Magnesium also affects
circulating levels of norepinephrine and the synthesis of serotonin and
- Americans Need
More Magnesium in Diet - WebMD, 7/23/04 -
"nearly two-thirds of us may not be getting enough magnesium ... Adult men
need 400-420 mg/day while adult women need 310-320 mg /day"
Lack Energy? Maybe It's Your Magnesium Level
- Science Daily, 5/10/04 - "inadequate magnesium is
associated with a need for increased oxygen during exercise. They found that
during moderate activity, those with low magnesium levels in muscle are
likely to use more energy—and therefore to tire more quickly—than those with
adequate levels" - See
- Magnesium may reduce risk of
diabetes - MSNBC, 5/7/04 - "The conclusions of
these three studies are generally supported by earlier large population
studies. Laboratory studies suggest that magnesium influences the action of
insulin in the body. A lack of magnesium may worsen insulin resistance,
triggering the onset of diabetes" - See
Magnesium Helps Prevent Arrhythmia After Cardiac Surgery - Doctor's
Low Magnesium Intake May be Associated with Increased Risk for Type 2
Diabetes - Doctor's Guide, 1/6/04 -
"Statistical analyses revealed a significant inverse
association between magnesium intake and risk of type 2
Lowers Type 2 Diabetes Risk - WebMD, 12/23/03
- Dietary Magnesium May
Help Prevent Development of Type 2 Diabetes
- Medscape, 12/23/03 -
"Magnesium-containing foods can prevent development
of type 2
diabetes in both men and women ... Comparing the highest with the lowest
quintile of total magnesium intake ... was 0.66 ... in women and 0.67 in
Does taking extra magnesium help prevent heart disease? - Natural Foods
- Magnesium Deficiency
Associated with Insulin-Resistance Syndrome
- New Hope Natural Media, 6/12/03
- Magnesium Beneficial
for Urinary Urge Incontinence
- New Hope Natural Media, 3/20/03
- Magnesium Plus
Albuterol More Effective Than Albuterol Alone in Asthma
- Medscape, 10/21/02
Low Dietary Magnesium Changes Cardiac Rhythm - Doctor's Guide, 3/4/02 -
"Low intakes of dietary magnesium may increase supraventricular ectopy ...
people who live in areas with soft water, who use diuretics, or who are
predisposed to magnesium loss may need to take in more dietary magnesium
than others ... Magnesium is central to a variety of cellular mechanisms
that control activity of muscle and nerve cells. Cardiac muscle seems to
have been more sensitive to this intake than was skeletal muscle ... They
point out some women may habitually eat a diet similar to the one in this
study and for long periods of time"
Magnesium Abnormalities Key In Dermatomyositis? - Doctor's Guide,
Adequate Magnesium Intake Reduces Risk For Cardiovascular Disease Type 1
Diabetics - Doctor's Guide, 1/18/02
- Magnesium Shows Promise
for Thrombolysis-ineligible Cardiac Patients
- Doctor's Guide, 11/14/01
- Got Magnesium?
Those With Heart Disease Should - WebMD, 11/9/00 -
"Similar magnesium supplements are available over-the-counter in the U.S.,
but they might not provide similar benefits. "The product we used is from
Germany, where supplements of this kind are regulated and quality is
monitored," Merz says. "Because that is not the case in the U.S., it is
impossible to know what you are getting in a supplement, or even whether it
contains any magnesium at all.""
- More Than Half of
All Women Report: 'We're Stressed!', Experts Say Diet, Supplements May Be
the Answer - WebMD, 6/2/00 -
""Stress affects nutrient needs by reducing
absorption, increasing excretion, [and] altering how the body uses -- or
increasing the daily requirements for -- certain nutrients," she says. For
example, the body releases stress hormones, such as cortisol, during
stressful times, and these stress hormones deplete your body's supply of
magnesium -- an element that plays a role the body's use of energy."
- Low Magnesium
Levels May Strongly Foreshadow Diabetes Development in Whites
- WebMD, 10/18/99
- Potassium-Magnesium Citrate
Effective In Correcting Thiazide-Induced Side Effects - Doctor's Guide,
supplementation, metabolic and inflammatory markers, and global genomic and
proteomic profiling: a randomized, double-blind, controlled, crossover trial in
overweight individuals - Am J Clin Nutr. 2010 Dec 15 -
"We observed that magnesium treatment significantly
decreased fasting C-peptide concentrations (change: -0.4 ng/mL after magnesium
treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and
appeared to decrease fasting insulin concentrations (change: -2.2 μU/mL after
magnesium treatment compared with 0.0 μU/mL after placebo treatment; P = 0.25)
... Urine proteomic profiling showed significant differences in the expression
amounts of several peptides and proteins after treatment" - See
magnesium supplements at Amazon.com.
magnesium supplementation reduces insulin resistance in non-diabetic subjects -
a double-blind, placebo-controlled, randomized trial - Diabetes Obes Metab.
2010 Nov 18 - "Mg supplementation resulted in a
significant improvement of fasting plasma glucose and some ISI compared to
placebo. Blood pressure and lipid profile didn't show significant changes. The
results provide significant evidence that oral Mg supplementation improves
insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects
emphasizing the need for an early optimisation of Mg status to prevent insulin
resistance and subsequently type 2 diabetes" - See
magnesium supplements at Amazon.com.
magnesium concentrations predict increase in left ventricular mass over 5 years
independently of common cardiovascular risk factors - Atherosclerosis. 2010
Sep 21 - "Mg(2+) at baseline (0.790+/-0.003mmol/l,
mean+/-SEM) inversely correlated with the difference in LVM over 5 years
(p<0.0001, females: p<0.002, males: p<0.024). In the lowest Mg(2+)-quintile
(Mg(2+)<=0.73mmol/l), LVM (187.4+/-3.1g at baseline) increased by 14.9+/-1.2g,
while in the highest Mg(2+)-quintile (Mg(2+)>=0.85mmol/l) LVM (186.7+/-3.4g at
baseline) decreased by -0.5+/-2.8g (p<0.0001 between quintiles). By
multivariable analysis including several cardiovascular risk factors and
antihypertensive treatment, serum Mg(2+) was associated with the increase in LVM
at a statistically high significant level (p<0.0001). LVM after 5 years was
significantly higher in subjects within the lower Mg(2+)-quintiles. This
association remained highly significant after adjustment for several
cardiovascular risk factors including arterial hypertension and diabetes
magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in
Communities (ARIC) Study - Am Heart J. 2010 Sep;160(3):464-70 -
"sudden cardiac death (SCD) ... Individuals in the
highest quartile of serum Mg were at significantly lower risk of SCD in all
models. This association persisted after adjustment for potential confounding
variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI
0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted
model ... This study suggests that low levels of serum Mg may be an important
predictor of SCD"
Intake in Relation to Systemic Inflammation, Insulin Resistance, and the
Incidence of Diabetes - Diabetes Care. 2010 Aug 31 -
"During 20-year follow-up, 330 incident diabetic cases were identified.
Magnesium intake was inversely associated with incidence of diabetes after
adjustment for potential confounders. The multivariable-adjusted hazard ratio of
diabetes for participants in the highest quintile of magnesium intake was 0.53
(95% confidence interval, 0.32-0.86; P(trend)<0.01) compared with those in the
lowest quintile. Consistently, magnesium intake was significantly inversely
associated with hs-CRP, IL-6, fibrinogen, and HOMA-IR; and serum magnesium
levels were inversely correlated with hs-CRP and HOMA-IR"
Intake and Risk of Self-Reported Type 2 Diabetes among Japanese - J Am Coll
Nutr. 2010 Apr;29(2):99-106 - "Dietary intake of
magnesium was inversely associated with age- and body mass index (BMI)-adjusted
diabetes incidence in both sexes. In multivariable analysis that adjusted
further for cardiovascular risk factors, the association was weakened in both
sexes, but the association in total participants remained statistically
significant. The odds ratios of diabetes with reference to the lowest quartile
of magnesium intake were 0.83 (95% confidence interval [CI], 0.69 to 1.09) for
the second quartile, 0.79 (95% CI, 0.59 to 1.07) for the third quartile, and
0.64 (95% CI, 0.44 to 0.94) for the highest quartile of magnesium intake (p for
trend = 0.04). CONCLUSIONS: Dietary intake of magnesium was associated with a
reduced risk of type 2 diabetes in Japanese populations"
effects of oral magnesium supplementation on insulin sensitivity and serum lipid
profile - Med Sci Monit. 2010 Jun 1;16(6):PI13-18 -
"assigned to 600 mg of pidolate Mg2+ daily ... In the Mg2+ supplementation group
the OGTT-derived IS indices of Stumvoll, Matsuda and Cedercholm in were
increased between baseline baseline and study-end. In contrast, none of these
parameters were changed in the control group. Reductions in total cholesterol,
LDL-cholesterol and triglyceride levels, along with a parallel increase in
HDL-cholesterol levels, were evident at study-end in the intervention group, but
not in the control group"
Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese
Men - J Nutr. 2010 Feb 17 - "When adjusted for
potential confounders, the hazard ratio and 95% CI in the highest quintile of
magnesium intake compared with the lowest quintile in men were 0.65 (95% CI,
0.40-1.03) for CRC (P-trend = 0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer
(P-trend = 0.01), and 0.97 (95% CI, 0.47-2.02) for rectal cancer (P-trend =
of magnesium on postprandial serum lipid responses in healthy human subjects
- Br J Nutr. 2009 Nov 27:1-4 - "The present study
indicated that Mg supplementation could inhibit fat absorption and improve
postprandial hyperlipidaemia in healthy subjects"
Magnesium Supplementation Reduces Ambulatory Blood Pressure in Patients With
Mild Hypertension - Am J Hypertens. 2009 Jul 16 -
"In the Mg(2+) supplementation group, small but
significant reductions in mean 24-h systolic and diastolic BP levels were
observed, in contrast to control group (-5.6 +/- 2.7 vs. -1.3 +/- 2.4 mm Hg,
P < 0.001 and -2.8 +/- 1.8 vs. -1 +/- 1.2 mm Hg, P = 0.002, respectively)"
Effects of oral magnesium supplementation on insulin sensitivity and blood
pressure in normo-magnesemic nondiabetic overweight Korean adults - Nutr
Metab Cardiovasc Dis. 2009 Apr 7 - "These results
suggested that magnesium supplementation does not reduce BP and enhance
insulin sensitivity in normo-magnesemic nondiabetic overweight people.
However, it appears that magnesium supplementation may lower BP in healthy
adults with higher BP"
effect of lowering blood pressure by magnesium supplementation in diabetic
hypertensive adults with low serum magnesium levels: a randomized,
double-blind, placebo-controlled clinical trial - J Hum Hypertens. 2008
Nov 20 - "Over 4 months, subjects in the
intervention group received 2.5 g of MgCl(2) (50 ml of a solution containing
50 g of MgCl(2) per 1000 ml of solution) equivalent to 450 mg of elemental
magnesium, and control subjects inert placebo ... SBP (-20.4+/-15.9 versus
-4.7 +/- 12.7 mm Hg, P=0.03) and DBP (-8.7+/-16.3 versus -1.2+/-12.6 mm Hg,
P=0.02) showed significant decreases, and high-density
lipoprotein-cholesterol (0.1+/-0.6 versus -0.1+/-0.7 mmol l(-1), P=0.04) a
significant increase in the magnesium group compared to the placebo group.
The adjusted odds ratio between serum magnesium and BP was 2.8 (95%CI:
1.4-6.9). Oral magnesium supplementation with MgCl(2) significantly reduces
SBP and DBP in diabetic hypertensive adults with hypomagnesaemia"
Long-term effect of magnesium consumption on the risk of symptomatic
gallstone disease among men - Am J Gastroenterol. 2008 Feb;103(2):375-82
- "The age-adjusted relative risks (RRs) for men
with total magnesium intake and dietary magnesium, when the highest and
lowest quintiles were compared, were 0.67 (95% confidence interval [CI]
0.59-0.77, P for trend <0.0001) and 0.67 (CI 0.59-0.76, P for trend
<0.0001), respectively. After adjusting for multiple potential confounding
variables, when extreme quintiles were compared, the multivariate RR of
total magnesium intake (RR 0.72, CI 0.61-0.86, P for trend = 0.006) and
dietary magnesium (RR 0.68, CI 0.57-0.82, P for trend = 0.0006) remained
significant with a dose-response relationship ... Our findings suggest a
protective role of magnesium consumption in the prevention of symptomatic
gallstone disease among men"
Long-Term Effect of Magnesium Consumption on the Risk of Symptomatic
Gallstone Disease Among Men - Am J Gastroenterol. 2007 Dec 12 -
"Our findings suggest a protective role of magnesium
consumption in the prevention of symptomatic gallstone disease among men"
Magnesium intake and risk of type 2 diabetes: a meta-analysis - J Intern
Med. 2007 Aug;262(2):208-14 - "The overall relative
risk for a 100 mg day(-1) increase in magnesium intake was 0.85"
Fiber and Magnesium Intake and Incidence of Type 2 Diabetes: A Prospective
Study and Meta-analysis - Arch Intern Med. 2007 May 14;167(9):956-65 -
"Higher cereal fiber and magnesium intakes may
decrease diabetes risk"
Rapid recovery from major depression using magnesium treatment - Med
Hypotheses. 2006 Mar 14 - "Case histories are
presented showing rapid recovery (less than 7 days) from major depression
using 125-300mg of magnesium (as glycinate and taurinate) with each meal and
at bedtime. Magnesium was found usually effective for treatment of
depression in general use"
Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
- Br J Cancer. 2007 Feb 12;96(3):510-3 -
"Statistically significant inverse trends in risk
were observed in overweight subjects for colon and proximal colon cancer
across increasing quintiles of magnesium uptake"
A randomized controlled study of effects of dietary magnesium oxide
supplementation on bone mineral content in healthy girls - J Clin
Endocrinol Metab. 2006 Oct 3 -
"Magnesium (300 mg elemental Mg per day in 2 divided
doses) or placebo, given orally, for 12 months ... Significantly increased
accrual (P = 0.05) in integrated hip BMC occurred in the Mg-supplemented vs.
Potassium magnesium supplementation for four weeks improves small distal
artery compliance and reduces blood pressure in patients with essential
hypertension - Clin Exp Hypertens. 2006 Jul;28(5):489-97 -
"magnesium, 70.8 mg/d; potassium, 217.2 mg/d ... On
K+ and Mg2+ supplementation, systolic and diastolic BP decreased 7.83 +/-
1.87 mm Hg and 3.67 +/- 1.03 mm Hg"
Oral magnesium supplementation in asthmatic children: a double-blind
randomized placebo-controlled trial - Eur J Clin Nutr. 2006 Jun 21 -
"Oral magnesium supplementation helped to reduce
bronchial reactivity to methacholine, to diminish their allergen-induced
skin responses and to provide better symptom control in pediatric patients
with moderate persistent asthma treated with inhaled fluticasone"
Magnesium intake from food and supplements is associated with bone mineral
density in healthy older white subjects - J Am Geriatr Soc. 2005
Nov;53(11):1875-80 - "Greater magnesium intake was
significantly related to higher BMD in white women and men"
Magnesium Intake, C-Reactive Protein, and the Prevalence of Metabolic
Syndrome in Middle-Aged and Older U.S. Women
- Diabetes Care. 2005 Jun;28(6):1438-1444 - "women
in the highest quintile of magnesium intake had 27% lower risk of the
metabolic syndrome ... compared with those in the lowest quintile of intake"
Magnesium intake in relation to risk of colorectal cancer in women -
JAMA. 2005 Jan 5;293(1):86-9 - "a high magnesium
intake may reduce the occurrence of colorectal cancer in women"
Magnesium Intake and Risk of Type 2 Diabetes in Men and Women
- Diabetes Care. 2004 Jan;27(1):134-140 -
"Our findings suggest a significant inverse
association between magnesium intake and
diabetes risk. This study supports the dietary recommendation to
increase consumption of major food sources of magnesium, such as whole
grains, nuts, and green leafy vegetables"
Dietary magnesium intake and the future risk of coronary heart disease (The
Honolulu Heart Program) - Am J Cardiol. 2003 Sep 15;92(6):665-9 -
"When adjustments were made for age and other nutrients (singly or
combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the
lowest versus highest quintiles ... We conclude that the intake of dietary
Mg is associated with a reduced risk of CHD"
Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic
Control in Type 2 Diabetic Subjects: A randomized double-blind controlled
trial - Diabetes Care 2003 Apr;26(4):1147-52 -
"At the end of the study, subjects who received
magnesium supplementation showed ... fasting glucose levels (8.0 +/- 2.4 vs.
10.3 +/- 2.1 mmol/l ... Oral supplementation with MgCl(2) solution restores
serum magnesium levels, improving insulin sensitivity and
metabolic control in type 2 diabetic
patients with decreased serum magnesium levels"
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