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Recent Longevity News for the seven days ending 11/24/10.  You should consult your doctor if you are taking any medications.

Excess fructose may play role in diabetes, obesity and other health conditions - Science Daily, 11/22/10 - "The link between excessive intake of fructose and metabolic syndrome is becoming increasingly established. However, in this review of the literature, the authors conclude that there is also increasing evidence that fructose may play a role in hypertension and renal disease. "Science shows us there is a potentially negative impact of excessive amounts of sugar and high fructose corn syrup on cardiovascular and kidney health," explains Dr. Johnson. He continues that "excessive fructose intake could be viewed as an increasingly risky food and beverage additive.""

High alpha-carotene levels associated with longer life - Science Daily, 11/22/10 - "Oxygen-related damage to DNA, proteins and fats may play a role in the development of chronic diseases like heart disease and cancer ... Carotenoids -- including beta-carotene, alpha-carotene and lycopene -- are produced by plants and microorganisms and act as antioxidants, counteracting this damage ... Compared with individuals with blood alpha-carotene levels between 0 and 1 micrograms per deciliter, the risk of death during the study period was 23 percent lower among who had concentrations between 2 and 3 micrograms per deciliter, 27 percent lower with levels between 4 and 5 micrograms per deciliter, 34 percent lower with levels between 6 and 8 micrograms per deciliter and 39 percent lower with levels of 9 micrograms per deciliter or higher" - Note:  There are over 600 carotenoids and some claim that taking large amounts of just one of them can cause a deficiency of the others.  See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.

Chocolate and Blood Pressure -- Some Bitter Results - Medscape, 11/22/10 - "The problem is that all of the studies -- epidemiologic, observational, and clinical trials -- haven't been well controlled ... The current design had 3-week ingestions of placebo, a cocoa drink, or a usual dose of cocoa drink plus theobromine, which is the compound in chocolate thought to prevent some of the cardiovascular complications ... They had very surprising results. For one thing, the group that got theobromine, or cocoa plus theobromine, in either dose had an increase in heart rate and an increase in blood pressure when measured peripherally and when measured on ABPM. That's not a good thing" - See the video on that link.  It makes you wonder if it's just that people that eat chocolate are the type of people that lead a certain lifestyle.

More than half of depression patients give up their treatment - Science Daily, 11/22/10 - "Most patients who take anti-depressants give up their treatment in less than six months, the minimum period recommended for treating severe depression and other derived pathologies ... only 25% continue their treatment for more than 11 month"

Protein in the urine: A warning sign for cognitive decline - Science Daily, 11/21/10 - "low amounts of albumin in the urine, at levels not traditionally considered clinically significant, strongly predict faster cognitive decline in older women ... participants with a urinary albumin-to-creatinine ratio of >5 mcg/mg at the start of the study experienced cognitive decline at a rate 2 to 7 times faster in all cognitive measures than that attributed to aging alone over an average 6 years of follow-up"

Pomegranate juice reduces damage to tissues, inflammation and infections, study suggests - Science Daily, 11/19/10 - "[dialysis] patients who drank pomegranate juice experienced reduced inflammation and the damage of oxidative stress caused by free radicals, was minimized. Furthermore, pomegranate juice drinkers were less likely to be hospitalized due to infections ... those who drank pomegranate juice also showed an improvement in cardiovascular risk factors, such as reduced blood pressure, improvement in lipid profile and fewer cardiovascular events, suggesting that they had better heart health" - See pomegranate at Amazon.com.

Blueberries linked to improved blood vessel health: Rat study - Nutra USA, 11/18/10 - "Our data provide clear evidence that the 8 week dietary treatment with 8 percent wild blueberry in the adult SHR with established endothelial dysfunction results in a significant moderation of the increased aortic vascular tone ... The berries were proposed to act via the NO pathway – nitric oxide is a potent vasodilator, or compound that promotes the dilation or relaxation of blood vessels, thereby easing blood pressure" - [Abstract] - See blueberry extract at Amazon.com.

`Fed Up' Travelers, Unions Balk at Airport Body Scans - Bloomberg, 11/17/10 - "You would need 1,000 or 2,000 airport scans just to equal one dental X-ray"

  • How Much Radiation Do You Get From Dental X-Rays? - Idaho State University - "A typical dental x-ray image exposes you to only about 2 or 3 mrem ... about 5 mrem for one cross-country flight because of the increased altitude" - It's something to consider, every time you fly across the United States you get the equivalent of about two dental x-rays.  That airport scanner is small compared to that.

Vitamin C may offer potential life-saving treatment for sepsis - Science Daily, 11/17/10 - "vitamin C can not only prevent the onset of sepsis, but can reverse the disease"

Aged garlic shows blood pressure improvement benefits: Study - Nutra USA, 11/17/10 - "an aged garlic extract may reduce systolic blood pressure by 10.2 mmHg ... the benefits were only observed in people with initial systolic pressure (SBP) of 140 mmHg or over, and that no effects were observed in people with lower SBP ... aged garlic extract of 3.84 grams (Kyolic, Garlic High Potency Everyday Formula 112, Wakunga/Wagner) or placebo for 12 weeks ... Results showed a “marked difference” between the garlic and control groups in subjects with ‘uncontrolled hypertension’" - [Abstract] - See garlic supplements at Amazon.com.

New 3-D model of RNA 'core domain' of enzyme telomerase may offer clues to cancer, aging - Science Daily, 11/3/10 (it says 11/3 but showed up in the news on 11/16) - "Some people think if we activate telomerase, we can live forever. However, we don't want our cells to be able to divide indefinitely. As they get older and older, they accumulate all kinds of DNA damage and defects; that is why we don't want to have a high level of telomerase activity in most of our cells"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Vitamin D and Cognitive Impairment in the Elderly U.S. Population - J Gerontol A Biol Sci Med Sci. 2010 Nov 2 - "The multivariate adjusted odds ratios (95% confidence interval) of cognitive impairment in participants who were 25(OH)D insufficient (≥50 < 75 nmol/L), deficient (≥25 < 50 nmol/L), and severely deficient (<25 nmol/L) in comparison with those sufficient (≥75 nmol/L) were 0.9 (0.6-1.3), 1.4 (1.0-2.1), and 3.9 (1.5-10.4), respectively (p for linear trend = .02). Log-transformed levels of 25(OH)D were also significantly associated with the odds of cognitive impairment (p = .02). Conclusions: These findings suggest that vitamin D deficiency is associated with increased odds of cognitive impairment in the elderly U.S. population" - See vitamin D at Amazon.com.

Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and Colo 205 Tumor Xenografts in Vivo - J Agric Food Chem. 2010 Nov 17 - "capsaicin induced cytotoxic effects in a time- and dose-dependent manner and increased reactive oxygen species (ROS) and Ca(2+) but decreased the level of mitochondrial membrane potential (ΔΨ(m)) in colo 205 cells. Data from Western blotting analysis indicated that the levels of Fas, cytochrome c, and caspases were increased, leading to cell apoptosis. Capsaicin decreased the levels of anti-apoptotic proteins such as Bcl-2 and increased the levels of pro-apoptotic proteins such as Bax. Capsaicin-induced apoptosis in colo 205 cells was also done through the activations of caspase-8, -9 and -3. In vivo studies in immunodeficient nu/nu mice bearing colo 205 tumor xenografts showed that capsaicin effectively inhibited tumor growth. The potent in vitro and in vivo antitumor activities of capsaicin suggest that capsaicin might be developed for the treatment of human colon cancer" - See capsaicin supplements at Amazon.com.

Greater Coffee Intake in Men Is Associated With Steeper Age-Related Increases in Blood Pressure - Am J Hypertens. 2010 Nov 18 - "Greater coffee intake in men was associated with steeper age-related increases in SBP and pulse pressure, particularly beyond 70 years of age and in overweight to obese men"

A Wild Blueberry-Enriched Diet ( Vaccinium angustifolium ) Improves Vascular Tone in the Adult Spontaneously Hypertensive Rat - J Agric Food Chem. 2010 Nov 24 - "The vasoconstriction elicited by Phe was reduced in the WB group, attributed to the NO pathway, favoring a lower vascular tone under basal conditions. Acetylcholine-induced vasorelaxation in the WB group was possibly mediated through the COX, but not the NO pathway. These findings document the potential of wild blueberries to modify major pathways of vasomotor control and improve the vascular tone in the adult SHR with endothelial dysfunction" - See blueberry extract at Amazon.com.

Dietary intake of vitamin D and cognition in older women: A large population-based study - Neurology. 2010 Nov 16;75(20):1810-6 - "Compared to women with recommended weekly vitamin D dietary intakes (n = 4,802; mean age 80.4 +/- 3.8 years), women with inadequate intakes (n = 794; mean age 81.0 +/- 3.8 years) had a lower mean SPMSQ score (p < 0.001) and more often had an SPMSQ score <8 (p = 0.002). We found an association between weekly vitamin D dietary intake and SPMSQ score (β = 0.002, p < 0.001). Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment (unadjusted odds ratio = 1.42 with p = 0.002; full adjusted odds ratio = 1.30 with p = 0.024)" - See vitamin D at Amazon.com.

Dietary patterns and breast cancer risk among Chinese women - Cancer Causes Control. 2010 Nov 16 - "a 74% decreased risk was observed among women in the highest quartile of the vegetable-fruit-soy-milk-poultry-fish dietary pattern relative to the lowest quartile (OR = 0.26, 95% CI = 0.17-0.42). The refined grain-meat-pickle pattern was positively associated with breast cancer risk (OR = 2.58, 95% CI = 1.53, 4.34). Women with a high intake of the vegetable-fruit-soy-milk-poultry-fish pattern and a low intake of the refined grain-meat-pickle pattern showed a decreased risk of breast cancer (adjusted OR = 0.26, 95% CI = 0.17-0.41)"

Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver - Biochem Biophys Res Commun. 2010 Nov 12 - "Our results indicate that resveratrol upregulates the expression of gluconeogenic genes by attenuating insulin signaling and by deacetylating FOXO1, which are SIRT1-independent in the cytosol and SIRT1-dependent in the nucleus, respectively"

Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial - Maturitas. 2010 Oct;67(2):144-50 - "In patients with uncontrolled hypertension (SBP ≥ 140 mmHg at baseline), systolic blood pressure was on average 10.2 +/- 4.3 mmHg (p=0.03) lower in the garlic group compared with controls over the 12-week treatment period. Changes in blood pressure between the groups were not significant in patients with SBP<140 mmHg at baseline. Aged garlic extract was generally well tolerated and acceptability of trial treatment was high (92%)" - See garlic supplements at Amazon.com.

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