Recent Longevity News for the seven days ending
You should consult your doctor if you are taking any medications.
resting heart linked to shorter life expectancy in stable heart disease
patients, study suggests - Science Daily, 10/26/10 -
"Compared to heart disease patients
with the lowest heart rate (58 beats per minute or less), those who had heart
rates greater than 78 had a 39 per cent increased risk of suffering a major
vascular event, a 77 per cent increased risk of cardiovascular disease death,
and a 65 per cent increased risk of all-cause deaths"
Consuming polyunsaturated fatty acids may lower the incidence of gum disease
- Science Daily, 10/26/10 - "There was an approximately 20% reduction in
periodontitis prevalence in those subjects who consumed the highest amount of
dietary DHA. The reduction correlated with
EPA was smaller, while the
correlation to LNA was not statistically significant" - See
Jarrow Max DHA at iHerb.
ingredient levels vary among red yeast rice supplements - Science Daily,
10/25/10 - "Across the 12 products, levels of total
monacolins ranged from 0.31 milligrams to 11.15 milligrams per capsule and
levels of monacolin K or lovastatin ranged from 0.10 milligrams to 10.09
milligrams per capsule. Four of the formulations had elevated levels of citrinin"
outcomes for HPV-positive head and neck cancer with cetuximab and IMRT, study
suggests - Science Daily, 10/25/10 - "Two year
progression free survival rates were 60 percent for those with HPV compared to
23 percent for those with HPV negative tumors (p=0.05)"
Vitamin E in front line of prostate cancer fight - Science Daily, 10/23/10 -
"the research team have discovered a particular form of T3, called
gamma-tocotrienol (γ-T3), can successfully kill off the
prostate cancer CSCs ...
Other research has found γ-T3 is also effective in suppressing other types of
cancer, including breast, colon, liver and gastric ... not all
preparations had the active constituent" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
Diabetes may affect as many as 1 in 3 Americans by 2050 - USA Today,
10/21/10 - "one in 10 U.S. adults have diabetes now. The
prevalence is expected to rise sharply over the next 40 years with as many as
one in three having the disease, primarily type 2 diabetes, according to the
report" - Note: I believe that's the main reason life expectancy in
the U.S. isn't that impressive. Americans do not get enough exercise and
they overeat. The portion size at restaurants is three times that of some
countries I've been to. Exercise also slows the rate of loss of telomere
shortening. Longer telomeres is associated with longevity. Even if
it's not full blown diabetes, even insulin resistance is associated will
multiple problems of aging and cancer. See my
Insulin and Aging page.
Vitamin D Deficiency Associated With Diabetic Retinopathy - Medscape,
10/22/10 - "People with diabetes had significantly lower mean
D levels than people without diabetes (22.9 vs 30.3 ng/mL; P < .001), according
to the poster. People with no eye disease had the highest serum vitamin D levels
(mean, 31.9 ng/mL), and those with proliferative retinopathy had the lowest
levels (mean, 21.1 ng/mL) ... People who took a daily multivitamin that included
vitamin D (n = 102) had a mean serum vitamin D level of 31.1 ng/mL; those who
did not take a multivitamin (n = 119) had vitamin D levels averaging only 22.0
ng/mL (P < .001), according to the poster. Dr. Payne noted that even those who
took daily multivitamins had a 44% incidence of vitamin D insufficiency" - See
vitamin D products at iHerb.
Cholesterol-lowering drug shrinks enlarged prostates in hamster model -
Science Daily, 10/21/10 - "Ezetimibe
reduced prostatic enlargement in aged hamsters
as effectively as
finasteride and combining the two drugs worked better than either one alone
... finasteride caused atrophy of the hamster prostate while ezetimibe did not"
Olive oil compounds may boost cardiac fat oxidation: Study - Nutra USA,
10/21/10 - "Obese rats supplemented with
oleuropein, and cafeic acid had higher oxygen
consumption, increased fat-oxidation, and lower carbon dioxide production than
non supplemented obese rats" - [Abstract]
olive leaf extracts at iHerb.
Professional athletes should drink more water, Spanish research finds -
Science Daily, 10/21/10 - "91% of professional
basketball, volleyball, handball and football players are dehydrated when they
begin their training sessions"
HPV Oral Cancers on Rise as Oral Sex Becomes More Popular, May Spread Human
Papilloma Virus - ABC News, 10/20/10 - "Cure rates
are higher than for smoking-related
throat cancers, but still only 50 percent" - The video claims that
they can't rule out the the virus can be transmitted via sharing a spoon or a
drink. They claim that if it spreads to the lymph nodes, your chances are
Growths: Mouth Growths - "if the
cancer has spread to lymph nodes, the 5-year survival rate is only 25%"
mostly whole grains, few refined grains linked to lower body fat - Science
Daily, 10/20/10 - "People who consume several servings
of whole grains per day while limiting daily
intake of refined grains appear to have less of a type of fat tissue thought to
play a key role in triggering
cardiovascular disease and type 2 diabetes
... Visceral Adipose Tissue ... VAT volume was approximately 10 % lower in
adults who reported eating three or more daily servings of whole grains and who
limited their intake of refined grains to less than one serving per day ...
Visceral fat surrounds the intra-abdominal organs while subcutaneous fat is
found just beneath the skin ... visceral fat is more closely tied to the
development of metabolic syndrome ...
participants who consumed, on average, three daily servings of whole grains but
continued to eat many refined grains did not demonstrate lower VAT volume"
injuries rapidly deplete vitamin E, study finds - Science Daily, 10/20/10 -
"An analysis of eight children with third-degree burns
over much of their body found they lost almost half of their stored vitamin E in
three weeks, even though they were being given about 150 percent of the
recommended daily allowance of vitamin E and other nutrients in a high-calorie
diet ... "the depletion of vitamin E may be a very significant problem in
patients with burn injury" and other forms of severe trauma"
testosterone linked to heightened risk of early death - Science Daily,
10/19/10 - "tracked for around 7 years ... One in four
of the men was classified as having low
testosterone, using measurements of either bioavailable testosterone (bio-T)
-- available for tissues to use -- of under 2.6 mmol/l or total testosterone
(TT) of under 8.1 mmol/l ... During the monitoring period almost twice as many
men with low testosterone died as did those with normal levels"
predisposition to certain skin cancers may be associated with vitamin D
deficiency - Science Daily, 10/18/10 - "Patients with basal cell nevus
syndrome, which predisposes them to develop non-melanoma
skin cancers, appear to
be at increased risk for vitamin D deficiency if they take steps to protect
themselves from sunlight ... When compared with the general population, patients
with basal cell nevus syndrome had lower average vitamin D levels and were three
times more likely to be deficient" - See
vitamin D products at iHerb.
High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 -
"The clinical takeaway message is that if you are a
postmenopausal woman and dieting, if you can take 24% of your total calories as
protein, and have adequate calcium and vitamin
D, you can prevent the bone loss that is
typically associated with weight loss"
Abstracts from this week's Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients
- Diabet Med. 2010 Nov;27(11):1318-21 - "Subjects were
randomized to 45 g chocolate with or without a
high polyphenol content for 8 weeks and then crossed over after a 4-week washout
period ... HDL cholesterol increased
significantly with high polyphenol chocolate (1.16 +/- 0.08 vs. 1.26 +/- 0.08 mmol/l,
P = 0.05) with a decrease in the total cholesterol: HDL ratio (4.4 +/- 0.4 vs. 4.1
+/- 0.4 mmol/l, P = 0.04). No changes were seen with the low polyphenol chocolate
in any parameters. Over the course of 16 weeks of daily chocolate consumption
neither weight nor glycaemic control altered from baseline" - The
Lindt - Excellence 90% Cocoa Bar are 3.5 ounces or 99 grams or about 90
grams of chocolate. So 45 grams would be half a bar per day.
consumption but not green tea consumption is associated with adiponectin levels
in Japanese males - Eur J Nutr. 2010 Oct 16 - "We
not only revealed that habitual coffee
consumption is associated with higher adiponectin
levels in Japanese males but also found a dose-dependent association between
coffee consumption and adiponectin levels. Therefore, our study suggested that
coffee components might play an important role in the elevation of adiponectin
level" - See my adiponectin page.
A higher adiponectin is a good thing.
syndrome in 25% of older people with intellectual disability - Fam Pract.
2010 Oct 11 - "intellectual
disabilities (IDs) ... The prevalence of the
metabolic syndrome in the population with ID is significantly higher than
that in the general Dutch population aged ≥50 years"
of olive oil and its minor phenolic constituents on obesity-induced cardiac
metabolic changes Nutr J. 2010 Oct 19;9(1):46 - "The present study
demonstrated for the first time that olive-oil,
oleuropein and cafeic-acid
enhanced fat-oxidation and optimized cardiac energy metabolism in obesity
conditions. Olive oil and its phenolic compounds improved myocardial oxidative
stress in standard-fed conditions" - See
olive leaf extracts at iHerb.
deficiency prevalence and cardiovascular risk in Israel - Eur J Clin Invest.
2010 Oct 18 - "The prevalence of
vitamin D deficiency or insufficiency (vitamin
D levels <30 ng mL(-1) ) for the entire study population was surprisingly high
for men and women (79·2% and 77·5%, respectively) ... Vitamin D deficiency is
associated with CVD and other risk factors in this Israeli study population. The
prevalence of the deficiency in Israel is similar to the prevalence found in
less sunny regions" - See
vitamin D products at iHerb.
and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study
- Neurology. 2010 Oct 19;75(16):1408-14 - "homocysteine
(tHcy) and holotranscobalamin (holoTC), the active fraction of
vitamin B12 ... The odds ratios (ORs) (95%
confidence interval [CI]) for AD were 1.16
(1.04-1.31) per increase of 1 μmol/L of tHcy at baseline and 0.980 (0.965-0.995)
for each increase of 1 pmol/L baseline holoTC ... This study suggests that both
tHcy and holoTC may be involved in the development of AD. The tHcy-AD link may
be partly explained by serum holoTC. The role of holoTC in AD should be further
Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease
- Circulation. 2010 Oct 18 - "Treatment with
acetaminophen resulted in a significant increase
in mean systolic (from 122.4+/-11.9 to 125.3+/-12.0 mm Hg P=0.02 versus placebo) and
diastolic (from 73.2+/-6.9 to 75.4+/-7.9 mm Hg P=0.02 versus placebo) ambulatory
blood pressures. On the other hand, heart rate, endothelial function, early
endothelial progenitor cells, and platelet function did not change"
between red meat consumption and metabolic syndrome in a Mediterranean
population at high cardiovascular risk: Cross-sectional and 1-year follow-up
assessment - Nutr Metab Cardiovasc Dis. 2010 Sep 26 -
"Subjects in the upper quartile of RM consumption were more likely to meet the criteria
for the MetS at baseline (OR, 2.3; 95% CI,
1.4-3.9; P-trend = 0.001) and after 1-year follow-up (OR, 2.2; 95% CI, 1.3-3.7;
P-trend = 0.034) compared with those in the quartile of reference, even after
adjusting for potential confounders. The longitudinal analyses showed that
individuals in the fourth quartile of RM consumption had an increased risk of
MetS (OR, 2.7; 95% CI, 1.1-6.8; P-trend = 0.009) or
central obesity incidence (OR, 8.1; 95% CI,
1.4-46.0; P-trend = 0.077) at the end of the follow-up compared to the lowest
disparity in death from colorectal cancer: does vitamin D deficiency contribute?
- Cancer. 2010 Oct 13 - "vitamin
D deficiency was associated significantly with CRC
mortality (HR, 2.11; 95% CI, 1.11-4.00), and the effect of race was decreased
(HR, 1.60" - See
vitamin D products at iHerb.
polymorphisms, dietary intake of red meat and dairy and prostate cancer risk
- Prostate. 2010 Oct 13 - "Red
meat consumption was positively associated with
PCa risk, and the association was stronger for more aggressive disease
(lowest vs. highest tertile OR = 1.55"
Neat Tech Stuff / "How To's":
Remote for iPhone, iPod touch, and iPad on the iTunes App Store -
Unbelievable!! I've got my TiVo connected to my office, my living room
and my bedroom via an HDMI wire thru the attic. This app works
perfectly as a TiVo remote from any room.
- A WiFi that uses you home’s wiring as an antenna.
Sounds like a great idea if it works:
Atheros Hybrid system merges WiFi with powerline networking in one tidy
bundle - Engadget, 10/21/10
Communications, Atheros, Wireless, WLAN, Wireless LAN, 2.4-GHz, 5-GHz,
2.4/5-GHz, 802.11a/b/g, 802.11g, 802.11n, 802.11, Radio-on-Chip,
Networking, Mobile, Semiconductor, System Solutions - Atheros,
Health Focus (Kidney
picolinate may lessen inflammation in diabetic nephropathy; Supplement linked to
decreased protein in the urine of diabetic mice - Science Daily, 9/22/10 -
"mice who received the supplement had lower levels of albuminuria (protein in
the urine), an indication of kidney disease ... the treated diabetic mice, who
were fed the diet with chromium picolinate, excreted about half as much albumin
compared to their untreated diabetic counterparts" - See
chromium products at iHerb.
of probiotic dietary supplementation for promoting healthy kidney function in
patients with chronic kidney disease - Adv Ther. 2010 Aug 16 -
ingestion of probiotics (90 billion colony forming units [CFUs]/day) was well
tolerated and safe during the entire trial period at all sites. BUN levels
decreased in 29 patients (63%, P<0.05), creatinine levels decreased in 20
patients (43%, no statistical significance), and uric acid levels decreased in
15 patients (33%, no statistical significance). Almost all subjects expressed a
perceived substantial overall improvement in QOL (86%, P<0.05)" - See
probiotic products at iHerb.
deficiency is associated with sudden cardiac death, combined cardiovascular
events, and mortality in haemodialysis patients - Eur Heart J. 2010 Aug 5 -
"sudden cardiac death (SCD) ... Patients with severe vitamin D deficiency
[25(OH)D of</= 25 nmol/L] had a 3-fold higher risk of SCD compared with those
with sufficient 25(OH)D levels >75 nmol/L [HR: 2.99, 95% confidence interval
(CI): 1.39-6.40]. Furthermore, CVE and all-cause mortality were strongly
increased (HR: 1.78, 95% CI: 1.18-2.69, and HR: 1.74, 95% CI: 1.22-2.47,
respectively), all persisting in multivariate models. There were borderline
non-significant associations with stroke and fatal infection while MI and deaths
due to heart failure were not meaningfully affected. Conclusion Severe vitamin D
deficiency was strongly associated with SCD, CVE, and mortality, and there were
borderline associations with stroke and fatal infection" - See
vitamin D products at iHerb.
Long-Term High Intake of Whole Proteins Results in Renal Damage in Pigs
- J Nutr. 2010 Jul 28 - "These findings suggest that
long-term intakes of protein at the upper limit of the AMDR from whole
protein sources may compromise renal health"
Polyunsaturated Fatty Acids in the Treatment of Kidney Disease - Am J Kidney
Dis. 2010 May 19 - "guidelines suggest that omega-3 polyunsaturated fatty acids
should be considered in progressive IgA nephropathy. Omega-3 polyunsaturated
fatty acids decrease blood pressure, a known accelerant of kidney disease
progression" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Omega-3 intakes may improve diabetic kidney health - Nutra USA, 4/12/10 -
"Albumin is the most abundant protein in human serum and in people with kidney
problems the protein leaks from the kidney into the urine. A level of 30 mg per
24 hours is reportedly representative of sufficient function ... people with a
higher average intake of omega-3s had albumin excretion levels 22.7 mg per 24
hours lower than people with the lowest average intakes of omega-3" - [Abstract] - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and
diabetic nephropathy - cohort analysis of the Diabetes Control and Complications
Trial (DCCT) - Diabetes Care. 2010 Mar 31 - "In a mean follow-up of 6.5
years, we observed a lower mean UAER [difference 22.7 mg/24 hr (95% CI 1.6,
43.8)] in the top vs. bottom third of dietary n-3 LC-PUFAs, but found no
association with incident albuminuria ... Dietary n-3 LC-PUFAs appear inversely
associated with the degree, but not with the incidence of albuminuria in type 1
diabetes" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Pine bark extract may benefit blood pressure-related kidney health - Nutra
USA, 3/5/10 - "55 hypertensive patients to participate in the randomized,
controlled study. Subjects were assigned to receive Ramipril [an ACE inhibitor]
(10 mg per day), and 29 of these people were randomly selected to also receive
Pycnogenol (150 mg per day) ... After six months in the Ramipril-only group the
albumin levels decreased by 26 per cent to 64 mg per 24-hour period, while
additional Pycnogenol produced levels that averaged 39 mg per 24-hour period,
equivalent to a 57 per cent decrease ... Statistically significant decreases in
patients’ blood pressure were also observed, with systolic and diastolic blood
pressures dropping by more than 30 and 8 per cent, respectively in the Ramipril-only
group, and by a further 3 to 6 per cent in the combination group ... Diastolic
and systolic blood flow improved by 8 and 12 per cent, in the combination group"
- [Abstract] - See
Pine Bark/Pycnogenol products at iHerb.
flow and function in hypertension: protective effects of pycnogenol in
hypertensive participants--a controlled study - J Cardiovasc Pharmacol Ther.
2010 Mar;15(1):41-6 - "evaluated the effects of Pycnogenol as an adjunct to
angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive
patients presenting with early signs of renal function problems. One group of 26
patients was medicated with 10 mg ramipril per day only; a second group of 29
patients took Pycnogenol in addition to the ACE inhibitor over a period of 6
months ... Urinary albumin decreased from 87 +/- 23 to 64 +/- 16 mg/d with
ramipril only. Additional Pycnogenol lowered albumin significantly better from
91 +/- 25 to 39 +/- 13 mg/day (P < .05). In both groups, serum creatinine was
lowered; however, only in the combination treatment group did the effect reached
statistical significance. In both groups, CRP levels decreased from 2.1 to 1.8
with ramipril and from 2.2 to 1.1 with the ramipril-Pycnogenol combination; the
latter reached statistical significance. Kidney cortical flow velocity was
investigated by Doppler color duplex ultrasonography. Both systolic and
diastolic flow velocities increased significantly after 6 months medication with
ramipril. The addition of Pycnogenol to the regimen statistically significantly
further enhanced kidney cortical flow velocities, by 8% for diastolic flow and
12% for systolic flow, relative to values found for the group taking ramipril
only" - See
Pine Bark/Pycnogenol products at iHerb.
Vitamin D deficiency likely among some kidney disease patients starting
dialysis - Science Daily, 2/25/10
from low potassium in heart failure patients with chronic kidney disease -
Science Daily, 2/22/10 - "In findings reported in January in Circulation: Heart
Failure, a journal of the American Heart Association, the researchers say that
even a mild decrease in serum potassium level increased the risk of death in
this patient group ... Hypokalemia, or low potassium, is common in heart-failure
patients and is associated with poor outcomes, as is chronic kidney disease ...
Death occurred in 48 percent of the patients with hypokalemia during the
57-month follow-up period, compared with only 36 percent of patients with normal
potassium. The vast majority of subjects, 87 percent, had mild hypokalemia"
potassium products at iHerb.
supplement has neutral effects on vascular and metabolic function but
improves renal function in patients with Type 2 diabetes mellitus -
Diabet Med. 2010 Jan;27(1):54-60 - "serum creatinine
was lower (-4.5 mumol/l, P = 0.01) in fish-oil-treated patients as compared
with control subjects" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Omega-3 may boost kidney health in diabetics: Study - Nutra USA, 2/3/10
- "Our results showed a significant decrease in
serum creatinine level after fish-oil supplement in Type 2 diabetes mellitus
patients" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Lack of Exercise Linked
to Increased Mortality in Chronic Kidney Disease - Medscape, 10/19/09
Acid for Anemia Management in Hemodialysis Patients: A Systematic Review and
Meta-analysis - Am J Kidney Dis. 2009 Sep 22 -
"Combining the 3 randomized clinical trials involving patients with baseline
hemoglobin levels <11 g/dL, change in hemoglobin level was greater for ascorbic
acid use compared with standard care (WMD, 0.9 g/dL; 95% CI, 0.5-1.2 g/dL).
Compared with standard care, ascorbic acid use also was associated with a
statistically significant decrease in rHuEPO dose (WMD, -17.1 U/kg/wk; 95% CI,
-26.0 to -8.2 U/kg/wk) and improvement in transferrin saturation (WMD, 7.9%; 95%
CI, 5.2-10.5%), with no change in ferritin concentration"
of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in
chronic kidney disease: a randomized controlled trial - J Hypertens. 2009
Sep;27(9):1863-72 - "patients were randomized to either
omega3FA (4 g), CoQ (200 mg), both supplements or control (4 g), daily for 8
weeks ... omega3FA, but not CoQ, reduced 24-h ambulatory heart rate (P<0.0001)
and blood pressure ... omega3FA reduced triglycerides 24%" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein
excretion and kidney function: meta-analysis of clinical trials - Am J Clin
Nutr. 2009 Apr 29 - "The dose of n-3 LCPUFAs ranged from
0.7 to 5.1 g/d, and the median follow-up was 9 mo. In the pooled analysis, there
was a greater reduction in UPE in the n-3 LCPUFA group than in the control
group: Cohen's d for all trials was -0.19 (95% CI: -0.34, -0.04; P = 0.01). In a
patient with 1 g UPE/d , this corresponds to a reduction of 190 mg/d. Effects on
GFR were reported in 12 trials. The decline in GFR was slower in the n-3 LCPUFA
group than in the control group, but this effect was not significant (0.11; 95%
CI: -0.07, 0.29; P = 0.24)"
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
D Benefits Dialysis Patients - Medscape, 4/1/09 -
"Over-the-counter vitamin D supplementation improves serum 25-hydroxyvitamin D
levels in patients with chronic kidney disease undergoing dialysis, without
raising serum calcium or phosphorus levels ... Studies in healthy patients have
provided supplementation up to 10,000 IU a day with no observed adverse effects"
vitamin D products at iHerb.
High Dietary Fibre Intake Associated With Decreased Inflammation in Chronic and
Non-Chronic Kidney Disease Patients - Doctor's Guide, 3/30/09 -
"when compared with patients in the high dietary fibre
intake group, those in the low intake group had significantly increased odds of
inflammation in both the CKD and non-CKD subgroups ... In the low fibre intake
group, CKD patients showed 51% inflammation versus 37% in the high intake group
(P < .05). The non-CKD population showed 29% inflammation with low fibre intake
versus 20% with high intake"
D Deficiency Prevalent in Children With Chronic Kidney Disease - Medscape,
3/5/09 - "The prevalence of deficiency in this
contemporary study group was 39%"
versus AScorbic acid for Preventing contrast-Induced nephropathy in patients
with renal insufficiency undergoing coronary angiography NASPI study-a
prospective randomized controlled trial - Am Heart J. 2009
Mar;157(3):576-583 - "High-dose
seems more beneficial than ascorbic acid in preventing contrast-induced renal
function deterioration in patients, especially diabetic patients, with renal
insufficiency undergoing coronary angiography" - See
NAC products at iHerb.
Chitosan-Loaded Gum Reduces Phosphate Levels in ESRD Patients - Medscape,
2/16/09 - "Chewing chitosan-loaded gum twice daily can
significantly decrease salivary phosphate and serum phosphate levels in
hemodialysis patients and may help improve treatment for hyperphosphatemia ...
At week 1, the patients’ salivary phosphate levels had decreased from 73.21 to
52.02 mg/dL (P < .01), and serum levels decreased from 7.60 to 5.38 mg/dL (P <
.00001). After 2 weeks, salivary phosphate levels were reduced to 33.19 mg/dL (P
< .00001) and serum levels decreased to 5.25 mg/dL" - See
chitosan products at iHerb.
Effect of Quercetin against Gentamicin-Induced Nephrotoxicity in Rats -
Pharm Bull. 2009 Jan;32(1):61-7 - "Gentamicin (GM) is an
antibiotic widely used in treating severe gram-negative infections. However, its
clinical use is limited by its nephrotoxicity ... Histopathological examination
of GM-treated rats revealed degenerative changes in glomeruli and tubules. On
the other hand, simultaneous administration of quercetin plus gentamicin
protected kidney tissues against nephrotoxic effects of gentamicin as evidenced
from amelioration of histopathological changes and normalization of kidney
biochemical parameters" - See
quercetin products at iHerb.
trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement
and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats
- J Nutr. 2008 Dec 23 - "Conjugated linoleic acid (CLA) slows the progression of
disease in models of chronic kidney disease ... To examine specific isomer
effects, study 2 used the same model with the following diets: 0.4% (g/g) cis-9,
trans-11 (c9,t11) CLA; 0.4% trans-10, cis-12 (t10,c12) CLA; a combination of
these 2 isomers (0.4% each); or CTL diets with no CLA. In study 1, fa/fa rats
given the CLA mixture had 11% smaller kidney weights and 28% smaller glomeruli,
and feed intake and body weight did not differ from the CTL rats. In study 2,
diet also did not affect body weights, but fa/fa rats given a diet containing
t10,c12 CLA had 7% lower kidney weights, 20% smaller glomeruli, and 39% lower
COX-2 protein levels than CTL rats. In conclusion, dietary t10,c12 CLA reduces
the enlargement of glomeruli in young obesity-associated nephropathy and is
associated with lower protein levels of renal COX-2" - See
CLA products at iHerb.
Vitamin B1 Could Reverse Early-stage Kidney Disease In Diabetes Patients
- Science Daily, 12/8/08 - "the team show 300 mg of
thiamine taken orally each day for three months reduced the rate of albumin
excretion in type 2 diabetes patients. The albumin excretion rate was
decreased by 41% from the value at the start of the study. The results also
showed 35% of patients with microalbuminuria saw a return to normal urinary
albumin excretion after being treated with thiamine ... were randomly
assigned a placebo or 3 x 100mg tablets of thiamine a day for three months"
Diabetes Patients: Fish May Help Kidneys - WebMD, 11/4/08 -
"fish consumption lowers abnormal levels of protein
in the urine in people with diabetes ... Abnormal amounts of protein appear
in the urine when the kidneys are damaged; it's a key indicator of kidney
disease ... Leslie Spry, MD, a kidney specialist in Lincoln, Neb., who
serves as a National Kidney Foundation spokesman, says he typically doesn't
tell patients to eat more fish but recommends fish oil supplements to
control triglycerides (blood fats)"
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
Vitamin D and glucose metabolism in chronic kidney disease - Curr Opin
Nephrol Hypertens. 2008 Nov;17(6):566-72 - "Vitamin
D therapy holds promise for improving health outcomes in chronic kidney
disease. Improved glucose metabolism is one potential mechanism through
which vitamin D may exert beneficial effects" - See
Vitamin D products at iHerb.
Oral active vitamin D is associated with improved survival in hemodialysis
patients - Kidney Int. 2008 Jul 16 - "Our study
shows that hemodialysis patients receiving oral active vitamin D had a
survival advantage inversely related to the vitamin dose" -
Vitamin D products at iHerb.
Vitamin D Promising Against IgA Nephropathy - Medscape, 6/3/08 -
"The patients were given oral calcitriol 0.5 mcg
twice weekly for 12 weeks. The team found a progressive decrease in urine
protein-creatinine ratio from 1.98 g/g to 0.81 g/g during the first 6 weeks.
This persisted throughout the study period ... There was a simultaneous
decrease in serum TGF-beta level, and the percentage of decrease in serum
TGF-beta level significantly correlated with percentage of change in
proteinuria" - See
vitamin D products at iHerb.
Vitamin D Linked to Reduced Mortality Rate in Chronic Kidney Disease -
Doctor's Guide, 5/7/08 - "For patients with moderate
to severe chronic kidney disease (CKD), treatment with activated vitamin D
may reduce the risk of death by approximately one-fourth" - See
vitamin D products at iHerb.
Kidney damage after renal ablation is worsened in endothelial nitric oxide
synthase (-/-) mice and improved by combined administration of L-arginine
and antioxidants - Nephrology (Carlton). 2008 Jun;13(3):218-27 -
"A combination of L-arginine and antioxidant
ameliorated renal damage"
Calcitriol May Improve
Survival in Predialysis Chronic Kidney Disease - Medscape, 2/25/08
prevents ifosfamide-induced nephrotoxicity in rats - Br J Pharmacol.
2008 Feb 18 - "NAC markedly reduces the severity of
renal dysfunction induced by ifosfamide with a significant decrease in
elevations of serum creatinine (57.8+/-2.3 vs 45.25+/-2.1 mumol l(-1)) as
well as a reduced elevation of beta(2)-microglobulin excretion (25.44+/-3.3
vs 8.83+/-1.3 nmol l(-1)) and magnesium excretion (19.5+/-1.5 vs 11.16+/-1.5
mmol l(-1)). Moreover, NAC significantly improved the ifosfamide-induced
glutathione depletion and the decrease of glutathione S-transferase
activity, lowered the elevation of lipid peroxides and prevented typical
morphological damages in renal tubules and glomeruli" - See
NAC products at iHerb.
Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To
Protect Kidneys - Science Daily, 2/18/08 - "The
inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage
that can be caused by the iodine-containing "dyes" that doctors use to
enhance the quality of such scans ... N-acetylcysteine is already widely
used to clear mucus in cystic fibrosis patients, and to treat overdoses of
acetaminophen" - See
NAC products at iHerb.
Effect of green tea on kidney tubules of diabetic rats - Br J Nutr. 2008
Feb 6;:1-8 - "It has been documented that green tea
(GT) and its catechin components improve renal failure and inhibit the
growth of mesangial cells ... GT treatment significantly (P < 0.01) reduced
the serum glucose, glycosylated protein, serum creatinine and blood urea N
levels by 29.6 (sem 3.7), 22.7 (sem 5.2), 38.9 (sem 10) and 41.7 (sem 1.9)
%, respectively ... the GT-treated group showed a significant 44 (sem 10.8)
% higher creatinine clearance (Ccr) ... GT reduced the urea N, creatinine,
glucose and protein excretion rates by 30 (sem 7.6), 35.4 (sem 5.3), 34.0 (sem
5.3) and 46.0 (sem 13.0) % compared with the 12 weeks diabetic group.
Administration of GT to 12 weeks diabetic rats significantly (P < 0.001)
prevented (99.98 (sem 0.27) % less) the accumulation of glycogen in the
kidney tubules. These results indicate that in STZ diabetes, kidney function
appears to be improved with GT consumption which also prevents glycogen
accumulation in the renal tubules, probably by lowering blood levels of
glucose. Therefore, GT could be beneficial additional therapy in the
management of diabetic nephropathy" - See
Jarrow green tea at iHerb.
Renoprotective action of l-carnitine in fructose-induced metabolic syndrome
- Diabetes Obes Metab. 2007 Dec 17 - "l-carnitine
(CA) administration ... The benefits of CA in this model suggest the
therapeutic use of CA to counter the kidney changes associated with
metabolic syndrome" - See
l-carnitine products at iHerb.
Protective Effects of Bilberry (Vaccinium myrtillus L.) Extract on
KBrO3-Induced Kidney Damage in Mice - J Agric Food Chem. 2007 Dec 20 -
"bilberry extract reduced the degree of oxidative
stress and kidney damage induced by KBrO 3. These findings demonstrate that
the protective effect of bilberry extract is attributed to its free radical
scavenging activity and lipid peroxidation inhibitory effect" - See
bilberry products at iHerb.
Guanidino Compounds After Creatine Supplementation in Renal Failure Patients
and their Relation to Inflammatory Status - Nephrol Dial Transplant.
2007 Nov 29 - "Specific guanidino compounds have
been described as uraemic toxins and their concentrations are increased in
renal failure due to dimished glomerular filtration, whereas the guanidino
compound creatine is used as a performance-enhancing substance in athletes.
The present study investigates the effects of creatine supplementation on
plasma guanidino compounds in a chronic haemodialysis population ...
Patients were treated with creatine (2 g/day) or placebo during two
treatment periods of 4 weeks ... Upon creatine supplementation,
guanidinoacetate concentrations decreased by 15%, due to inhibition of
creatine synthesis. Concentrations of alpha-keto-delta-guanidinovaleric acid
increased three-fold and argininic acid concentrations doubled" - See
creatine products at iHerb.
Effect of Curcumin on Inflammation and Oxidative Stress in Cisplatin-Induced
Experimental Nephrotoxicity - J Agric Food Chem. 2007 Nov 15 -
"curcumin has a protective effect on cisplatin-induced
experimental nephrotoxicity, and this effect is attributed to its direct
anti-inflammatory and strong antioxidant profile. Hence, curcumin has a
strong potential to be used as a therapeutic adjuvant in cisplatin
nephrotoxicity" - See
Curcumin/turmeric products at iHerb.
Chronic green tea extract supplementation reduces hemodialysis-enhanced
production of hydrogen peroxide and hypochlorous acid, atherosclerotic
factors, and proinflammatory cytokines - Am J Clin Nutr. 2007
Nov;86(5):1539-47 - "Catechins reduce hemodialysis-induced
production of hydrogen peroxide and hypochlorous acid, atherosclerotic
disease risk factors, and proinflammation" - See
Jarrow green tea at iHerb.
Metabolic effects of two low protein diets in chronic kidney disease stage 4
5 a randomized controlled trial - Nephrol Dial Transplant. 2007 Nov 2 -
"in CKD patients a protein intake of 0.55g/kg/day,
compared with a 0.8g/kg/day, guarantees a better metabolic control and a
reduced need of drugs, without a substantial risk of malnutrition"
Fish oil attenuates adrenergic overactivity without altering glucose
metabolism during an oral glucose load in haemodialysis patients - Br J
Nutr. 2007 Nov 1;:1-7 - "Fish oil decreases adrenal
activation induced by mental stress and has an insulin sensitizing effect in
healthy subjects ... Fish oil supplementation blunted both re-increase in
thermogenic response and concomitant increase in plasma epinephrine, but not
in plasma norepinephrine, over the last 2 h of the experiment. Fish oil did
not alter either whole-body glucose metabolism or substrate oxidation. These
data show that in haemodialysis patients, fish oil attenuates adrenal
overactivity induced by oral glucose but does not modulate whole-body
glucose metabolism and insulin sensitivity"
Relationship between vitamin D and muscle size and strength in patients on
hemodialysis - J Ren Nutr. 2007 Nov;17(6):397-407 -
"Treatment with active vitamin D was associated with
greater muscle size and strength in this cohort of HD patients"
Serum levels of folate and cobalamin are lower in depressed than in
nondepressed hemodialysis subjects - J Ren Nutr. 2007 Sep;17(5):343-9 -
"As with the general population, lower serum folate,
RBC folate, and serum cobalamin levels were found in depressed as compared
to nondepressed subjects on HD. Plasma levels of these vitamins may be one
of many factors related to depression, but larger studies with stronger
designs are needed to confirm the results of this study"
Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis
patients - J Ren Nutr. 2007 Sep;17(5):296-304 -
"gamma tocopherol (308 mg) and DHA (800 mg) ... In the treatment group, but
not in the placebo group, there were significant decreases in IL-6 (21.4 +/-
3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9
+/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4
+/- 0.3 10(3)/microL), at P < .05 for all"
Vitamin D levels and early mortality among incident hemodialysis patients
- Kidney Int. 2007 Aug 8 - "Compared to patients
with the highest 25D or 1,25D levels who received therapy, untreated
deficient patients were at significantly increased risk for early mortality"
Effect of n-3 fatty acids on nutritional status and inflammatory markers in
haemodialysis patients - Nephrology (Carlton). 2007 Aug;12(4):331-6 -
"There was a significant increase in EPA (P = 0.01)
after treatment, and there was a significant decrease in inflammatory
markers (IL-6 and TNF-alpha, P = 0.0001) after supplementation in the tested
group ... A dietary regime with fish oil could be used in dialysis patients
to slow down the development of atherosclerosis and improve nutritional
Effects of folic acid and vitamin B complex on serum C-reactive protein and
albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007
Jun 29 - "Folic acid and vitamin B complex
co-administration effectively lowers tHcy and hs-CRP levels and increases
albumin levels in stable hemodialysis subjects, underscoring their potential
benefit to attenuate the state of inflammation and possibly improve the
nutritional status in patients on hemodialysis"
Diabetics With Kidney Disease Lack Vitamin D - Doctor's Guide, 6/5/07 -
"Diabetic patients with chronic
kidney disease have insufficient levels of vitamin D compared to their
non-diabetic counterparts, both before and after treatment, suggesting
increased vitamin D supplementation may be necessary in diabetic patients
who have chronic kidney disease"
Oil May Help Kidney Disease Sufferers - Science Daily, 4/30/07 -
"daily doses of fish oil in the form
of a tablet or liquid had been shown to decrease inflammation - a common
problem in people with kidney disease" - See Mega Twin EPA at
Vitamin D Insufficiency and Deficiency in Patients With End-Stage Renal
Disease: the Role and Effect of Vitamin D Analogues on Survival -
Vitamin D and outcomes in chronic kidney disease - Curr Opin Nephrol
Hypertens. 2007 Mar;16(2):77-82 - "Data currently suggests that the administration of vitamin D confers a
survival benefit to patients on dialysis. There is no clear mechanism,
however, to explain this association"
Folic acid 5 or 15 mg/d similarly reduces plasma homocysteine in patients
with moderate-advanced chronic renal failure - Nephrology (Carlton).
Severe vitamin D deficiency in chronic renal failure patients on peritoneal
dialysis - Clin Nephrol. 2006 Oct;66(4):247-55 -
"Vitamin D deficiency is more common
in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that
these patients should be considered for vitamin D supplementation"
Carnitine Treatment Improved Quality-of-Life Measure in a Sample of
Midwestern Hemodialysis Patients - JPEN J Parenter Enteral Nutr. 2006
Jan-Feb;30(1):10-5 - "24 weeks of IV
carnitine therapy, SF-36 scores were improved and erythropoietin doses were
reduced in hemodialysis patients, relative to the control group" -
Effects of Herbal
Supplements on the Kidney - Medscape, 11/14/05
Hemodialysis Causes Antioxidant Loss Leading to Long-Term Complications
- Doctor's Guide, 4/8/05 - "the hemodialysis process can cause loss of these necessary antioxidants"
Vitamin D Injections May Significantly Improve Survival In Dialysis Patients
- Science Daily, 3/11/05 - "At the
end of the two-year study period, 76 percent of those receiving any form of
activated vitamin D were still alive, compared with 59 percent of those not
receiving the therapy"
- Dialysis Patients: Longer Lives With Vitamin D? - WebMD, 3/1/05 -
"vitamin D injections, given to patients with kidney failure, results in a significantly
reduced risk of death compared to those who do not receive the treatment"
- Preventing Kidney Disease? - Dr. Weil, 1/28/05
- No Difference between N-Acetylcysteine and Fenoldopam for Thwarting Contrast-Induced Nephropathy - Doctor's Guide, 11/8/04 -
"A randomized study
failed to show a significant difference in the ability of oral N-acetylcysteine (NAC) and intravenous fenoldopam (FEN) to prevent the deterioration in renal function"
- Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease. A Single Center Observational Study - Am J Nephrol. 2004 Sep 22;24(5):503-510 -
"In the group undergoing maintenance hemodialyis, we found that 97% of the patients had
vitamin D levels in the suboptimal range
... vitamin D insufficiency and deficiency are highly prevalent in patients with CKD and may play a role in the development of hyperparathyroidism"
- Soy Benefits Type 2 Diabetes - WebMD, 8/3/04 -
"Diabetes is the leading cause of kidney failure. The earliest sign of this complication is small amounts of protein in
urine ... Those who added the soy protein powder to their diets had a 10% reduction in protein found in urine ... the soy protein supplement boosted "good" HDL cholesterol by 4%" - [Abstract]
Research and Applications for CoQ10 - Life Extension Magazine, 8/04 -
"biomedical researchers are discovering that
CoQ10 shows promising effects against disorders as far-ranging as kidney failure, heart disease, muscular dystrophy, and macular
- The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy - Semin Nephrol. 2004 May;24(3):225-43 -
"treatment for 2 years with a daily dose of 1.8 g of EPA and 1.2 g of DHA slowed the progression of renal disease in high-risk patients" - See Mega Twin EPA at
- Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease - J Nephrol. 2003 Jul-Aug;16(4):535-9
- "Our results suggest that ESRD patients on dialysis have 'B12 resistance', and that they should have, in addition to their FOL
therapeutic regimen, i.v. B12 treatment to reduce their elevated tHcy levels"
- Can Broccoli Prevent Lupus? - WebMD, 11/6/03 -
"I3C is believed to act as an anti-estrogen ... I3C-fed mice had far fewer kidney problems than the
mice whose diets were not supplemented, and researchers say this is the reason that they lived much longer. Kidney disease is one of the main, life-threatening complications of lupus" - See
iHerb I3C products.
- Vitamin B12 Improves Homocysteine Levels and Lipid Profiles in Patients with End-Stage Renal Disease - Doctor's Guide, 10/6/03 -
1, patients were prescribed oral doses of folic acid 5 mg/day and vitamin B12 0.6mg/day. Through out Phase 2, participants were given intravenous doses of vitamin B12 1mg every other day in addition to folic acid 5 mg/day ... By the completion of the study, patients exhibited
significantly lower serum
tHcy (29.4 verses 21.1 mg/dL), total cholesterol (222 verses 196 mg/dL),
and low-density lipoprotein cholesterol levels (139 versus 109 mg/dL). Serum high-density lipoprotein (HDL) cholesterol levels increased significantly among the participants"
- Benefits of fish oil supplementation for hemodialysis patients - J Am Diet Assoc. 2003 Sep;103(9):1174-7 -
indicated that pruritus symptoms improved with fish oil supplementation, but not with supplementation with two other oils. In a study designed to determine whether fish oils could prevent vascular access graft thrombosis,
graft patency rates were approximately 76% in the fish oil and approximately 15% in the placebo group (P>.03). In a pilot study, subjects given fish oil required 16% less erythropoietin and experienced
a 3.6% increase in serum albumin levels"
- Vitamin E supplementation increases LDL resistance to ex vivo oxidation in hemodialysis patients
- Int J Vitam Nutr Res. 2003 Jul;73(4):290-6 -
"Since oral vitamin E supplementation prevents oxidative stress and significantly increases LDL resistance to ex vivo oxidation, supplementation by natural antioxidants such as vitamin E may be beneficial in hemodialysis patients"
- Thiol-Containing Antioxidant Shows Promise in Preventing Contrast Nephropathy - Doctor's Guide, 8/25/03 -
acetylcysteine, a thiol-containing antioxidant, shows promise in preventing contrast nephropathy in patients with chronic renal insufficiency"
- Does High Cholesterol Harm Your Kidneys? - Dr. Weil, 8/22/03 -
"apparently healthy men with low HDL (high density lipoprotein), the “good” cholesterol, and high LDL (low density lipoprotein) or “bad”
cholesterol and triglycerides have twice the normal risk of reduced kidney function ... You can raise HDL by increasing exercise, drinking alcohol moderately, and eating only healthy fats (monounsaturates
such as olive oil and omega-3s from sources like salmon and sardines). Taking prescription statin drugs also will help, although I prefer natural alternatives such as red rice yeast"
- Coenzyme Q10 Beneficial for People with Kidney Failure - New Hope Natural Media, 7/17/03
- N-Acetyl Cysteine Prevents Kidney Damage from Coronary Procedure - New Hope Natural Media, 5/1/03 -
"Up to 15% of people undergoing coronary angiography may experience kidney damage
from the contrast dye ... randomly assigned to receive either 600 mg of oral
NAC twice a day on the day before and the day of the procedure or a similar looking placebo ... Only 4% of those taking NAC, compared with 12% of those taking the placebo, experienced a 25% increase in blood
creatinine within 48 hours of receiving the contrast dye" - See
- Vitamin C Reduces Oxidant Stress In Renal Failure - Doctor's Guide, 3/26/03 -
"The acute administration of
vitamin C reduces oxidant stress in renal failure, and improves nitric oxide-mediated resistance-vessel dilatation ... In addition, vitamin C was found to increase the dilator response to acetylcholine in resistance vessels"
- High-Protein Diets Can Hurt Kidneys - WebMD, 3/17/03
- Remember Sodium? We're Still Getting Too Much - Intelihealth, 3/14/03 -
"High sodium levels also raise the risk of
osteoporosis and kidney problems"
- Cardiovascular End Points Reduced With Antioxidant Acetylcysteine In Haemodialysis Patients - Doctor's Guide, 2/28/03 -
"They were assigned to
receive either acetylcysteine 600 mg twice daily or a placebo ... Primary end point was a composite variable composed of cardiac events that included fatal and non-fatal myocardial infarction, death from cardiovascular disease, necessity for either coronary angioplasty or by-pass
surgery, ischaemic stroke, peripheral vascular disease requiring amputation or need for angioplasty ... A primary end point was established in 18 of the 64 [28%] haemodialysed
patients who received acetylcysteine, and 33 of 70 [47%] patients undergoing haemodialysis assigned to the control group"
- [Abstract] - See
- Acetylcysteine for Prevention of Acute Deterioration of Renal Function Following Elective Coronary Angiography and Intervention: A Randomized Controlled Trial - JAMA, 2/5/03 -
"Acetylcysteine protects patients with moderate chronic
renal insufficiency from contrast-induced deterioration in renal function after coronary angiographic procedures, with minimal adverse effects and at a low
cost" - See
- Shining a Light on the Health Benefits of Vitamin D - New York Times, 1/28/03 -
"His proudest accomplishments, he says, include
discoveries that show how activated vitamin D can be used to treat
osteoporosis, kidney failure and
- Acetylcysteine Can Reduce Cardiovascular Events in Patients with Endstage Renal Disease - Doctor's Guide, 10/1/02 -
acetylcysteine appears to significantly reduce cardiovascular events among
- Acetylcysteine Prevents Renal Problems After Angiography - Doctor's Guide, 3/18/02 -
"Changes in creatinine mean values after 48 hours were -0.4
(+/-0.3) and +0.1 (+/-0.3) mg/dL for treatment and control groups, respectively (p<0.001). The benefit was larger in patients with baseline creatinine levels higher than 2 mg/dL, at -0.4 (+/-0.4) compared to +0.5 (+/-0.3) mg/dL (p<0.001)"
- Calcium Supplementation Prevents Bone Loss in Renal Transplant Patients - Doctor's Guide, 5/13/01
drug benefits kidney disease patients, analysis finds - Science Daily,
Proteinuria May Help
Predict Outcomes in Chronic Kidney Disease - Medscape, 2/16/10
Rapamycin may be potential treatment for kidney disease - Science Daily,
Small amounts of lead may damage children's kidneys - Science Daily,
Kidney Function Decline Increases Risk Of Heart Failure And Premature Death
- Science Daily, 11/5/09 - "Among 4,378 eligible
participants in the study, those with rapid kidney decline (1,083 patients)
demonstrated a 32% increased risk of experiencing heart failure, a 48%
increased risk of having a heart attack, and a 67% increased risk of
developing peripheral arterial disease ... Patients whose kidney function
dropped by more than 5.6% per year demonstrated a 30% increased risk of
developing heart disease and a 22% increased risk of dying prematurely
compared to patients with stable kidney function"
Diet Sodas May Be Hard on the Kidneys - WebMD, 11/2/09 -
"Women who drank two or more diet sodas a day had a
30% drop in a measure of kidney function during the lengthy study follow-up
... Thirty percent is considered significant ... Put another way: the women
who drank two or more diet sodas a day had a decline in their glomerular
filtration rate, a measure of kidney function, of 3 milliliters per minute
per year. ''With natural aging, kidney function declines about 1 mL per
minute per year after age 40"
Impaired Kidney Function Linked To Cognitive Decline In Elderly -
Science Daily, 9/29/09 - "poor kidney function,
assessed at the beginning of the study, was linked with a more rapid rate of
decline in cognition over the next several years – not in visuospatial
ability or perceptual speed, but in three specific areas: episodic, semantic
and working memory ... The rate of decline in cognition was equivalent to
that of a person seven years older at baseline"
Association of Kidney Function With Coronary Atherosclerosis and
Calcification in Autopsy Samples From Japanese Elders: The Hisayama Study
- Am J Kidney Dis. 2009 Sep 16 - "The autopsy
findings presented here suggest that CKD is associated significantly with
severity of coronary atherosclerosis. Patients with CKD should be considered
a high-risk population for advanced coronary atherosclerosis"
Chronic Kidney Disease Linked To Malfunctioning Mitochondria - Science
Fresh Meats Often Contain Additives Harmful To Kidney Disease Patients -
Science Daily, 7/23/09
Approach To Screening For Serious Kidney Disease - Science Daily, 7/7/09
Blood Sugar: Killer For Kidney Disease Patients? - Science Daily, 5/7/09
Pills, Less Quality Of Life For Kidney Patients - Science Daily, 5/7/09
Kidney Disease Cause Cancer? - Science Daily, 4/30/09
Creatinine Levels Linked to Diabetes - Medscape, 3/13/09 -
"The multiple-adjusted odds ratio for those who had
serum creatinine between 0.40 and 0.60 mg/dL was 1.91 compared with those
who had levels between 0.71 and 0.80 mg/dL"
Combination Reduces Kidney Disease Risk In Diabetics - Science Daily,
Kidney Disease Affects Response To Blood Thinner - Science Daily, 3/1/09
Hypertension Drug Dramatically Reduces Proteinuria In Kidney Disease
Patients - Science Daily, 2/22/09 - "patients
taking 128 mg of candesartan experienced more than a 33% reduction in
proteinuria compared with those receiving 16 mg candesartan by the end of
the study. This reduction was in addition to the reduction in proteinuria
that the patients would have had when they first started taking candesartan
at 16 mg daily"
Healthy People With High Urinary Protein Levels Have Elevated Kidney Disease
Risk - Science Daily, 2/12/09 - "individuals
with high urinary protein levels are at high risk for losing their kidney
function and needing dialysis or a kidney transplant. The higher the level
of proteins in the urine, the higher the risk of needing dialysis or a
kidney transplant and the more rapid the rate of kidney function decline"
Commonly Used Measure of Chronic Kidney Disease Found Not Cost-Effective
- Doctor's Guide, 1/29/09
Blood Pressure Test Reveals Heart Disease Risk In Patients With Early Stages
Of Chronic Kidney Disease - Science Daily, 1/28/09
Blood And Urine Protein Predicts Chronic Kidney Disease Progression -
Science Daily, 1/28/09
Kidney Donors’ Life Spans Not Shortened - WebMD, 1/28/09
Form Of Intravenous Iron Treats Anemia In Chronic Kidney Disease Patients On
Dialysis - Science Daily, 1/28/09
Impaired Kidney Function Raises Risk Of Heart Problems In The Elderly -
Science Daily, 1/22/09
Phosphorus-lowering Drugs Linked To Lower Mortality In Dialysis Patients
- Science Daily, 12/17/08
Diabetes Drug Shows Potential For Treating One Cause Of Chronic Kidney
Disease - Science Daily, 12/16/08
Equation Provides More Accurate Estimates Of Kidney Function - Science
Overnight Hemodialysis Dramatically Improves Survival, Study Shows -
Science Daily, 11/8/08
People Who Develop Kidney Stones Are At Increased Risk For Chronic Kidney
Disease - Science Daily, 11/8/08
Chronic Kidney Disease Increased Sharply In The United States In Past Decade
- Science Daily, 10/8/08 - "A 30 percent increase in
chronic kidney disease over the past decade has prompted the U.S. Renal Data
System (USRDS) to issue for the first time a separate report documenting the
magnitude of the disease, which affects an estimated 27 million Americans
and accounts for more than 24 percent of Medicare costs"
Blood Pressure Takes Big Toll On Small Filtering Units Of The Kidney -
Science Daily, 9/19/08
Healthy People With Elevated Levels Of Uric Acid Are At Risk Of Developing
Kidney Disease - Science Daily, 9/17/08 -
"Elevated uric acid levels in the blood indicate an increased risk of
new-onset kidney disease ... it may be appropriate to prescribe uric
acid–lowering drugs, such as allopurinol and probenecid, to these otherwise
healthy individuals ... individuals in the slightly elevated uric acid group
were 1.26 times as likely to develop kidney disease as those in the low uric
acid group. The odds of developing kidney disease among volunteers in the
elevated uric acid group were 1.63 times greater than that of individuals in
the low uric acid group"
Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease -
Science Daily, 5/29/08 - "For patients with type 2
diabetes, a condition called non-alcoholic fatty liver disease (NAFLD) may
be an important risk factor for diabetes-related chronic kidney disease
(CKD)" - See my liver disease page
for way to reduce the risk of NAFLD.
Telmisartan is more effective than losartan in reducing proteinuria in
patients with diabetic nephropathy - Kidney Int. 2008 May 21 -
"telmisartan is superior to losartan in reducing
proteinuria in hypertensive patients with diabetic nephropathy, despite a
similar reduction in blood pressure" - Just one more reason I
feel telmisartan should be the first line treatment for hypertension if
natural methods such as coenzyme Q10 don't work. See telmisartan at
Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, or
Both for Patients With Proteinuria? A Best Evidence Review - Medscape,
5/20/08 - "Most significantly, the addition of
ARBs reduced proteinuria to a
greater degree than ARBs alone (ratio of means 0.76 at 1 to 4 months and
0.75 at 5 to 12 months). Combination therapy was also superior to treatment
with ACEIs alone ... The 2 important conclusions that can be drawn from this
meta-analysis are that ARBs are not superior to ACEIs in improving
proteinuria, and that the combination of these 2 treatments appears superior
in this outcome compared with either treatment alone ... Two of the biggest
safety concerns regarding the combination therapy include the risks for
hyperkalemia and acute worsening of renal function. A review of the
literature, however, suggests that these risks may not be significantly
worse with combination treatment vs monotherapy"
Creatinine Increase In Elderly Means Increased Renal Disease, Mortality,
Study Shows - Science Daily, 4/15/08
Acid May Provide Early Clues To Diabetic Kidney Disease - Science Daily,
Inhibitors vs ARBs in HTN and in CKD - Medscape, 1/4/08 -
"In the setting of chronic kidney disease (CKD),
concludes the other study, which is a meta-analysis, ACE inhibitor and ARB
monotherapy are similarly effective at reducing proteinuria, but a
combination of the two angiotensin-2-suppressing drugs works better than
either agent individually . But a blanket recommendation to combine them
would be premature, according to the authors, because there is little
evidence that the combination would improve clinical outcomes over
monotherapy, and the safety of such combination therapy is largely
Periodontal Disease Is Associated With Chronic Kidney Disease -
Medscape, 1/30/08 - "subjects with periodontal
disease and those who were
edentulous were nearly twice as likely to have CKD (adjusted odds
ratios, 1.60 and 1.85, respectively)"
Breakdown Of Kidney's Ability To Clean Its Own Filters Likely Causes Disease
- Science Daily, 1/29/08
Inhibitors or ARBs in Hypertension? In Chronic Kidney Disease? -
Medscape, 1/17/07 - "ARBs and ACE inhibitors were
similarly effective at lowering proteinuria, ARBs were more effective than
calcium-channel blockers, and a combination of ARBs and ACE inhibitors was
more effective than either agent alone"
effect of losartan on hemoglobin concentration and renal outcome in diabetic
nephropathy of type 2 diabetes - Kidney Int. 2007 Dec 19 -
"Compared with placebo, losartan treatment was
associated with a significant decrease of hemoglobin, with the largest
between-group difference at 1 year. After adjustment, there were significant
relative risk reductions for losartan compared with placebo for ESRD and for
ESRD or death regardless of the baseline hemoglobin even in those patients
with a baseline hemoglobin below 120 g l(-1). Hence, the renoprotective
properties of losartan were maintained despite a significant lowering of the
Blood Pressure Drugs: Is Timing Key? - WebMD, 12/13/07 -
"The study was small, involving just 32 patients
with chronic kidney disease taking more than one blood pressure medication
... When the patients switched just one of their blood pressure drugs from
morning to bedtime, 28 experienced normalization of nighttime blood pressure
patterns within eight weeks ... Most patients also showed decreases in
protein levels in their urine indicative of better kidney function"
Pioglitazone Lowers Cardiovascular Risk in Diabetic Patients with Kidney
Disease - Doctor's Guide, 12/12/07
Existing Drugs Show Promise For Treating End-stage Renal Disease In Lupus
- Science Daily, 11/27/07
Way To Detect Lupus-associated Kidney Disease - Science Daily, 11/25/07
Thiazolidinediones: A novel class of drugs for the prevention of diabetic
nephropathy? - Kidney Int. 2007 Dec;72(11):1301-1303 -
"Miyazaki et al. report that rosiglitazone, a
thiazolidinedione insulin sensitizer and a potent peroxisome proliferator-activated
receptor gamma agonist, not only effectively improves glycemic control but
also halts progression of albuminuria in type 2 diabetic patients with
early-stage diabetic nephropathy. These findings could offer a new
prevention of diabetic nephropathy in insulin-resistant diabetic patients"
May Limit Radiation Kidney Damage In BMT Patients - Science Daily,
Atorvastatin Helps Protect Kidneys in SPARCL Patients - Doctor's Guide,
11/12/07 - "Treatment of stroke patients with
atorvastatin can preserve kidney function in patients with or without
chronic kidney disease, metabolic syndrome or type 2 diabetes"
Chronic Kidney Disease Rises While Most People With The Condition Remain
Unaware - Science Daily, 11/9/07
Adding Carvediol Therapy Prevents Progression of Chronic Kidney Disease
- Doctor's Guide, 11/6/07
13% of Americans Have Kidney Disease - WebMD, 11/6/07 -
"Thirteen percent of Americans now have chronic
kidney disease, up 3% over the last decade, mostly due to higher rates of
diabetes and high blood pressure ... A recent CDC report on the same NHANES
data suggested that 17% of Americans have chronic kidney disease. Coresh and
colleagues came up with a lower number because the CDC analysis included
people with earlier signs of kidney disease, while the Coresh team counted
only those with persistent kidney disease"
Rosiglitazone May Increase Mortality Among Diabetic Patients Undergoing
Haemodialysis - Doctor's Guide, 11/5/07
Renoprotection provided by losartan in combination with pioglitazone is
superior to renoprotection provided by losartan alone in patients with type
2 diabetic nephropathy - Kidney Blood Press Res. 2007;30(4):203-11 -
"Renoprotection conferred by losartan combined with
pioglitazone is superior to that conferred by losartan alone in subjects
with type 2 diabetic nephropathy. The combination is generally well
Genzyme Says FDA OKs
Renvela for Dialysis Patients - Medscape, 10/22/07
Double Cardiovascular Benefit For People With Chronic Kidney Disease -
Science Daily, 10/5/07
Higher Death Rates in Kidney Patients With Newly Recognized Disease -
Doctor's Guide, 10/1/07
Kidney Dialysis Best After Dark? - WebMD, 9/19/07
Lowering Homocysteine Levels Does Not Improve Outcomes For Patients With
Chronic Kidney Disease - Science Daily, 9/11/07
Rosiglitazone decreases albuminuria in type 2 diabetic patients - Kidney
Int. 2007 Sep 5 - "The percentage decrease in
albuminuria correlated with the decrease in fasting plasma glucose ... Our
study indicates that thiazolidinediones may be useful to prevent nephropathy
in type 2 diabetic patients"
- ACE Inhibitors, ARBs
Improve Survival in Heart Failure Patients With Kidney Disease -
- Telmisartan Staves
Off Overt Diabetic Nephropathy - Medscape, 6/27/07 -
"During a mean follow-up of 1.3 years, transition
rates to overt nephropathy were significantly lower with telmisartan 40 mg
(22.6%) and telmisartan 80 mg (16.7%) than with placebo (49.9%)"
Telmisartan May Help Preserve Renal Function in Patients With Hypertension,
Diabetes - Medscape, 6/1/07 -
"In patients with hypertension and type 2 diabetes, telmisartan and ramipril
both may help preserve cardiovascular and renal function by increasing
nitric oxide (NO) activity of the renal endothelium"
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers
in patients with congestive heart failure and chronic kidney disease -
Am Heart J. 2007 Jun;153(6):1064-73 -
"The inhospital use of either an
ACE-I or ARB was associated with significantly reduced 30-day mortality (OR
0.45, 95% CI 0.28-0.59) after adjusting for multiple risk factors.
Similarly, the discharge prescription of either an ACE-I or ARB was
associated with a significant reduction in adjusted 1-year mortality ...
Angiotensin-converting enzyme inhibitors and ARB are underused in patients
with heart failure with chronic kidney disease"
Inhibitors May Slow Progression of IgA Renal Disease - Medscape, 5/24/07
- Novel ARB
Provides Greater Reductions in Proteinuria in Diabetics With Overt Nephropathy
- Medscape, 5/22/07 - "One year of
treatment with the novel angiotensin receptor blocker (ARB) telmisartan provided
greater reductions in proteinuria when compared with losartan, a drug approved
for the treatment of diabetic nephropathy to prevent renal-disease progression"
Early Treatment With ACE Inhibitors Urged To Reduce Long-Term Dialysis Risk
- Science Daily, 5/21/07 - "For
young patients with the kidney disease IgA nephropathy (IgAN), early
treatment with angiotensin-converting enzyme (ACE) inhibitors can reduce the
long-term risk of irreversible kidney damage"
ACE Inhibitors Help Preserve Kidney Function in IgA Nephropathy -
Doctor's Guide, 5/16/07
Treating hypertension in the patient with overt diabetic nephropathy -
Semin Nephrol. 2007 Mar;27(2):182-94 -
"The renoprotective and proteinuria-decreasing
effects of angiotensin-converting enzyme inhibitors and angiotensin-receptor
blockers recommend these agents as the standard of care in type 2 diabetic
Statins Linked to Lower Risk of Infection in Kidney Dialysis Patients -
Doctor's Guide, 4/10/07
Do statins have a beneficial effect on the kidney? - Medscape, 1/4/07 -
"Statins appear to have a small
beneficial effect on the rate of kidney function decline (particularly in
patients with cardiovascular disease), and proteinuria"
High-normal Uric Acid Linked With Mild Cognitive Impairment In The Elderly
- Science Daily, 1/3/07 - "older
people with serum (blood) uric-acid levels in the high end of the normal
range are more likely to process information slowly and experience failures
of verbal and working memory ... Higher levels of uric acid are linked with
known risk factors for dementia, including high blood pressure,
atherosclerosis, Type 2 diabetes and the "metabolic syndrome" of abdominal
obesity and insulin resistance"
NICE Recommends Mimpara(R) (Cinacalcet) for Treatment of a Serious
Complication of Kidney Disease - Doctor's Guide, 11/6/06
ACE Inhibitors Reduce Kidney Disease Risk in Diabetics with High Blood
Pressure - Doctor's Guide, 11/2/06 -
"Taking an ACE inhibitor, alone or
as part of the combination treatment, provided further protection against
diabetic kidney disease"
Obesity May Up Risk of Kidney Failure - WebMD, 5/22/06
Fosrenol Significantly Reduces Tablet Burden for End-Stage Renal Disease
Patients With Hyperphosphatemia and Improves Patient and Physician
Satisfaction, a New Study Reports - Doctor's Guide, 4/21/06
Lipitor Demonstrates Improvement in Kidney Function in Patients With
Coronary Heart Disease - Doctor's Guide, 3/13/06 -
"Patients with coronary heart
disease (CHD) and elevated cholesterol who took Pfizer Inc's cholesterol-
lowering medicine Lipitor (atorvastatin calcium) experienced improved kidney
function, and those improvements were significantly greater among patients
taking the highest dose (80 mg)"
Concern Over Rapid Rise Of Chronic Kidney Disease - Science Daily,
3/13/06 - "This figure has doubled
over the past decade and is expected to continue to rise by 5-8% annually
... The rise in end stage renal disease worldwide probably reflects the
global epidemic of type 2 diabetes and the ageing of the populations in
While Incidence of Acute Renal Failure Rises, Risk Of Death Declines -
Doctor's Guide, 2/28/06
Lipid Marker Linked to Worsening of Kidney Disease - Doctor's Guide,
Kidney Disease Drug Saves Lives At Low Cost - Science Daily, 12/3/05
New Higher Dose Formulation of Fosrenol (lanthanum carbonate) Approved to
Reduce Serum Phosphorus in End-Stage Renal Disease Patients - Doctor's
Results Encouraging with Interferon Alpha Plus Iressa (Gefitinib) or Gleevec
(imatinib mesylate) in Metastatic Renal Cell Carcinoma - Doctor's Guide,
Sevelamer May Be Better than Calcium Carbonate for Treating
Hyperphosphataemia in Dialysis Patients - Doctor's Guide, 11/16/05
Recombinant Human Erythropoietin Effective Against Anaemia of Chronic Kidney
Disease, But Potentially Dangerous in Higher Doses - Doctor's Guide,
StaphVAX Reduces Recurrent Staphylococcus Aureus Bacteraemia in End-Stage
Renal Disease Patients - Doctor's Guide, 11/14/05
Fosrenol Has Long-Term Safety and Efficacy in End-Stage Renal Disease
Patients Treated for up to 6 Years - Doctor's Guide, 11/14/05
Atorvastatin Improves Inflammatory State of Patients with Chronic Kidney
Disease - Doctor's Guide, 11/14/05
Frequent Use of NSAIDs and COX-2 Inhibitors in the Elderly Can Lead to Rapid
Progression of Chronic Kidney Disease - Doctor's Guide, 11/14/05
Low-Dose Epoetin Beta Offers Improved Renal Anaemia Management for
Haemodialysis Patients - Doctor's Guide, 11/11/05
Citrate-containing Dialysate an Option for Chronic Dialysis Patients Unable
to Receive Anticoagulants - Doctor's Guide, 11/11/05
Long-Term Exposure to Warfarin Associated with Aortic Valve Calcification in
Haemodialysis Patients - Doctor's Guide, 11/11/05
Study Finds Patients with Moderate to Severe Chronic Kidney Disease Go
Undiagnosed - Doctor's Guide, 11/10/05
New Publication Demonstrates Long-Term Efficacy, Safety and Tolerability of
Fosrenol - Doctor's Guide, 10/24/05
Adults with CKD Not Receiving Proper Tests - Physician's Weekly,
Nocturnal Dialysis Improves Heart Disease In Patients With End-stage Kidney
Failure - Science Daily, 10/1/05
Mayo Researchers Explore Reasons for Complications With Kidney Failure
Patients - Doctor's Guide, 8/16/05
Many with Chronic Kidney Disease Don't Receive Recommended Medical Care
- Doctor's Guide, 8/4/05
Dialysis Treatment Choice Affects Risk of Death in End-Stage Kidney Disease
- Doctor's Guide, 8/2/05
Odds of Hospitalization Appear Lower for Patients Treated with
Doxercalciferol Compared to Calcitriol: Presented at WCN - Doctor's
- New machines
offer kidney dialysis at home - MSNBC, 7/11/05
Lanthanum Carbonate Appears to Reduce Serum Phosphorus Levels in Patients
With End Stage Renal Disease Without Compromising Bone Health: Presented at
WCN - Doctor's Guide, 7/11/05
Long-Term Data Finds Lanthanum Carbonate to Have Strong Safety Profile in
Patients With End Stage Renal Disease: Presented at WCN - Doctor's
Discovery May Prevent Life-threatening Wasting Disease In Patients With
Chronic Kidney Disease - Science Daily, 6/10/05
FDA Approves Zemplar (Paricalcitol) Capsules For Earlier Treatment Of Kidney
Disease Complication - Doctor's Guide, 5/27/05
Cardiovascular Risk Factors Could Indicate Kidney Problems - Doctor's
Guide, 5/12/05 - "While generalized
atherosclerosis (hardening of arteries and blood vessels) has been
increasingly recognized as a cause of end-stage renal disease (ESRD), a
recent study of over 8,500 patients discovered that this same disease also
affects renal function in those who do not suffer from ESRD"
New in Vitro Data Show Fosrenol May Have Greater Phosphate Binding Affinity
than Sevelamer Hydrochloride - Doctor's Guide, 5/5/05
Hemodialysis Causes Antioxidant Loss Leading To Long-term Complications
- Science Daily, 4/26/05
New Data Shows Telmisartan (Micardis/Pritor) Provides Effective and
Well-Tolerated Blood Pressure Lowering in Chronic Kidney Disease Patients
- Doctor's Guide, 4/4/05
Science waking up to while-you-sleep dialysis
- USA Today, 3/25/05
High Phosphate Levels Linked to Increased Mortality Risk in Chronic Kidney Disease - Doctor's Guide, 1/19/05
- Few Americans Are Aware They Have Chronic Kidney Disease - Science Daily, 12/29/04 -
"Kidney disease can be well advanced before it's found with creatinine alone ... People with chronic kidney disease are at high risk for premature death, heart attacks and strokes as well as hypertension, anemia, bone disease and malnutrition"
- American Society of Nephrology Renal Week 2004 - Medscape, 11/30/04
- First Human Trial Of Bioartificial Kidney Shows Promise For Acute Renal Failure - Science Daily, 11/9/04
- Preventing Diabetes-Related Kidney Disease - WebMD, 11/3/04
- Liquid Amphotericin B Treatment Safe Alternative Treatment in Kidney Dysfunction - Doctor's Guide, 11/3/04
- Epoetin Alfa Shows Impressive Results for Anemia Correction in Pre-Dialysis Kidney Patients - Doctor's Guide, 11/1/04
- Specialized Care Provides Edge for Patients with Kidney Disease - Doctor's Guide, 11/1/04
- Simvastatin Demonstrates Benefits in Patients With Chronic Renal Insufficiency - Doctor's Guide, 11/1/04
- IV Sodium Ferric Gluconate Complex Tops Oral Iron in Anemic Kidney Patients - Doctor's Guide, 11/1/04
- Innovative Program Improves Coronary Risk Factors in Kidney Disease Patients - Doctor's Guide, 11/1/04
- FDA Approves Fosrenol (Lanthanum Carbonate) To Reduce Phosphate Levels In End-Stage Renal Disease - Doctor's Guide, 10/27/04
- Kidney Problems, Heart Failure Deaths Linked - WebMD, 10/19/04
- Chronic Kidney Failure Climbing Rapidly in U.S. - WebMD, 10/8/04
- Studies Strengthen Kidney And Heart Disease Link - Science Daily, 9/29/04
- Even Modest Kidney Disease Ups Heart Risk - WebMD, 9/22/04
- Atorvastatin Improves Renal Function in Patients With CHD - Medscape, 7/2/04 -
"In 704 patients not treated with statins, mean decrease in CrCl was 5.2% (P < .001). In 97 patients receiving various statins as part of their usual care, CrCl increased by 4.9% (P = .003). In
783 structured care patients receiving atorvastatin, CrCl increased by 12%"
- Why Is Hypertension in Chronic Kidney Disease Treated Differently than Other Hypertension? - Doctor's Guide, 4/30/04
- Treatment for Kidney Disease Complication - Physician's Weekly, 4/5/04
- Intensified Treatment of Diabetic Nephropathy Slows Renal Disease Progression - Doctor's Guide, 4/1/04
- Osteoarticular Complications Common in Patients Undergoing Haemodialysis - Doctor's Guide, 3/16/04
- FDA Approves of Sensipar (Cinacalcet HCl) for Treatment of Secondary Hyperparathyroidism - Doctor's Guide, 3/9/04
- FDA Approves New Kidney Disease Drug [Sensipar] - Intelihealth, 3/9/04
- Patients Give More Favourable Ratings to Peritoneal Dialysis Than to Haemodialysis - Doctor's Guide, 2/11/04
- Combination Therapy Important for Management of Diabetic Renal Disease - Doctor's Guide, 12/29/03
- New Non-Surgical Risk Factors Identified for Primary Access Failure in End Stage Renal Disease - Doctor's Guide, 12/11/03
- Peritoneal Dialysis May Offer Longer-Term Survival Than Haemodialysis - Doctor's Guide, 12/5/03
- Elevated C-reactive Protein Level Predicts Ischaemic Heart Disease in Patients Undergoing Peritoneal Dialysis - Doctor's Guide, 12/2/03
- Care Questioned For Dialysis Patients - Intelihealth, 12/2/03
- Dialysis in High-risk Patients Appears to Have Limited Effect on Survival - Doctor's Guide, 11/27/03
- No Direct Evidence of Short- or Long-Term Complications Found with Intravenous Iron Therapy - Doctor's Guide, 11/21/03
- Long-Acting Epoetin Safely Treats Anaemia in Elderly or Diabetic Dialysis Patients - Doctor's Guide, 11/21/03
- Cinacalcet Might Put More Dialysis Patients on Target for Parathyroid Hormone - Doctor's Guide, 11/19/03
- Cinacalcet HCl Is Safe and Effective for Secondary Hyperparathroidism in Haemodialysis Patients - Doctor's Guide, 11/18/03
- Once-Monthly Darbepoetin Alfa Protects Patients With Chronic Kidney Disease From Anaemia - Doctor's Guide, 11/18/03
- Sevelamer Saves Bone in Dialysis Patients - Doctor's Guide, 11/17/03
- Cystatin C Finds Those at Risk for Later Renal Failure - Doctor's Guide, 11/18/03
- Paricalcitol Safely and Effectively Treats Secondary Hyperparathyroidism in Haemodialysis Patients - Doctor's Guide, 11/17/03
- Fenofibrate Slows Renal Decline in Type 2 Diabetes - Doctor's Guide, 11/17/03
- At-Home Dialysis An Effective Option for More Patients With Advanced Kidney Disease - Doctor's Guide, 11/13/03
- Cockroft-Gault Formula Best Tool for Evaluating Renal Function in Diabetes Patients - Doctor's Guide, 10/27/03
- Anaemia in Diabetics Often Unrecognised, Undetected, and Untreated - Doctor's Guide, 10/16/03 -
"Although anaemia is a key
indicator of renal disease, a significant complication caused by diabetes, most diabetics are not tested for anaemia and remain unaware of an association between anaemia and kidney disease ... reduced quality of life was evident by reports of being down or depressed (21%), very down or depressed (17%), or feeling
- Calcium Acetate Treatment Causes Hypercalcemia and Vascular Calcification in Haemodialysis Patients - Doctor's Guide, 10/9/03
- Haemofiltration Benefits Chronic Renal Failure Patients Undergoing Coronary Procedures - Doctor's Guide, 10/3/03
- Zaleplon Improves Sleep Quality In Patients on Maintenance Haemodialysis - Doctor's Guide, 10/3/03
- Continent Urinary Reconstruction For Severe Bladder Dysfunction Safe, Effective In Pediatric Patients With End-Stage Renal Disease - Doctor's Guide, 10/1/03
- Multidisciplinary, Timely Preparation of Patients to Enter End Stage Renal Disease May Improve Mortality - Doctor's Guide, 9/30/03
- High-Dose Furosemide Increases Urine Volume and Electrolyte Excretion in Chronic Peritoneal Dialysis Patients Without Affecting Urea, Creatinine Clearance - Doctor's Guide, 9/28/03
- Isolation and Dedicated Equipment May Be Unnecessary For Hepatitis C Infected Dialysis Patients - Doctor's Guide, 9/25/03
- Epoetin-Sparing Effect Not Associated With Dialyser Membrane Type In Haemodialysis Patients - Doctor's Guide, 9/25/03
- Study: Pain Killers Do Not Damage Kidneys - Physician's Weekly, 9/15/03
- Sevelamer Reduces Serum Phosphorus Without Causing Hypercalcemia in Patients With End-Stage Renal Disease - Doctor's Guide, 9/15/03
- High-Dose Vancomycin Given During Dialysis Equivalent to Standard Dose After Dialysis - Doctor's Guide, 9/12/03
- Anaemia Correction Improves Cardiac and Renal Function in Patients with Congestive Heart Failure - Doctor's Guide, 9/9/03
- Interferon and Ribavirin Safe for Patients With Hepatitis C-Related Renal Insufficiency - Doctor's Guide, 9/8/03
- Captopril Offers Significant Survival Benefit for Patients With Moderate Renal Disease - Doctor's Guide, 9/4/03
- Family Members, Other Patients Important Sources Of Staphylococcus Aureus For Patients On Peritoneal Dialysis - Doctor's Guide, 9/4/03
- Clopidogrel Plus Aspirin Ineffective for Graft Thrombosis, Increases Bleeding Risk During Haemodialysis - Doctor's Guide, 9/3/03
- Mean Transferrin Saturation, Length of Dialysis, and Albumin Levels Predict Anaemia in Pediatric Patients - Doctor's Guide, 8/25/03
- Oral Heme Iron Polypeptide Effectively Sustains Response To Erythropoietin Therapy In Haemodialysis Patients - Doctor's Guide, 8/15/03
- Hydrostatic Intraperitoneal Pressure Provides Objective Parameter For Determining Dialysis Dose In Children - Doctor's Guide, 8/15/03
- Pyocystis Can Occur In Anuric Patients - Doctor's Guide, 8/13/03
- Early Anaemia in Paediatric Renal Patients Linked to Prolonged Hospitalisation, Death - Doctor's Guide, 8/12/03
- Multi-Dose Epoetin Pen Appears Safe, Effective In Patients With Renal Anaemia - Doctor's Guide, 8/12/03
- Long-term Haemodialysis Patients Show Survival Advantage When Treated with Paricalcitol Over Calcitriol for Secondary Hyperparathyroidism - Doctor's Guide, 7/31/03
- Better Dialysis Survival With Zemplar - WebMD, 7/30/03
- Profound Effects On Immune Function Of Iron Therapy In End-Stage Renal Disease - Doctor's Guide, 7/30/03 -
"Iron therapy, given to treat anaemia
in combination with recombinant human erythropoietin (rhEPO) in patients with end-stage renal disease (ESRD), depresses immune
function by inhibiting TNF-a production and increasing IL-4"
- High Cholesterol Raises Kidney Risks - WebMD, 7/21/03
- Lower cholesterol for healthy kidneys - USA Today, 7/20/03 -
"men who had low levels of
HDL or "good cholesterol"
and elevated "bad" or LDL cholesterol were twice as likely to have evidence of kidney malfunction"
- Coronary Biomarker Level Increases Associated with Increased Mortality Risk in End-Stage Renal Disease - Doctor's Guide, 7/21/03
- Dialysis Dose, Membrane Type Do Not Reduce Infection Risk During Haemodialysis - Doctor's Guide, 7/11/03
- Flucloxacillin Effective Against Staphylococcal Infections During Continuous Venovenous Haemofiltration - Doctor's Guide, 7/7/03
- r.hu-Erythropoietin Therapy May Slow or Reverse Renal Function Loss Process - Doctor's Guide, 7/7/03
- Peritoneal Dialysis May Be More Likely To Achieve Renal Function Recovery In Atheroembolic Renal Failure - Doctor's Guide, 7/3/03
- Reversing Kidney Failure May Be Possible [morphogenic protein, or BMP-7] - WebMD, 7/2/03
- Phosphate Reduction Starts Within One Week Of Treatment With Fosrenol (Lanthanum Carbonate) - Doctor's Guide, 6/30/03
- Visual Loss After Haemodialysis Can Be Caused By Posterior Ischaemic Neuropathy - Doctor's Guide, 6/26/03
- Daily Night-time Haemodialysis May Provide Advantages Over Other Schedules - Doctor's Guide, 6/26/03
- Diabetic Kidney Disease Often Missed - WebMD, 6/24/03
- Long-Term ACE Inhibitor Treatment Promotes Renal Health and Improved Lipid Profiles - Doctor's Guide, 6/12/03 -
"In the group switched from a
diuretic, the mean urinary albumin excretion was reduced from 37.0 to 23.2 at 12 months. In that same time period, the urinary albumin excretion decreased from 38.9 to 25.3 in the group switched from calcium channel blockers ... After switching to
serum total cholesterol in the switched groups was significantly decreased from the baseline value (P<0.05) -- from 223.5 mg/dL to 210.7 mg/dL
in the group switched from diuretics; from 215.6 mg/dL to 209.3 mg/dL in the group switched from calcium channel blockers ...
Serum levels of low-density lipoprotein and high-density lipoprotein were also improved in the switched groups"
- Adding Felodipine to Ramipril Slows Progression in Nondiabetic Renal Disease - Doctor's Guide, 6/12/03
- Enalapril Has Renoprotective Effect in Chronic Allograft Nephropathy - Doctor's Guide, 6/12/03
- Fosrenol (Lanthanum Carbonate) Demonstrates Long-Term Benefit In End Stage Renal Disease - Doctor's Guide, 6/11/03
- Nephrogenic Fibrosing Dermopathy Linked to Aberrant Tissue Healing - Doctor's Guide, 6/11/03
- Subcutaneous Darbepoetin Alfa Maintains Optimal Haemoglobin Levels in Dialysis - Doctor's Guide, 6/10/03
- Diuretic Use Linked to End-Stage Renal Disease [ESRD] - Medscape, 5/16/03 -
"We're concerned that there could be a long time lag between use of thiazide
diuretics and ESRD, even as long as 10 to 15 years"
- Fosrenol (Lanthanum Carbonate) Shows Favourable Effects On Bone In Bone Biopsy Study - Doctor's Guide, 5/13/03
- Sevelamer Hydrochloride Reduces Hyperparathyroidism in End-Stage Renal Disease - Doctor's Guide, 4/29/03
- Experts Release New Chronic Kidney Disease Bone Guidelines - Medscape, 4/8/03
- Kidney Ultrasound Should Be Performed in-House - Medscape, 4/7/03
- Implantable Defibrillators May Save the Lives Of Many Cardiac Patients on Haemodialysis - Doctor's Guide, 4/7/03
- Once-Monthly Aranesp (Darbepoetin Alfa) Maintains Hemoglobin Levels In Chronic Kidney Disease Patients With Anemia - Doctor's Guide, 4/4/03
- Long-Term Fosrenol (Lanthanum Carbonate) Controls Harmful Phosphate In End-Stage Kidney Disease - Doctor's Guide, 4/4/03
- FDA Grants Approvable Letter For Fosrenol (Lanthanum Carbonate) For Treatment Related To Kidney Disease - Doctor's Guide, 3/3/03
- Whirlpools Pose Hidden Danger to Kidney - WebMD, 2/6/03
- Most Haemodialysis Patients Have Headache Before, During Treatment - Doctor's Guide, 2/6/03
- Hypertensive Patients With Renal Impairment Have Fewer Side Effects From Efonidipine - Doctor's Guide, 2/6/03
- Low-Level Lead Exposure Harms Kidneys - Doctor's Guide, 1/22/03 -
"the progression of kidney failure was much slower in patients who received
chelation therapy compared with those who got the placebo"
- Atherosclerosis Affects Age-Related Renal Changes - Doctor's Guide, 1/2/03 -
"Atherosclerosis speeds up
kidney shrinkage and increases in serum creatinine levels on top of the known effects of aging ... the investigators conclude that atherosclerosis accelerates the decrease of renal size and the increase in serum creatinine with age"
- FDA Approves New Peritoneal Dialysis Solution Extraneal (Icodextrin) - Doctor's Guide, 12/23/02
- Intravenous Administration Required When Using Eprex/ Erypo (Epoetin Alfa) In Chronic Renal Failure Patients - Doctor's Guide, 12/3/02
- More Deaths In For-Profit Dialysis Centers - WebMD, 11/19/02
- Lowering Systolic Blood Pressure Reduces Risk of Diabetic Nephropathy Progression - Doctor's Guide, 11/7/02
- Periodontal Diseases Increase C-Reactive Protein In Haemodialysis Patients - Doctor's Guide, 11/7/02
- Renal Transplant Safe, Successful in Wegener's Granulomatosis - Medscape, 11/4/02
- Fosrenol Safe, Effective for Hyperphosphatemia of Hemodialysis - Medscape, 11/4/02
- Hypertension Is Adequately Controlled In Only 30 Percent Of Haemodialysis Patients - Doctor's Guide, 11/4/02
- Intravenous Push Of Iron Sucrose Safe, Effective In Haemodialysis Patients - Doctor's Guide, 11/4/02
- Darbepoetin Alfa Once Every Other Week Treats Anaemia In Patients With Chronic Kidney Disease Not On Dialysis - Doctor's Guide, 11/4/02
- Once-Weekly Epoetin Alfa Effective Against Anaemia in Chronic Kidney Disease - Doctor's Guide, 11/4/02
- Adequate Dialysis Allows Chronic Renal Failure Patients to Recover Sense of Smell - Doctor's Guide, 11/4/02
- Stop Recombinant Human Erythropoetin if Signs of Pure Red Blood Aplasia Appear - Doctor's Guide, 11/4/02
- Sirolimus-Based Immunotherapy Allows Elimination Of Cyclosporine, Improves Renal Function - Doctor's Guide, 11/4/02
- Cardiac Drugs' Effectiveness Depends on Cardiovascular Status Prior to Starting Haemodialysis - Doctor's Guide, 11/4/02
- Fosrenol (Lanthanum Carbonate) Effective, Safe Treatment For Hyperphosphatemia - Doctor's Guide, 11/4/02
- In Hypertensive Individuals, Lead Exposure is Associated with Chronic Kidney Disease - Doctor's Guide, 11/3/02
- IV Iron Therapy Better than Oral Iron for Paediatric Patients Undergoing Dialysis - Doctor's Guide, 11/3/02
Treatment of diabetic nephropathy with angiotensin II receptor antagonist -
Clin Exp Nephrol. 2003 Mar;7(1):1-8 - "Treatment with
irbesartan was associated with a relative risk of endstage renal disease that was 23% lower than that in both other groups [calcium channel blocker or placebo]. These differences were not accounted for by differences in the blood pressures that were achieved"
- Iron Therapy Contraindicated In Haemodialysis Patients' - Doctor's Guide, 10/30/02
- Haemofiltration Better Than Peritoneal Dialysis In Infection-Related Renal Failure - Doctor's Guide, 9/19/02
- FDA Approves Avapro (Irbesartan) For The Treatment Of Diabetic Nephropathy (Kidney Disease) In Patients With High Blood Pressure And Type 2 Diabetes - Doctor's Guide, 9/18/02
- Losartan Reduces Incidence of End-Stage Renal Disease in Type 2 Diabetics, Also Lowers Cost Burden - Doctor's Guide, 9/4/02
- Surgery In Mild And Moderate Renal Failure Decreases Need For Dialysis - Doctor's Guide, 9/3/02
- Nephron Sparing Surgery Controls Cancer, Preserves Renal Function - Doctor's Guide, 8/12/02
- Survival and Quality of Life Support Aggressive Treatment of Acute Renal Failure - Doctor's Guide, 8/9/02
- Recombinant Hepatitis B Vaccine Suitable In Children With Chronic Renal Failure - Doctor's Guide, 8/8/02
- Increased Toxin Concentrations Worsen Renal Function - Doctor's Guide, 8/8/02
- Links Suggested Between Malnutrition, Inflammation and Atherosclerosis in Haemodialysed Patients - Doctor's Guide, 8/2/02
- Once-Weekly Recombinant Human Erythropoietin Maintains Haemoglobin Concentrations in Haemodialysis Patients - Doctor's Guide, 7/19/02
- Dialyzers May Remove Heparin Antibodies and Reduce Occurrence of Severe Thrombocytopenia - Doctor's Guide, 7/19/02
- Undiagnosed but Treatable Fabry Disease Found in End-Stage Renal Disease - Doctor's Guide, 7/18/02
- Low Molecular Weight Heparin Superiority in Hemodialysis Due to Endothelium Dependent Mechanisms - Doctor's Guide, 7/18/02
- Age and Comorbidities Predict Outcome After Acute Tubular Necrosis - Doctor's Guide, 7/17/02
- Intravenous Darbepoetin Alfa Is More Effective Than Intravenous Recombinant Human Erythropoetin - Doctor's Guide, 7/17/02
- Heart Disease In Haemodialysis Patients Could Be Related To Mean Platelet Volume - Doctor's Guide, 7/8/02
- Older Dialysis Patients At Greater Risk for Malnutrition - Doctor's Guide, 5/9/02
- Androgen Therapy In Dialysis Patients Shows Benefits Over Erythropoietin - Doctor's Guide, 4/25/02
- Adding Candesartan to Angiotensin Converting Enzyme Inhibitor in Renal Disease - Doctor's Guide, 4/25/02
- Study Confirms Recommended Dialysis Dose - Doctor's Guide, 4/23/02
- High-Protein Diets Cause Dehydration - WebMD, 4/22/02
- Darbepoetin Alfa Effective Even When Given at Four-Week Intervals - Doctor's Guide, 4/22/02
- No Evidence that ACE Inhibitors, Aspirin Reduce Mortality in Dialysis Patients - Doctor's Guide, 4/22/02
- At-Home Dialysis Therapy May Benefit A Greater Range of Patients - Doctor's Guide, 4/19/02
- Dialysis May Alter Cognitive Function - Doctor's Guide, 4/17/02
- Intervention Can Improve Barriers To Adequate Dialysis Care - Doctor's Guide, 4/17/02
- Helicobacter Status Not Related To Dyspepsia Or Gastroparesis In Uremic Patients - Doctor's Guide, 4/12/02
- Overhydration Contributes To Hypoalbuminemia In Peritoneal Dialysis - Doctor's Guide, 4/8/02
- Decline In Renal Function After Dialysis Can Be Halved - Doctor's Guide, 2/11/02
- New Guidelines Urge Easy Tests To Diagnose Kidney Disease In Millions Who Don't Know Organs Are Dying - Intelihealth, 2/5/02
- Working Kidney Built From Embryo Clone - Intelihealth, 1/31/02
- Daily Haemodialysis Reduces Mortality In Acute Renal Failure - Doctor's Guide, 1/31/02
- Under-Controlled Hypertension Paves Way For Other Ills - Doctor's Guide, 1/16/02
- Study Suggests Time Of Day May Affect Dialysis - Intelihealth, 12/5/01
- Recombinant Human Growth Hormone Improves Malnourished Kidney Failure Patients - Doctor's Guide, 11/13/01
- Aspirin Plus Beta-Blocker Reduce Risk of Post-Myocardial Infarction Deaths in Patients with End-stage Renal Disease - Doctor's Guide, 11/12/01
- Inadequate Antibiotic Doses Often Given During Recovery from Acute Renal Failure - Doctor's Guide, 11/7/01
- Aranesp (Darbepoetin) May Maintain Hemoglobin Levels Despite Infrequent Dosing in Chronic Renal Failure - Doctor's Guide, 10/16/01
- Blood Pressure Drug May Help Kidneys - Intelihealth, 9/19/01
- Cozaar (Losartan) Slows Progression of Kidney Disease in Type 2 Diabetes - Doctor's Guide, 9/19/01
- Irbesartan Protects Against Kidney Disease Progression in Hypertension, Type 2 Diabetes - Doctor's Guide, 9/4/01
- Baycol (Cerivastatin) Not To Be Used In Combination With Gemfibrozil, Says Bayer - Doctor's Guide, 7/25/01 -
"Statins are known to cause a rare side effect of muscle breakdown ... In a
very small percentage of patients, there is a risk of muscle breakdown resulting in kidney damage, which in rare instances can lead to life-threatening kidney failure ... The risk of muscle breakdown is greater in patients taking gemfibrozil
as well as other fibric acid derivatives (a group of cholesterol-lowering drugs), cyclosporine (an immunosuppressant), erythromycin (an antibiotic), azole antifungals, or lipid-lowering doses of niacin (nicotinic acid) together with statins including cerivastatin."
- No link between painkillers, kidney failure - USA Today, 7/18/01
- Regular Use of Pain Medicines Doesn't Damage Kidneys - WebMD, 7/17/01
- Kidney Disease Not Identified Early Enough - Doctor's Guide, 7/9/01
- Native Kidney Function More Important To Growth Is Than Dialysis Clearance - Doctor's Guide, 6/29/01
- Peritoneal Dialysis Patients May Not Be Getting Needed Anemia Treatment - Doctor's Guide, 6/29/01
- Multidisciplinary Pre-Dialysis Program Lessens Morbidity In Patients With Chronic Renal Failure - Doctor's Guide, 6/29/01
- Icodextrin Might Decrease Appetite Suppression And Malnutrition In Peritoneal Dialysis Patients - Doctor's Guide, 6/28/01
- Peritoneal Dialysis Could Be More Widely Used For Kidney Disease - Doctor's Guide, 6/28/01
- Renagel (Sevelamer) Controls Phosphorus, Avoids Cardiac Calcification in End-Stage Renal Disease - Doctor's Guide, 6/26/01
- Study Indicates Calcium-Free Kidney Drug May Ward Off Heart Trouble - Intelihealth, 6/26/01 -
"The top killer of people on dialysis is not their kidneys,
but heart disease. Some experts believe the calcium-based pills given to most kidney patients may also dangerously harden their arteries"
- Irbesartan Protects Against Kidney Disease Progression In Hypertensive Diabetics - Doctor's Guide, 6/25/01
- Pravastatin Improves Graft And Patient Survival In Kidney Transplant - Doctor's Guide, 5/28/01
- High Blood Pressure Significant Risk Factor for Kidney Rejection - Doctor's Guide, 5/28/01
- Cozaar (Losartan) Significantly Reduces Progression of Kidney Disease in Type 2 Diabetics - Doctor's Guide, 5/24/01
- Irbesartan Slows Kidney Disease In Diabetics - Doctor's Guide, 5/20/01
- Diovan (Valsartan) Effective in Reducing Microalbuminuria - Doctor's Guide, 5/17/01 -
"Diovan® (valsartan), is more effective in reducing microalbuminuria (p<0.001), an early sign of diabetic kidney disease,
compared to the calcium channel blocker, amlodipine"
- Under-Treatment of Hypertension Contributing to Chronic KidneyDisease in United States - Doctor's Guide, 5/15/01 -
"Hypertension is a leading factor in developing kidney disease. While the majority of people
in the study were treated for hypertension, only 11 percent reduced their blood pressure to recommended levels"
- Canada Approves Hectoral (Vitamin D Pro-Hormone) For End-Stage Renal Dialysis Patients - Doctor's Guide, 5/4/01
- Weighing In on Kidney Disease Linked to Obesity, Researchers Warn of 'Newly Emerging Epidemic' - WebMD, 4/26/01 -
""It's well established that obesity is related
to diabetes -- in fact 80% of diabetics are type 2, and those are almost all people who are at least overweight if not obese. And then we've shown in the past eight or nine years that ... in normal healthy individuals blood pressure goes up ... with a fairly substantial increase in weight, and if you lose weight
blood pressure comes back down. The contention is that over a period of time there's going to be a detriment to the kidneys," ... in at least some cases the proteinuria seen in people with ORG can be halted or reversed with weight loss and/or the use of blood-pressure lowering drugs called ACE-inhibitors"
- Midodrine Hydrochloride May Help Avoid Hypotension In Dialysis Patients - Doctor's Guide, 4/20/01
- Angiotensin II Antagonist Plus Conventional Treatment Improves Blood Pressure Control, Kidney Function - Doctor's Guide, 4/6/01 -
"Adding candesartan cilexetil to conventional therapy significantly reduced
albuminuria by a mean of 25 percent, fractional albumin clearance by a mean of 35 percent, 24-hour systolic blood pressure by a mean of 10 mmHg, and GFR by a mean of 5 ml/minute/1.73 m2. The mean reduction in diastolic blood pressure (3 mmHg) was not statistically significant"
- Alert: Pepcid Can Cause Sleepiness in Kidney Failure Patients - WebMD, 3/28/01 -
"The warning comes because FDA officials have verified a direct connection between levels of the drug and an increase
in creatinine, a waste product found in the urine that is considered a sign of kidney failure"
- Novel Erythropoietin Stimulating Protein Maintains Hemoglobin Concentration, Requires Less Frequent Dosing - Doctor's Guide, 10/19/00
- Daily Dialysis Improves Quality Of Life In End Stage Renal Disease - Doctor's Guide, 10/18/00
- Another Danger for Smokers: Kidney Disease - WebMD, 10/16/00
- Angiotensin-converting Enzyme Inhibitors, Beta Blockers May Postpone Kidney Failure - Doctor's Guide, 10/13/00
- FDA Approves Renagel Tablets (Sevelamer Hydrochloride) For Hemodialysis Patients - Doctor's Guide, 7/13/00
- Antihypertensive Therapy May Delay Kidney Failure In Polycystic Kidney Disease - Doctor's Guide, 3/30/00
- Carnitor Approved In US For End Stage Renal Disease - Doctor's Guide, 12/22/99
- Renal Stenting Improves Kidney Function - Doctor's Guide, 9/27/99
- Low-Protein Diet Postpones Dialysis In Chronic Kidney Failure Patients - Doctor's Guide, 2/16/99
- FDA Approves Renagel Capsules For Patients With End Stage Renal Disease - Doctor's Guide, 11/2/98
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