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Recent Longevity News for the seven days ending 7/21/10.  You should consult your doctor if you are taking any medications.

Probiotics use in mothers limits eczema in their babies - Science Daily, 7/20/10 - "compared mothers who drank one glass of probiotic milk a day to women who were given a placebo. Use of the probiotic milk -- which the mothers drank beginning at week 36 in their pregnancy up through to three months after birth -- reduced the incidence of eczema by 40 percent in children up to age two, the researchers found"

Widely used chemicals linked to ADHD in children - Science Daily, 7/20/10 - "PFCs are highly stable compounds used in industrial and commercial products like stain-resistance coatings, food packaging, and fire-fighting foams. In a 2003-2004 survey, NHANES examined 2,094 blood samples taken from the U.S. population and found more than 98 percent of the sample had detectable serum levels of PFCs, according to the study. Once absorbed into the body, it can take years for some types of PFCs to be partially eliminated ... children with this outcome tend to have higher levels of PFCs in their blood." Because the PFC measurements were collected at the same time as the parental report of ADHD diagnosis, Hoffman said it is unknown whether children with ADHD engage in behavior leading to increased PFC exposure or if higher serum PFC levels in children result in ADHD"

Prolonged mobile phone use may be linked to tinnitus - Science Daily, 7/20/10 - "Regularly using a mobile phone for at least four years seems to be associated with a doubling in the risk of developing chronic tinnitus"

Natural substance NT-020 aids aging brains in rats, study finds - Science Daily, 7/20/10 - "Aging has been linked to oxidative stress, and we have previously shown that natural compounds made from blueberries, green tea, and amino acids, such as carnosine, are high in antioxidants and have anti-inflammatory and anti-oxidative activity .... The combination of these nutrients, called NT-020, creates a synergistic effect that promotes the proliferation of stem cells in the aged animals ... NT-020 may have not only a positive effect on the stem cell niche ... NT-020 may have far-reaching effects on organ function beyond the replacement of injured cells, as demonstrated by cognitive improvement in the NT-020 group"

  • Nutrient blend improves function of aging brain: rat study - Nutra USA, 7/21/10 - "NT-020 is a combination of blueberry, green tea extract, carnosine and vitamin D3 ... The NT-020 group demonstrated increased adult neural stem cell proliferation in the two main stem cell niches in the brains and improvement in learning and memory"

Of bugs and brains: Gut bacteria affect multiple sclerosis - Science Daily, 7/20/10 - "This study shows for the first time that specific intestinal bacteria have a significant role in affecting the nervous system during MS -- and they do so from the gut, an anatomical location very, very far from the brain ... Perhaps treatments for diseases such as multiple sclerosis may someday include probiotic bacteria that can restore normal immune function in the gut… and the brain"

Painters at significantly increased risk of bladder cancer, study finds - Science Daily, 7/19/10 - "Painters are at significantly increased risk of developing bladder cancer ... plasterers, glaziers, wallpaper hangers, artists and decorators were classified as "painters" in some studies"

Do cleaning products cause breast cancer? - Science Daily, 7/20/10 - "Women who reported the highest combined cleaning product use had a doubled risk of breast cancer compared to those with the lowest reported use. Use of air fresheners and products for mold and mildew control were associated with increased risk. To our knowledge, this is the first published report on cleaning product use and risk of breast cancer" - Note:  Being exposed to chemicals is unavoidable for most people but one of my pet peeves is people that go out of their way to add them such as fabric softeners, that junk they add to the dryer that claim your clothes get softer (they both have a cheap scent that annoying to many), using scented laundry detergent (Tide make a fragrance/color free/dermatologist tested), fragrant candles, fragrant plug-in devices, etc.  I remember several years ago CNN did a segment on chemicals and they did a blood test on the reporter as part of the segment and he had something like a 100 of these chemical in his blood.  Many were from the makeup used before the camera.

Fitness, Fatness, and Blood Pressure - Medscape, 7/19/10 - "In this cohort, consisting mainly of white men (average age, 46 years), normal-weight individuals had a mean systolic blood pressure 12 mm Hg lower than obese individuals (115 vs 127 mm Hg, p<0.001). In contrast, individuals with high levels of fitness, those in the highest quartile, had a 6 mm Hg lower systolic blood pressure than those least fit (119 vs 125 mm Hg, p<0.001)"

Probiotics in pregnancy could have diabetes benefits: Study - Nutra USA, 7/16/10 - "those women who had taken probiotics had a reduced frequency of gestational diabetes mellitus (GDM): 13 percent for the diet/probiotics group, compared to 36 percent for the diet/placebo group and 34 percent for the control group ... In addition, the dietary counseling during pregnancy reduced the risk of fetal overgrowth, which is thought to predispose to later obesity" - [Abstract] - See probiotics at Amazon.com.

Those who exercise when young have stronger bones when they grow old - 5/3/10 - "those who actively did sports, and also those who used to do sports, had greater bone density than those who had never done sports ... men who had stopped training more than six years ago still had larger and thicker bones in the lower leg than those who had never done sport ... The bones respond best when you're young, and if you train and load them with your own bodyweight during these years, it has a stimulating effect on their development" - Note: That date says 5/3/10 but showed up on 7/15/10.  If it was published on the earlier date I would have picked it up then.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Nutrition and aging skin: sugar and glycation - Clin Dermatol. 2010 Jul-Aug;28(4):409-11 - "The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements"

Effects of Vitamin D Supplementation on Blood Pressure - South Med J. 2010 Jul 8 - "From 244 retrieved papers, four RCTs involving 429 participants met our inclusion criteria for this meta-analysis. Vitamin D supplementation reduced systolic blood pressure (SBP) by 2.44 mm Hg (weighted mean difference [WMD]: -2.44, 95% confidence interval [CI]: -4.86, -0.02), but not diastolic blood pressure (DBP) (WMD: -0.02, 95% CI: -4.04, 4.01) compared with calcium or placebo. Subgroup analysis suggested that the change of blood pressure did not vary markedly across the dose of vitamin D supplementation, study length, or intervention. CONCLUSIONS:: Oral vitamin D supplementation may lead to a reduction in systolic blood pressure but not diastolic blood pressure" - See vitamin D at Amazon.com.

Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study - Br J Nutr. 2010 Jun;103(12):1792-9 - "Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P = 0.003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P = 0.035 for birth weight and P = 0.028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable" - See probiotics at Amazon.com.

Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway - Biochem Biophys Res Commun. 2010 Jul 10 - "Curcumin extracted from the rhizomes of C. longa L has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the antitumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP. In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin" - See curcumin products at Amazon.com.

Egg consumption and CHD and stroke mortality: a prospective study of US adults - Public Health Nutr. 2010 Jul 16:1-10 - "'high' egg consumption (>/=7 times/week v. <1 time/week) was not associated with significantly increased CHD mortality (HR = 1.13, 95 % CI 0.61, 2.11 (men); HR = 0.92, 95 % CI 0.27, 3.11 (women)). There was a statistically significant inverse association between 'high' egg consumption and stroke mortality among men (HR = 0.27, 95 % CI 0.10, 0.73), but the estimate was imprecise because of sparse data. We did not observe a statistically significant positive association between 'high' egg consumption and CHD or stroke mortality in analyses restricted to individuals with diabetes, but these analyses may be limited due to the small number of diabetics. CONCLUSIONS: We did not find a significant positive association between egg consumption and increased risk of mortality from CHD or stroke in the US population. These results corroborate the findings of previous studies"

Intake of Fish and n-3 Fatty Acids and Future Risk of Metabolic Syndrome - J Am Diet Assoc. 2010 Jul;110(7):1018-1026 - "After controlling for potential cardiovascular risk factors, multivariate OR for metabolic syndrome was 0.43 (95% CI 0.23 to 0.83) for men who ate fish daily when compared with those eating fish less than once a week. Similarly, metabolic syndrome risk was halved for men in the top decile of n-3 fatty acid intake when compared with those in the bottom decile (OR 0.53, 95% CI 0.28 to 0.99). In particular, fish intake was significantly associated with triglyceride level and high-density lipoprotein cholesterol level among the metabolic syndrome components. For women, apparent associations were not observed between fish intake or n-3 fatty acid intake and metabolic syndrome risk. CONCLUSIONS: In a prospective study, high consumption of fish and n-3 fatty acids was significantly associated with a lower risk of metabolic syndrome among men, but not among women. Whether or not encouraging fish intake can help prevent the development of metabolic syndrome warrants further studies" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Vitamin d and risk of cognitive decline in elderly persons - Arch Intern Med. 2010 Jul 12;170(13):1135-41 - "The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25(OH)D deficient (levels <25 nmol/L) in comparison with those with sufficient levels of 25(OH)D (>/=75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted random-effects models demonstrated that the scores of participants who were severely 25(OH)D deficient declined by an additional 0.3 MMSE points per year more than those with sufficient levels of 25(OH)D. The relative risk for substantial decline on Trail-Making Test B was 1.31 (95% CI, 1.03-1.51) among those who were severely 25(OH)D deficient compared with those with sufficient levels of 25(OH)D. No significant association was observed for Trail-Making Test A. CONCLUSION: Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention" - See vitamin D at Amazon.com.

Dietary Antioxidants and Long-term Risk of Dementia - Arch Neurol. 2010 Jul;67(7):819-25 - "Compared with participants in the lowest tertile of vitamin E intake, those in the highest tertile were 25% less likely to develop dementia (hazard ratio, 0.75" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

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