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Recent Longevity News for the seven days ending 6/30/10.  You should consult your doctor if you are taking any medications.

How dietary supplement may block cancer cells - Science Daily, 6/29/10 - "The research showed that I3C causes the destruction of that molecule and thereby blocks the growth of breast cancer cells ... Cdc25A is present at abnormally high levels in about half of breast cancer cases, and it is associated with a poor prognosis ... The molecule also occurs at abnormally high levels in cancers of the breast, prostate, liver, esophagus, endometrium and colon, and in non-Hodgkin lymphoma, and in other diseases such as Alzheimer's disease ... I3C can have striking effects on cancer cells ... When the substance was given orally to the mice, it reduced tumor size by up to 65 percent. They also showed that I3C had no affect on breast-cell tumors in which the Cdc25A molecule had a mutation in that key location" - See indole 3 carbinol at Amazon.com.

ARBS and Cancer -- Are We Looking at Junk Science? - Medscape, 6/28/10 - Good video.

  • Would VALUE Cancer Data Negate Findings of Report? - Medscape, 6/25/10 - "from a pathophysiological viewpoint, the finding in the meta-analysis of increased cancer with ARBs in such a short time period--two to four years--does not make sense: it takes around 10 years to develop lung and other cancers from smoking, the hypertension doctors argue. Some said they had discussed the findings with oncologists, who think the concept is farfetched"

Statins associated with lower cancer recurrence following prostatectomy - Science Daily, 6/28/10 - "the data showed that overall, statin use reduced the risk of biochemical recurrence by 30 percent ... Among men taking statins equivalent to 20 mg of simvastatin a day, the risk of recurrence was reduced 43 percent and among the men taking the equivalent of more than 20 mg of simvastatin a day, the risk of recurrence was reduced 50 percent. Men who took a statin dose the equivalent of less than 20 mg of simvastatin daily saw no benefit"

Dark chocolate lowers blood pressure, research finds - Science Daily, 6/28/10 - "Flavanols have been shown to increase the formation of endothelial nitric oxide, which promotes vasodilation and consequently may lower blood pressure. There have, however, been conflicting results as to the real-life effects of eating chocolate. We've found that consumption can significantly, albeit modestly, reduce blood pressure for people with high blood pressure but not for people with normal blood pressure ... The pressure reduction seen in the combined results for people with hypertension, 5mm Hg systolic, may be clinically relevant -- it is comparable to the known effects of 30 daily minutes of physical activity (4-9mm Hg) and could theoretically reduce the risk of a cardiovascular event by about 20% over five years" - See flavonoids at Amazon.com.

Ingredient in red wine may prevent some blinding diseases - Science Daily, 6/26/10 - "Resveratrol -- found in red wine, grapes, blueberries, peanuts and other plants -- stops out-of-control blood vessel growth in the eye ... There are three major eye diseases that resveratrol treatment may help: age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity" - See resveratrol products at Amazon.com.

Vitamin D and mental agility in elders - Science Daily, 6/25/10 - "The participants, ages 65 to 99 years, were grouped by their vitamin D status, which was categorized as deficient, insufficient, or sufficient. Only 35 percent had sufficient vitamin D blood levels. They had better cognitive performance on the tests than those in the deficient and insufficient categories, particularly on measures of "executive performance," such as cognitive flexibility, perceptual complexity, and reasoning. The associations persisted after taking into consideration other variables that could also affect cognitive performance" - See vitamin D at Amazon.com.

High fructose, trans fats lead to significant liver disease, says study - Science Daily, 6/22/10 - "mice fed the normal calorie chow diet remained lean and did not have fatty liver disease. Mice fed high calorie diets (trans-fat alone or a combination of trans-fat and high fructose) became obese and had fatty liver disease ... it was only the group fed the combination of trans-fat and high fructose which developed the advanced fatty liver disease which had fibrosis ... This same group also had increased oxidative stress in the liver, increased inflammatory cells, and increased levels of plasma oxidative stress markers"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress - Br J Nutr. 2010 Jun 28:1-7 - "genistein (Gen) ... these results suggest that Gen confers protection against Ovx-induced neurodegeneration by attenuating oxidative stress, lipid peroxidation and the mitochondria-mediated apoptotic pathway in a region- and dose-dependent manner" - See soy isoflavones at Amazon.com.

Epigallocatechin gallate-mediated protection against tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent - Metabolism. 2010 Jun 24 - "Pretreatment with EGCG inhibited the secretion of monocyte chemoattractant protein-1 and the activation of activator protein-1 in porcine aortic endothelial cells stimulated with tumor necrosis factor-alpha. Moreover, EGCG up-regulated the expression of HO-1 and further induced the secretion of bilirubin. The observed anti-inflammatory effects of EGCG were mimicked by the HO-1 inducer cobalt protoporphyrin and abolished by HO-1 gene silencing. These data suggest that the protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling" - See green tea extract at Amazon.com.

Vitamin D Treatment for the Prevention of Falls in Older Adults: Systematic Review and Meta-Analysis - J Am Geriatr Soc. 2010 Jun 23 - "Of 1,679 potentially relevant articles, 10 met inclusion criteria. In pooled analysis, vitamin D therapy (200-1,000 IU) resulted in 14% (relative risk (RR)=0.86, 95% confidence interval (CI)=0.79-0.93; I(2)=7%) fewer falls than calcium or placebo (number needed to treat =15). The following subgroups had significantly fewer falls: community-dwelling (aged <80), adjunctive calcium supplementation, no history of fractures or falls, duration longer than 6 months, cholecalciferol, and dose of 800 IU or greater. Meta-regression demonstrated no linear association between vitamin D dose or duration and treatment effect. Post hoc analysis including seven additional studies (17 total) without explicit fall definitions yielded smaller benefit (RR=0.92, 95% CI=0.87-0.98) and more heterogeneity (I(2)=36%) but found significant intergroup differences favoring adjunctive calcium over none (P=.001). CONCLUSION: Vitamin D treatment effectively reduces the risk of falls in older adults" - See vitamin D at Amazon.com.

Effects of (-)-Epicatechin on Myocardial Infarct Size and Left Ventricular Remodeling After Permanent Coronary Occlusion - J Am Coll Cardiol. 2010 Jun 22;55(25):2869-2876 - "In the 48-h group, treatment reduced infarct size by 52%. There were no differences in hemodynamics among the different groups (heart rate and aortic and LV pressures). Western blots revealed no differences in AKT or ERK phosphorylation levels. At 3 weeks, PCO control animals demonstrated significant increases in LV end-diastolic pressure, heart and body weight, and LV chamber diameter versus sham. The PCO plus (-)-epicatechin group values were comparable with those of the sham plus (-)-epicatechin group. Treatment resulted in a 33% decrease in myocardial infarction size. The LV pressure-volume curves demonstrated a right shift in control PCO animals, whereas the (-)-epicatechin curves were comparable with those of the sham group. The LV scar area strains were significantly improved with (-)-epicatechin" - See green tea extract at Amazon.com.

Individual Isomers of Conjugated Linoleic Acid Reduce Inflammation Associated with Established Collagen-Induced Arthritis in DBA/1 Mice - J Nutr. 2010 Jun 23 - "corn oil (CO) ... Dietary c9t11- and combined-CLA similarly decreased the arthritic score (29%, P = 0.036, P = 0.049, respectively, when normalized to initial score) and paw thickness (0.11 mm, P = 0.027, P = 0.035, respectively) compared with CO. Dietary t10c12-CLA reduced the arthritic score (41%, P = 0.007 when normalized) and paw thickness (0.12 mm, P = 0.013) relative to CO. Reduced interleukin-1beta on d 7 and 21 for all CLA treatments (n = 3) relative to CO suggested that antiinflammatory effects of CLA isomers might work by common mechanisms of known pathways involved in chronic inflammation. In conclusion, dietary CLA reduced inflammation associated with CIA, and both c9t11-CLA and t10c12-CLA exhibited antiinflammatory effects" - See conjugated linoleic acid at Amazon.com.

Dietary Fiber Intake Is Associated with Reduced Risk of Mortality from Cardiovascular Disease among Japanese Men and Women - J Nutr. 2010 Jun 23 - "Total, insoluble, and soluble dietary fiber intakes were inversely associated with risk of mortality from CHD and total CVD for both men and women. For men, the multivariable HR (95% CI) for CHD in the highest vs. the lowest quintiles were 0.81 [(95% CI, 0.61-1.09); P-trend = 0.02], 0.48 [(95% CI, 0.27-0.84); P-trend < 0.001], and 0.71 [(95% CI, 0.41-0.97); P-trend = 0.04] for total, insoluble, and soluble fiber, respectively. The respective HR (95% CI) for women were 0.80 [(95% CI, 0.57-0.97); P-trend = 0.01], 0.49 [(95% CI, 0.27-0.86); P-trend = 0.004], and 0.72 [(95% CI, 0.34-0.99); P-trend = 0.03], respectively. For fiber sources, intakes of fruit and cereal fibers but not vegetable fiber were inversely associated with risk of mortality from CHD. In conclusion, dietary intakes of fiber, both insoluble and soluble fibers, and especially fruit and cereal fibers, may reduce risk of mortality from CHD"

Early physical activity promotes lower prevalence of chronic diseases in adulthood - Hypertens Res. 2010 Jun 24 - "Physical activity in youth was associated with lower rates of occurrence of arterial hypertension (odds ratio (OR)=0.42 (95% confidence interval (CI)=0.29-0.62)) and type 2 diabetes mellitus (OR=0.29 (95% CI=0.15-0.56)) in adulthood, but current physical activity was not related to these outcomes"

Hemoglobin A1c between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: The Insulin Resistance Atherosclerosis Study (IRAS) - Diabetes Care. 2010 Jun 23 - "impaired glucose tolerance (IGT) ... impaired fasting glucose (IFG) ... A1C(5.7-6.4%) is less sensitive for detecting at-risk individuals than IFG and IGT, particularly among non-Hispanic whites. Single determinations of FPG and 2-h PG appear more precise correlates of insulin resistance and secretion than A1C and in general better for other metabolic disorders"

Genistein induces growth inhibition and g2/m arrest in nasopharyngeal carcinoma cells - Nutr Cancer. 2010 Jul;62(5):641-7 - "These findings provide new insights into the potential intervention of NPC with genistein"

Multiple antimelanoma potential of dry olive leaf extract - Int J Cancer. 2010 Jun 21 - "dry olive leaf extract (DOLE) ... Taken together, the results of this study indicate that DOLE possesses strong anti-melanoma potential. When DOLE was applied in combination with different chemotherapeutics, various outcomes, including synergy and antagonism were observed" - See olive leaf extract at Amazon.com.

Aerobic fitness and multidomain cognitive function in advanced age - Int Psychogeriatr. 2010 Jun 22:1-11 - "The moderately-fit group achieved significantly better scores on the global cognitive score (U = 97, p = 0.04), and a significant correlation was found between peak VO2 and attention, executive function, and global cognitive score (rs = .37, .39, .38 respectively). The trend for superior cognitive scores in the moderate-fitness compared to the low-fitness groups was unequivocal, both in terms of accuracy and reaction time.  Conclusion: Maintenance of higher levels of cardiovascular fitness may help protect against cognitive deterioration, even at an advanced age"

Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival - Cancer Epidemiol Biomarkers Prev. 2010 Jun 15 - "After an average of 8 years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake (>/=1 versus <1 serving per month; HR for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43; 95% CI, 0.25-0.74). There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables" - See sulforaphane at Amazon.com.

Neat Tech Stuff / "How To's":

  • 4 True Matrix HDMI 1.3a Powered Switch w/ Remote Controller - At $195 it's expensive but solves a lot of home entertainment problems.  It's got four inputs, the numbers and four outputs, the letters.  For example if input one was TiVo, input two Blu-ray, input three DVD, input four karaoke and output A was the living room, output B the family room, output C the kitchen and output D the bedroom, you could select any of those four inputs from any of those room.  On the remote, if you were in the family room and you wanted Blu-ray, you would select B2 on the remote.  Plus it's 1080 resolution which you don't get from the other video outputs (second best component - the red, blue green, third best S-video, last place composite - the yellow RCA).  Monoprice also has the best prices I've seen on the required in wall HDMI cables to do that.  I've got no affiliation with them.  A Powermid or Logitech remote extender will allow the remotes to work in all the rooms.  For a long or easier HDMI cable CAT6 wire, see HDMI Over CAT5/CAT6 Wallplate Extender Kit HDMI.  Also see Arkview HDMI Extension cable over Cat5/6 RJ45 Extender adapter (Up to 200-Feet) as HDMI is a problem past 75 feet.

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