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Recent Longevity News for the seven days ending 3/17/10.  You should consult your doctor if you are taking any medications.

Coffee’s anti-diabetes benefit strengthen - Nutra USA, 3/16/10 - "coffee is one of the richest sources of polyphenols in the Western diet, with one cup of the stuff providing 350 milligrams of phenolics. Of these, the most abundant compounds coffee are chlorogenic acids, making up to 12 per cent of the green coffee bean. The most abundant of these compounds is caffeic acid ... adiponectin levels increased by 6 per cent. Adiponectin is a protein hormone linked to various metabolic processes, and levels are inversely related to body fat levels ... the impact of inflammation on the progression of diabetes may support an anti-diabetic role for the beverage" - [Abstract]

Turmeric Cream Decreases Signs of Aging - Medscape, 3/16/10 - "A new moisturizing cream containing turmeric extract, an ingredient found in curry, significantly improves the appearance of facial spots, fine lines, and wrinkles, according to results from 2 split-face studies (1 with an all-white and 1 with an all-Asian patient population) presented here at the American Academy of Dermatology 68th Annual Meeting" - See curcumin products at Amazon.com.

Studies provide more support for health benefits of coffee - Science Daily, 3/15/10 - "Although it is sometimes referred to as "the devil's brew," coffee contains several nutrients (eg, calcium) as well as hundreds of potentially biologically active compounds (eg, polyphenols) that may promote health"

Treating vitamin D deficiency significantly reduces heart disease risk, studies find - Science Daily, 3/15/10 - "Preventing and treating heart disease in some patients could be as simple as supplementing their diet with extra vitamin D ... For the first study ... 47 percent of the patients who increased their levels of vitamin D between the two visits showed a reduced risk for cardiovascular disease ... In the second study ... The patients in each category who increased their vitamin D levels to 43 nanograms per milliliter of blood or higher had lower rates of death, diabetes, cardiovascular disease, myocardial infarction, heart failure, high blood pressure, depression, and kidney failure. Currently, a level of 30 nanograms per milliliter is considered "normal" ... Increasing vitamin D intake by 1000 to 5000 international units (IU) a day may be appropriate" - See vitamin D at Amazon.com.

Magnesium may decrease colon cancer risk: Study - Nutra USA, 3/15/10 - "Intakes of the mineral of at least 327 milligrams per day were found to reduce the risk of colon cancer by 52 per cent, compared to intakes less than 238 milligrams per day, while no benefits were observed in women" - [Abstract] - See magnesium supplements at Amazon.com.

High-intensity interval training is time-efficient and effective, study suggests - Science Daily, 3/12/10 - "Doing 10 one-minute sprints on a standard stationary bike with about one minute of rest in between, three times a week, works as well in improving muscle as many hours of conventional long-term biking less strenuously ... less extreme HIT method may work well for people (the older, less fit, and slightly overweight among us) whose doctors might have worries about them exercising "all-out.""

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

High Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese Men - J Nutr. 2010 Feb 17 - "When adjusted for potential confounders, the hazard ratio and 95% CI in the highest quintile of magnesium intake compared with the lowest quintile in men were 0.65 (95% CI, 0.40-1.03) for CRC (P-trend = 0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer (P-trend = 0.01), and 0.97 (95% CI, 0.47-2.02) for rectal cancer (P-trend = 0.93)" - See magnesium supplements at Amazon.com.

Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study - Menopause. 2010 Mar;17(2):326-31 - "The fall-off in frequency of hot flashes on the 4th and 8th weeks of intervention was more evident in women receiving St John's wort, and the differences between groups were statistically significant (P = 0.005 and P < 0.001, respectively). Furthermore, comparing both study groups, we showed that the decrease in the severity of flashes in women who received St John's wort was more evident on the 4th and 8th weeks (P = 0.004 and P < 0.001, respectively). CONCLUSIONS:: St John's wort can be used as an effective treatment for the vasomotor symptoms of perimenopausal or postmenopausal women" - See St. John's wort at Amazon.com.

Effect of Niacin Therapy on Cardiovascular Outcomes in Patients With Coronary Artery Disease - J Cardiovasc Pharmacol Ther. 2010 Mar 5 - "Compared to placebo group, niacin therapy significantly reduced coronary artery revascularization (RR [relative risk]: 0.307 with 95% CI: 0.150-0.628; P = .001), nonfatal myocardial infarction ([MI]; RR: 0.719; 95% CI: 0.603-0.856; P = .000), stroke, and TIA ([transient ischemic attack] RR: 0.759; 95%CI: 0.613-0.940; P = .012), as well as a possible but nonsignificant decrease in cardiac mortality (RR: 0.883: 95% CI: 0.773-1.008; p= 0.066). CONCLUSIONS: In a meta-analysis of seven trials of secondary prevention, niacin was associated with a significant reduction in cardiovascular events and possible small but non-significant decreases in coronary and cardiovascular mortality" - See niacin at Amazon.com.

Caffeine Exposure and the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies - J Alzheimers Dis. 2010 Feb 24 - "When considering only the cohort studies, the RR was 0.80 (95%CI: 0.71-90; I;{2}=8.1%). The negative association was weaker when only women were considered (RR=0.86, 95%CI: 0.73-1.02; I;{2}=12.9%). A linear relation was observed between levels of exposure to caffeine and the RR estimates: RR of 0.76 (95%CI: 0.72-0.80; I;{2}= 35.1%) per 300 mg increase in caffeine intake. This study confirm an inverse association between caffeine intake and the risk of PD, which can hardly by explained by bias or uncontrolled confounding"

Exercise Plays a Preventive Role Against Alzheimer's Disease - J Alzheimers Dis. 2010 Feb 24 - "Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders"

Caffeine Intake is Associated with a Lower Risk of Cognitive Decline: A Cohort Study from Portugal - J Alzheimers Dis. 2010 Feb 24 - "Caffeine intake (> 62 mg/day [3rd third] vs. < 22 mg/day [1st third]) was associated with a lower risk of cognitive decline in women (RR=0.49, 95%CI 0.24-0.97), but not significantly in men (RR=0.65, 95%CI 0.27-1.54)" - Note:  I don't know how they determine that 0.65 isn't significant.

Caffeine as a Protective Factor in Dementia and Alzheimer's Disease - J Alzheimers Dis. 2010 Feb 24 - "In the CAIDE study, coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life. In conclusion, coffee drinking may be associated with a decreased risk of dementia/AD. This may be mediated by caffeine and/or other mechanisms like antioxidant capacity and increased insulin sensitivity. This finding might open possibilities for prevention or postponing the onset of dementia/AD"

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