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Recent Longevity News for the seven days ending 11/25/09.  You should consult your doctor if you are taking any medications.

Polyphenols and polyunsaturated fatty acids boost the birth of new neurons, study finds - Science Daily, 11/24/09 - "a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells ... mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus, both of which are greatly damaged in patients with Alzheimer's disease ... Polyphenols can be found in tea, beer, grapes, wine, olive oil, cocoa, nuts and other fruits and vegetables. Polyunsaturated fatty acids can be found in blue fish and vegetables such as corn, soya beans, sunflowers and pumpkins"

Dietary Antioxidants Could Help Preserve Muscle Strength in Older Adults - Medscape, 11/23/09 - "In a study in older adults, dietary intake of vitamins C and E was linked with muscle strength, leading the researchers to suggest at a meeting in Atlanta this past weekend that a diet high in antioxidants could play an important role in preserving muscle function in older adults ... Muscle strength is really a marker of aging ... Muscle strength starts declining when people are in their 40s, but it decreases dramatically after age 60 ... At this point, it's not clear whether vitamins C and E specifically help preserve muscle strength, or if intake of these micronutrients is a marker of a healthy diet"

Alzheimer's: Destructive amyloid-beta protein may also be essential for normal brain function - Science Daily, 11/23/09 - "Alzheimer's disease is thought to be caused by the build-up of a brain peptide called amyloid-beta. That's why eliminating the protein has been the focus of almost all drug research pursuing a cure for the devastating neurodegenerative condition ... amyloid-beta is also necessary to maintain proper brain functioning"

Fat around the middle increases the risk of dementia - Science Daily, 11/23/09 - "Anyone carrying a lot of fat around the middle is at greater risk of dying prematurely due to a heart attack or stroke ... If they nevertheless manage to live beyond 70, they run a greater risk of dementia ... women who were broader around the waist than the hips in middle age ran slightly more than twice the risk of developing dementia when they got old"

Multiple health concerns surface as winter, vitamin D deficiences arrive - Science Daily, 11/23/09 - "About 70 percent of the population of the United States has insufficient levels of vitamin D" - See vitamin D at Amazon.com.

Resveratrol could prove HRT alternative, study - Nutra USA, 11/23/09 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein ... Because it (resveratrol) stimulated the transcription of endogenous estrogen receptor (ER) and proapoptotic effects, this phytoestrogen is the most promising candidate as an HRT alternative and chemopreventive reagent for breast cancer ... The researchers added that their results indicated that daidzein causes a slight cell-stimulating effect in the absence of E2, which may lead to an increased risk of breast cancer in postmenopausal women taking supplements containing these phytoestrogens" - [Abstract] - See resveratrol products at Amazon.com.

Antioxidant found in vegetables has implications for treating cystic fibrosis - 11/20/09 - "a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration ... the antioxidant thiocyanate normally existing in the body protects lung cells from injuries caused by accumulations of hydrogen peroxide and hypochlorite, the active ingredient in household bleach. These potentially harmful chemicals are made by the body as a reaction to infection and injury. In addition, thiocyanate also protects cells from hypochlorite produced in reactions involving MPO, an enzyme released from germ-fighting white blood cells during inflammation"

Artificial Sweetener May Lower Blood Pressure - WebMD, 11/20/09 - "Systolic blood pressure dropped an average of 6.9 points in the OFS group, compared with 3.5 in the placebo group ... Diastolic blood pressure decreased an average of 7.3 points in the OFS group vs. 2.3 in the placebo group ... Levels of total cholesterol, low-density lipoprotein ( LDL or “bad” cholesterol), and triglycerides also dropped more in participants given OFS than in those who took placebo tablets" - See:

  • Fructooligosaccharide - Wikipedia, the free encyclopedia - "Fructooligosaccharides (FOS) also sometimes called oligofructose or oligofructan, is a class of oligosaccharides used as an artificial or alternative sweetener. FOS exhibits sweetness levels between 30 and 50 percent of sugar in commercially-prepared syrups. [1] Its use emerged in the 1980s in response to consumer demand for healthier and calorie-reduced foods. The term oligosaccharide refers to a short chain of sugar molecules (in the case of FOS, fructose molecules). Oligo means few, and saccharide means sugar"
  • See inulin at Amazon.com.

Green Tea May Prevent Kidney Stones - WebMD, 11/20/09 - "The results showed that as the amount of green tea extract applied increased, the calcium oxalate crystals became flatter and flatter ... Researchers say flatter crystals form less stable kidney stones that break up more easily" - See green tea extract at Amazon.com.

Common plastics chemicals -- phthalates -- linked to ADHD symptoms - Science Daily, 11/19/09 - "Researchers found a significant positive association between phthalate exposure and ADHD, meaning that the higher the concentration of phthalate metabolites in the urine, the worse the ADHD symptoms and/or test scores" - Also see:

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells - J Nutr Biochem. 2009 Oct 2 - "While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein. Moreover, resveratrol significantly enhanced p53-dependent transcriptional activity, but slightly reduced NF-kappaB-dependent transcriptional activity. On knockdown analysis, genistein, resveratrol and glycitein all reduced the Bcl-2/Bax ratio in the presence of apoptosis-inducing stimuli, and estrogen receptor (ER) alpha silencing had no effect on these reductions. In contrast, in the absence of apoptosis-inducing stimuli, only resveratrol reduced the ratio, and ERalpha silencing abolished this reduction. Thus, resveratrol might be the most promising candidate for HRT and chemoprevention of breast cancer due to its estrogenic activity and high antitumor activity" - See resveratrol products at Amazon.com.

Low Total and Nonheme Iron Intakes Are Associated with a Greater Risk of Hypertension - J Nutr. 2009 Nov 18 - "Low nonheme iron intake at baseline was associated with a greater increase in systolic BP (SBP) and pulse pressure over time after adjustment for multiple possible confounding factors (P-trend = 0.002 and 0.0005, respectively). Conversely, participants in the 3rd tertile of nonheme iron intake at baseline had a 37% lower risk of hypertension after 5.4 y of follow-up compared with those in the first tertile (P-trend = 0.04). Heme iron intake was not associated with BP changes or risk of hypertension. Meat intake was positively associated with an increase in SBP (P-trend = 0.04). However, that relation became nonsignificant after adjusting for dietary pattern scores. Baseline hemoglobin and ferritin concentrations were not associated with changes in BP or incidental hypertension. Our data support a possible role of low nonheme iron intake, independent of heme iron intake, in the development of hypertension"

Efficacy of testosterone gel in the treatment of erectile dysfunction in hypogonadal hemodialysis patients: a pilot study - Int J Impot Res. 2009 Nov 19 - "T administration significantly increased serum T levels to the normal range, and was associated with statistically significant improvements of the scores of the IIEF domains (erectile function from 7.6+/-8.0 to 12.8+/-7.8; intercourse satisfaction from 3.4+/-4.5 to 4.8+/-3.1; orgasmic function from 4.8+/-3.1 to 3.4+/-2.9; sexual desire from 3.4+/-2.9 to 4.4+/-0.6; overall sexual satisfaction from 2.6+/-1.3 to 3.8+/-1.0). But scores of the IIEF did not normalize. Frequency of weekly sexual intercourse increased from 0.4+/-0.4 to 1.1+/-0.8 (P<0.05) after 6 months. There were no adverse effects" - Note:  One problem with testosterone administration is that it increased estradiol by about the same percentage.  I'm 60 years old and my testosterone was above the limits just by taking a half tablet of letrozole per day.  I've cut it to a quarter tablet but haven't had it rechecked.  Letrozole has been shown to double or triple testosterone and lower estrogen at the same time plus there's not the testicle shrinkage problem that some claim (click here) is only from watching the view (joke).  Some studies indicate that you might want to keep estrogen around 25 for men.  See letrozole at OffshoreRx1.com.  See:

  • Androgel prescribing information - androgel.com - "Serum estradiol (E2) concentrations increased significantly within 30 days of starting treatment with AndroGel 5 or 10 g/day and remained elevated throughout the treatment period but remained within the normal range for eugonadal men"
  • High, Low Estradiol Levels and Mortality in Men With Systolic HF - Medscape, 5/19/09 - "Both low and high serum levels of estradiol, compared with mid-range levels, are significantly and independently associated with increased all-cause mortality in men with chronic systolic heart failure"
  • Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men - Eur J Endocrinol. 2008 Dec 2 - "Ten elderly and nine young healthy men were randomized to receive letrozole 2.5 mg daily or placebo for 28 days in a crossover design. Results: Both in young and elderly men, active treatment significantly increased serum testosterone (+128 and +99%, resp.) and decreased estradiol levels (-41 and -62%, resp.). Fasting glucose and insulin levels decreased in young men after active intervention (-7 and -37%, resp.) compared to placebo. Leptin levels fell markedly in both age groups (-24 and -25%, resp.), while adiponectin levels were not affected by the intervention. Lipid profile was slightly impaired in both groups, with increasing LDL-cholesterol levels (+14%) in the younger age group and 10% lower levels of ApoA1 in the elderly. A decline in IGF-1 levels (-15%) was observed in the younger age group. No changes in weight or BMI were observed in either young or old men"
  • Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism - Eur J Endocrinol. 2008 May;158(5):741-7 - "Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process ... treated with 2.5 mg letrozole once a week for 6 months ... Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men ... Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended"
  • Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition - J Clin Endocrinol Metab. 2005 Oct;90(10):5717-22 - "As assessed after 28 d of treatment, letrozole lowered E2 by 46% in the young men (P = 0.002) and 62% in the elderly men (P < 0.001). In both age groups, letrozole, but not placebo, significantly increased LH levels (339 and 323% in the young and the elderly, respectively) and T (146 and 99%, respectively) (P value of young vs. elderly was not significant). Under letrozole, peak LH response to GnRH was 152 and 52% increase from baseline in young and older men, respectively"
  • Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism - Diabetes Obes Metab. 2005 May;7(3):211-5 - "Six weeks of treatment decreased serum estradiol from 120 +/- 20 to 70 +/- 9 pmol/l (p = 0.006). None of the subjects developed an estradiol level of less than 40 pmol/l. LH increased from 4.5 +/- 0.8 to 14.8 +/- 2.3 U/l (p < 0.001). Total testosterone rose from 7.5 +/- 1.0 to 23.8 +/- 3.0 nmol/l (p < 0.001) without a concomitant change in sex hormone-binding globulin level. Those treated with Letrozole 17.5 mg per week had an excessive LH response"

Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat - Diabetes Obes Metab. 2009 Nov 16 - "n-3 PUFA treatment resulted in a significant improvement (i.e. decrease) in the postprandial response for triglyceride (45%) (p < 0.05), apoB48 (45%) (p < 0.03) and LBP (33%) (p < 0.05) compared to controls (measured as area under the clearance curve). In contrast, we observed a significant elevation in postprandial haptoglobin (165%) (p < 0.001) in obese rats supplemented with 10% n-3 PUFA. Treatment with 5% n-3 PUFA in the JCR:LA-cp obese animals resulted in a complementary decrease in total body weight gain (6%) (p < 0.001) and an increase (i.e. improvement) in adiponectin (33%) (p < 0.05) compared to controls, without a concomitant reduction in food intake" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones - Diabetes Obes Metab. 2009 Nov 17 - "A composite of combined placebo and comparator controlled trials demonstrated a significant weighted mean difference of-0.06 mm for CIMT (95% CI-0.09 to-0.02, p = 0.001) and-0.72 ms(-1) for PWV (95% CI-1.28 to-0.16, p = 0.011) in favour of thiazolidiendione treatment" - Note:  I still take pioglitazone for anti-aging.  See my Insulin and Aging page.  See  pioglitazone at OffshoreRx1.com.

Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men - Cancer Causes Control. 2009 Nov 18 - "Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30-0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC" - See vitamin D at Amazon.com.

Health Focus (C-reactive protein):

Related Topics:

Alternative News:

  • Serum vitamin C concentration and hs-CRP level in middle-aged Japanese men and women - Atherosclerosis. 2009 Aug 7 - "Inverse associations between serum vitamin C concentrations and hs-CRP levels were established for both men and women. Multivariable-adjusted mean values of hs-CRP for the lowest to highest quintiles of vitamin C levels were 0.75, 0.65, 0.61, 0.61 and 0.47mg/L (P for trend <0.001) for men, and 0.56, 0.51, 0.49, 0.41 and 0.41mg/L (P for trend <0.001) for women. The inverse association between vitamin C and hs-CRP was stronger for non-smoking men and women, non-overweight women and postmenopausal women ... Serum vitamin C concentrations were found to be inversely associated with hs-CRP levels in both men and women, primarily among non-smokers, non-overweight women and postmenopausal women"
  • Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals - Eur J Clin Nutr. 2009 Apr 8 - "The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 DHA boost for heart health in high-risk men: Study - Nutra USA, 3/6/09 - "supplementation with DHA for 45 days resulted in decreased levels of the number of circulating white blood cells (neutrophils) by 11.7 per cent, and these reductions were maintained until the end of the 90-day study (10.5 per cent reduction) ... levels of C-reactive protein (CRP) had decreased by 15 per cent, and IL-6 had decreased by 23 per cent ... Furthermore, levels of the anti-inflammatory matrix metalloproteinase-2 rose by 7 per cent ... In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men - J Nutr. 2009 Jan 21 - "DHA supplementation for 45 and 91 d decreased the number of circulating neutrophils by 11.7 and 10.5%, respectively (P < 0.05). It did not alter the circulating concentrations of other inflammatory markers tested within 45 d, but at 91 d it reduced (P < 0.05) concentrations of C-reactive protein (CRP) by 15%, interleukin-6 by 23%, and granulocyte monocyte-colony stimulating factor by 21% and DHA increased the concentration of antiinflammatory matrix metalloproteinase-2 by 7%. The number of circulating neutrophils was positively associated with the weight percent (wt %) of 20:4(n-6) in RBC lipids, and negatively to the wt % of 20:5(n-3) and 22:6(n-3). Concentrations of CRP and serum amyloid A were positively associated with the sum of SFA and negatively with the wt % of 18:1(n-9) and 17:0 in RBC lipids; CRP was also positively associated with the wt % of 20:2(n-6). The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - See Jarrow Max DHA at Amazon.com.
  • Inflamed Gums Linked To Heart Disease - Science Daily, 12/20/08 - "a protein associated with inflammation (called CRP) is elevated in people who are at risk for heart disease. But where's the inflammation coming from? ... infected gums may be one place ... something as simple as taking good care of your teeth and gums can greatly reduce your risk of developing serious diseases"
  • Pine bark extract may help joints and hearts: Study - Nutra USA, 12/11/08 - "The decrease of systemic inflammatory markers, particularly CRP, suggests Pycnogenol properties may be potent enough to arrest the spread of inflammation from osteoarthritic joints to the whole organisms ... subjects received either two daily doses of 50 mg Pycnogenol or placebo for three months ... people receiving the pine bark extract experienced significant reductions in CRP levels from an average of 3.9 mg/L at the start of the study to 1.1 mg/L after three months. This is equivalent to a 71 per cent reduction ... Moreover, a reduction in the blood levels of reactive oxygen species (ROS) of 30 per cent was recorded" - See Pycnogenol at Amazon.com.
  • Vitamin C Lowers Levels Of Inflammation Biomarker Considered Predictor Of Heart Disease - Science Daily, 11/14/08 - "for people with elevated CRP levels, the amount of CRP reduction achieved by taking vitamin C supplements in this study is comparable to that in many other studies of cholesterol-lowering drugs called statins. They noted that several larger statin trials lowered CRP levels by about 0.2 milligrams per liter; in this latest study, vitamin C lowered CRP by 0.25 milligrams per liter" - See vitamin C products at Amazon.com.
  • Vitamin C-lipid metabolites: Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers - Med Sci Monit. 2008 Nov;14(11):CR547-551 - "ascorbic acid (AA), calcium ascorbate (CaA) ... PureWay-C(R) supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C(R). PureWay-C(R) provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C(R) shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C(R) also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C(R) is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C(R)" - See vitamin C products at Amazon.com.
  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • What Else May Probiotics Do In Adults? - Science Daily, 5/20/08 - "It was found that probiotics have an anti-inflammatory potential seen as a decrease in serum CRP levels and as a reduction in bacteria-induced production of proinflammatory cytokines in peripheral blood mononuclear cells"
  • Whole Grains Shrink Belly Fat? - Dr. Weil, 3/31/08 - "the whole grains may have helped by stabilizing the dieters' blood sugar, which in turn may have had a beneficial effect on CRP levels"
  • Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in u.s. Adults - J Nutr. 2008 Apr;138(4):753-60 - "Among the flavonoid compounds investigated, quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had inverse associations with serum CRP concentration"
  • Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers - Atherosclerosis. 2008 Mar 14 - "Sufficient dietary intake of n-3PUFA may attenuate inflammatory reaction and this effect is more evident among high-risk populations such as male smokers although the small numbers of female ex-smokers and nonsmokers limited statistical power to draw strong conclusions about these groups" - See Mega Twin EPA at Amazon.com.
  • Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study - Am J Clin Nutr. 2008 Feb;87(2):424-30 - "Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha" - See citicholine at Amazon.com.
  • The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome - J Clin Nutr. 2008 Jan;87(1):79-90 - "Both hypocaloric diets were effective means of improving CVD risk factors with moderate weight loss. There were significantly (P < 0.05) greater decreases in CRP and percentage body fat in the abdominal region in participants consuming whole grains than in those consuming refined grains"
  • More support for whole grains for healthy hearts - Nutra USA< 1/7/08 - "25 women and 25 men (average age 46, average BMI 35.8 kg per sq. m) were assigned to consume a reduced calorie diet (reduced by 500 kcal/d) with half of the subjects then randomly assigned to obtain all of their grain servings from whole grains or to avoid wholegrain foods for 12 weeks ... CRP levels fell by 38 per cent in the whole-grain"
  • The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome - Int J Clin Pract. 2007 Nov;61(11):1942-8 - "After 52 weeks of treatment, there was a change of carotid IMT of +0.009 +/- 0.003 mm in the placebo group and -0.005 +/- 0.002 mm in the niacin group (p = 0.021 between groups). Endothelial function improved by 22% in the group treated with niacin (p < 0.001), whereas no significant changes were seen in the placebo group. High sensitivity C-reactive protein decreased by 20% in the group treated with niacin for 52 weeks (p = 0.013). Niacin increased HDL-C (p < 0.001) and decreased low-density lipoprotein cholesterol and triglycerides (p < 0.001) significantly, and there were no adverse effects on fasting glucose levels after 52 weeks of treatment" - See niacin at Amazon.com or niacin at Amazon.com.
  • Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007 Jun 29 - "Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis"
  • Effect of a High-Fiber Diet vs a Fiber-Supplemented Diet on C-Reactive Protein Level - Arch Intern Med. 2007 Mar 12;167(5):502-6 - "Overall, the mean C-reactive protein (CRP) level changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the high-fiber DASH diet group and to 3.6 mg/L (-18.1%) in the fiber-supplemented diet group ... fiber intake of about 30 g/d) from a diet naturally rich in fiber or from a supplement can reduce levels of CRP"
  • High-Fiber Diets, Fiber Supplements Reduce CRP Levels - Medscape, 3/14/07 - "The participants were then randomized to either the DASH (Dietary Approaches to Stop Hypertension), high-fiber diet (mean intake, nearly 28 g of fiber per day), or to a fiber supplement (psyllium) on top of their regular diet (mean intake, totaling 27 g/day). After 3 weeks on one diet, participants crossed over to the other fiber diet ... Overall, the mean CRP level changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the high-fiber DASH diet group and to 3.6 mg/L (-18.1%) in the fiber-supplemented diet group (P = .02)"
  • Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products - Am J Clin Nutr. 2006 Jul;84(1):223-9 - "Greater intake of n-3 PUFAs derived from marine products, as measured with a self-administered questionnaire, was independently related to a lower prevalence of high CRP concentrations in this older Japanese population with a diet rich in marine products. Our findings suggest that even very high intakes of n-3 PUFAs may lower serum CRP concentrations"
  • Does Inflammation Cause Heart Disease? - Dr. Weil, 5/18/06
  • Assessing Inflammation Levels? - Dr. Weil, 5/16/06
  • Fiber Good, and Not Just for Your Gut - WebMD, 4/13/06 - "Compared with those who ate the least fiber, those who ate the most were 63% less likely to have high levels of C-reactive protein (CRP)"
  • Vitamin C could reduce inflammation - Nutra USA, 3/8/06 - "High blood levels of vitamin C were associated with a 45 per cent reduced risk of inflammation (with respect to CRP levels)"
  • Fish Help the Heart by Fighting Inflammation - WebMD, 7/5/05 - "compared with those who said they didn't eat fish, those who ate at least 10.5 ounces of fish per week had 33% lower C-reactive protein and 33% lower tumor necrosis factor-alpha (another indicator of inflammation) levels as well as much lower levels of other signs of inflammation"
  • Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects - Br J Nutr. 2005 May;93(5):619-25 - "dietary TAC is inversely and independently correlated with plasma concentrations of hs-CRP and this could be one of the mechanisms explaining the protective effects against CVD of antioxidant-rich foods such as fruits, whole cereals and red wine"
  • Study links good carbs to healthier hearts - MSNBC, 5/2/05 - "the CRP levels of women whose diets consisted primarily of refined grains were 10 percent higher than women who consumed a lot of good carbs such as fiber-rich whole grains, fruits and vegetables"
  • Exercise May Reduce Metabolic Syndrome Risks - WebMD, 11/15/04 - "physical fitness was associated with lower levels of an inflammation marker associated with heart disease, known as C-reactive protein"
  • New Research: What is Your Optimal TSH Level? - About.com, 9/30/04 - "normalizing the TSH with a target TSH level of less than 2 mIU/mL is advisable to lower CRP levels and homocysteine levels, and possibly the cholesterol levels"
  • Red Wine Beats Gin for Heart Health - WebMD, 8/13/04 - "those who drunk red wine also had lower levels of C-reactive protein and two other inflammatory markers"
  • Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk - Am J Clin Nutr. 2004 Jun;79(6):992-8 - "Low concentrations of pyridoxal-5'-phosphate (PLP), the active metabolite of vitamin B-6, are associated with high C-reactive protein (CRP) concentrations"
  • Vitamin C supplement to beat diabetes and heart disease - Nutra USA, 4/14/04 - "Researchers at the University of California say that participants who took about 500 milligrams of vitamin C supplements per day saw a 24 per cent drop in plasma C-reactive protein (CRP) levels after two months" - See iHerb or Vitacosticon vitamin C products.
  • Reduction of C-reactive protein levels through use of a multivitamin - Am J Med. 2003 Dec 15;115(9):702-7 - "multivitamin use was associated with lower C-reactive protein levels"
  • Mediterranean Diet Lowers C-reactive Protein Levels - Medscape, 11/11/03 - "For each 10-point increase in diet score, there was a corresponding 0.22 mg/dL reduction in C-reactive protein levels, a 0.21 pg/ml reduction in interleukin-6, a 12.5 mg/dL decrease in fibrinogen, and a 0.87 mmol/L decrease in homocysteine levels (P < .05), he said. Also, white blood cell count decreased significantly"
  • Dietary Changes Can Reduce Cholesterol and C-Reactive Protein as Much as Medication - New Hope Natural Media, 9/18/03 - "One group was treated with a statin medication (20 mg of lovastatin per day) and another received placebo. A third group ate a modified daily diet that included an additional 2 grams of plant sterols provided in a margarine, 20 grams of insoluble fiber from psyllium, oats and barley, 43 grams of soy protein from soy milk and soy meat-substitutes, and 1 ounce of whole almonds. At the end of the study, total cholesterol levels had decreased 6% in the placebo group, 23% in the statin group and 22% in the modified-diet group. Levels of LDL-cholesterol dropped 8% in the placebo group, 31% in the statin group and 29% in the modified-diet group. CRP levels decreased 10% in the placebo group, 33% in the statin group and 28% in the modified-diet group"
  • Inflammation Syndrome a Red-Hot Topic - Natural Foods Merchandiser, 9/03 - "What are some of the key anti-inflammatory supplements? ... At the top of the list are omega-3 fish oils, gamma-linolenic acid (GLA, an omega-6 fat that behaves more like an omega-3) and vitamin E. Several studies have shown that natural vitamin E supplements lower CRP levels by 30 percent to 50 percent"
  • Weight Loss Eases Harmful Inflammation - WebMD, 2/4/02 - "They measured levels of a blood chemical called "C-reactive protein," or CRP. This chemical goes up when inflammation in the body rises. Then, 25 of the women were put on a weight-loss program ... On average, CRP levels fell by 32% after a weight loss of about 33 pounds over 14 months"
  • Inflammation and Heart Disease - Life Extension Magazine, 1/01
  • Diet and Exercise Alone Shown to Lower C-Reactive Protein - Doctor's Guide, 11/14/01 - "Hs-CRP, a marker of low level inflammation, has been found to be a strong predictor of myocardial infarction and stroke in men and women, as well as subsequent clinical events in patients following major cardiac events ... a structured program involving a low-fat, Mediterranean diet and a supervised, three-times weekly exercise program for three months ... Values of hs-CRP dropped 31 percent after the three months ... body fat was reduced by 5 percent ... exercise capacity improved 36 percent"
  • A Prescription for Alarm - Nutrition Science News, 9/01 - "Taking natural vitamin E supplements to reduce levels of C-reactive protein, an inflammatory compound that increases the risk of heart disease by 4.5 times.  Heart disease is increasingly viewed as a disease of blood-vessel inflammation"
  • Enzymes Can Hasten Pain Relief - Nutrition Science News, 2/01 - "Enzymes work not by stopping or blocking inflammation, but by supporting and quickening the process . . . By the third day after the operation, levels of C-reactive protein—a measure of inflammation - were threefold higher in the control group"

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