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Recent Longevity News for the seven days ending 1/14/09.  You should consult your doctor if you are taking any medications.

Study: DHA supplements may help premature baby girls - USATODAY.com, 1/13/09 - "premature girls given the high-DHA diet scored about 5 points higher on a 100-point test, which translates to a 55% reduction in the proportion of girls with a "mild mental delay" and an 80% reduction in the proportion of girls with "significant" mental delay" - See Jarrow Max DHA at Amazon.com.

Hormone Therapy Linked to Brain Shrinkage, But Not Lesions - Doctor's Guide, 1/13/09 - "Two new studies show that hormone therapy for women is linked to brain shrinkage, but not to small vascular lesions in the brain"

Vitamin D Is The 'It' Nutrient Of The Moment - Science Daily, 1/12/09 - "Vitamin D is quickly becoming the "it" nutrient with health benefits for diseases, including cancer, osteoporosis, heart disease and now diabetes ... Diet alone may not be sufficient to manage vitamin D levels" - See vitamin D at Amazon.com.

CoQ10 bioavailability boost from soft gels: Study - Nutra USA, 1/12/09 - "Researchers from Canada’s KGK Synergize compared CoQ10 formulations from hard and soft gel capsules, and found the reduced form from the latter resulted in a 3.3-fold higher blood level of CoQ10 than the former ... formulated by Soft Gel Technologies" - See iHerb search of "Soft Gel Technologies".  I'm sticking with QH-Absorb by Jarrow because I don't trust the NOW brand.  I feel that it probably just hasn't been studied yet.

Protein That Regulates Hormones Critical To Women's Health Found In Pituitary - Science Daily, 1/12/09 - "Jackson's interest in the effects of oxytocin, also known as the "love hormone," ... Viagra acts in the posterior pituitary by enabling electrical impulses to release more oxytocin"

Antipsychotic Drugs Double Risk Of Death Among Alzheimer's Patients - Science Daily, 1/8/09 - "New research into the effects of antipsychotic drugs commonly prescribed to Alzheimer’s patients concludes that the medication nearly doubles risk of death over three years"

For Fats, Longer May Not Be Better - Science Daily, 1/8/09 - "Researchers have uncovered why some dietary fats, specifically long-chain fats, such as oleic acid (found in olive oil), are more prone to induce inflammation. Long-chain fats, it turns out, promote increased intestinal absorption of pro-inflammatory bacterial molecules called lipopolysaccharides (LPS)"

Homocysteine may be best predictor of CV risk in elderly - theheart.org, 1/8/09 - "for primary prevention, homocysteine appears to be the best predictor of cardiovascular mortality in the very elderly [1]. The research also confirms what many had already suspected—that the Framingham Risk Score (FRS) is not very accurate at predicting risk in this age group"

Hormone Therapy Associated With Reduced Colorectal Cancer Risk - Science Daily, 1/8/09 - "The combination of estrogen plus progestin, which women stopped taking in droves following the news that it may increase their risk of breast cancer, may decrease their risk of colorectal cancer ... Any use of estrogen therapy was associated with a 17 percent reduced risk in colorectal cancer. Among those who used estrogen, the largest reductions were seen among those who were current users (25 percent reduced risk) and users of ten or more years duration (26 percent reduced risk)"

Chemopreventive Agents In Black Raspberries Identified - Science Daily, 1/8/09 - "anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated apoptosis in the esophagus of rats treated with an esophageal carcinogen" - [Nutra USA]

Best Bottled Water? - Dr. Weil, 1/8/09 - "Two systems that I use personally are the D-3 distiller from Glacier Water Treatment Systems, and the Purefecta System from Pall Corp. I also like cheaper carbon block/KDF systems" - See water distillers at Amazon.com.

Coffee may protect against oral cancers - MSNBC, 1/6/09 - "drinking coffee lowers the risk of developing cancer of the oral cavity or throat ... cancer of the mouth, pharynx and esophagus .... Compared with people who did not drink coffee, those who drank one or more cups per day had half the risk of developing these cancers ... the reduction in risk included people who are at high risk for these cancers, namely, those who were current drinkers and/or smokers at the start of the study"

Vitamin C and BP - Medscape, 1/6/09 - "plasma vitamin-C concentrations were inversely associated with blood pressure in young women [1]. The results suggest that this nutrient may favorably influence blood pressure in healthy young adults ... plasma ascorbic acid at year 10 was inversely associated with systolic and diastolic BP. Those in the highest quartile of plasma vitamin C had 4.66-mm-Hg lower systolic BP and 6.04-mm-Hg lower diastolic BP (p=0.0002) than those in the lowest quartile ... Block says she has recently authored two papers detailing possible mechanisms by which vitamin C could lower BP. These show that vitamin C significantly lowers F2-isprostane, a marker of oxidative stress, and CRP, a marker of inflammation [2,3]. "Both inflammation and oxidative stress are pretty well established as having a role in hypertension ... Vitamin C is a powerful antioxidant in vitro, and in some animal studies it has been shown to act as a vasodilator, possibly by enhancing the bioavailability of nitric oxide" - See vitamin C products at Amazon.com.

Old Gastrointestinal Drug Slows Aging, Researchers Say - Science Daily, 1/6/08 - "Recent animal studies have shown that clioquinol – an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases ... clioquinol acts directly on a protein called CLK-1, often informally called "clock-1," and might slow down the aging process ... Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging ... clioquinol was withdrawn from the market after being blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. However, because no rigorous scientific study was conducted at the time, and because clioquinol was used safely by millions before and after the Japanese outbreak, some researchers think its connection to SMON has yet to be proven" - I Googled clioquinol and I don't think it's available anywhere.

High Systolic Pressure a Positive Sign in Chronic Heart Failure - Medscape, 1/5/09 - "In patients with chronic heart failure, higher systolic blood pressures paradoxically predict better survival ... The decrease in mortality rates associated with a 10 mm Hg higher systolic blood pressure was 13.0%...in the heart failure population ... in patients with cardiac disease but without chronic heart failure affecting systolic function, mean arterial blood pressure is largely determined by peripheral vasoconstriction, and higher systolic pressure indicates poor elasticity of the arteries ... In patients with heart failure, however, systolic pressure reflects the ejection fraction and cardiac output ... a higher blood pressure is associated with a decreased mortality as it serves as an indirect measure of cardiac function"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Green tea, black tea consumption and risk of lung cancer: A meta-analysis - Lung Cancer. 2009 Jan 5 - "For green tea, the summary RR indicated a borderline significant association between highest green tea consumption and reduced risk of lung cancer (RR=0.78, 95% CI=0.61-1.00). Furthermore, an increase in green tea consumption of two cups/day was associated with an 18% decreased risk of developing lung cancer (RR=0.82, 95% CI=0.71-0.96). For black tea, no statistically significant association was observe through the meta-analysis (highest versus non/lowest, RR=0.86, 95% CI=0.70-1.05; an increment of two cups/day, RR=0.82, 95% CI=0.65-1.03). In conclusion, our data suggest that high or an increase in consumption of green tea but not black tea may be related to the reduction of lung cancer risk" - See green tea extract at Amazon.com.

Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes - Atherosclerosis. 2008 Dec 6 - "In patients with type 2 diabetes already on metformin, addition of pioglitazone as compared to glimepiride, improved endothelial function despite similar glycemic control. The improvement in endothelial function was mainly due to a reduction in insulin resistance"

Breast cancer cell response to genistein is conditioned by BRCA1 mutations - Biochem Biophys Res Commun. 2009 Jan 3 - "We showed that growth of BRCA1 mutant cells was strongly inhibited by genistein whereas it only had a weak effect in cells expressing wild-type BRCA1 protein. BRCA1 mutant cells hypersensitivity could be linked to higher expression of ERbeta gene, which suggests that genistein may be an efficient inhibitor of cancer development in BRCA1 mutant breast cancer cells"

Prospective cohort study of lifetime physical activity and breast cancer survival - Int J Cancer. 2008 Nov 17 - "A decreased risk of breast cancer death and all deaths was observed among women in the highest versus the lowest quartiles of recreational activity"

Green tea drinking, high tea temperature and esophageal cancer in high- and low-risk areas of Jiangsu Province, China: A population-based case-control study - Int J Cancer. 2008 Nov 6 - "Results showed that ever drinking green tea elevated OR in both counties (Dafeng OR = 1.2, 95% CI = 0.9-1.5; Ganyu: OR = 1.9, 95% CI = 1.4-2.4). Drinking tea at high temperature was found to increase cancer risk in both areas (Dafeng: OR = 1.9, 95% CI = 1.2-2.9; Ganyu OR = 3.1 95% CI = 2.2-4.3). However, after further adjustment for tea temperature, ever drinking tea was not related to cancer in either county (Dafeng: OR = 1.0, 95% CI = 0.7-1.3; Ganyu: OR = 1.3, 95% CI = 0.9-1.7). For dose-response relationships, we observed positive relationship with monthly consumption of tea (p for trend = 0.067) and tea concentration (p for trend = 0.006) after further adjustment for tea temperature. In conclusion, green tea drinking was not inversely associated with esophageal cancer in this study. However, drinking tea at high temperatures significantly increased esophageal cancer risk. There was no obvious difference of green tea drinking between low- and high-risk areas"

Low-risk factor profile, estrogen levels, and breast cancer risk among postmenopausal women - Int J Cancer. 2008 Nov 7 - "the risk of breast cancer was markedly lower for women with a favourable risk profile than for other women and lower estrogen levels is a possible explanation"

Serum undercarboxylated osteocalcin as biomarker of vitamin k intake and risk of prostate cancer: a nested case-control study in the heidelberg cohort of the European prospective investigation into cancer and nutrition - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):49-56 - "From cell studies, Vitamin K is known to exert anticancer effects on a variety of cancer cell lines, including prostate cancer cells. Recently, we reported an inverse association between dietary intake of menaquinones (vitamin K(2)), but not phylloquinone (vitamin K(1)), and risk of prostate cancer ... There was indication of a lower prostate cancer risk in carriers of the A allele (compared with GG carriers) of the +2255 VKORC1 polymorphism with increasing menaquinone intake (P(interaction) = 0.14) whereas no distinct effect modification was observed for the ucOC/iOC ratio (P(interaction) = 0.37). The increased risks of advanced-stage and high-grade prostate cancer with higher serum ucOC/iOC ratio strengthen the findings for dietary menaquinone intake" - See vitamin K at Amazon.com.

Menopausal hormone therapy and risk of colorectal cancer - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):196-203 - "evaluated colorectal cancer risk associated with the duration and recency of specific menopausal hormone therapy formulations (i.e., unopposed estrogen versus estrogen plus progestin) and regimens (i.e., sequential versus continuous estrogen plus progestin use) ... We observed a decreased risk of colorectal cancer among ever users of unopposed estrogen therapy (RR, 0.83; 95% CI, 0.70-0.99). Among estrogen users, the largest reduced risk was observed for current users (RR, 0.75; 95% CI, 0.54-1.05) and users of >/=ten years duration (RR, 0.74; 95% CI, 0.56-0.96). We found a reduced risk among users of estrogen plus progestin therapy (RR, 0.78; 95% CI, 0.60-1.02), with sequential regimen users (progestin <15 days per cycle) having the largest risk reduction (RR, 0.64; 95% CI, 0.43-0.95). Past users of >/=5 years ago (RR, 0.55; 95% CI, 0.32-0.98) had the largest risk reduction. In this study, estrogen plus progestin use, especially sequential regimen use, was associated with the largest overall reduction of colorectal cancer risk"

Sex Hormone Levels, Breast Cancer Risk, and Cancer Receptor Status in Postmenopausal Women: the ORDET Cohort - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):169-76 - "This study provides further evidence that high levels of circulating testosterone increase the risk of developing breast cancer in postmenopausal women. The cancers that develop are mainly estrogen receptor positive. Although HER2(+) and HER2(-) breast cancers were both associated with high total testosterone, they showed opposing associations with estrogen"

Urinary melatonin levels and postmenopausal breast cancer risk in the nurses' health study cohort - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9 - "An increased concentration of urinary aMT6s was statistically significantly associated with a lower risk of breast cancer (odds ratio for the highest versus lowest quartile of morning urinary aMT6s, 0.62 ... Results from this prospective study add substantially to the growing literature that supports an inverse association between melatonin levels and breast cancer risk" - see melatonin at Amazon.com.

Long-term Alcohol Consumption and Risk of Endometrial Cancer Incidence: A Prospective Cohort Study - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):355-8 - "During a mean follow-up of 17.6 years, 687 endometrial cancer cases were identified in the Swedish cancer registries. We found no association between alcohol consumption and endometrial cancer risk after adjustment for age, body mass index, and smoking"

Tea consumption and risk of breast cancer - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):341-5 - "Tea consumption was not related to breast cancer risk overall (P for trend = 0.18). However, when stratified by age, an inverse association was observed among women less than 50 years: those consuming three or more cups per day had a 37% reduced breast cancer risk when compared with women reporting no tea consumption (age and study site-adjusted odds ratios, 0.63; 95% confidence intervals, 0.44-0.89; P = 0.01) with a significant test for trend (P = 0.01). The inverse association noted among younger women was consistent for in situ and invasive breast cancer, and for ductal and lobular breast cancer ... We observed evidence to support a potential beneficial influence for breast cancer associated with moderate levels of tea consumption (three or more cups per day) among younger women. Further research is needed to confirm this association"

High apoB/apoA-I ratio is associated with increased progression rate of carotid artery intima-media thickness in clinically healthy 58-year-old men: Experiences from very long-term follow-up in the AIR study - Atherosclerosis. 2008 Dec 3 - "The results indicate that apoB/apoA-I ratio is an important risk factor for predicting atherosclerotic progression rate during very long-term follow-up in clinically healthy middle-aged men"

Neat Tech Stuff:

  • I bought one of those Fujitsu ScanSnap S510 .pdf scanners that I mentioned last week.  I'm really impressed with it.  It makes things a lot easier.  Whether it's mail that I'm not ready to trash or a receipt for taxes, I just scan it into a directory and trash the hard copy.  Then when I get time I go though the scanned folder and rename and put it in the appropriate folder.  I also have my tax spreadsheet linked to the receipt and bank statement or credit card statement which I plan to put on a CD for each year.  I think that Rack2 software is junk though.  I can see why they are starting to give it away with the ScanSnap.  There is so much you can't do that it makes it worthless in my opinion.  I'd go with Adobe Acrobat 9 Pro or Adobe Acrobat 9 Pro Extended instead.  The ScanSnap actually comes with Adobe 8 Standard but it's not upgradeable.  The only advantage I can see with Rack2 over Adobe is the cool looking binder feature put I feel the display in Acrobat is more useful.
  • New Honda Hybrid Contender Challenges Champ Prius - wired.com, 1/10/09 - "During a day behind the wheel last month, we managed an impressive 42.4 mpg without even trying. When we pushed the Econ Mode button and used Eco Assist to mind our hypermiling P's and Q's, the Insight returned an amazing 65.6 mpg. That's on par with the best figures we've seen from the Prius"
  • Click here for a two minute video of my new office (you can tell I've got a lot of important things to do in my spare time).

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