Recent Longevity News for the seven days ending 10/10/07. You should consult your doctor if you are taking any medications.
Hormone Hoax: No Extra Benefit From Bioidentical Hormones - Doctor's Guide, 10/9/07 - "bioidentical compounded hormones (BCHs) ... conventional hormone therapy (CHT) ... Symptom relief from CHT and BCHs was similar except regarding sexual issues, where the response was significantly better for BCH than CHT"
Vitamin C May Slow Skin Wrinkling - WebMD, 10/8/07 - "After adjusting for other factors likely to influence skin aging, such as sun exposure and smoking, vitamin C and linoleic acid were independently associated with skin aging ... After digestion, linoleic acid is converted to DHA and EPA -- two fatty acids" - See vitamin C products at Amazon.com and Mega Twin EPA at Amazon.com. - Note: I'm not sure that is correct. Linoleic acid is an omega-6, which is not converted to DHA and EPA. Most Americans get about ten time too much omega-6 already.
Limiting Refined Carbohydrates May Stall AMD Progression - Science Daily, 10/8/07 - "Our data showed those people in the high-glycemic-index group were at greater risk of AMD progression, especially those already in the late stages ... Participants who consumed the most refined carbohydrates were 17 percent more likely to develop blinding AMD than the group that consumed the least"
Folic Acid Lowers Blood Arsenic Levels, Study Shows - Science Daily, 10/8/07 - "treatment with 400 micrograms a day of folic acid, the U.S. recommended dietary allowance, reduced total blood arsenic levels in the study population by 14 percent"
Stimulant Treatment Linked With Improved Long-Term School Outcomes in ADHD - Medscape, 10/8/07 - "compared with the children with ADHD who did not receive stimulants, those who did were 1.8 times less likely to be held back a grade, and they had a lower rate of absenteeism"
Inflammation Linked to Eye Disease - WebMD, 10/8/07 - "participants with the highest CRP levels at the study's start were 40% more likely to develop early-stage AMD during the study, compared to those with the lowest initial CRP levels"
Drinking Tea May Slow Bone Loss - WebMD, 10/8/07 - "A new study shows elderly women who drank tea had higher bone density in their hips and less bone loss than women who didn't drink tea ... Previous studies have suggested that phytochemicals in tea, such as flavonoids, may be responsible for the protective effect against bone loss due to their estrogen-like properties"
Ginkgo Biloba Less Effective for Raynaud's Disease Than Nifedipine - Medscape, 10/8/07 - "According to the poster, the percentage change of attack rate after 8 weeks of treatment was 50.1% in the group N and 31% in the group ... If the patient felt strongly about not using the nifedipine, I probably would tell them [gingko] is something you could use, but it's not as effective"
Prostate Cancer Survival Varies by Season - washingtonpost.com, 10/7/07 - "Summer and autumn months correspond to times when vitamin D is highest (in Norway). Although the study does not prove vitamin D is the determining factor, it does suggest that this possibility should be studied further ... Compared with men diagnosed in the summer and fall, those diagnosed in the winter and spring were 20 percent more likely to die within three years after diagnosis" - See vitamin D at Amazon.com.
Put the kettle on: Tea is steeped in health benefits - USATODAY.com, 10/7/07 - "Tea polyphenols, compounds with antioxidant activity, may protect against heart disease and a variety of cancers ... green and black tea, when substituted for drinking water, inhibits the growth of human prostate cancer cells implanted in mice ... compounds in green tea positively affect genes involved in cancer susceptibility and DNA repair" - See green tea extract at Amazon.com.
Short-Course N-Acetylcysteine Effective for Acetaminophen Overdose - Medscape, 10/5/07 - "A shortened course of as few as six oral doses of N-acetylcysteine appears to be an effective treatment for certain patients with acute acetaminophen poisoning" - See n-acetyl cysteine at Amazon.com.
Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer - Medscape, 10/5/07 - "Dr. Brenner's group observed a modest risk reduction of colorectal cancer among regular users of low-dose aspirin (adjusted odds ratio = 0.77). A stronger association was found with regular use of statins (OR 0.65). The strongest risk reduction was seen in subjects who used combination low-dose aspirin and statins (OR 0.63), especially if both drugs were used for at least 5 years (OR 0.38)"
Even Mild Thyroid Problems Double Risk Of Heart Condition - Science Daily, 10/5/07 - "individuals who had a TSH level equal or greater than 10 mU/L had a two-fold risk of developing heart failure, compared to those who had normal thyroid levels"
Novel Combination of Bazedoxifene and Conjugated Oestrogens Relieves Hot Flashes Safely; Improves Vaginal Dryness and Sexual Function - Doctor's Guide, 10/5/07 - "The combination of bazedoxifene and conjugated oestrogens (BZA/CE) appears to provide a new option for postmenopausal women with vaginal dryness, hot flashes and other menopausal symptoms"
Microsoft Rolls Out Health Records - New York Times, 10/4/07 - "Microsoft is starting its long-anticipated drive into the consumer health care market by offering free personal health records on the Web ... The organizations that have signed up for HealthVault projects with Microsoft include the American Heart Association, Johnson & Johnson LifeScan, NewYork-Presbyterian Hospital, the Mayo Clinic and MedStar Health"
Broccoli compound identified for heart benefits - Nutra USA, 10/3/07 - "the indole-based compound, indole-3-carbinol, was able to reduce the secretion of apolipoprotein B-100 (apoB) by 56 per cent, and thereby confer cardiovascular benefits" - See indole 3 carbinol at Amazon.com.
Identification and Management of Metabolic Syndrome - Medscape, 10/3/07 - "Metabolic Risk Factor Goals and Recommendations ..."
Creatine In Addition To Exercise Enhances Strength In Older Adults - Science Daily, 10/2/07 - "The exercise training resulted in improvements of functional ability and strength in all participants, but those taking the CrM and CLA showed even greater gains in muscle endurance, an increase in fat-free mass and a decrease in the percentage of body fat" - See creatine at Amazon.com and conjugated linoleic acid at Amazon.com.
Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds:
Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study - Breast Cancer Res Treat. 2007 Oct 5 - "a 20% reduction in breast cancer risk was observed with vitamin E supplement use among women with low-dietary vitamin E intake ... A non-significant 20% risk reduction was observed among vitamin B supplement users with low B dietary intake (OR = 0.8; 95% CI, 0.6-1.1). Frequent use of a vitamin B supplement was adversely associated with breast cancer risk among those with high dietary vitamin B intake (OR = 1.4"
Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: Their inhibition by resveratrol - Cancer Lett. 2007 Oct 3 - "Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in various cellular events, including tumor invasion and metastasis ... Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol" - See resveratrol products at Amazon.com.
Comparison of Effectiveness of Rosuvastatin Versus Atorvastatin on the Achievement of Combined C-Reactive Protein (<2 mg/L) and Low-Density Lipoprotein Cholesterol (<70 mg/dl) Targets in Patients With Type 2 Diabetes Mellitus (from the ANDROMEDA Study) - Am J Cardiol. 2007 Oct 15;100(8):1245-1248 - "CRP was effectively decreased in patients with type 2 diabetes receiving rosuvastatin or atorvastatin, whereas rosuvastatin decreased LDL cholesterol significantly more than atorvastatin"
A Meta-Analysis of 94,492 Patients With Hypertension Treated With Beta Blockers to Determine the Risk of New-Onset Diabetes Mellitus - Am J Cardiol. 2007 Oct 15;100(8):1254-1262 - "Beta-blocker therapy resulted in a 22% increased risk for new-onset DM ... beta blockers resulted in a 15% increased risk for stroke"
Breakfast glycemic index affects subsequent daily energy intake in free-living healthy children - Am J Clin Nutr. 2007 Oct;86(4):980-987 - "At all ages, among children who consumed their next meal in the early postprandial phase (after 3-4 h), children with a lower GI(br) consumed more calories throughout the remainder of the day than did children with a higher GI(br), independent of major dietary confounders"
Dietary glycemic index and glycemic load are associated with high-density-lipoprotein cholesterol at baseline but not with increased risk of diabetes in the Whitehall II study - Am J Clin Nutr. 2007 Oct;86(4):988-994 - "At baseline, dietary GI and GL were associated inversely with HDL cholesterol, and GI was associated directly with triacylglycerols. Dietary GI and GL were related inversely to fasting glucose and directly to 2-h postload glucose ... The proposed protective effect of low-dietary GI and GL diets on diabetes risk could not be confirmed in this study"
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women - Am J Clin Nutr. 2007 Oct;86(4):1073-1081 - "Total choline + betaine intake was inversely associated with tHcy, as was choline from 2 water-soluble choline-containing compounds. Remethylation of tHcy may be more dependent on the betaine pathway when methyl sources are low as a result of either inadequate folate intake or heavier alcohol consumption"
Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study - Am J Clin Nutr. 2007 Oct;86(4):1160-1166 - "The relative risk (RR) of breast cancer in the highest (versus lowest) quintiles of GI and GL was 1.57 (95% CI: 1.04, 2.36; P for trend = 0.040) and 2.53 (95% CI: 1.54, 4.16; P for trend = 0.001), respectively. Total carbohydrate intake was not associated with greater breast cancer risk, but high carbohydrate from high-GI foods was. When women were categorized by baseline menopausal status and body mass index (BMI; in kg/m(2)), the increased risk of dietary GL was confined to those who were premenopausal (RR = 3.89; 95% CI: 1.81, 8.34) and who had normal BMI (ie, <25)"
Serum zinc and pneumonia in nursing home elderly - Am J Clin Nutr. 2007 Oct;86(4):1167-1173 - "Normal serum zinc concentrations in nursing home elderly are associated with a decreased incidence and duration of pneumonia, a decreased number of new antibiotic prescriptions, and a decrease in the days of antibiotic use. Zinc supplementation to maintain normal serum zinc concentrations in the elderly may help reduce the incidence of pneumonia and associated morbidity"
Fructose intake is a predictor of LDL particle size in overweight schoolchildren - Am J Clin Nutr. 2007 Oct;86(4):1174-1178 - "After control for adiposity, the only dietary factor that was a significant predictor of LDL particle size was total fructose intake"
Dietary carbohydrate and the progression of age-related macular degeneration: a prospective study from the Age-Related Eye Disease Study - Am J Clin Nutr. 2007 Oct;86(4):1210-1218 - "The latter gives an estimate that 7.8% of new advanced AMD cases would be prevented in 5 y if people consumed the low-dGI diet"
Dietary nutrient intakes and skin-aging appearance among middle-aged American women - Am J Clin Nutr. 2007 Oct;86(4):1225-1231 - "Higher intakes of vitamin C and linoleic acid and lower intakes of fats and carbohydrates are associated with better skin-aging appearance. Promoting healthy dietary behaviors may have additional benefit for skin appearance in addition to other health outcomes in the population"
Tea drinking is associated with benefits on bone density in older women - Am J Clin Nutr. 2007 Oct;86(4):1243-1247 - "In the cross-sectional analysis, total hip aBMD was 2.8% greater in tea drinkers (x: 806; 95% CI: 797, 815 mg/cm(2)) than in non-tea drinkers (784; 764, 803 mg/cm(2)) (P < 0.05). In the prospective analysis over 4 y, tea drinkers lost an average of 1.6% of their total hip aBMD (-32; -45, -19 mg/cm(2)), but non-tea drinkers lost 4.0%" - See green tea extract at Amazon.com.
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease - Am J Clin Nutr. 2007 Oct;86(4):899-906 - "We also present evidence that the unique ability of fructose to induce an increase in uric acid may be a major mechanism by which fructose can cause cardiorenal disease"
Isoflavone intake in persons at high risk of cardiovascular events: implications for vascular endothelial function and the carotid atherosclerotic burden - Am J Clin Nutr. 2007 Oct;86(4):938-945 - "In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden"
Insoluble cereal fiber reduces appetite and short-term food intake and glycemic response to food consumed 75 min later by healthy men - Am J Clin Nutr. 2007 Oct;86(4):972-979 - "A serving of 33 g insoluble fiber reduced appetite, lowered food intake, and reduced glycemic response to a meal consumed 75 min later"
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R - Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer" - See curcumin products at Amazon.com.
Carnosine Is Neuroprotective Against Permanent Focal Cerebral Ischemia in Mice - Stroke. 2007 Oct 4 - "Carnosine is neuroprotective in focal cerebral ischemia and appears to influence deleterious pathological processes that are activated after the onset of ischemia" - See l-carnosine at Amazon.com.
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: A randomized double-blind study - Atherosclerosis. 2007 Aug 4 - "All patients showed definite reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels" - See ubiquinol products at Amazon.com.
Low Serum Testosterone and Mortality in Older Men - J Clin Endocrinol Metab. 2007 Oct 2 - "Men whose total testosterone levels were in the lowest quartile (<241 ng/dl) were 40% (HR=1.40; 95% CI, 1.14-1.71) more likely to die than those with higher levels ... In cause-specific analyses, low testosterone predicted increased risk of cardiovascular (HR, 1.38; 95% CI, 1.02- 1.85) and respiratory disease (HR, 2.29; 95% CI, 1.25-4.20) mortality, but was not significantly related to cancer death (HR, 1.34"
Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents - Osteoporos Int. 2007 Sep 14 - "Daily vitamin D was more effective than weekly, and monthly administration was the least effective"
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