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Dietary Intake of
Saturated Fatty Acids and Incident Stroke - Medscape, 5/15/13 -
"We sought to test the hypothesis that SFA intake is
associated inversely with risk of stroke and its subtypes and positively
with coronary heart disease among Japanese, whose average SFA intake is
lower than that of Westerners ... We found inverse associations between SFA
intake and total stroke [multivariable hazard ratio (95% confidence
interval) for the highest vs. lowest quintiles = 0.77 (0.650.93), trend P =
0.002], intraparenchymal haemorrhage [0.61 (0.430.86), P for trend =
0.005], and ischaemic stroke [0.84 (0.671.06), trend P = 0.08], primarily
for deep intraparenchymal haemorrhage [0.67 (0.450.99), P for trend = 0.04]
and lacunar infarction [0.75 (0.53, 1.07), trend P = 0.02]. We also observed
a positive association between SFAs intake and myocardial infarction [1.39
(0.932.08), trend P = 0.046] primarily among men. No associations were
observed between SFAs intake and incidence of subarachnoid haemorrhage or
sudden cardiac death"
Re-Analysis Refutes Diet Guidelines Favoring Vegetable Fats - WebMD,
2/6/13 - "The first group was told to consume
linoleic acid, in the form of safflower oil and safflower oil
polyunsaturated margarine, at levels equal to 15 percent of total calorie
intake. This, said Ramsden, is equivalent to roughly twice the amount that
Americans currently consume ... While omega-3 consumption was not affected,
the men were also asked to lower their saturated fat intake so that it made
up less than 10 percent of their diets. They did so by substituting
safflower oil for animal fats ... The second group continued their routine
nutritional habits ... By newly crunching all the original data the NIH team
found that, compared to the no-dietary-change group, the linoleic acid group
faced a higher risk of death, from both heart disease specifically as well
as from all causes overall ... the NIH team found no evidence to support the
notion that linoleic acid confers health benefits. The review highlighted
the possibility that boosting omega-6 consumption may actually increase the
risk for developing heart disease ... Polyunsaturates are not just involved
in cholesterol-lowering. They may also be involved in inflammation,
oxidation or clotting"
link between high-fat 'Western' diet and atherosclerosis identified -
Science Daily, 10/8/12 - "endothelial lipase (EL),
an enzyme associated with the development of atherosclerosis ... In the
current study, a strain of mice susceptible to atherosclerosis was fed a
normal diet enriched with either palmitic acid (a common saturated fat) or
eicosapentaenoic acid (an omega-3 fatty acid, or polyunsaturated fat, found
in fish oil, among other foods). After 12 weeks, the mice's aortas were
examined for changes in the expression of EL and inflammatory factors.
Aortas of mice fed the saturated fat diet showed a significant increase in
EL and detrimental changes in inflammatory factors, while those of mice fed
the polyunsaturated fat diet showed a significant decrease in EL and
beneficial changes in inflammatory factors ... when the macrophages were
given rosiglitazone, the expression of EL increased markedly. The addition
of omega-3 fatty acids to the cells blocked this increase. "This would
suggest that besides raising LDL cholesterol levels, rosiglitazone can raise
the risk of cardiovascular disease by increasing EL,""
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Fatty diets may be associated with reduced semen quality - Science
Daily, 3/14/12 - "The study of 99 men in the USA
found an association between a high total fat intake and lower total sperm
count and concentration. It also found that men who ate more omega-3
polyunsaturated fats (the type of fat often found in fish and plant oils)
had better formed sperm than men who ate less ... if men make changes to
their diets so as to reduce the amount of saturated fat they eat and
increase their omega-3 intake, then this may not only improve their general
health, but could improve their reproductive health too ... the relationship
between dietary fats and semen quality was largely driven by the consumption
of saturated fats. Men consuming the most saturated fats had a 35% lower
total sperm count than men eating the least, and a 38% lower sperm
Mediterranean Diet May Protect Brain - WebMD, 2/13/12 -
"white matter hyperintensity volume (WMHV) ... WMHV
is an indicator of small blood vessel damage in the brain and is detected by
magnetic resonance screening (MRI) ... researchers compared the brain scans
and diets of 966 adults with an average age of 72 ... those who most closely
followed a Mediterranean diet had a lower measure of WMHV than those who did
not. Each increase in the Mediterranean diet score was associated with a
corresponding decrease in white matter hyperintensity volume score ... the
aspect of the Mediterranean diet that seemed to matter most was the ratio of
monounsaturated fat to saturated fat"
dietary fat, cholesterol linked to increased risk of breast cancer -
Science Daily, 1/6/11 - "This mouse model is
believed to closely parallel the pathogenesis of human breast cancer. PyMT
mice were placed on a diet that contained 21.2 percent fat and 0.2 percent
cholesterol, reflective of a typical Western diet. A control group of PyMT
mice was fed a normal chow that had only 4.5 percent fat and negligible
amounts of cholesterol ... tumors began to develop quickly in mice fed the
fat/cholesterol-enriched chow. In this group, the number of tumors was
almost doubled, and they were 50 percent larger than those observed in mice
that ate a normal diet. "The consumption of a Western diet resulted in
accelerated tumor onset and increased tumor incidences, multiplicity, and
burden, suggesting an important role for dietary cholesterol in tumor
formation," ... There was also a trend towards an increased number of lung
metastasis in mice fed the fatty diet"
How Saturated Fatty Acids 'Anger' The Immune System (And How To Stop Them)
- Science Daily, 11/5/09
Dietary Fat Linked To Pancreatic Cancer - Science Daily, 6/26/09 -
"Participants who consumed high amounts of saturated
fats had 36% higher relative rates of pancreatic cancer compared with those
who consumed low amounts"
High-fat Diet Could Promote Development Of Alzheimer's Disease - Science
Daily, 10/28/08 - "the main neurological markers for
Alzheimer's disease are exacerbated in the brains of mice fed a diet rich in
animal fat and poor in omega-3s"
Memory Loss Linked To Poor Diet, Study Suggests - Science Daily, 6/19/08
- "Researchers from the Medical University of South
Carolina (MUSC) have linked memory loss to a diet high in saturated fat and
High In Saturated Fat Contributes To Prostate Cancer Treatment Failure,
Study Suggests - Science Daily, 5/8/08 -
"Patients on a HSF diets were significantly more likely to have a PSA
failure and had significantly shorter PSA-failure free survival than men on
a LSF diet (26.6 vs. 44.7 months, respectively). At 5 years post radical
prostatectomy, 65% of patients who consumed HSF diets had no evidence of
prostate cancer compared to 80% of men who ate a LSF diet"
Even One Fatty Meal Affects Arteries - WebMD, 8/8/06
High in Saturated Fat May Reduce Protective Effect of HDL - Medscape, 8/7/06 -
"The anti-inflammatory activity of
HDL appears to decrease after consumption of saturated fat, but improves on
consumption of polyunsaturated fat"
fats are worse than you think - MSNBC, 5/19/06 -
"too much saturated fat may be
problematic, even if your cholesterol isnt high, because of its possible
effects on insulin functions, potentially raising the risk of diabetes,
cancer, ovarian disorders and other health problems"
Burger Diet Raises Breast Cancer Risk - WebMD, 7/15/03 -
"The increase was most closely linked with animal fat -- specifically from animal fat -- and,
more specifically, red meat and high-fat dairy foods"
of human postprandial lipemia by changing ratios of polyunsaturated to saturated
(P/S) fatty acid content of blended dietary fats: a cross-over design with
repeated measures - Nutr J. 2013 Aug 16;12(1):122 -
"This human postprandial study evaluated 3 edible fat blends with differing
polyunsaturated to saturated fatty acids (P/S) ratios (POL = 0.27, AHA = 1.00,
PCAN = 1.32) ... Varying P/S ratios of test meals significantly altered prandial
high density lipoprotein-cholesterol (HDL-C) concentrations (P < 0.001) which
increased with decreasing P/S ratio (POL > AHA > PCAN)"
Plasma phospholipid fatty
acids, dietary fatty acids and prostate cancer risk - Int J Cancer. 2013 Apr
11 - "Animal and experimental studies have demonstrated
that long-chain n-3 fatty acids inhibit the development of prostate cancer,
whereas n-6 fatty acids might promote it ... Collaborative Cohort Study using a
random sample of 1,717 men and 464 prostate cancer cases to investigate
associations between fatty acids assessed in plasma phospholipids (PPLs) or diet
(estimated using a 121-item food frequency questionnaire) and prostate cancer
risk ... Prostate cancer risk was positively associated with %PPL saturated
fatty acids (SFAs); HR [95% CI] = 1.51 [1.06, 2.16] (Q5 vs. Q1, fifth vs. first
quintile); p-trend = 0.003. HRs (Q5 to Q2 vs. Q1) were significantly elevated
for %PPL palmitic acid. %PPL oleic acid was inversely associated with risk, HR =
0.62 [0.43, 0.91] (Q5 vs. Q1); p-trend = 0.04. No statistically significant
linear trends were observed for dietary intakes. The HRs were elevated for
moderate intakes of linoleic acid (Q2 and Q3 vs. Q1, 1.58 [1.10, 2.28] and 1.70
[1.18, 2.46], respectively), but the increase was not significant for higher
intakes (Q4 and Q5). No association varied significantly by tumour
aggressiveness (all p-homogeneity > 0.1). Prostate cancer risk was positively
associated with %PPL SFA, largely attributable to palmitic acid and inversely
associated with %PPL monounsaturated fatty acids, largely attributable to oleic
acid. Higher risks were also observed for dietary n-6 polyunsaturated fats,
primarily linoleic acid"
Small-to-Medium-Chain Saturated Fatty Acids Is Associated with Peripheral
Leukocyte Telomere Length in Postmenopausal Women - J Nutr. 2013 Apr 24 -
"Intake of short-to-medium-chain saturated fatty acids
(SMSFAs; aliphatic tails of ≤12 carbons) was inversely associated with TL"
Fatty Acids, and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
- Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):697-707 -
"NIH-American Association of Retired Persons (AARP)
Diet and Health Study. Diet was assessed at baseline with self-administered
food-frequency questionnaires ... Total fat and mono- and polyunsaturated
fat intakes were not associated with incidence of prostate cancer. Saturated
fat intake was related to increased risk of advanced prostate cancer (HRQuintile
5 vs. Qunitile 1 (Q1 vs. Q5), 1.21; 95% CI, 1.00-1.46; Ptrend = 0.03) and
fatal prostate cancer (HRQ5 vs. Q1, 1.47; 95% CI, 1.01-2.15; Ptrend = 0.04).
α-Linolenic acid (ALA) intake was related to increased risk of advanced
prostate cancer (HRQ5 vs. Q1, 1.17; 95% CI, 1.04-1.31; Ptrend = 0.01).
Eicosapentanoic acid (EPA) intake was related to decreased risk of fatal
prostate cancer (HRQ5 vs. Q1, 0.82; 95% CI, 0.64-1.04; Ptrend = 0.02)"
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Jarrow Max DHA at iHerb.
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a
Canadian First Nation at risk for the development of type 2 diabetes -
Public Health Nutr. 2013 Mar 21:1-5 - "Intake of
dietary n-3 fatty acids may be protective against whereas SFA intake may
promote insulin resistance in this high-risk Canadian First Nation sample.
Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the
prevention of glycaemic disease among First Nations peoples" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
dietary intake of saturated fat is associated with reduced semen quality
among 701 young Danish men from the general population - Am J Clin Nutr.
2012 Dec 26 - "The objective was to examine the
association between dietary fat intake and semen quality among 701 young
Danish men from the general population ... A lower sperm concentration and
total sperm count in men with a high intake of saturated fat was found. A
significant dose-response association was found, and men in the highest
quartile of saturated fat intake had a 38% (95% CI: 0.1%, 61%) lower sperm
concentration and a 41% (95% CI: 4%, 64%) lower total sperm count than did
men in the lowest quartile. No association between semen quality and intake
of other types of fat was found"
intake of saturated fatty acids and mortality from cardiovascular disease in
Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
Study? - Am J Clin Nutr. 2010 Aug 4 - "The aim
of this study was to test the hypothesis that SFA intake is associated with
the risk of cardiovascular disease mortality in Japanese whose average SFA
intake is low ... We observed inverse associations of SFA intake with
mortality from total stroke [n = 976; multivariable hazard ratio (95% CI)
for highest compared with lowest quintiles: 0.69 (0.53, 0.89); P for trend =
0.004], intraparenchymal hemorrhage [n = 224; 0.48 (0.27, 0.85); P for trend
= 0.03], and ischemic stroke [n = 321; 0.58 (0.37, 0.90); P for trend =
0.01]. No multivariable-adjusted associations were observed between SFA and
mortality from subarachnoid hemorrhage [n = 153; 0.91 (0.46, 1.80); P for
trend = 0.47] and heart disease [n = 836; 0.89 (0.68, 1.15); P for trend =
0.59]. CONCLUSION: SFA intake was inversely associated with mortality from
total stroke, including intraparenchymal hemorrhage and ischemic stroke
subtypes, in this Japanese cohort"