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Health Conditions > Retinopathy
Fatty Fish May Curb Eye Risks for Diabetics, Study Finds - WebMD, 8/18/16 -
"The team found that those who routinely consumed 500
milligrams (mg) a day of omega-3 fatty acid in their diets (equal to two
servings of fatty fish per week) were 48 percent less likely to develop diabetic
retinopathy than those who consumed less" - See
fish oil supplements at Amazon.com.
Vitamin D Deficiency Linked
to Diabetic Retinopathy - Medscape, 5/28/16 - "The mechanism could be
twofold, he said. Studies suggest that vitamin D might improve insulin secretion
in type 2 diabetes and may also directly reduce vascular endothelial growth
factors. (Thus, deficiency would have the opposite effects.) ... For any
diabetic retinopathy, the odds ratio (OR) between those with and without vitamin
D deficiency was 1.391 (P = .011). For nonproliferative diabetic retinopathy,
the OR was 1.209 (P = .001), and for proliferative retinopathy 1.315 (P < .001).
For all the studies combined, the odds ratio was 1.267 (P < .001)" - See
vitamin D at Amazon.com.
Protective Effects of Panax notoginseng Saponins against High
Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cell
- Evid Based Complement Alternat Med. 2016;2016:5326382 -
"Diabetic retinopathy, a leading cause of visual
loss and blindness, is characterized by microvascular dysfunction.
Hyperglycemia is considered the major pathogenic factor for diabetic
retinopathy and is associated with increased oxidative stress in the retina
... Panax notoginseng Saponins (PNS) in retinal capillary endothelial cells
(RCECs) ... These results indicate that PNS exerts a protective effect
against high glucose-induced injury in RCECs, which may be partially
attributed to its antioxidative function" - See
ginseng at Amazon.com.
Vaccinium myrtillus extract prevents or delays the onset of
diabetes--induced blood-retinal barrier breakdown - Int J Food Sci Nutr.
2015 Jan 13 - "bilberries (Vaccinium myrtillus) ...
V. myrtillus extract ... VME may prevent or delay the onset of early
diabetic retinopathy. These findings have important implications for
prevention of diabetic retinopathy using a dietary bilberry supplement"
bilberry at Amazon.com.
Vitamin D deficiency increases the risk of retinopathy in Chinese patients
with Type 2 diabetes - Diabet Med. 2014 Sep 3 -
"Vitamin D deficiency is an independent risk factor for diabetic retinopathy
and sight-threatening diabetic retinopathy. The prevalence of
sight-threatening diabetic retinopathy doubles when the serum
25-hydroxyvitamin D level is < 15.57 ng/ml" - See
vitamin D at Amazon.com.
Relationship between metformin use, vitamin B12 deficiency,
hyperhomocysteinemia and vascular complications in patients with type 2
diabetes - Endocr J. 2013 Sep 8 -
"Metformin-induced B12 lowering in diabetes was associated with elevation of
homocysteine, and hyperhomocysteinemia was independently related to
retinopathy" - See
vitamin B12 at Amazon.com.
Statins may prevent diabetic-related blindness, study suggests - Science
Daily, 2/17/11 - "oral treatment with the drug
atorvastatin blocked the formation of free radicals in the retina, which
restored proper levels of nerve growth factor and preserved neurons in the
retina. "It removed the break on the pro-form nerve growth factor to develop
into its mature form," she said. The drug was orally administered to rats in
doses proportional to levels given to human patients with cardiovascular
problems ... In a related study, also in the March edition of the journal
Diabetologia, El-Remessy and her colleagues found that epicathecin, a
component of green tea, also prevented the adverse actions of proNGF in the
retina. It does not affect the maturation of proNGF into NGF, explained
El-Remessy, but regulated a receptor downstream that proNGF uses to send a
signal to kill the neuron. Epicathechin prevents the death by inhibiting
that receptor. "We are still getting the same result, that we are preventing
neuronal death and restoring neuronal function, but just in a different
way,"" - See
green tea extract at Amazon.com.
omega 3s help to prevent several forms of blindness - Science Daily,
2/9/11 - "The cost of omega-3 supplementation is
about $10 a month, versus up to $4,000 a month for anti-VEGF therapy ... In
the new study, they document another protective mechanism: a direct effect
on blood vessel growth (angiogenesis) that selectively promotes the growth
of healthy blood vessels and inhibits the growth of abnormal vessels ... In
addition, Smith and colleagues isolated the specific compound from omega-3
fatty acids that has these beneficial effects in mice (a metabolite of the
omega-3 fatty acid DHA, known as 4-HDHA), and the enzyme that produces it
(5-lipoxygenase, or 5-LOX). They showed that COX enzymes are not involved in
omega-3 breakdown, suggesting that aspirin and NSAIDs -- taken by millions
of Americans -- will not interfere with omega-3 benefits ... Finally, the
study demonstrated that 5-LOX acts by activating the PPAR-gamma receptor,
the same receptor targeted by "glitazone" drugs such as Avandia, taken by
patients with type 2 diabetes to increase their sensitivity to insulin.
Since these drugs also increase the risk for heart disease, boosting omega-3
intake through diet or supplements might be a safer way to improve insulin
sensitivity in patients with diabetes or pre-diabetes" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Blood glucose levels that predict 10-year risk of retinopathy identified
- Science Daily, 2/14/11
Influence of glycosylated hemoglobin on sight-threatening diabetic
retinopathy: A population-based study - Diabetes Res Clin Pract. 2011
Feb 3 - "sight-threatening diabetic retinopathy
(STDR) ... A statistically significant difference (p<0.05) was noted in the
duration of diabetes, gender, body mass index, HbA1c, micro- and
macro-albuminuria between both non-STDR and STDR groups as compared to the
no-diabetic retinopathy (DR) group. On multivariate analysis, HbA1c
(non-STDR: odd's ratio OR=1.23; 95% confidence interval CI=1.15-1.32;
p<0.0001; STDR: OR=1.31 95% CI=1.14-1.52; p<0.0001) was found to be
significantly associated with non-STDR and STDR when compared with the no-DR
group. The Receiver Operating Characteristic analysis showed that the
cut-off value of 8.0 had 75.6% sensitivity and 58.2% specificity with 64.9%
maximum area under the curve ... HbA1c value >8.0% was significantly related
with STDR. In a screening programme, the cut-off value of HbA1c >8.0%
provided a maximum yield of STDR"
Inhibition of the receptor for advanced glycation endproducts (RAGE)
protects pancreatic β-cells - Biochem Biophys Res Commun. 2010 Nov 24 -
"Advanced glycation endproducts (AGEs) and the
receptor for AGEs (RAGE) have been linked to the pathogenesis of diabetic
complications, such as retinopathy, neuropathy, and nephropathy. AGEs may
induce β-cell dysfunction and apoptosis, another complication of diabetes
... Inhibition of RAGE prevented AGE-induced pancreatic β-cell apoptosis,
but could not restore the function of glucose stimulated insulin secretion
(GSIS) in rat islets. In summary, the results of the present study
demonstrate that AGEs are integrally involved in RAGE-mediated apoptosis and
impaired GSIS dysfunction in pancreatic β-cells. Inhibition of RAGE can
effectively protect β-cells against AGE-induced apoptosis, but can not
reverse islet dysfunction in GSIS"
evidence on benefits of high blood pressure drugs in diabetic eye disease
- Science Daily, 1/18/10
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