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Home > Anti-aging Research > Rapamycin

Rapamycin

Sirolimus - Wikipedia - "Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2)"

News & Research:

  • This pill could make your dog (and maybe you) live longer - CNN, 10/6/16 - "We knew we could go to Mexico and get rapamycin or order it online, but we wanted to be guided by a veterinarian, by a professional ... a month after his stroke, Sherman was so weak, he had to be fed by hand and carried everywhere ... rapamycin changed all that ... The third day after taking rapamycin, he could eat on his own. By the seventh day, he was walking on his own ... Sixteen months later, the dog who had been given two months to live is still alive, and while clearly old, he's still active and able to run around the yard ... The list of things that can go wrong is long and horrifying: cancer, diabetes, infections and more ... Of the 53 patients on the lowest dose of rapamycin, 22 suffered some side effect, most commonly mouth sores ... he prefers to think in terms of treatments that will delay the onset of diseases of aging, such as dementia or heart disease. In mice, rapamycin has been shown to slow these two types of declines, as well as several others"
  • Research explains action of drug that may slow aging, related disease - Science Daily, 5/20/14 - "Rapamycin, an antibiotic and immunosuppressant approved for use about 15 years ago, has drawn extensive interest for its apparent ability -- at least in laboratory animal tests -- to emulate the ability of dietary restriction in helping animals to live both longer and healthier ... this medication has some drawbacks, including an increase in insulin resistance that could set the stage for diabetes ... a combination of rapamycin and another drug to offset that increase in insulin resistance might provide the benefits of this medication without the unwanted side effect ... Laboratory mice that have received rapamycin have reduced the age-dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had less cancer and lived substantially longer than mice fed a normal diet ... the drug metformin can address that concern"

Abstracts:

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