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Pulmonary Hypertension

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Alternative News:

• Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension - J Hypertens 2022 Oct 1 - "Vascular calcification has been considered as a potential therapeutic target in pulmonary hypertension. Mg2+ has a protective role against calcification ... Monocrotaline (MCT)-induced and chronic hypoxia-induced pulmonary hypertension ... Mg2+ supplement is a powerful strategy to treat pulmonary hypertension by mitigating pulmonary arterial calcification as the calcification triggered physiological and pathological changes to PASMCs" - See magnesium supplements at Amazon.com.
• SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF) - Circulation. 2016 Jan 26 - "These studies validate a rodent model of metabolic syndrome and PH-HFpEF, suggesting a potential role of nitrite and metformin as a preventative treatment for this disease" - See metformin at The Antiaging Store.
• Genistein, a Soy Phytoestrogen, Reverses Severe Pulmonary Hypertension and Prevents Right Heart Failure in Rats - Hypertension. 2012 Jul 2 - "PH was induced in male rats by 60 mg/kg of monocrotaline. After 21 days, when PH was well established, rats received daily injection of genistein (1 mg/kg per day) for 10 days or were left untreated to develop RHF by day 30. Effects of genistein on human pulmonary artery smooth muscle cell and endothelial cell proliferation and neonatal rat ventricular myocyte hypertrophy were assessed in vitro. Severe PH was evident 21 days after monocrotaline, as peak systolic right ventricular pressure increased to 66.35+/-1.03 mm Hg and right ventricular ejection fraction reduced to 41.99+/-1.27%. PH progressed to RHF by day 30 (right ventricular pressure, 72.41+/-1.87 mm Hg; RV ejection fraction, 29.25+/-0.88%), and mortality was ≈75% in RHF rats. Genistein therapy resulted in significant improvement in lung and heart function as right ventricular pressure was significantly reduced to 43.34+/-4.08 mm Hg and right ventricular ejection fraction was fully restored to 65.67+/-1.08% similar to control. Genistein reversed PH-induced pulmonary vascular remodeling in vivo and inhibited human pulmonary artery smooth muscle cell proliferation by ≈50% in vitro likely through estrogen receptor-β. Genistein also reversed right ventricular hypertrophy (right ventricular hypertrophy index, 0.35+/-0.029 versus 0.70+/-0.080 in RHF), inhibited neonatal rat ventricular myocyte hypertrophy, and restored PH-induced loss of capillaries in the right ventricle. These improvements in cardiopulmonary function and structure resulted in 100% survival by day 30. Genistein restored PH-induced downregulation of estrogen receptor-β expression in the right ventricle and lung. In conclusion, genistein therapy not only rescues preexisting severe PH but also prevents the progression of severe PH to RHF" - See genistein at Amazon.com.
• Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats - Hypertension. 2009 Jul 13 - "Pulmonary hypertension was associated with an upregulation of NAD(P)H oxidase in small pulmonary arteries, which was significantly attenuated by resveratrol treatment. Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension" - See resveratrol products at Amazon.com.
• Can 2 Garlic Cloves a Day Keep the Doc Away? - WebMD, 4/4/05 - "Ku's team recently found that allicin -- a compound found in garlic -- prevents a mild form of pulmonary hypertension in rats. Now they find that the garlic compound prevents a much more severe form of pulmonary hypertension in rats"

News & Research:

• Endothelin Drugs Benefit Those With Pulmonary Hypertension - Science Daily, 9/10/09
• FDA Approves Tadalafil Tablets for Pulmonary Arterial Hypertension - Doctor's Guide, 5/26/09
• Antioxidant Deficiency Linked To Pulmonary Hypertension - Science Daily, 9/23/08 - "Antioxidant augmentation in patients might be used to increase nitric oxide vasodilator effects, reduce pulmonary artery pressures and potentially improve clinical outcomes"
• Serum Sodium Predicts Mortality 10 Times Higher In PAH Patients - Science Daily, 6/13/08
• Most Common Cause of Pulmonary Hypertension - Medscape, 2/5/07
• Pulmonary Hypertension May Indicate Hemoglobinuria - Doctor's Guide, 12/15/05
• Drug May Ease Pulmonary Hypertension - WebMD, 11/16/05
• Ongoing and Completed Clinical Trials in Pulmonary Hypertension Are Driving the Need for New Practice Guidelines - Doctor's Guide, 11/4/05
• Combination Therapy with Inhaled Iloprost and Bosentan Effective in Pulmonary Arterial Hypertension - Doctor's Guide, 11/3/05
• Sildenafil Use in Pulmonary Hypertension Appears Useful; Raises Controversy - Doctor's Guide, 11/3/05
• First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary Hypertension - Doctor's Guide, 9/30/05
• FDA Approves Revatio (Sildenafil Citrate) As Treatment for Pulmonary Arterial Hypertension - Doctor's Guide, 6/6/05
• FDA Grants Orphan Drug Status to PulmoLAR, Treatment for Pulmonary Arterial Hypertension - Doctor's Guide, 5/12/05
• Medical Researchers Say Statins, Other Cholesterol-Depleting Agents Affect Hypertension - Science Daily, 4/12/05
• FDA Approves Ventavis (Iloprost) for Treatment of Pulmonary Arterial Hypertension - Doctor's Guide, 12/29/04
• Pulmonary Hypertension, November 2004 - Medscape, 12/20/04
• Sildenafil May Be Effective for Pulmonary Arterial Hypertension - Medscape, 10/28/04
• FDA Grants Orphan Drug Designation for Ambrisentan, Treatment for Pulmonary Arterial Hypertension - Doctor's Guide, 8/3/04
• New Pulmonary Hypertension Guideline Challenges Use of Calcium Channel Blockers - Doctor's Guide, 7/13/04
• Significant Benefit With Sildenafil in Primary Pulmonary Hypertension - Doctor's Guide, 4/28/04
• Inhaled Iloprost Demonstrates Long-term Benefit In Pulmonary Hypertension - Doctor's Guide, 10/6/03
• Fasudil Beneficial for Pulmonary Hypertension Patients - Doctor's Guide, 10/1/03
• Medical Therapy for Pulmonary Arterial Hypertension Increases Need for Early Detection - Doctor's Guide, 7/14/03
• Potential New Treatment For Pulmonary Hypertension In Sickle Cell Patients - Intelihealth, 6/26/03
• Oral Beraprost Sodium May Improve Survival in Chronic Thromboembolic Pulmonary Hypertension - Doctor's Guide, 6/11/03
• No Impact On Ocular Health With High-Dose Sildenafil For Pulmonary Hypertension - Doctor's Guide, 5/7/03
• Primary Pulmonary Hypertension Abnormalities Correlate With Disease Severity - Doctor's Guide, 4/3/03
• Intravascular Ultrasound Best to Identify Pulmonary Hypertension - Medscape, 3/25/03
• Pulmonary Endarterectomy Can Be Curative for Primary Pulmonary Hypertension - Doctor's Guide, 2/2/03
• Additional Remodulin (Treprostinil) Efficacy and Safety Data Published - Doctor's Guide, 1/24/03
• Primary Pulmonary Hypertension Improves with Chronic Trepostinil - Doctor's Guide, 11/22/02
• Monitor Liver Functioning In Pulmonary Arterial Hypertension Patients Taking Bosentan - Doctor's Guide, 11/5/02
• Viagra (Sildenafil) May Improve Exercise Tolerance in Patients with Pulmonary Hypertension - Doctor's Guide, 9/20/02
• Sildenafil Alleviates Pulmonary Hypertension - Doctor's Guide, 9/19/02
• Severe Pulmonary Hypertension Responds Well To Inhaled Iloprost - Doctor's Guide, 8/1/02
• Inhaled Iloprost Relieves Symptoms of Severe Pulmonary Hypertension - Medscape, 8/1/02
• Sildenafil (Viagra) Effective In Treating Pulmonary Hypertension - Doctor's Guide, 6/10/02
• Valve Surgeries: Inhaled Prostacyclin Aids Pulmonary Hypertension - Doctor's Guide, 3/21/02
• Intravascular Ultrasound Helps to Pinpoint Pulmonary Emboli - Doctor's Guide, 1/24/02
• Tracleer (Bosentan), Oral Treatment For Pulmonary Arterial Hypertension, Available In US - Doctor's Guide, 12/5/01
• FDA Approves Important New Therapy For Rare But Fatal Disorder - Intelihealth, 11/21/01
• FDA Approves Tracleer (Bosentan) Tablets for Pulmonary Arterial Hypertension - Doctor's Guide, 11/21/01
• Treprostinil (Remodulin) Improves Quality Of Life In Some Patients With Pulmonary Arterial Hypertension - Doctor's Guide, 11/19/01
• Hepatopulmonary Syndrome And Portopulmonary Hypertension - Doctor's Guide, 11/12/01
• First Oral Drug [bosentan] for Deadly Lung Disease - WebMD, 10/5/01
• Dual Antagonist Promising In Pulmonary Hypertension - Doctor's Guide, 10/5/01
• Viagra (Sildenafil) Used to Treat Pulmonary Hypertension - Doctor's Guide, 9/25/01
• FDA Advisory Committee Recommends Approval of Remodulin For Pulmonary Arterial Hypertension - Doctor's Guide, 8/10/01
• Prostacyclin (Iloprost) Aerosol Feasible Option For Children With Pulmonary Hypertension - Doctor's Guide, 5/31/01
• British Doctors Use Viagra (Sildenafil) to Treat Pulmonary Hypertension - Doctor's Guide, 5/31/01
• Sildenafil (Viagra) May Help Patients With Pulmonary Hypertension - Doctor's Guide, 5/23/01 - "sildenafil (Viagra), given intravenously, causes pulmonary vasodilation while reducing pulmonary vascular resistance and increasing cardiac output"
• Transplantation Remains Valuable Option For End-Stage Pulmonary Hypertension - Doctor's Guide, 1/30/01
• Bosentan Increases Exercise Function In Patients With Pulmonary Hypertension - Doctor's Guide, 11/14/00
• Hearing Loss A Threat To Children Who Survive Persistent Pulmonary Hypertension - Doctor's Guide, 8/14/00
• Increased Use Of Fenfluramine Linked To Increased Pulmonary Hypertension - Doctor's Guide, 3/15/00
• Surgery Benefits Chronic Thromboembolic Pulmonary Hypertension Patients - Doctor's Guide, 8/20/99