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> Phenethyl Isothiocyanate (PEITC)
Phenethyl Isothiocyanate (PEITC)
News & Research:
Plant-based compound slows breast cancer in a mouse model - Science
Daily, 8/2/12 - "The natural plant compound
phenethyl isothiocyanate (PEITC) hinders the development of mammary tumors
in a mouse model with similarities to human breast cancer progression ...
PEITC has shown to be effective as a chemopreventative agent in mice for
colon, intestinal, and prostate cancer, by inducing apoptosis ...
administering PEITC for 29 weeks was linked with a 56.3% reduction in
mammary carcinoma lesions greater than 2mm ... Since chemoprevention trials
are both expensive and time-consuming and necessitate years of follow-up,
the authors feel that, "The discovery of biomarker(s) associated with
exposure and activity is critical for clinical development of promising
cancer chemopreventative agents."
Phenethyl isothiocyanate inhibits androgen receptor-regulated
transcriptional activity in prostate cancer cells through suppressing PCAF
- Mol Nutr Food Res. 2013 May 10 - "The
glucosinolate-derived phenethyl isothiocyanate (PEITC) has recently been
demonstrated to reduce the risk of prostate cancer (PCa) and inhibit PCa
cell growth ... Our results indicate that PEITC inhibits AR-regulated
transcriptional activity and cell growth of PCa cells through
miR-17-mediated suppression of PCAF, suggesting a new mechanism by which
PEITC modulates PCa cell growth"
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