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Home > Anti-aging Research > Nicotinamide riboside

Nicotinamide riboside

Specific Recommendations:

News & Research:

  • Vitamin nicotinamide riboside protects mice from diabetes complications - Science Daily, 5/27/16 - "As had been shown in previous studies, NR greatly protected the prediabetic and T2D mice from weight gain due to the high-fat diet. But the new study also showed that NR had other beneficial effects on whole body metabolism in the prediabetic and T2D mice. It protected high-fat fed mice from hepatic steatosis -- the build-up of fat globules in the liver -- which was severe in the prediabetic and T2D mice that did not receive NR. NR also reduced liver damage in the mice on high-fat diets, and greatly improved blood sugar levels in the prediabetic and T2D mice ... NR also protected against peripheral nerve damage, or neuropathy, a common, serious complication of prediabetes and T2D ... about 60 to 70 percent of people with diabetes have some form of neuropathy. Peripheral neuropathy is a leading cause of diabetic foot ulcers and limb amputation in people with T2D" - See See nicotinamide riboside at Amazon.com.
  • Vitamin stops the aging process of organs - Science Daily, 4/28/16 - "As mice, like all mammals, age, the regenerative capacity of certain organs (such as the liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging ... We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them ... This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it ... Parallel studies have revealed a comparable effect on stem cells of the brain and skin ... So far, no negative side effects have been observed following the use of NR, even at high doses" - See nicotinamide riboside at Amazon.com.
  • Beyond Resveratrol: The Anti-Aging NAD Fad - Scientific American, 3/11/15 - "A prominent theory of aging holds that decaying of mitochondria is a key driver of aging. While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration, as well as the complete absence of zipping around the supper table ... NAD boosters might work synergistically with supplements like resveratrol to help reinvigorate mitochondria and ward off diseases of aging. Elysium is banking on this potential synergy—its NR-containing supplement includes a resveratrol-like substance called pterostilbene (pronounced tero-STILL-bean), which is found in blueberries and grapes ... Why pterostilbene instead of resveratrol? ... While resveratrol has hogged the anti-aging spotlight over the past decade, unsung researchers in places like Oxford, Miss., have quietly shown that pterostilbene is a kind of extra-potent version of resveratrol. The pterostilbene molecule is nearly identical to resveratrol's except for a couple of differences that make it more "bioavailable" (animal studies indicate that about four times as much ingested pterostilbene gets into the bloodstream as resveratrol). Test-tube and rodent studies also suggest that pterostilbene is more potent than resveratrol when it comes to improving brain function, warding off various kinds of cancer and preventing heart disease." - Note: This was a year old article that showed up on my Facebook. I read some of the reviews on Amazon. Nothing gets my goat more that people who think something that delays aging has to give you a buzz such as caffeine. That said, some of the reviews for nicotinamide riboside said it negatively affected their sleep and made them for fatigued and depressed. The negative reviews for Niagen seems to be from those that think it has to give you a buzz (err!!).  I'm sticking with this for now: Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.  Also see Niagen at Amazon.com.

Abstracts:

  • Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice - Sci Rep. 2016 May 27;6:26933 - "NR improved glucose tolerance, reduced weight gain, liver damage and the development of hepatic steatosis in prediabetic mice while protecting against sensory neuropathy. In T2D mice, NR greatly reduced non-fasting and fasting blood glucose, weight gain and hepatic steatosis while protecting against diabetic neuropathy. The neuroprotective effect of NR could not be explained by glycemic control alone ... Quantitative metabolomics established that hepatic NADP(+) and NADPH levels were significantly degraded in prediabetes and T2D but were largely protected when mice were supplemented with NR" - [Nutra USA] - See nicotinamide riboside at Amazon.com.
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