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MitoQ

Specific Recommendations:

• MitoQ at Amazon.com

News & Research:

• Novel antioxidant makes old blood vessels seem young again - Science Daily, 4/19/18 - "Half took 20 milligrams per day of a supplement called MitoQ, made by chemically altering the naturally-occurring antioxidant Coenzyme Q10 to make it cling to mitochondria inside cells ... The other half took a placebo ... The researchers found that when taking the supplement, dilation of subjects' arteries improved by 42 percent, making their blood vessels, at least by that measure, look like those of someone 15 to 20 years younger. An improvement of that magnitude, if sustained, is associated with about a 13 percent reduction in heart disease, Rossman said. The study also showed that the improvement in dilation was due to a reduction in oxidative stress" - See MitoQ at Amazon.com.
• Common antioxidant could slow symptoms of aging in human skin - Science Daily, 5/30/17 - "The effects we are seeing are not temporary. Methylene blue appears to make fundamental, long-term changes to skin cells ... In addition to methylene blue, the researchers also tested three other known antioxidants: N-Acetyl-L-Cysteine (NAC), MitoQ and MitoTEMPO (mTEM) ... In these experiments, methylene blue outperformed the other three antioxidants, improving several age-related symptoms in cells from both healthy donors and progeria patients. The skin cells (fibroblasts, the cells that produce the structural protein collagen) experienced a decrease in damaging molecules known as reactive oxygen species, a reduced rate of cell death and an increase in the rate of cell division throughout the four-week treatment" - Note:  The problem is that methylene blue isn't available to purchase anywhere.  The other three (N-Acetyl-L-Cysteine (NAC), MitoQ and MitoTEMPO (mTEM)) are.  See MitoQ at Amazon.com.
• Novel antioxidant makes old arteries seem young again, study shows - Science Daily, 5/6/14 - "When the research team gave old mice -- the equivalent of 70- to 80-year-old humans -- water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years ... MitoQ completely restored endothelial function in the old mice. They looked like young mice ... Biochemists manufactured MitoQ by adding a molecule to ubiquinone (also known as coenzyme Q10), a naturally occurring antioxidant. The additional molecule makes the ubiquinone become concentrated in mitochondria ... the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice" - See MitoQ at Amazon.com.
• Antioxidant drug knocks down multiple sclerosis-like disease in mice - Science Daily, 12/26/13 - "The antioxidant -- called MitoQ -- has shown some promise in fighting neurodegenerative diseases. But this is the first time it has been shown to significantly reverse an MS-like disease in an animal ... the researchers induced mice to contract a disease called experimental autoimmune encephalomyelitis, or EAE, which is very similar to MS in humans ... After 14 days, the EAE mice that had been treated with the MitoQ exhibited reduced inflammatory markers and increased neuronal activity in the spinal cord -- an affected brain region in MS -- that showed their EAE symptoms were being improved by the treatment. The mice also showed reduced loss of axons, or nerve fibers and reduced neurological disabilities associated with the EAE. The mice that had been pre-treated with the MitoQ showed the least problems. The mice that had been treated with MitoQ after EAE also showed many fewer problems than mice who were just induced to get the EAE and then given no treatment"
  • MitoQ - Wikipedia - "The active antioxidant component of MitoQ is ubiquinone, which is identical to the active antioxidant in Coenzyme Q10" - See ubiquinol products at Amazon.com.
• Antioxidant has potential in the Alzheimer's fight - Science Daily, 12/14/11 - "When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down ... Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in ... an antioxidant can delay the onset of all the indicators of Alzheimer's disease, including cognitive decline. The researchers administered an antioxidant compound called MitoQ to mice genetically engineered to develop Alzheimer's. The results of their study were published in the Nov. 2 issue of the Journal of Neuroscience ... Oxidative stress is believed to cause neurons in the brain to die, resulting in Alzheimer's ... The brain consumes 20 percent of the oxygen in the body even though it only makes up 5 percent of the volume, so it's particularly susceptible to oxidative stress ... MitoQ selectively accumulates in the mitochondria" - Note:  I couldn't find the ingredients but it sounds like a form of co-enzyme Q10.  Here's the form I take: ubiquinol products at Amazon.com
  • Antipodean Pharmaceuticals - MitoQ Technology

Abstracts:

• Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists - Journal of the International Society of Sports Nutrition volume 18, Article number: 58 (2021) - "19 middle-aged (age: 44 ± 4 years) recreationally trained (VO2peak: 58.5 ± 6.2 ml·kg− 1·min− 1, distance cycled per week during 6 months prior to study enrollment: 158.3 ± 58.4 km) male cyclists completed 45 min cycling at 70% VO2peak followed by an 8 km time trial after 28 days of supplementation with MitoQ (20 mg·day− 1) and a placebo ... Mean completion time for the time trial was 1.3% faster with MitoQ (12.91 ± 0.94 min) compared to placebo (13.09 ... These data suggest that MitoQ supplementation may be an effective nutritional strategy to attenuate exercise-induced increases in oxidative damage to lipids and improve cycling performance" - [Nutra USA] - See MitoQ at Amazon.com.
• The targeted anti‐oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue - Physiol Rep. 2018 Apr; 6(7): e13667 - "In summary, MitoQ causes mitochondrial swelling and depolarization in PT cells by a mechanism unrelated to anti‐oxidant activity, most likely because of increased IMM permeability due to insertion of the alkyl chain"
• Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function - J Hypertens. 2013 Dec 4 - "Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, n=8-11) were treated with low-dose losartan (2.5mg/kg per day); MitoQ10 (500μmol/l); a combination of MitoQ10 and losartan (M+L); or vehicle for 8 weeks. Systolic pressure and pulse pressure were significantly lower in M+L rats (167.1±2.9mmHg; 50.2±2.05mmHg) than in untreated SHRSP (206.6±9mmHg, P<0.001; 63.7±2.7mmHg, P=0.001) and demonstrated greater improvement than MitoQ10 or low-dose losartan alone, as measured by radiotelemetry. Left ventricular mass index was significantly reduced from 22.8±0.74 to 20.1±0.61mg/mm in the combination group"