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Home > Health Conditions > Hyperthyroidism

Hyperthyroidism

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Abstracts:

  • Thyroid function and the risk of dementia: The Rotterdam Study - Neurology. 2016 Sep 16 - "Higher TSH was associated with lower dementia risk in both the full and normal ranges of thyroid function (hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.83-0.98; and HR 0.76, 95% CI 0.64-0.91, respectively). This association was independent of cardiovascular risk factors. Dementia risk was higher in individuals with higher free thyroxine (HR 1.04, 95% CI 1.01-1.07). Absolute 10-year dementia risk decreased from 15% to 10% with higher TSH in older women. Higher TSH was associated with better global cognitive scores"
  • Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes? - Endocr J. 2016 Apr 6 - "Untreated subjects with lower TSH showed the greatest declines in MMSE scores during follow-up that was not observed in those with serum TSH ≥1.0 μIU/mL"
  • Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based Cohort Study - J Clin Endocrinol Metab. 2014 Feb 24 - "Overt hypo- and hyperthyroidism are associated with an increased risk of depression ... depressive symptoms [Center for Epidemiologic Studies Depression Scale (CES-D)] were assessed. A CES-D of 16 or greater is indicative of a depressive disorder ... follow-up (mean 8.0 y) ... persons in the lowest TSH tertile (0.3-1.0 mU/L) had more depressive symptoms [CES-D score (mean): 7.95 vs 6.63, P = .014] as well as an increased risk of a CES-D of 16 or greater [10.7% vs 5.0%, odds ratio (95% confidence interval) 2.22 (1.18-4.17)], compared with persons in the highest normal range TSH tertile (1.6-4.0 mU/L)"
  • Endogenous subclinical thyroid disorders, physical and cognitive function, depression and mortality in older individuals - Eur J Endocrinol. 2011 Jul 18 - "To what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression and mortality in older individuals remains a matter of debate ... Participants with overt thyroid disease or use of thyroid medication were excluded ... Sixty-four (5.3%) individuals had subclinical hypothyroidism and 34 (2.8%) had subclinical hyperthyroidism. As compared to euthyroidism (n=1121), subclinical hypo- and hyperthyroidism were not significantly associated with impairment of physical or cognitive function, or depression. On the contrary, participants with subclinical hypothyroidism did less often report more than one activity limitation (odds ratio 0.44, 95% confidence interval (CI) 0.22 to 0.86). After a median follow-up of 10.7 years 601 participants were deceased. Subclinical hypo- and hyperthyroidism were not associated with increased overall mortality risk (hazard ratio 0.89 , 95% CI 0.59 to 1.35 and 0.69, 95% CI 0.40 to 1.20, respectively). Conclusions. The present study does not support disadvantageous effects of subclinical thyroid disorders on physical or cognitive function, depression or mortality in an older population"
  • Is the association between overt hyperthyroidism and mortality causal? Critical review and meta-analysis - Eur J Endocrinol. 2011 Jul 1 - "In patients diagnosed with hyperthyroidism mortality is increased by approximately 20%"
  • Natural history of subclinical hyperthyroidism in elderly patients with TSH between 0.1 and 0.4 mIU/l: a prospective study - Clin Endocrinol (Oxf). 2010 May;72(5):685 - "In elderly patients with endogenous SCH and TSH between 0.1 and 0.4 mIU/l progression to clinical hyperthyroidism is uncommon (approximately 1% per year), spontaneous TSH normalization may occur, and persistence of SCH for many years is the most likely"
  • Natural history of subclinical hyperthyroidism in elderly patients with TSH between 0.1 and 0.4 mIU/L: a prospective study - Clin Endocrinol (Oxf). 2009 Sep 10 - "subclinical hyperthyroidism (SCH) ... The only independent predictor of progression of SCH was an initial TSH value < 0.2 mIU/L. Conclusions: In elderly patients with endogenous SCH and TSH between 0.1 and 0.4 mIU/L progression to clinical hyperthyroidism is uncommon (approximately 1% per year), spontaneous TSH normalization may occur, and persistence of SCH for many years is the most likely"
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