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Anti-aging Research > Green coffee bean extract
Green Coffee Bean Extract
News & Research:
in coffee may help prevent obesity-related disease - Science Daily, 11/14/14
- "chlorogenic acid, or CGA, significantly reduced insulin resistance and
accumulation of fat in the livers of mice who were fed a high-fat diet ... which
is found in great abundance in coffee, but also in other fruits and vegetables
like apples, pears, tomatoes and blueberries ... CGA was not only effective in
preventing weight gain, but it also helped maintain normal blood sugar levels
and healthy liver composition ... CGA is a powerful antioxidant that reduces
inflammation" - See chlorogenic acid at Amazon.com.
Green Coffee Bean Extract: Helpful or All Hype? - U.S. News, 8/1/13
Could Coffee Bean Extract Help Control Blood Sugar? - WebMD, 4/9/13 -
"Vinson's study analyzed 30 men and women of normal
weight who did not have diabetes. They took supplements containing between
100 milligrams (mg) and 400 mg of the green coffee extract in a capsule with
water, followed by glucose tolerance tests at several points afterward ...
All doses of the extract appeared to lower participants' blood sugar levels,
Vinson said, but a dose of 400 mg was associated with a 24 percent drop 30
minutes after taking the extract and a 31 percent drop 120 minutes later ...
Vinson said he believes the sugar-lowering effects of green coffee extract
are due to its concentration of chlorogenic acids -- antioxidants found in
apples, cherries, plums and other fruits and vegetables. High temperatures
used to roast coffee beans typically break down chlorogenic acids, he said,
so coffee beverages contain less of them than extracts found in supplements"
Effects of subacute
ingestion of chlorogenic acids on sleep architecture and energy metabolism
through activity of the autonomic nervous system: a randomised,
placebo-controlled, double-blinded cross-over trial - Br J Nutr. 2017 Apr
17:1-6 - "Chlorogenic acids (CGA) are the most abundant
polyphenols in coffee. Continuous consumption of CGA reduces body fat and body
weight ... A period of 5-d CGA consumption significantly increased fat oxidation
during sleep, suggesting that beverages containing CGA may be beneficial to
reduce body fat and prevent obesity. Consumption of CGA shortened sleep latency
and did not adversely affect sleep quality" - [Nutra
USA] - See
green coffee bean extract at Amazon.com
(usually standardized to 50% chlorogenic acids).
coffee-induced improvements in human vascular function by chlorogenic acids and
its metabolites: Two randomized, controlled, crossover intervention trials -
Clin Nutr. 2016 Nov 30 - "polyphenol intake has been
linked to improvements in human vascular function, although data on
hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We
aimed to investigate the impact of coffee intake rich in chlorogenic acid on
human vascular function and whether CGAs are involved in potential effects ...
flow-mediated dilatation (FMD) ... FMD responses to coffee intake was closely
paralleled by the appearance of CGA metabolites in plasma ... pure
5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg)
on FMD was also investigated ... Coffee intake acutely improves human vascular
function, an effect, in part, mediated by 5-CQA and its physiological
Chlorogenic Acid Extends
the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway -
J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and
tea, two of the most popular drinks around the world, share many in common from
chemical components to beneficial effects on human health. One of their shared
components, the polyphenols, most notably chlorogenic acid (CGA), was supposed
to account for many of the beneficial effects on ameliorating diseases occurred
accompanying people aging, such as the antioxidant effect and against diabetes
and cardiovascular disease ... We found that CGA could extend the lifespan of C.
elegans by up to 20.1%, delay the age-related decline of body movement, and
improve stress resistance"
acid and caffeine in combination inhibit fat accumulation by regulating hepatic
lipid metabolism-related enzymes in mice - Br J Nutr. 2014
Sep;112(6):1034-40 - "chlorogenic acid (CGA) ... forty
mice were randomly assigned to four groups and fed diets containing no CGA or
caffeine, CGA, caffeine, or CGA+caffeine for 24 weeks ... There was a decrease
in the body weight and IPAT weight of mice fed the CGA+caffeine diet. There was
a significant decrease in the serum and hepatic concentrations of total
cholesterol, TAG and leptin of mice fed the CGA+caffeine diet ... These results
indicate that CGA+caffeine suppresses fat accumulation and body weight gain by
regulating the activities and mRNA and protein expression levels of hepatic
lipid metabolism-related enzymes and that these effects are stronger than those
exerted by CGA and caffeine individually" - See
green coffee bean extract at Amazon.com.
and neuroprotective effects of chlorogenic acid - Nutr Neurosci. 2014 Aug 17
- "chlorogenic acid (CGA) ... A literature search was
conducted using PubMed ... Recent research suggests that dietary consumption of
CGA could produce a wide range of health benefits and physiological effects.
There is also mounting evidence that the consumption of polyphenols, including
CGA, in the diet could reduce the risk of developing neurodegenerative
- Chlorogenic acid
- Wikipedia - "Chlorogenic acid can be found in
bamboo Phyllostachys edulis. as well as in many other plants. It is
one of the major phenolic compounds identified in peach and in
prunes. It also is one of the phenols found in green coffee bean
of chlorogenic acid on blood pressure: a systematic review and meta-analysis of
randomized clinical trials - J Hum Hypertens. 2014 Jun 19 -
"Meta-analysis revealed a statistically significant
reduction in systolic blood pressure in favour of CGA (mean difference (MD):
-4.31 mm Hg; 95% confidence interval (CI): -5.60 to -3.01; I2=65%; P<0.00001).
Meta-analysis also showed a significant reduction in diastolic blood pressure
favouring CGA (MD: -3.68 mm Hg; 95% CI: -3.91 to -3.45; I2=97%; P<0.00001)"
artichoke extract at Amazon.com
and chlorogenic acid at Amazon.com.
Decaffeinated green coffee bean extract attenuates diet-induced obesity and
insulin resistance in mice - Evid Based Complement Alternat Med.
2014;2014:718379 - "decaffeinated green coffee bean
extract appeared to reverse HFD-induced fat accumulation and insulin
resistance by downregulating the genes involved in adipogenesis and
inflammation in visceral adipose tissue" - See
green coffee bean extract at Amazon.com.
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