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Home > Anti-aging Research > Ghrelin

Ghrelin

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  • Subchronic treatment with grape-seed phenolics inhibits ghrelin production despite a short-term stimulation of ghrelin secretion produced by bitter-sensing flavanols - Mol Nutr Food Res. 2016 Jul 15 - "Grape-seed phenolic compounds have recently been described as satiating agents in rats when administered as a whole phenolic extract (GSPE) ... The sustained satiating effects of GSPE are related to a long-term decrease in ghrelin expression" - See Best Naturals Grape Seed Extract 400 mg Veggie Capsule, 120 Count.
    • Ghrelin - wikipedia.org - "When the stomach is empty, ghrelin is secreted. When the stomach is stretched, secretion stops.a It acts on hypothalamic brain cells both to increase hunger, and to increase gastric acid secretion and gastrointestinal motility to prepare the body for food intake"
  • Big Breakfast May Be Best for Diabetes Patients - WebMD, 9/26/13 - "randomly assigned 59 people with type 2 diabetes to either a big or small breakfast group ... after 13 weeks, blood sugar levels and blood pressure dropped dramatically in people who ate a big breakfast every day. Those who ate a big breakfast enjoyed blood sugar level reductions three times greater than those who ate a small breakfast, and blood pressure reductions that were four times greater ... About one-third of the people eating a big breakfast ended up cutting back on the daily diabetic medication they needed to take. By comparison, about 17 percent of the small breakfast group had to increase their medication prescriptions during the course of the trial ... Rabinovitz speculated that a big breakfast rich in protein causes suppression of ghrelin, which is known as the "hunger hormone."
  • Eating a big breakfast fights obesity and disease - Science Daily, 8/5/13 - "Metabolism is impacted by the body's circadian rhythm -- the biological process that the body follows over a 24 hour cycle. So the time of day we eat can have a big impact on the way our bodies process food ... 93 obese women were randomly assigned to one of two isocaloric groups. Each consumed a moderate-carbohydrate, moderate-fat diet totaling 1,400 calories daily for a period of 12 weeks. The first group consumed 700 calories at breakfast, 500 at lunch, and 200 at dinner. The second group ate a 200 calorie breakfast, 500 calorie lunch, and 700 calorie dinner ... By the end of the study, participants in the "big breakfast" group had lost an average of 17.8 pounds each and three inches off their waist line, compared to a 7.3 pound and 1.4 inch loss for participants in the "big dinner" group ... those in the big breakfast group were found to have significantly lower levels of the hunger-regulating hormone ghrelin"
  • New research: Limiting carbs to dinner-time increases satiety, reduces risk for diabetes and cardiovascular disease - Science Daily, 11/11/12 - "randomly assigned 78 police officers to either the experimental diet (carbohydrates at dinner) or a control weight loss diet (carbohydrates throughout the day). 63 subjects finished the six-month program ... researchers examined the experimental diet's effect on the secretion of three hormones: leptin, considered to be the satiety hormone, whose level in the blood is usually low during the day and high during the night; ghrelin, considered the hunger hormone, whose level in the blood is usually high during the day and low during the night; and adiponectin, considered the link between obesity, insulin resistance and the metabolic syndrome, whose curve is low and flat in obese people ... the innovative dietary manipulation led to changes in daylight hormonal profiles in favor of the dieters: the satiety hormone leptin's secretion curve became convex during daylight hours with a nadir in the late day; the hunger hormone ghrelin's secretion curve became concave, peaking only in the evening hours; and the curve of adiponectin, considered the link between obesity, insulin resistance and the metabolic syndrome, was elevated. At the same time this dietary pattern led to lower hunger scores, and better anthropometric (weight, abdominal circumference and body fat), biochemical (blood sugar, blood lipids) and inflammatory outcomes compared to the control group"
  • Eggs at Breakfast May Delay Hunger - WebMD, 5/11/12 - "researchers tracked 20 overweight or obese people, giving them either a breakfast containing eggs or cold cereal for one week. Although the breakfasts offered different protein foods, the meals themselves were equally matched in terms of calories, carbohydrates, protein, and fat ... people who had eggs in the morning felt fuller before lunch, and they also ate less food from the buffet compared to those who had cereal. Egg eaters also had lower levels of ghrelin and higher amounts of PYY3-36 during the three hours between breakfast and lunch. This suggests they felt less hungry and more satisfied between meals ... Long-term weight loss trials to compare the manipulation of protein quality without increasing protein quantity should be explored" - Note:  I fully agree.  I just seems very easy to keep my weight in check when I have eggs for breakfast.
  • Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults - Eur J Clin Nutr. 2010 Jul 28 - "A variety of dietary fibers have been shown to alter satiety hormone gene expression and secretion. The objective of this study was to examine plasma satiety hormone concentrations in healthy subjects consuming either PolyGlycopleX (PGX) or control (skim milk powder) for 21 days ... Primary outcomes measured at three visits (V1, V2 and V3) were plasma active glucagon-like peptide-1 (GLP-1) total ghrelin, peptide YY (PYY) and insulin. Results: There was a significant effect of visit for fasting PYY with control participants experiencing decreased PYY levels over time while PGX prevented this decline. When stratified by body mass index (BMI), PGX increased fasting PYY levels from week 1 to week 3 compared with control in participants with BMI <23 kg/m(2). There was a significant effect of visit for fasting ghrelin with levels decreasing in both PGX and control groups over time. No differences were detected in fasting GLP-1 levels. Although there was a 14% reduction in fasting insulin between V1 and V3 with PGX this was not significantly different from control" - Note:  I don't know how they determine that a 14% reduction isn't significant.  See PGX at Amazon.com.
  • Exercise Suppresses Appetite By Affecting Appetite Hormones - Science Daily, 12/19/08 - "A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin"
  • What makes people fat, why diets don't work, and what triggers appetite? - Dr. Murray's Natural Facts, 3/17/04 - "preliminary evidence indicates that PGX™ has powerful effects on reducing regulatory compounds that stimulate appetite like ghrellin while at the same time increasing the levels of regulatory compounds that block the appetite like PYY, CCK, and adiponectin. Further studies being conducted by Dr. Vuksan will likely show that PGX™ exerts powerful effects on these appetite regulators" - See PGX at Amazon.com PGX products.

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