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Home > Health Conditions > Female Sexuality

Female Sexuality/Sexual Arousal Disorder

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  • Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial - Menopause. 2016 Oct 10 - "assigned to receive 750 mg/d of T terrestris or placebo for 120 days ... All participants answered the Female Sexual Function Index and the Sexual Quotient-female version questionnaires ... FSFI questionnaire results demonstrated an improvement in all domains in both groups (P < 0.05) except for lubrication which was improved only in the study group. QS-F results showed a significant improvement in the domains of desire (P < 0.01), arousal/lubrication (P = 0.02), pain (P = 0.02), and anorgasmia (P < 0.01) in women who used T terrestris, whereas no improvement was observed in the placebo group (P > 0.05). Moreover, free and bioavailable testosterone levels showed a significant increase in the T terrestris group" - See Tribulus terrestris at Amazon.com.
  • Efficacy of Intravaginal Dehydroepiandrosterone (DHEA) on Moderate to Severe Dyspareunia and Vaginal Dryness, Symptoms of Vulvovaginal Atrophy, and of the Genitourinary Syndrome of Menopause - Medscape, 3/22/16 - "The daily intravaginal administration of 0.50% (6.5 mg) DHEA (Prasterone) has shown clinically and highly statistically significant effects on the four coprimary parameters suggested by the US Food and Drug Administration. The strictly local action of Prasterone is in line with the absence of significant drug-related adverse events, thus showing the high benefit-to-risk ratio of this treatment based upon the novel understanding of the physiology of sex steroids in women"
  • Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study - Biomed Res Int. 2015;2015:284154 - "high-concentration ashwagandha root extract (HCARE) ... subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks ... treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI Total score (p < 0.001), FSFI domain score for "arousal" (p < 0.001), "lubrication" (p < 0.001), "orgasm" (p = 0.004), and "satisfaction" (p < 0.001), and also FSDS score (p < 0.001) and the number of successful sexual encounters (p < 0.001) at the end of the treatment" - [Nutra USA] - See ashwagandha at Amazon.com.
  • Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study - Phytother Res. 2015 Apr 24 - "Trigonella foenum-graecum (fenugreek) seed extract ... There was a significant increase in free testosterone and E2 in the active group as well as sexual desire and arousal compared with the placebo group. The results indicate that this extract of T. foenum-graecum may be a useful treatment for increasing sexual arousal and desire in women" - See fenugreek at Amazon.com.
  • Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects - Phytother Res. 2013 Jan 24 - "The study design was a 6-week, double-blind, randomized controlled trial (n = 75) involving chronic administration of kava (one tablet of kava twice per day; 120 mg of kavalactones per day, titrated in non-response to two tablets of kava twice per day; 240 mg of kavalactones) or placebo for participants with generalized anxiety disorder. Results showed no significant differences across groups for liver function tests, nor were there any significant adverse reactions that could be attributed to kava. No differences in withdrawal or addiction were found between groups. Interesting, kava significantly increased female's sexual drive compared to placebo (p = 0.040) on a sub-domain of the Arizona Sexual Experience Scale (ASEX), with no negative effects seen in males. Further, it was found that there was a highly significant correlation between ASEX reduction (improved sexual function and performance) and anxiety reduction in the whole sample" - See kava at Amazon.com.
  • The use of dehydroepiandrosterone in the treatment of hypoactive sexual desire disorder: A report of gender differences - Eur Neuropsychopharmacol. 2012 Oct 17 - "Data regarding the efficacy of dehydroepiandrosterone (DHEA) in the treatment of hypoactive sexual desire disorder (HSDD) are scarce and inconsistent. We aimed to determine possible gender differences in the efficacy of DHEA as a treatment for HDSS. Postmenopausal women (n=27), and men (n=21) with HSDD, were randomized to receive either DHEA 100mg daily or placebo for 6 weeks in a controlled, double blind study ... In women only, significant interaction effects were observed for sexual arousal (p<0.05), satisfaction (p<0.05), and cognition (trend; p=0.06). For arousal, a significant improvement was observed for the DHEA treated group at 6 weeks (p=0.001). Significant correlations were observed between bioavailable T and sexual cognitions, arousal and orgasm, while DHEAS was correlated with satisfaction. In the men, significant correlations were observed between testosterone and arousal (r=.45), sexual drive (r=.50) and orgasm (r=.55). In women with HSDD, DHEA treatment had a significant beneficial effect on arousal, whereas no efficacy was demonstrated in men, indicating a possible gender difference. This improvement seems to be mediated via DHEA's metabolism to testosterone. Our positive results suggest that the neurosteroid DHEA may be effective as a treatment for women with HSDD if administered at a dose of at least 100mg per day" - See DHEA at Amazon.com.
  • Menopause pill may boost sex life - USATODAY.com, 12/20/11 - "This is the first evidence that low doses of DHEA (dehydroepiandrosterone), a hormone secreted by the adrenal glands, can help sexual function as well as menopausal symptoms ... women taking DHEA had a statistically significant increase in sexual interest and activity, with similar results for women in the HRT group. Sexual activity was also higher among the women taking tiboline, but the increase was not statistically significant" - See DHEA at Amazon.com.
  • Unhealthy lifestyle is associated with sexual dysfunction - Science Daily, 7/6/11 - "A new study published in The Journal of Sexual Medicine reveals that several unhealthy lifestyle factors, such as weight problems, physical inactivity, high alcohol consumption, tobacco smoking, and hard drugs are associated with sexual dysfunctions in men. Additionally, an unhealthy lifestyle is more common in persons who are sexually inactive ... Among those who had a sexual partner, risk of experiencing sexual dysfunction was greater in men who lead unhealthy lives by 71% in those with substantially increased waist circumference and more than 800% in men using hard drugs. Women who used hashish had almost 3 times increased risk of anorgasmia (difficulties or inability to reach climax during sexual activity with a partner) compared to non-users"
  • Role of androgens in women's sexual dysfunction - Menopause. 2010 Jun 8 - "Significantly lower levels of two precursor hormones, dehydroepiandrosterone sulfate and androstene-3beta,17beta-diol, were found in women with sexual dysfunction ... Although the significance of the former awaits further study, androgen deficiency in women with HSDD was not confirmed. Given the unknown long-term effects of testosterone supplementation, women receiving testosterone therapy should be informed that a deficit of testosterone activity in women with HSDD has not been identified" - See DHEA at Amazon.com.
  • Intravaginal dehydroepiandrosterone (Prasterone), the physiological and a highly efficient treatment of vaginal atrophy - Menopause. 2009 May 8 - "All three doses (0.25%, 0.5%, and 1.0%) of DHEA ovules applied daily intravaginally induced a highly significant beneficial change in the percentage of vaginal parabasal and superficial cells and pH as well as in the most bothersome symptom at 2 weeks. At the standard 12-week time interval, 0.5% DHEA caused a 45.9 +/- 5.31 (P < 0.0001 vs placebo) decrease in the percentage of parabasal cells, a 6.8 +/- 1.29% (P < 0.0001) increase in superficial cells, a 1.3 +/- 0.13 unit (P < 0.0001) decrease in vaginal pH, and a 1.5 +/- 0.14 score unit (P < 0.0001) decrease in the severity of the most bothersome symptom. Similar changes were seen on vaginal secretions, color, epithelial surface thickness, and epithelial integrity. Comparable effects were observed at the 0.25% and 1.0% DHEA doses ... Local Prasterone, through local androgen and estrogen formation, causes a rapid and efficient reversal of all the symptoms and signs of vaginal atrophy with no or minimal changes in serum steroids, which remain well within the normal postmenopausal range. This approach avoids the fear of systemic effects common to all presently available estrogen formulations and adds a novel physiological androgenic component to therapy"
  • Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration - Menopause. 2009 May 8 - "The present data show that local daily intravaginal DHEA administration at DHEA doses of 3.25-13 mg was able to rapidly and efficiently achieve correction of all the signs and symptoms of vaginal atrophy and improve sexual function and caused no or minimal changes in serum sex steroid levels, which all remain within the normal postmenopausal range, thus avoiding the risks of all estrogen formulations"
  • Efficacy and safety of low-dose regimens of conjugated estrogens cream administered vaginally - Menopause. 2009 May 8 - "At week 12, improvements in VMI with daily and twice-weekly use of low-dose CE cream (27.9% and 25.8%, respectively) were significantly greater compared with placebo (3.0% and 1.0%, respectively; P < 0.001). Improvements in vaginal pH with daily and twice-weekly CE cream (-1.6 for both) were also significantly greater relative to placebo (-0.4 and -0.3, respectively; P < 0.001). VMI and vaginal pH responses were sustained through 52 weeks. Both CE cream regimens significantly reduced most bothersome symptom scores compared with placebo (P </= 0.001), including those for dyspareunia (P </= 0.01). There was no report of endometrial hyperplasia or carcinoma. Adverse events occurred with similar frequency among the active and placebo groups during the double-blind phase"
  • Menopause tied to sexual dysfunction - MSNBC, 4/9/07 - "Women who have particularly low levels of the hormone DHEA during menopause may be more likely to have sexual dysfunction ... Women with relatively low blood levels of the hormone were 59 percent more likely to report sexual problems than those with high levels"
  • Sex Drive Need a Tune-Up? - Dr. Weil, 9/25/06
  • DHEA Sulphate Levels May Signify Low Libido - Doctor's Guide, 6/18/04
  • Hormone Linked to Low Sex Drive in Women - HealthDay, 6/16/04 - "this study has shown low testosterone bears no relationship to low libido in women under 45 years of age. We found a strong relationship between the low scores for desire, arousal and responsiveness and low DHEA levels in women under 45" - See iHerb or Vitacosticon DHEA products.
  • Why Aging Women Need Testosterone - Life Extension Magazine, 4/04 - "Controlled studies show that slightly increasing testosterone levels in aging women restores sexual drive, arousal, and frequency of sexual fantasies. In fact, low testosterone levels in women of all ages seem to suppress libido and cause sexual dysfunction. Restoring youthful testosterone in women has been shown to improve mood and well being, and to provide many other health-enhancing benefits"
  • Exercise Improves Libido in Menopausal Women - Clinical Psychiatry News, 12/03
  • Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 - "Testosterone and dihydrotestosterone plasma levels, and plasma E1 and E2 levels increased significantly and progressively in both groups ... Cortisol F plasma levels progressively decreased throughout the study. Both groups also experienced significantly reduced LH and FSH plasma levels. GH and IGF-1 levels significantly increased in both groups. Supplementation did not induce changes in endometrial thickness ... These data support and confirm that DHEA must be considered a valid compound and drug for [hormone therapy] in postmenopausal women and not just a 'dietary supplement" - See iHerb or Vitacosticon DHEA products.
  • Red Clover Extract Helps Vaginal Dryness - WebMD, 7/9/03
  • Oil [Zestra] May Help Women With Arousal Problems - WebMD, 1/30/03 - "Women with FSAD reported satisfaction with sexual arousal less than one-third of the time while using the placebo oil, but 85% of the time with Zestra" - See Zestra at Zestra at drugstore.comicon.
  • Stress, Cortisol and Health - Supplement Watch Newsletter, 10/02 - "several lines of evidence have converged to solidify the concept that stress makes us fat (because of cortisol), thins our bones (because of cortisol), shrinks our brains (because of cortisol), suppresses our immune system (because of cortisol), saps our energy levels (because of cortisol), and kills our sex drive (because of cortisol) ... Take a daily multivitamin/multi-mineral supplement - because calcium, magnesium, vitamin C and B-complex vitamins are needed for a proper stress response ... Chief among the supplements with documented cortisol-controlling effects are Phosphatidylserine, Beta-sitosterol, Magnolia bark, Theanine, Epimedium, Ashwagandha and Passionflower"
  • Sexual Enhancement Supplements (Including L-arginine, Yohimbe, and Epimedium (Horny Goat Weed)) review - ConsumerLab.com, 9/24/02 - "In a four-week, double-blind study, 77 women with decreased libido were given either the combination product (ArginMax) or placebo. As expected, a high percentage of participants taking placebo showed improvement. However, participants taking the product showed statistically greater improvement such as increased reported sexual desire level in 71% of participants given the treatment vs. 42% in the placebo group" - See Drugstore.com/GNC ArginMax products.
  • Possible treatment for female sexual dysfunction - Life Extension Foundation, 9/01
  • The Effects of L-Arginine and Yohimbine on Sexual Arousal in Postmenopausal Women with FSAD - University of Texas at Austin Dept. of Psychiatry
  • Nutritional Supplement [Arginmax] Reported to Improve Women's Sexual Function - Medscape, 6/8/01
  • Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction, Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 - "ArginMax -- a dietary cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic acid, and other vitamins and minerals -- is being heralded as one component of a lifestyle that improves sexual performance and helps prevent problems associated with intimacy"
  • Women and Sex Drive -  Life Enhancement Magazine, 12/99

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