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Efficacy of Synbiotics in
Patients with Slow Transit Constipation: A Prospective Randomized Trial -
Nutrients. 2016 Sep 28;8(10) - "A total of 100 patients with slow transit
constipation were randomized to receive either a synbiotic or placebo twice
daily for 12 weeks ... Over 12 weeks, 64.6% of the patients who received the
synbiotic experienced clinical improvement, compared to 29.2% of the patients in
the placebo group (p < 0.01). During the intervention period, patients who were
treated with the synbiotic exhibited increased stool frequency, improved stool
consistency, decreased CTT, and improved constipation-related symptoms"
- [Nutra USA] -
synbiotic products at Amazon.com,
probiotic products at Amazon.com
inulin at Amazon.com.
Effect of the probiotic
strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency
in healthy subjects with low defecation frequency and abdominal discomfort: a
randomised, double-blind, placebo-controlled, parallel-group trial - Br J
Nutr. 2015 Sep 18 - "The OR for having a defecation
frequency above baseline for ≥50 % of the time was 1.31 (95 % CI 0.98, 1.75),
P=0.071, for probiotic treatment overall. Tightening the criteria for being a
responder to an increase of ≥1 d/week for ≥50 % of the time resulted in an OR of
1.55 ... A treatment effect on average defecation frequency was found
(P=0.0065), with the frequency being significantly higher compared with placebo
at all weeks for probiotic treatment overall (all P<0.05). Effects on defecation
frequency were similar for the two doses tested, suggesting that a ceiling
effect was reached with the one billion dose. Overall, 4 weeks' supplementation
with the probiotic strain BB-12® resulted in a clinically relevant benefit on
defecation frequency" - [Nutra
USA] - See
probiotic products at Amazon.com.
‘Level 1’ evidence that probiotics boost ‘transit time’: Danisco & Fonterra
- Nutra USA 6/22/11 - "the benefits were “at least
equivalent to that of dietary fiber” ... The researchers recruited 100 healthy
people with an average age of 44 and randomly assigned them to receive high or
low daily doses of B. lactis HN019, or placebo for 14 days. High dose was
defined as 17.2 billion colony forming units (CFU), while the low dose was 1.8
billion CFU ... At the end of the study results showed an improvement in transit
time in the high dose group of 33 percent, and 25 percent in the low dose group.
There was no change in the placebo group, added the researchers" - [Abstract]
probiotics at Amazon.com.
Probiotics may ease bowel movements for elderly: Study - Nutra USA, 5/13/11
- "The probiotic product (VSL Pharmaceuticals)
reportedly contained 450 billion viable lyophilized bacteria from eight
different strains, including Lactobacillus plantarum, L. paracasei, L.
bulgaricus, L. acidophilus, Bifidobacterium breve, B. longum, B. infantis, and
Streptococcus thermophilus ... people consuming the probiotic experienced a
lower incidence of diarrhea (60 percent lower), compared to placebo ... In
addition, laxative use decreased by 26 percent amongst people in the probiotic
group, compared to placebo, added the Israeli scientists ... A significant
reduction of Clostridium difficile prevalence was found in the probiotic group"
- [Abstract] - See
probiotics at Amazon.com.
safety of daily magnesium oxide treatment for children with chronic constipation
- Science Daily, 3/8/11 - "The authors concluded that
serum magnesium concentrations increase significantly after daily magnesium
oxide intake, but the magnitude of the increase appears modest. Younger age, but
not prolonged use of daily magnesium oxide might be a relative risk factor, and
it should be determined by further studies whether serum magnesium concentration
should be assessed in these subjects"
Bifidobacterium breve effective in the treatment of childhood constipation?
Results from a pilot study - Nutr J. 2011 Feb 23;10(1):19 -
"Probiotics are increasingly used in the treatment of
functional gastrointestinal disorders. Studies in constipated adults with a
Bifidus yoghurt (containing Bifidobacterium breve, Bifidobacterium bifidum and
Lactobacillus acidophilus) showed a significant increase in defecation frequency
... The defecation frequency per week significantly increased from 0.9 (0-2) at
baseline to 4.9 (0-21) in week 4 (p< 0.01). The mean stool consistency score
increased from 2.6 (2-4) at baseline to 3.5 (1-6) in week 4 (p = 0.03). The
number of faecal incontinence episodes per week significantly decreased from 9.0
(0-35) at baseline to 1.5 (0-7) in week 4 (p <0.01). Abdominal pain episodes per
week significantly decreased from 4.2 (0-7) at baseline to 1.9 (0-7) in week 4
(p = 0.01). No side effects occurred" - See
Bifidobacterium breve products at iHerb.
Fermented milk containing Lactobacillus casei strain Shirota reduces
incidence of hard or lumpy stools in healthy population - Int J Food Sci
Nutr. 2011 Feb 15 -
"Healthy subjects with Bristol Stool Form Scale (BS)
score < 3.0 were randomized to fermented milk treatment for 3 weeks or
non-intervention control. The primary endpoint was the proportion of
subjects that produced hard or lumpy stools (HLS) ≥ 25% of bowel movements
(H-HLS). Secondary endpoints included changes in BS score,
constipation-related symptom scores and stool parameters. Efficacy was
analyzed in 39 subjects. After 3 weeks of treatment the proportion of H-HLS
subjects had significantly decreased from 73.7% to 36.8%, whereas in the
control group the proportion had increased from 75.0% to 85.0% during the
same period (P = 0.002). The BS score was significantly improved after the
treatment compared with the control (P < 0.001). In conclusion, daily
consumption of fermented milk containing LcS reduced the incidence of HLS"
Garden of Life, Primal Defense, HSO Probiotic Formula, 180 + 36 = 216
Caplets at iHerb which includes the Lactobacillus casei strain.
The Use of
Probiotics in Healthy Volunteers With Evacuation Disorders and Hard Stools: A
Double-blind, Randomized, Placebo-controlled Study - J Clin Gastroenterol.
2010 Aug 6 - "Subjects treated with the mixed probiotic
strains L. plantarum LP01 and B. breve BR03 or B. animalis subsp. lactis BS01
reported a significant improvement in the number of weekly bowel movements and
in the main troubles associated with evacuations, particularly consistency of
feces and ease of expulsion. Discomfort items such as abdominal bloating and
anal itching, burning, or pain also registered a relevant improvement in the
active groups receiving probiotics" - See
probiotics at Amazon.com.
Probiotics work out against constipation, says study - Nutra USA,
8/10/07 - "the frequency of bowel movements doubled
over the weeks following the start of probiotic supplementation, increasing
from two per week to 4.2 after two weeks, to 3.8 after four weeks" [Abstract]
Natural "Bowel Recipe" More Effective in Reducing Straining - Medscape,
10/23/06 - "A "bowel recipe" consisting of wheat
bran, applesauce, and prune juice appears to be more effective than a
commercial psyllium fiber supplement in reducing straining in women with
pelvic floor dysfunction"
- My three-year-old daughter
suffers from constipation - Dr. Weil, 6/26/03
- Conquering Constipation --
Naturally? - Dr. Weil, 2/20/03 -
"The bowel regulator I recommend most frequently is
Triphala, a mixture of three fruits from India from the Ayurvedic tradition,
available in capsule form at health food stores" - See
iHerb Triphala products.
Constipation - American Academy of Family Physicians
Constipation - emedicine.com
Constipation - familydoctor.org
Treatments for constipation
Allows Sale of Drug to Treat Constipation - New York Times, 4/25/08
Constipation Most Common Cause Of Children's Abdominal Pain - Science
Novel Treatments May Help Alleviate Constipation, Irritable Bowel Syndrome
In Women - Science Daily, 5/22/07
Suffering From Chronic Constipation? - Doctor's Guide, 11/22/06
Amitizia (Lubiprostone) Shown Effective and Well-Tolerated in People Older
than Age 65, a Population Considerably Affected by Chronic Idiopathic
Constipation - Doctor's Guide, 5/30/06
Amitizia (Lubiprostone), the First Selective Chloride Channel Activator for
the Treatment of Chronic Idiopathic Constipation, Launches in the United
States - Doctor's Guide, 4/24/06
FDA OKs Drug to Treat Constipation - WebMD, 2/1/06
FDA Approves New Prescription Drug for Adults for Treatment of Chronic
"Idiopathic" Constipation - Doctor's Guide, 1/31/06 -
"The FDA today approved Amitiza (lubiprostone), the
first drug of its chemical type, for the treatment of chronic constipation
in the adult population where there is no known cause for the condition"
Lubiprostone a New Option for Treatment of Constipation: Presented at WCOG
- Doctor's Guide, 9/16/05
Debunking Constipation Myths: The Truth About High Fiber Diets And Laxatives
- Science Daily, 1/14/05
- Constipation Myths
Debunked - WebMD, 1/4/05
FDA Approves Zelnorm (Tegaserod Maleate) as Treatment for Chronic
Constipation - Doctor's Guide, 8/23/04
Recommend Zelnorm for Constipation - WebMD, 7/15/04
Tegaserod Helps Relieve Constipation - Doctor's Guide, 10/27/03
- Treatment Approach to
Functional Constipation? - Medscape, 9/11/03 -
"The clinical approach for slow-transit constipation
usually consists of dietary changes, including increased fluid and
fiber intake, stool softeners, and various
laxatives. Some prokinetic agents may also be considered, including
prostaglandin analogs (misoprostol) and serotonin-receptor agonists such as
cisapride (under restricted use only) and tegaserod (recently approved for
irritable bowel syndrome with constipation)"
Constipation Appears Common in Chronic Pain Patients on Controlled-Release
Oxycodone - Doctor's Guide, 2/21/03
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