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Anti-aging Research > Coleus forskholii.
News & Research:
supplement may help treat recurrent bladder infections - USA Today,
4/8/07 - "If these results could be duplicated in
human studies, forskolin could offer a new treatment option for recurrent"
urinary tract infection"
Weight-control Options - Functional Foods & Nutraceuticals, 8/02
Nutracon News - Nutrition Science News, 9/01 -
"Although forskolin is active in the same metabolic
pathway as ephedrine, it starts further down the pathway. Forskolin enhances
adenylate cyclase, an enzyme that splits a high-energy molecule of adenosine
triphosphate (ATP) to yield cyclic adenosine monophosphate (cAMP).
Typically, an increase in cAMP leads to activation of other enzymes, among
which is lipase. Lipase disposes of triglycerides, known as the building
blocks of fatty tissue, which has a positive effect on body composition. The
net effect is an increase in lean body mass and trimmed waistline"
Supplement Update: Coleus Forskohlii - ThinkMuscle.com -
"The breakdown of fat for fuel (lipolysis) is
actually regulated by cAMP. Forskolin has been shown to not only enhance
lipolysis but it may also inhibit fat storage from occurring. This is very
good news for individuals trying to lose bodyfat and get lean"
Forskolin, a hedgehog
signaling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis
in rats - Br J Pharmacol. 2016 Sep 2 - "Our
findings indicate that forskolin has a promising antifibrotic effect which
could be partially attributed to its antioxidant, anti-inflammatory effects
as well as inhibition of Hh signaling" - See
Coleus forskohlii products at Amazon.com.
forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet
Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese
Subjects: A Randomized Controlled Trial - Nutrients. 2015 Nov 17 -
"Limited studies have shown that Coleus forskohlii
extract may aid in weight management ... Thirty participants completed the
trial and they were randomly assigned to receive either 250 mg of C.
forskohlii extract (n = 15) or a placebo twice daily for 12 weeks ... The
experimental group showed a favorable improvement in insulin concentration
and insulin resistance (p = 0.001; 0.01 respectively) compared to the
Relationship between cyclic AMP production and lipolysis induced by
forskolin in rat fat cells - J Lipid Res 1992 Feb;33(2):225-31
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