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Home > Anti-aging Research > Calorie Restriction.

Calorie Restriction

News & Research:

  • Fasting ramps up human metabolism, study shows - Science Daily, 1/31/19 - "The researchers monitored changing levels of metabolites -- substances formed during the chemical processes that grant organisms energy and allow them to grow. The results revealed 44 metabolites, including 30 that were previously unrecognized, that increased universally among subjects between 1.5- to 60-fold within just 58 hours of fasting ... In previous research, the G0 Cell Unit identified various metabolites whose quantities decline with age, including three known as leucine, isoleucine, and ophthalmic acid. In fasting individuals, these metabolites increase in level, suggesting a mechanism by which fasting could help increase longevity ... These are very important metabolites for maintenance of muscle and antioxidant activity, respectively ... For example, they found a global increase in substances produced by the citric acid cycle, a process by which organisms release energy stored in the chemical bonds of carbohydrates, proteins and lipids. The marked increase suggests that, during fasting, the tiny powerhouses running every cell are thrown into overdrive."
  • Less fat, more hair and younger skin: Study in mice shows benefits from calorie-restricted diet - Science Daily, 10/30/17 - "After six months, the body mass of the mice fed a caloric restriction (CR) diet was 40% lower than that of the mice fed an unrestricted diet. This change was not due to the mice losing weight; the mice fed a CR diet did not gain as much weight as the mice that could eat ad libitum. As the fat that helps keep the body warm diminished in CR mice, the adaptive response of their skin was to stimulate fur growth, and after six months, their fur was more uniform, thicker and longer ... Skin vascularization also changed. Compared with the obese group, the CR group had three times more blood vessels in their skin. This change increased blood flow to skin cells ... Conversely, signs of premature skin aging appeared in the overweight mice. "The change in vasoconstriction helped the slimmer mice stay warm, and their skin also remained young," ... CR mice lost muscle mass and became lethargic"
  • Face cream ingredient found to mimic life-extending effects of a calorie restriction diet - Science Daily, 12/16/15 - "scientists have shown for the first time that allantoin, which is found in botanical extracts of the comfrey plant and is an ingredient of many anti-ageing creams, can mimic the effect of calorie restriction and increase lifespan in worms by more than 20% ... worms treated with allantoin, rapamycin, trichostatin A and LY-294002 not only lived longer, but also stayed healthier longer. Additionally, when the same compounds were tested in mutant worms they extended lifespan in a way expected from calorie restriction" - See allantoin products at Amazon.com.
  • Long life: Balancing protein and carb intake may work as well as calorie restriction - Science Daily, 5/28/15 - "The investigators compared three 8-week diets varying in protein-to-carbohydrate ratio under conditions where food was restricted or food was available at all times. Of the three, low protein, high carbohydrate (LPHC) diets offered when food was always available delivered similar benefits as calorie restriction in terms of insulin, blood sugar, and cholesterol levels, despite increased food intake ... Even though the mice on LPHC diets ate more when food was always available, their metabolism was higher than that of mice on the calorie-restricted diet, and they did not gain more weight. Calorie restriction did not provide any additional benefits for LPHC mice"
  • Metformin use associated with reduced risk of developing open-angle glaucoma - Science Daily, 5/28/15 - "patients prescribed the highest amount of metformin (greater than 1,110 grams in two years) had a 25 percent reduced risk of OAG risk compared with those who took no metformin. Every one-gram increase in metformin was associated with a 0.16 percent reduction in OAG risk, which means that taking a standard dose of 2 grams of metformin per day for two years would result in a 20.8 percent reduction in risk of OAG ... this study points out the importance of understanding the potential impact of CR (caloric restriction) mimetic drugs on the risk of developing other medical conditions that affect older persons" - See metformin at The Antiaging Store.
  • Caloric restriction: A fountain of youth for aging muscles? - Science Daily, 4/22/15 - "while 14 weeks of calorie restriction did not significantly affect the middle-aged rats, it reduced muscle mass in the young rats. Calorie restriction slowed the glycolytic rate in the muscles and increased the cells' dependency for OXPHOS versus glycolysis in older rats, which was linked to improvement of normalized muscle mass. The team also found that "14 weeks of CR reprogrammed cellular metabolism, where the relative contribution of OXPHOS and glycolysis in muscles of middle-aged rats with CR was similar to that in muscles of young rats"
  • Improved Survival in Cancer Patients With High Vitamin D - Medscape, 5/1/14 - "overall survival for colorectal and breast cancer patients in the highest quartile of circulating 25-hydroxyvitamin D [25(OH)D] levels was significantly better than it was for those in the lowest quartile of 25(OH)D levels ... Overall survival was also significantly better for lymphoma patients in the highest 25(OH)D quartile compared with those in the lowest quartile ... Considering that vitamin D deficiency is widespread around the world, our suggestion is to ensure everyone has sufficient levels of this important nutrient — that is, circulating 25(OH)D levels — greater than 75 nmol/L ... when investigators compared 25(OH)D levels in the range of 40 to 70 nmol/L to levels <19 nmol/L, they found that a 10-nmol/L increase in circulating vitamin D levels upon cancer diagnosis was associated with a 4% reduction in all-cause mortality among all cancer patients in whom a dose-response relationship was assessed" - See vitamin D at Amazon.com.
  • Pill linked to long life in mice - BBC News, 7/31/13 - "Scientists believe the drug, metformin, may mimic the effects of extreme calorie restriction ... Metformin is one of the most widely prescribed treatments for type-2 diabetes, which occurs mainly in people above the age of 40. It is also used to treat metabolic syndrome, a combination of diabetes, high blood pressure and obesity ... The scientists gave one of two different doses of metformin to middle-aged male mice and found that lower doses increased lifespan by about 5%, and also delayed the onset of age-associated diseases" - Note:  I've been taking it in low doses for years to help combat aging.  See metformin at The Antiaging Store.
  • How diabetes drug delays aging in worms - Science Daily, 3/28/13 - "Following a calorie-restricted diet has been shown to improve health in later life and extend lifespan in a number of animals, ranging from the simple worm to rhesus monkeys. The type 2 diabetes drug metformin has been found to have similar effects in animals ... Overall, treatment with metformin adds up to 6 days of life for the worm which is equivalent to around a third of its normal lifespan. It seems to work by altering metabolism in the bacteria that live in the worm, which in turn limits the nutrients that are available to the worm host and has a similar effect to restricting the diet ... However, when they added an excess of sugar to the diet, the team found that the life-extending effects of metformin were cancelled out" - See metformin at The Antiaging Store.
  • A Few Extra Pounds Linked to a Longer Life - WebMD, 1/1/13 - "The review, of 97 studies that included a combined 2.88 million people, questions the notion that people of normal weight live longest ... People with BMIs under 30 but above normal were less likely to die during the studies compared to people with normal BMIs ... A reduction in the risk of death from all causes was about 6% lower for people who were overweight ... Those people considered obese based on BMI, however, were worse off. They were about 18% more likely to die of any cause compared to those of normal weights"
  • Dieting Monkeys Don't Always Live Longer, Says Study - ABC News, 8/29/12 - "As the latest Nature dispatch found, the NIA monkeys fed a calorie-restricted diet didn't live any longer than monkeys on a higher-calorie diet. No matter what they ate, maximum lifespan seems to hover around 40 years of age. Half the monkeys that began the study as youngsters were still alive, but the researchers say, based on survival patterns, they predict the remaining calorie-restrictors and controls will all live to be about the same age ... These latest findings are at odds with the WNPRC study in which calorie-restricted monkeys have far outlived the controls ... the study design might account for some of the disparities ... For one thing, the Wisconsin monkeys subsisted on a diet that shared many of the same unhealthy aspects of a typical Western diet ... The NIA monkeys were already eating so healthy to begin with, the calorie reduction may not have provided much more of a health advantage"
  • Calorie-restricted diet keeps heart young - Science Daily, 6/6/12
  • Red wine antioxidant could give metabolism a boost - USATODAY.com, 11/1/11 - "For the study, Schrauwen's team gave resveratrol to 11 obese, but otherwise healthy men. The men took 150 milligrams of the supplement a day for 30 days. To get that much resveratrol from wine would mean drinking over two gallons of wine a day ... resveratrol acted much like a low-calorie diet in terms of reducing energy expenditure and improving metabolism and overall health ... Changes included a lower metabolic rate, reduced fat in the liver, lower blood pressure and lower blood sugar. The men also had changes in the way their muscles burned fat ... In obesity, it's not clear whether burning fewer calories is a good or a bad thing ... It suggests, however, that cells were functioning more efficiently, as they do on a calorie-restricted diet" - [ABC News] - See resveratrol products at Amazon.com.
  • Live longer with fewer calories? Key enzyme involved in aging process found - Science Daily, 10/31/11 - "We are able to show that caloric restriction slows down aging by preventing an enzyme, peroxiredoxin, from being inactivated. This enzyme is also extremely important in counteracting damage to our genetic material ... Prx1 is damaged during aging and loses its activity. Caloric restriction counteracts this by increasing the production of another enzyme, Srx1, which repairs Prx1. Interestingly, the study also shows that aging can be delayed without caloric restriction by only increasing the quantity of Srx1 in the cell. Repair of the peroxiredoxin Prx1 consequently emerges as a key process in aging ... Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, we can now speculate whether increased repair of Prx1 during aging can counteract, or at least delay, the development of cancer"
  • Research from Everest: Can leucine help burn fat and spare muscle tissue during exercise? - Science Daily, 8/28/11 - "Research on Mt. Everest climbers is adding to the evidence that an amino acid called leucine -- found in foods, dietary supplements, energy bars and other products -- may help people burn fat during periods of food restriction, such as climbing at high altitude, while keeping their muscle tissue ... We knew that leucine has been shown to help people on very low-calorie, or so-called 'calorie-restricted diets', stay healthy at sea level ... the findings also could help people at lower altitudes who want to lose weight while preserving their lean body mass, or who are elderly and don't eat or exercise enough to maintain their strength" - See leucine products at Amazon.com.
  • Fat and healthy? Study finds slim isn't always superior - Science Daily, 8/15/11 - "obese people who are otherwise healthy live just as long as their slim counterparts, and are less likely to die of cardiovascular causes ... Kuk's team looked at 6,000 obese Americans over a 16-year span, comparing their mortality risk with that of lean individuals" - Note:  I though this in because it makes you wonder if being cranky all your life from calorie restriction is worth it.
  • Mouse study turns fat-loss/longevity link on its head - Science Daily, 5/3/11 - "studied the effect of food restriction on fat and weight loss in 41 genetically different strains of mice. The scientists then correlated the amount of fat reduction to life span ... The answer: Mice that maintained their fat actually lived longer. Those that lost fat died earlier ... People are best advised to adopt a moderate approach, not losing all fat but definitely not keeping unhealthy amounts of fat, either ... None of the mice in this study were what we would consider to be obese"
  • Routine periodic fasting is good for your health, and your heart, study suggests - Science Daily, 4/3/11 - "fasting not only lowers one's risk of coronary artery disease and diabetes, but also causes significant changes in a person's blood cholesterol levels ... fasting was also found to reduce other cardiac risk factors, such as triglycerides, weight, and blood sugar levels ... During the 24-hour fasting periods, HGH increased an average of 1,300 percent in women, and nearly 2,000 percent in men"
  • Exercise and caloric restriction rejuvenate synapses in lab mice - Science Daily, 8/2/10
  • Eat less, live longer? - New Scientist, 6/3/10 - "One piece of evidence for this idea comes from studies in fruit flies and rodents. If these animals are fed special diets with less amino acids - the building blocks of proteins - they can eat as many calories as they want and still live longer ... The protein theory is bad news for people on low-carbohydrate weight-loss plans like the Atkins diet. "I'd be wary of diets that put a heavy emphasis on protein," says Piper. "It's hard to see how that could be healthy." Fontana goes one step further, saying that high-protein diets could risk accelerated ageing and cancer ... There may be another reason for vegans to celebrate. Studies on flies and rodents suggest that cutting intake of one particular amino acid, called methionine, lengthens life to a similar degree as calorie restriction. Proteins in meat and other animal products have high levels of methionine, so a vegan diet would score well by that measure, too"
  • Calorie restriction leads scientists to molecular pathways that slow aging, improve health - Science Daily, 4/15/10 - "About 30 percent of the animals on calorie restriction die at an advanced age without any diseases normally related to aging," Fontana says. "In contrast, among animals on a standard diet, the great majority (94 percent) develop and die of one or more chronic diseases such as cancer or heart disease. In 30 percent to 50 percent of the animals on calorie restriction, or with genetic mutations in these aging-related pathways, healthspan is equal to lifespan. They eventually die, but they don't get sick."
  • Overweight Older People Live Longer - WebMD, 1/28/10 - "people who met the criteria for being overweight were 17% less likely to die compared to people of normal weight ... In the newly reported research, overweight study participants in their 70s followed for up to 10 years had a 13% lower risk of death than participants classified as normal weight ... Obese and normal-weight study participants had a similar risk of death over the 10 years of follow-up. Underweight study participants had the highest risk of death, even after the researchers adjusted for the wasting effects of disease"
  • Calorie restriction: Scientists take important step toward 'fountain of youth' - Science Daily, 12/26/09 - "They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under these same conditions. The reduced glucose caused normal cells to have a higher activity of the gene that dictates the level of telomerase, an enzyme that extends their lifespan and lower activity of a gene (p16) that slows their growth. Epigenetic effects (effects not due to gene mutations) were found to be a major cause in changing the activity of these genes as they reacted to decreased glucose levels" - See my Insulin and Aging page.  Insulin controls glucose levels.  Insulin resistance causes high glucose.
  • Scientists find molecular trigger that helps prevent aging and disease - Science Daily, 11/18/09 - "diabetes reduces activation of CBP, leading Dr. Mobbs to conclude that a high-calorie diet that leads to diabetes would have the opposite effect of dietary restriction and would accelerate aging"
  • Click here of a 10/5/09 news clip (I put it on YouTube) that claims that metformin may provide the same anti-aging benefits as calorie restriction (you won't need to look like a POW).  Metformin is another one I take for anti-aging.  In addition to the calorie restriction type benefits, see my Insulin and Aging page.
  • The Way You Eat May Affect Your Risk For Breast Cancer - Science Daily, 8/4/09
  • Reduced Diet Thwarts Aging, Disease In Monkeys - Science Daily, 7/9/09 - "We observed that caloric restriction reduced the risk of developing an age-related disease by a factor of three and increased survival ... The incidence of cancerous tumors and cardiovascular disease in animals on a restricted diet was less than half that seen in animals permitted to eat freely. Remarkably, while diabetes or impaired glucose regulation is common in monkeys that can eat all they want, it has yet to be observed in any animal on a restricted diet" Makes you wonder why the next is true:
  • Study: Overweight People Live Longer - WebMD, 6/25/09 - "There is more evidence that people who are overweight tend to live longer than people who are underweight, normal weight, or obese ... Those classified as underweight were 73% more likely to die ... Those classified as extremely obese with BMI of 35 or greater were 36% more likely to die ... Those classified as obese with BMI 30-34.9 had about the same risk of death ... Those classified as overweight with BMI 25-29.9 were 17% less likely to die"
  • Glucose-To-Glycerol Conversion In Long-lived Yeast Provides Anti-aging Effects - Science Daily, 5/13/09
  • Calorie Restriction Causes Temporal Changes In Liver Metabolism - Science Daily, 5/4/09
  • Not So Sweet: Over-consumption Of Sugar Linked To Aging - Science Daily, 3/9/09 - "We know that lifespan can be extended in animals by restricting calories such as sugar intake ...it's not sugar itself that is important in this process but the ability of cells to sense its presence ... the lifespan of yeast cells increased when glucose was decreased from their diet. They then asked whether the increase in lifespan was due to cells decreasing their ability to produce energy or to the decrease in signal to the cells by the glucose sensor ... cells unable to consume glucose as energy source are still sensitive to the pro-aging effects of glucose. Conversely, obliterating the sensor that measures the levels of glucose significantly increased lifespan"
  • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging" - See resveratrol products at Amazon.com.
  • Fewer Calories, Better Memory? - WebMD, 1/26/09 - "older men and women who follow a restricted-calorie diet score better on verbal memory tests than those who do not make such diet changes"
  • Eating Less May Not Extend Human Life: Caloric Restriction May Benefit Only Obese Mice - Science Daily, 1/26/09 - "For lean mice – and possibly for lean humans, the authors of a new study predict – the anti-aging strategy known as caloric restriction may be a pointless, frustrating and even dangerous exercise ... Today there are a lot of very healthy people who look like skeletons because they bought into this ... Contrary to what is widely believed, caloric restriction does not extend (the) life span of all strains of mice ... caloric restriction begun in older mice – both in DBA and leaner C57 individuals – actually shortened life span"
  • Both Major Theories About Human Cellular Aging Supported By New Research - Science Daily, 12/30/08 - "old age is the final stage of a developmental program AND the result of a lifelong accumulation of unrepaired cellular and molecular damage ... When fatty acids build up, yeast cells explode from within, scattering their contents and spreading inflammation to neighboring cells ... In addition to cell death, the accumulation of fatty acids sets off chemical reactions that ultimately produce a lipid called diacylglycerol, which impairs many of the yeast's stress response-related defenses ... Low-calorie diets, which have been shown to increase lifespan and delay age-related disorders in nonhuman primates and other organisms, altered the way fats were processed in the yeast cells"
  • Why Starving Cells Prolong Life - Science Daily, 10/13/08
  • Differences Between People And Animals On Calorie Restriction - Science Daily, 9/24/08 - "In the majority of the animal models of longevity, extended lifespan involves pathways related to a growth factor called IGF-1 (insulin-like growth factor-1), which is produced primarily in the liver. Production is stimulated by growth hormone and can be reduced by fasting or by insensitivity to growth hormone. In calorie-restricted animals, levels of circulating IGF-1 decline between 30 percent and 40 percent ... For years, we have been following a cohort of people from the CR Society who have been on long-term calorie restriction. We found no difference in IGF-1 levels between people on calorie restriction and those who are not ... The CR Society members, who call themselves CRONies (Calorie Restriction with Optimal Nutrition), had been on a calorie-restriction diet for an average of seven years when Fontana did the measurements, but their IGF-1 levels were virtually identical to sedentary people who ate a standard, Western diet ... there are two major influences on IGF-1 levels: calorie intake and protein intake ... His team has been following a population of strict vegans for several years. They tend to eat less protein than the CRONies from the CR Society, so he compared IGF-1 levels between the two groups ... The vegans had significantly less circulating IGF-1 ... The strict vegans took in about 10 percent of their total calories from protein, whereas those on calorie restriction tended to get about 23 or 24 percent of calories from protein ... If our research is on the right track, maybe humans don't need to be so calorie restricted. Limiting protein intake to .7 or .8 grams per kilogram per day might be more effective"
  • Cutting Calories Could Limit Muscle Wasting In Later Years - Science Daily, 9/16/08 - "The researchers found increasing amounts of iron in the muscle cells of aging rats fed a typical unrestricted diet. The older the rats got, the more iron accumulated in the mitochondria and the more damage was done to its RNA and DNA. Rats of the same ages that were kept on a calorie-restricted diet — about 60 percent of the food typically ingested — seemed to maintain more normal iron levels in mitochondria"
  • Looking For The Fountain Of Youth? Cut Your Calories, Research Suggests - Science Daily, 7/3/08 - "While scientists do not know how calorie restriction affects the aging process in rodents, one popular hypothesis is that it slows aging by decreasing a thyroid hormone, triiodothyronine (T3), which then slows metabolism and tissue aging" - All the studies I've read seem to support the opposite:
  • Substance In Red Wine, Resveratrol, Found To Keep Hearts Young - Science Daily, 6/4/08 - "Resveratrol is active in much lower doses than previously thought and mimics a significant fraction of the profile of caloric restriction at the gene expression level ... In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study's authors, were associated with prevention of the decline in heart function associated with aging" - See resveratrol at Amazon.com.
  • Low-dose resveratrol may slow ageing: for mice at least - Nutra USA, 6/4/08 - "animals in the calorie-restriction and low-dose resveratrol groups had altered gene expression profiles in 90 and 92 per cent, respectively, in the heart ... In short, a glass of wine or food or supplements that contain even small doses of resveratrol are likely to represent "a robust intervention in the retardation of cardiac ageing,"" - See resveratrol at Amazon.com.
  • Red wine may protect heart from aging’s toll - MSNBC. 6/3/08 - "Resveratrol at low doses can retard some aspects of the aging process, including heart aging, and it may do so by mimicking some of the effects of caloric restriction, which is known to retard aging in several tissues and extend life span" - See resveratrol products at iHerb.
  • When It Comes To Living Longer, It's Better To Go Hungry Than Go Running, Mouse Study Suggests - Science Daily, 5/14/08 - "at least two studies which examined people who engage in high-volume exercise versus people who restricted their calorie intake, had a similar outcome: caloric restriction has physiological benefits that exercise alone does not ... One theory is that exercise places stress on the body, which can result in damage to the tissues and DNA. Another theory is that caloric restriction leads to physiological changes which benefit the body" - I still think it boils down to the ravages of higher insulin and blood sugar which increase advanced glycation end products a major cause of aging.
  • How Dietary Restriction Slows Down Aging - Science Daily, 4/17/08
  • Severely restricting calories could lead to longer life - Nutra USA, 10/30/07
  • Severely Restricted Diet Linked To Physical Fitness Into Old Age - Science Daily, 10/25/07
  • Eat Less To Live Longer: Calorie Restriction Linked To Long Healthy Lives - Science Daily, 9/20/07
  • Dietary Restriction Cleans Cells - Science Daily, 8/23/07
  • Eat Less, Live Longer? Gene Links Calorie Restriction To Longevity - Science Daily, 5/2/07
  • Dogs Lived 1.8 Years Longer On Low Calorie Diet: Gut Flora May Explain It - Science Daily, 4/19/07
  • How Eating Less Might Make You Live Longer - Science Daily, 3/5/07 - "even short-term caloric restriction can produce beneficial physiological changes leading to improved health. Whether caloric restriction and the associated health benefits can be sustained over longer term remains to be established in humans"
  • Body Composition May Be Key Player In Controlling Cancer Risks - Science Daily, 1/3/07 - "This study suggests that body composition, being lean as opposed to being obese, has a greater protective effect against cancer"
  • Weight Loss From Calorie Restriction Decreases BMD in Older Adults - Medscape, 12/13/06 - "weight loss from calorie restriction produced significant decreases in bone-mineral density (BMD) in older adults"
  • One for the Ages: A Prescription That May Extend Life - New York Times, 10/31/06 - "One leading candidate, a newly synthesized form of resveratrol — an antioxidant present in large amounts in red wine — is already being tested in patients. It may eventually be the first of a new class of anti-aging drugs. Extrapolating from recent animal findings, Dr. Richard A. Miller, a pathologist at the University of Michigan, estimated that a pill mimicking the effects of calorie restriction might increase human life span to about 112 healthy years ... Some researchers have even described Type 2 diabetes, which is marked by insensitivity to the hormone insulin, as simply an accelerated form of aging"
  • Calorie Restriction without Hunger! - Life Extension Magazine, 7/06 - "excess insulin functions as a death hormone that devastates virtually every cell and organ system in the body"
  • Calorie Restriction May Prevent Alzheimer's Through Promotion Of Longevity Program In The Brain - Science Daily, 6/14/06 - "a high caloric intake based on saturated fat promotes AD type beta-amyloidosis, while caloric restriction based on reduced carbohydrate intake is able to prevent it"
  • Metabolic Benefits of Calorie Restriction - Medscape, 6/12/06 - "A total of 48 overweight but otherwise healthy adults (body-mass index, 25-30 kg/m2; mean age, 38) were assigned to one of four groups: weight maintenance, 25% calorie restriction, 12.5% calorie restriction plus exercise, or very low calorie intake (890 calories daily until weight was reduced by 15%) ... At 6 months, all three intervention groups showed significant weight loss (10%-14% of baseline weight), as well as significant reductions in fasting insulin levels and DNA damage"
  • Calorie Restriction Appears Better Than Exercise At Slowing Primary Aging - Science Daily, 5/31/06 - "Sedentary rats who ate a standard diet had the shortest average life-spans," Holloszy says. "Those who exercised by running on a wheel lived longer, but animals on calorie restriction lived even longer"
  • Trim Calories for Healthier Aging? - WebMD, 5/10/06
  • Cutting Calories Slightly Can Reduce Aging Damage - Science Daily, 5/8/06 - "feeding rats just 8 percent fewer calories a day and moderately increasing the animals' activity extended their average lifespan and significantly overturned the negative effects of cellular aging on liver function and overall health ... the study results support the theory that cell death and aging-related organ damage are caused by unstable molecules known as free radicals and by cellular oxidation and inflammation"
  • Big Study Looks at Longevity-Low Calorie Link - Intelihealth, 4/26/06
  • Thinner And Younger - Science Daily, 4/5/06
  • Calorie Restriction May Improve Biomarkers of Longevity - Medscape, 4/4/06
  • Cut Calories, Boost Longevity? - WebMD, 4/4/06 - "By the study's end, fasting insulin and DNA damage had dropped for all participants whose calories had been limited, but not for the comparison group"
  • Starve Yourself to Live Longer? - ABC  News, 4/4/06 - "the decreased body temperature and insulin levels are particularly important in this study because they are good indicators of increased longevity and are often referred to as the biomarkers of longevity"
  • Low-Cal Diet May Slow Heart's Aging - WebMD, 1/17/06
  • Caloric Restriction Appears to Prevent Primary Aging in the Heart - Doctor's Guide, 1/12/06 - "This decline in diastolic function is a marker of primary aging ... Diastolic function declines in most people as they get older, but in this study we found that diastolic function in calorie-restricted people resembled diastolic function in individuals about 15 years younger ... Our hypothesis is that low-grade, chronic inflammation is mediating primary aging"
  • Researchers Find Pathways Linking Caloric Restriction To Aging Process - Science Daily, 11/18/05
  • Bare-minimum diet: Is long life the payoff? - USA Today, 10/23/05 - "very low-calorie diet seems to shield these animals from type 2 diabetes, a common disease of old age ... The average blood pressure for people on the diet was 100/60 — about what is expected for an average 10-year-old ... mice on the diet, which provides food at near-starvation levels, appear cranky. "If you take the lid off the cage, they immediately bite you,""
  • How Cutting Calories May Increase Longevity - WebMD, 10/13/05 - "mice that were fed 30% to 40% fewer calories produced more nitric oxide than those who followed an unrestricted diet"
  • Extremely Low-Calorie Diet Won't Extend Life - WebMD, 8/30/05
  • Caloric Restriction Won't Dramatically Extend Life Span In Humans: UCLA Research - Science Daily, 8/30/05
  • Eat less for a healthier life - MSNBC, 5/6/05 - "Laboratory studies show that calorie restriction can lead to fewer and smaller breast cancers. It also appears to inhibit all cancers by slowing down the development of cancer cells, increasing their self-destruction and reducing DNA damage"
  • Do Carbs, Calories Affect Alzheimer's Risk? - WebMD, 1/13/05 - "mice eating fewer calories and carbohydrates than those allowed to eat all they wanted showed no signs of Alzheimer's-like disease, even though they had been bred to have the condition"
  • Riverside Professor Receives First Age-Reversal Prize - Science Daily, 1/7/05 - "According to Spindler's research, the fewer calories an animal consumes - provided malnutrition is avoided - the slower an animal ages and the lower the death rate from cancer, heart disease and diabetes"
  • Caloric Restriction and Life Expectancy - Medscape, 12/22/04
  • Cutting Calories May Cut Parkinson's Risk - Doctor's Guide, 13/13/04
  • Save Up Your Energy Reserves For A Longer Life! - Science Daily, 12/10/04
  • Calorie Restriction Lowers Heart Risk - WebMD, 4/19/04
  • Calorie Restriction Prolongs Life, Even Late - WebMD, 3/23/04
  • Study: Low-Calorie Diet Extends Life - Intelihealth, 3/23/04
  • Restricting calories may increase life span - MSNBC, 3/22/04 - "a strict, low-calorie diet increased the life span of aged mice by more than 40 percent ... the new research shows that even 19-month-old mice, about the human equivalent of 60 to 65 years, can have a longer life when eating fewer calories"
  • Restrict Calories, Live Longer? - WebMD, 12/31/03
  • Eat Less to Live Longer? - Dr. Weil, 12/29/03
  • Fasting Benefits Glucose Metabolism, Nerve Cells - Physician's Weekly, 7/28/03 - "skipping meals frequently can help mice maintain healthier glucose and insulin levels ... when mice were given a neurotoxin mimicking the effects of Alzheimer's in humans, the subjects on the intermittent fasting diet were more resistant to nerve damage or death than mice with unlimited or reduced calorie diets ... mice on the fasting regimen were more likely to produce the protein BDNF, which protects the growth and health of nerve cells"
  • BioMarker Pharmaceuticals Develops Anti-Aging Therapy - Life Extension Magazine, 6/03 - "The BioMarker scientists found that all the glucoregulatory agents reproduced some of the gene expression effects of CR [calorie restriction], but that metformin was the undisputed star of the group, being twice as effective as the others in reproducing the effects of CR"
  • Skipping Meals Keeps Rodents Healthy - WebMD, 4/28/03
  • Survival to 90 Years Linked to Low Weight in Young Adulthood and Exercise - Doctor's Guide, 4/8/03 - "baseline height and weight were not associated with mortality. However, a higher weight at age 21 was associated with increased odds of dying before reaching 90 years (OR=1.04 per 5 lb increase, P 0.0001). Those who exercised were 24-31% less likely to die by the age of 90 (OR=0.76, P 0.0001 for less than 1 hour per day, OR=0.69, P 0.0001 for 1 hour or more per day). Similarly, being in the mid tertile of BMI at baseline (22-24 for men, 20-23 for women) was associated with decreased odds of dying before age 90 (OR=0.70, P 0.0001)"


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