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Conditions > Atrial Fibrillation
Atrial Fibrillation/Cardiac Arrhythmia
Vitamin D Status at ICU
Admission May Predict A-Fib and Bedsores - Medscape, 2/28/17 -
"Patients with Vitamin D levels below 20 ng/mL were
nearly four times as likely to develop new-onset atrial fibrillation, with an
odds ratio of 3.59 (95% CI, 1.01–12.70). On regression analysis, the risk for
the condition decreased by 15% for each unit increase in vitamin D ... A second
study of 402 surgical ICU patients found that 11 percent developed
hospital-acquired pressure ulcers. Patients with vitamin D levels below 20 ng/mL
were more than twice as likely to develop the ulcers (OR 2.51; 95% CI,
1.06–5.97). On regression analysis, the risk of ulcers fell by 11% with each
unit increase in vitamin D" - See
vitamin D at Amazon.com.
C may decrease risk of atrial fibrillation after cardiac surgery - Science
Daily, 2/1/17 - "The single study on the recurrence of
AF after a successful cardioversion, which was carried out in Greece, found that
vitamin C decreased the risk of AF recurrence by 87% ... In the non-US cardiac
surgery trials, vitamin C decreased the length of hospital stay by 12.6% and
intensive care unit stay by 8.0% ... Oral administration of vitamin C decreased
the occurrence of post-operative AF by 73%, whereas intravenous administration
decreased it by 36%. On the other hand, oral administration shortened the length
of hospital stay by only 7% (0.4 days), whereas intravenous administration
decreased it by 16% (1.5 days). Thus, the effect of intravenous vitamin C
administration was greater for the length of hospital stay, but less for the
occurrence of post-operative AF" - See
American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
Metformin and Lower AF Risk
Among Patients With T2DM - Medscape, 10/13/14 -
"After adjusting for co-morbidities and medications, metformin independently
protected the diabetic patients from new-onset AF with a hazard ratio of .81
(95% confidence interval 0.76–0.86, p < 0.0001). Metformin significantly
decreased the extent of pacing-induced myolysis and the production of reactive
oxygen species" - [Abstract]
metformin at IAS.
curve revealed for association between fish consumption and atrial fibrillation
- Science Daily, 6/24/13 - "The study found a U-shaped
association between consumption of marine n-3 polyunsaturated fatty acids (n-3
PUFA) and the risk of developing AF, with people who have both low and high
intakes found to suffer more from AF than those with median intakes. The lowest
risk of AF was found in those who consumed around 0.63 g marine n-3 PUFA per
day, which corresponds to around two servings of fatty (oily) fish per week ...
Earlier studies have reported that regular consumption of fish can exert
beneficial effects in preventing the development of AF. Notably, in the
Cardiovascular Health study², which included 4,815 participants, a 28% lower
risk of AF was observed among people who consumed fish one to four times per
week compared with those who ate fish less than once per month. However, such
observed associations have not been confirmed in all cohort studies"
CKD and Low
Magnesium: Pay Attention - Medscape, 2/6/13 - "When
adjusted for differences in age and sex among quartiles, the lowest magnesium
group had the highest incidence of new atrial fibrillation events (9.4 episodes
per 1000 person-years). The rates for the other 3 quartiles were quite similar
(6.9, 7.1, and 6.3 events per 1000 person-years for the second, third, and
fourth quartiles, respectively). In multivariable models controlled for the
multiple potential differences including glomerular filtration rate, those with
the lowest levels of magnesium continued to be at highest risk for the
development of atrial fibrillation (hazard ratio, 1.48; 95% confidence interval,
1.02- 2.14; P = .04)" - See magnesium supplements at Amazon.com.
Magnesium and the Development of Atrial Fibrillation in the Community: The
Framingham Heart Study - Circulation. 2012 Nov 21 -
"We studied 3,530 participants (mean age, 44 years; 52% women) from the
Framingham Offspring Study who attended a routine examination, and were free of
AF and cardiovascular disease ... 20 years of follow-up ... The age- and
sex-adjusted incidence rate of AF was 9.4 per 1,000 person-years (95% confidence
interval, 6.7 to 11.9) in the lowest quartile of serum magnesium (≤1.77 mg/dl),
compared with 6.3 per 1,000 person-years (95% confidence interval, 4.1 to 8.4)
in the highest quartile (≥1.99 mg/dl). In multivariable-adjusted models,
individuals in the lowest quartile of serum magnesium were approximately 50%
more likely to develop AF (adjusted hazard ratio, 1.52, 1.00 to 2.31; P=0.05),
compared with those in the upper quartiles ... Because hypomagnesemia is common
in the general population, a link with AF may have potential clinical
implications" - See Jarrow
Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.
of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids with Incident Atrial
Fibrillation in Older Adults: The Cardiovascular Health Study - Circulation.
2012 Jan 26 - "In multivariable Cox models adjusted for
other risk factors, the RR in the top versus lowest quartile of total n-3 PUFA
(EPA+DPA+DHA) levels was 0.71 (95%CI=0.57-0.89, P-trend=0.004); and of DHA
levels, 0.77 (95%CI=0.62-0.96, P-trend=0.01). EPA and DPA levels were not
significantly associated with incident AF. Evaluated non-parametrically, both
total n-3 PUFA and DHA showed graded and linear inverse associations with
incidence of AF" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Dietary Fish Oil on Atrial Fibrillation After Cardiac Surgery - Am J
Cardiol. 2011 Jul 13 - "Two hundred patients were
randomized to receive fish oil (providing 4.6 g/day of long-chain ω-3 fatty
acids) or a control oil starting 3 weeks before surgery; 194 subjects completed
the study, with 47 of 97 subjects in the control group and 36 of 97 subjects in
the fish oil group developing AF (odds ratio 0.63, 95% confidence interval [CI]
0.35 to 1.11). There was a nonstatistically significant delay in time to onset
of AF in the fish oil group (hazard ratio 0.66, 95% CI 0.43 to 1.01). There was
a significant decrease in mean length of stay in the intensive care unit in the
fish oil group (ratio of means 0.71, 95% CI 0.56 to 0.90). In conclusion, in a
mixed cardiac surgery population, supplementation with dietary fish oil did not
result in a significant decrease in the incidence of postsurgical AF. However,
there was a significant decrease in time spent in the intensive care unit"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Slowing a Speedy Heart Rate? - Dr. Weil, 4/29/10
Influence of coffee and caffeine consumption on atrial fibrillation in
hypertensive patients - Nutr Metab Cardiovasc Dis. 2010 Feb 16 -
"Coffee and caffeine consumption influence
spontaneous conversion of atrial fibrillation. Normotensive non-habitual
coffee consumers are more likely to convert arrhythmia within 48h from the
onset of symptoms. Hypertensive patients showed a U-shaped relationship
between coffee consumption and spontaneous conversion of AF, moderate coffee
consumers were less likely to show spontaneous conversion of arrhythmia.
Patients with left ventricular hypertrophy showed a reduced rate of
spontaneous conversion of arrhythmia"
Omega-3 fatty acid
supplementation reduces one-year risk of atrial fibrillation in patients
hospitalized with myocardial infarction - Eur J Clin Pharmacol. 2008 Feb
29 - "N-3 PUFA reduced the relative risk of the
hospitalization for AF [hazard ratio (HR) 0.19, 95% CI 0.07-0.51] and was
associated with a further and complementary reduction in all-cause mortality
(HR 0.15, 95% CI 0.05-0.46)" - See Mega Twin EPA at Amazon.com.
the prevention of postoperative atrial fibrillation: a prospective,
randomized, placebo-controlled pilot study - Eur Heart J. 2008 Feb 8 -
"The result of this study indicates that NAC
treatment decreases the incidence of postoperative AF" - See
n-acetyl cysteine at Amazon.com.
Recurrence of Atrial Fibrillation Reduced With Alpha-Linolenic Acid-Enriched
Diet - Doctor's Guide, 10/17/07 - "The survival
rate was 25.52% in the control group versus 63.09% in the ALA group at the
end of the 12-month period" - Note: ALA is the shorter chain omega-3
found in vegetable sources such as flaxseed.
Fish Intake and Risk of Incident Atrial Fibrillation - Circulation. 2004
Jul 19 -
"Among elderly adults, consumption of tuna or other
broiled or baked fish, but not fried fish or fish sandwiches, is associated
with lower incidence of AF"
- Fish Containing N-3
Fatty Acids Reduce Risk of AF - Medscape, 7/19/04 -
"Intake of fatty fish containing N-3 fatty acids
reduces the risk of atrial fibrillation (AF), but fish sandwiches or fried
fish are not protective"
- See Mega Twin EPA at
Moderate alcohol use associated with increased risk for atrial fibrillation
- Science Daily, 7/14/14 - "Consistent with previous
research, the study found an association between high alcohol consumption,
defined as more than three drinks per day, and increased risk for atrial
fibrillation and a strong association with binge drinking ... the risk for
atrial fibrillation increased 8 percent with each additional drink per day"
Thyroid problems linked to irregular heart rhythm - Science Daily,
Moderate alcohol consumption may increase risk of atrial fibrillation in
people with heart disease - Science Daily, 10/1/12 -
"Moderate alcohol consumption was measured as one to
14 drinks a week for women and one to 21 drinks a week for men. Binge
drinking was classified as five or more drinks a day ... The incidence rate
of atrial fibrillation rose to 6.3% of the low intake group, 7.8% in the
moderate and 8.3% in the high intake groups"
Irregular Heart Rhythm Linked to Mental Problems - WebMD, 2/27/12 -
"More people with AF than without showed signs of
mental decline and had problems performing activities of daily living, such
as showering, dressing, and feeding themselves. They were also at greater
risk for being diagnosed with dementia than their AF-free counterparts"
Moderate-to-heavy alcohol intake may increase risk of atrial fibrillation
- Science Daily, 2/14/11
Better treatment of atrial fibrillation and its risks - Science Daily,
Cardiac procedure significantly reduces risk of Alzheimer's disease and
stroke, researchers find - Science Daily, 5/13/10 -
"patients with atrial fibrillation treated with
catheter ablation are less likely to develop Alzheimer's disease or other
forms of dementia, and have a significantly reduced risk of stroke and death
compared to A-fib patients with who are not treated with ablation"
People with diabetes are at higher risk of atrial fibrillation - Science
prevalence of atrial fibrillation found among cross-country skiers -
Science Daily, 2/9/10
Study: Ablation Beats Drugs for Atrial Fibrillation - WebMD, 1/26/10
Atrial Fibrillation Linked To An Increased Risk Of Death In Diabetic
Patients - Science Daily, 3/11/09
Low Testosterone Levels Associated With Lone Atrial Fibrillation in Men
- Medscape, 2/20/09 - "Mean testosterone levels in
men with lone AF were significantly lower than those in healthy controls,
the authors report, but mean estradiol levels did not differ significantly
between the 2 groups"
Surgeons Announce Advance In Atrial Fibrillation Surgery - Science
Reduced incidence of new-onset atrial fibrillation with angiotensin II
receptor blockade: the VALUE trial - J Hypertens. 2008 Mar;26(3):403-411
- "These findings suggest that angiotensin II
receptor blockers may result in greater benefits than calcium antagonists in
hypertensive patients at risk of new-onset AF"
Elevated IL-6 Levels Associated With Increased Atrial Fibrillation Risk
- Medscape, 2/26/08 - "a doubling of IL-6 level was
independently associated with a 49% increase in the odds of developing AF"
Focus On Atrial Fibrillation Recognizes Growing Importance Of Common
Arrhythmia - Science Daily, 2/18/08
Blood Pressure Or Irregular Heartbeat Linked To Alzheimer's Disease
Progression - Science Daily, 11/5/07 - "10 with
high blood pressure (systolic pressure over 160) at the time of AD diagnosis
showed a rate of memory loss roughly 100 percent faster than those with
normal blood pressure ... 10 with atrial fibrillation at the time of the
diagnosis showed a rate of memory decline that was 75 percent faster than
those with normal heartbeats"
Incidence of Atrial Fibrillation Significantly Reduced by Candesartan
Cilexetil Therapy in Heart Failure Patients - Doctor's Guide, 7/5/06
Dabigatran Etexilate Has Long-Term Safety and Efficacy in Patients With
Atrial Fibrillation - Doctor's Guide, 5/19/06
Taller People More Likely To Develop Atrial Fibrillation - Science
Magnetically Guided Catheter Zaps Atrial Fibrillation - Doctor's Guide,
Atrial Fibrillation Undertreated in the Elderly - Doctor's Guide,
One in Four Adults Over 40 Could Develop Irregular Heartbeat - Doctor's
Rate Control May Edge Out Rhythm Control For Atrial Fibrillation -
Doctor's Guide, 12/5/02
Simpler Way To Treat Abnormal Heart Beat - Intelihealth, 12/5/02
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