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Home > Anti-aging Research > papaverine, phentolamine, and alprostadil

Trimix (alprostadil plus papaverine plus phentolamine)

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  • Erectile Dysfunction - eMedicine - "Alprostadil, a synthetic PGE1, is the most common single agent used for intracavernosal injections. When combined with papaverine and Regitine, the mixture is called Trimix and it has roughly twice the efficacy of alprostadil alone. In one study of 683 men, 94% reported having erections suitable for penetration after alprostadil injections"
  • ABC of sexual health: Erectile dysfunction - bmj.com - "Triple therapy (a combination of papaverine, phentolamine, and alprostadil) is used for patients in whom individual drugs have failed"
  • Papaverine plus phentolamine plus alprostadil (trimix) - clinicalevidence.com - "a mix of alprostadil plus papaverine plus phentolamine (trimix) was more effective than intracavernosal alprostadil in producing erections in men who failed to get erections with bimix"
  • Erectile Dysfunction in Diabetes: Pills for Penile Failure - diabetes.org - "The commonly used mixture is alprostadil, papaverine, and phentolamine, referred to as trimix. Although urologists have used these drugs for a decade or more, the FDA only approved alprostadil for this use in 1995. While pain may be more frequent with alprostadil than with the mixture, the incidence of prolonged erection (5%) and priapism (1%) are rare and make it the drug of choice"
  • Treatment Options for Erectile Dysfunction in Patients Failing Oral DrugTherapy - corporate-ir.net
  • Doppler Evaluation of Erectile Dysfunction – Part 1 - Medscape, 1/9/07 - "Injection should always be made in the distal two-third part of the penis on one side only because of the presence of a septum in between the two corpora cavernosa in the proximal part of the penis, which is deficient distally, thus allowing bilateral perfusion of the injected vasoactive substance"


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