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Anti-aging Research >
Antidepressants & Psychotropics >
News & Research:
- Bad Taste Of Drugs May
Affect Treatment Compliance, Study Findings Suggest - Doctor's Guide,
"four tricyclic anti-depressants Schiffman and
Zervakis studied (clomipramine HCI, desipramine HCI, doxepin HCI and
imipramine HCI) produced similar taste complaints among all subjects"
- Clomipramine More
Effective Than Desipramine For Body Dysmorphic Disorder - Doctor's
Guide, 10/26/99 -
"Clomipramine at 25-75 mg was found to be
significantly more effective than placebo in reducing irritability as well
as other symptoms associated with PMDD"
- New Guidelines To Set
Standards For Best Treatment Of OCD - Doctor's Guide, 5/12/97 -
"Experts rated the side effects of the four SSRIs
(fluoxetine, fluvoxamine, paroxetine and sertraline) as generally better
tolerated than the one SRI, clomipramine"
Which antidepressants have demonstrated superior efficacy? A review
of the evidence - Int Clin Psychopharmacol. 2007
Nov;22(6):323-329 - "Criteria were defined
to judge the strength of evidence. Two pivotal studies in
moderate-to-severe major depressive disorder that demonstrate
superiority on the primary efficacy measure, or alternatively one
pivotal study supported by consistent results from meta-analyses,
was considered to constitute evidence for definite superiority.
Three antidepressants met these criteria: clomipramine, venlafaxine,
and escitalopram. Three antidepressants were found to have probable
superiority: milnacipran, duloxetine, and mirtazapine. Only
escitalopram was found to have definite superiority in the treatment
of severe depression; probable superiority was identified for
venlafaxine and possible superiority for milnacipran and clomipra"
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